LOCUS       NM_009197               4180 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus solute carrier family 16 (monocarboxylic acid
            transporters), member 2 (Slc16a2), mRNA.
ACCESSION   NM_009197
VERSION     NM_009197.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4180)
  AUTHORS   Valcarcel-Hernandez,V., Vancamp,P., Butruille,L., Remaud,S. and
            Guadano-Ferraz,A.
  TITLE     Combined deletion of Mct8 and Dio2 impairs SVZ neurogliogenesis and
            olfactory function in adult mice
  JOURNAL   Neurobiol Dis 199, 106572 (2024)
   PUBMED   38901782
  REMARK    GeneRIF: Combined deletion of Mct8 and Dio2 impairs SVZ
            neurogliogenesis and olfactory function in adult mice.
REFERENCE   2  (bases 1 to 4180)
  AUTHORS   Liu,Y., Ng,L., Liu,H., Heuer,H. and Forrest,D.
  TITLE     Cone photoreceptor differentiation regulated by thyroid hormone
            transporter MCT8 in the retinal pigment epithelium
  JOURNAL   Proc Natl Acad Sci U S A 121 (30), e2402560121 (2024)
   PUBMED   39018199
  REMARK    GeneRIF: Cone photoreceptor differentiation regulated by thyroid
            hormone transporter MCT8 in the retinal pigment epithelium.
REFERENCE   3  (bases 1 to 4180)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4180)
  AUTHORS   Salas-Lucia,F., Escamilla,S., Bianco,A.C., Dumitrescu,A. and
            Refetoff,S.
  TITLE     Impaired T3 uptake and action in MCT8-deficient cerebral organoids
            underlie Allan-Herndon-Dudley syndrome
  JOURNAL   JCI Insight 9 (7), e174645 (2024)
   PUBMED   38376950
  REMARK    GeneRIF: Impaired T3 uptake and action in MCT8-deficient cerebral
            organoids underlie Allan-Herndon-Dudley syndrome.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4180)
  AUTHORS   Hoen,E., Goossens,F.M., Falize,K., Mayerl,S., van der Spek,A.H. and
            Boelen,A.
  TITLE     The Differential Effect of a Shortage of Thyroid Hormone Compared
            with Knockout of Thyroid Hormone Transporters Mct8 and Mct10 on
            Murine Macrophage Polarization
  JOURNAL   Int J Mol Sci 25 (4), 2111 (2024)
   PUBMED   38396788
  REMARK    GeneRIF: The Differential Effect of a Shortage of Thyroid Hormone
            Compared with Knockout of Thyroid Hormone Transporters Mct8 and
            Mct10 on Murine Macrophage Polarization.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4180)
  AUTHORS   Dumitrescu,A.M., Liao,X.H., Weiss,R.E., Millen,K. and Refetoff,S.
  TITLE     Tissue-specific thyroid hormone deprivation and excess in
            monocarboxylate transporter (mct) 8-deficient mice
  JOURNAL   Endocrinology 147 (9), 4036-4043 (2006)
   PUBMED   16709608
REFERENCE   7  (bases 1 to 4180)
  AUTHORS   Friesema,E.C., Ganguly,S., Abdalla,A., Manning Fox,J.E.,
            Halestrap,A.P. and Visser,T.J.
  TITLE     Identification of monocarboxylate transporter 8 as a specific
            thyroid hormone transporter
  JOURNAL   J Biol Chem 278 (41), 40128-40135 (2003)
   PUBMED   12871948
REFERENCE   8  (bases 1 to 4180)
  AUTHORS   Boussouar,F., Mauduit,C., Tabone,E., Pellerin,L., Magistretti,P.J.
            and Benahmed,M.
  TITLE     Developmental and hormonal regulation of the monocarboxylate
            transporter 2 (MCT2) expression in the mouse germ cells
  JOURNAL   Biol Reprod 69 (3), 1069-1078 (2003)
   PUBMED   12773420
  REMARK    GeneRIF: Energy metabolism in the context of Sertoli cell-germ cell
            metabolic cooperation where lactate is produced in somatic cells
            and transported to germ cells occurs via monocarboxylate
            transporters.
REFERENCE   9  (bases 1 to 4180)
  AUTHORS   Chureau,C., Prissette,M., Bourdet,A., Barbe,V., Cattolico,L.,
            Jones,L., Eggen,A., Avner,P. and Duret,L.
  TITLE     Comparative sequence analysis of the X-inactivation center region
            in mouse, human, and bovine
  JOURNAL   Genome Res 12 (6), 894-908 (2002)
   PUBMED   12045143
REFERENCE   10 (bases 1 to 4180)
  AUTHORS   Debrand,E., Heard,E. and Avner,P.
  TITLE     Cloning and localization of the murine Xpct gene: evidence for
            complex rearrangements during the evolution of the region around
            the Xist gene
  JOURNAL   Genomics 48 (3), 296-303 (1998)
   PUBMED   9545634
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ177309.1, CX218841.1, BM935188.1 and BC080678.1.
            
            On Aug 17, 2006 this sequence version replaced NM_009197.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC080678.1, AB265788.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                CJ177309.1         1-64
            65-758              CX218841.1         1-694
            759-1046            BM935188.1         272-559
            1047-4180           BC080678.1         883-4016
FEATURES             Location/Qualifiers
     source          1..4180
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 46.29 cM"
     gene            1..4180
                     /gene="Slc16a2"
                     /gene_synonym="Mct8; Xpct"
                     /note="solute carrier family 16 (monocarboxylic acid
                     transporters), member 2"
                     /db_xref="GeneID:20502"
                     /db_xref="MGI:MGI:1203732"
     exon            1..634
                     /gene="Slc16a2"
                     /gene_synonym="Mct8; Xpct"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..1824
                     /gene="Slc16a2"
                     /gene_synonym="Mct8; Xpct"
                     /note="X-linked PEST-containing transporter; solute
                     carrier family 16 member 2; MCT 8; Monocarboxylate
                     transporter 8 (MCT 8) (X-linked PEST-containing
                     transporter)"
                     /codon_start=1
                     /product="monocarboxylate transporter 8"
                     /protein_id="NP_033223.2"
                     /db_xref="CCDS:CCDS30330.1"
                     /db_xref="GeneID:20502"
                     /db_xref="MGI:MGI:1203732"
                     /translation="MALPSPASEEAEGPCQEANQEYQEPVCSPVPEPEPEPEPEPEPD
                     PEPVPVPPPEPQPEPEPQPLPDPAPLPELGFEAEPVQEPEPTPTVETRGTARGFQPPE
                     GGFGWIVVFAATWCNGSIFGIHNSVGILYSMLLEEEKEKNRQVEFQAAWVGALAMGMI
                     FFCSPIVSIFTDRLGCRITATTGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFA
                     FQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIKMLGDKIKLAQTFQVLSTFM
                     FVLTLLSLTYRPLLPSSQDTPSKRGAHTLRQRFLVQFRKYFNMRVFRQRTYRIWAFGI
                     AAAALGYFVPYVHLMKYVEDKFKEIKETWVLLVCIGATSGLGRLVSGHISDSIPGLKK
                     IYLQVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQA
                     SQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAVILFFVPLMHQ
                     RMFKKEQRDSSKDKMLSHDPDPNGELLPGSPTPEEPI"
     exon            635..779
                     /gene="Slc16a2"
                     /gene_synonym="Mct8; Xpct"
                     /inference="alignment:Splign:2.1.0"
     exon            780..1230
                     /gene="Slc16a2"
                     /gene_synonym="Mct8; Xpct"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1374
                     /gene="Slc16a2"
                     /gene_synonym="Mct8; Xpct"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1603
                     /gene="Slc16a2"
                     /gene_synonym="Mct8; Xpct"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..4157
                     /gene="Slc16a2"
                     /gene_synonym="Mct8; Xpct"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4138..4143
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc16a2"
                     /gene_synonym="Mct8; Xpct"
                     /note="hexamer: AATAAA"
     polyA_site      4157
                     /gene="Slc16a2"
                     /gene_synonym="Mct8; Xpct"
                     /note="major polyA site"
ORIGIN      
        1 gagagggctt gaggggaccg tctgtcgcgg gacaggctgg ccagctcggg cgctgggagg
       61 aggaggaggc agggtctcag gcagccgcgg cggcagtgct cggagcggca ggagcagtag
      121 cagcagaaac aagtaccagc cagacaacag ctcctccggc aagccacagt cagtccccta
      181 gccgcgatgg cgctgccaag cccggcgagc gaggaagctg aggggccctg tcaggaggca
      241 aaccaggaat atcaggagcc ggtgtgtagt cctgtgcccg agccggagcc agagccggag
      301 cccgaaccgg agcctgaccc cgagccggtg ccagtgcccc cgcccgagcc tcagcctgag
      361 cccgagcccc agcccctacc cgatcctgca cccctgccgg agctgggctt tgaggctgag
      421 ccagtgcaag aacccgagcc cacgcccact gtggaaaccc gaggcaccgc gcgtggcttt
      481 cagcctcccg aaggtggctt cggctggata gtggtgtttg cagccacctg gtgcaacggc
      541 tccatcttcg gcatccataa ctctgttggt atcctctact ccatgctact agaggaggaa
      601 aaagagaaaa atcgccaagt ggagttccaa gcagcatggg tcggagccct cgctatgggc
      661 atgatcttct tctgttctcc cattgtgagt atattcactg accgtttggg ctgccgaatc
      721 acagccacca ccggggccgc tgttgctttc attggcctcc acaccagctc cttcaccagc
      781 tccctaagcc tgcgctactt cacctatggg attctgtttg gttgtggctg ctcattcgcc
      841 tttcaaccat cactcgtcat cctgggccac tactttcaac gtcgcctagg tctagccaat
      901 ggtgtggtat ctgctggaag tagcatcttc tccatgtctt ttcccttcct catcaaaatg
      961 ctgggggata aaatcaagct ggcccaaacc ttccaggtgc tgagtacctt catgtttgtc
     1021 cttacgctgc tctcactcac ttaccggccc ctcctgccaa gctcccagga caccccaagc
     1081 aagagaggtg cccacaccct gcgacagcgc tttctggttc agttcagaaa gtacttcaac
     1141 atgcgtgtat tccgccagcg cacttaccgt atctgggcct ttgggatcgc tgctgctgcc
     1201 cttggttact tcgtccccta cgtgcacctg atgaaatatg tggaagataa gttcaaggag
     1261 atcaaggaga cctgggtgct cttggtgtgc attggggcta cgtcaggcct cggacgtctc
     1321 gtctcgggcc acatcagtga ctccatccct ggacttaaga agatatactt gcaggtcctc
     1381 tcattcctgc tcctgggctt gatgtccatg atgatccccc tatgccggga cttcgggggc
     1441 cttatcgttg tctgcctctt cctgggccta tgtgatggct tcttcattac catcatggct
     1501 cccattgcat ttgagctggt gggacccatg caggcctcac aggccattgg ctacctcctg
     1561 ggcatgatgg ccctgccaat gattgctggg ccccccattg caggcctcct tcgaaactgc
     1621 tttggtgatt accatgtggc cttctacttt gcgggtgtcc ccccaatcat tggagctgtg
     1681 atccttttct tcgtccctct gatgcatcaa aggatgttta agaaagagca gagagattcc
     1741 agcaaggata agatgctgtc ccacgatcca gaccccaacg gagaactgct gccaggctcc
     1801 ccaacacctg aagagcccat ttaatgcctc tgtcttgcca ttgtgtgctc cttccccccc
     1861 ccactccacc cctcatccta ccctgcttag catttacatt ttttgccacc agcacacttg
     1921 ttcccaaacc tgtgcacaca gcatttcagc cacctgacca tctcctctga gccaatgctc
     1981 tcggtgttcc aaactcatta accaaattct ccccatgaat gccttgaaac ttgccaggct
     2041 cttctcccag aatctgggaa agtgtgggat caccccctgg cctttggatc ctcccccata
     2101 tatactttct aactctttgc ggggaggaca gggatgggat ctctagcccc agattgttag
     2161 tcacccacta caatcaattg ccaaaggtgc tactgtgtcc ccagaaccca gtgagacaga
     2221 cctaagcctc tgtttgctga ggaatttgtt gccatccatc cttgggaacc atttgggaat
     2281 tgtgagaagg aaggccaaag gagaccagga gccttgtttt gcatcgaagc tcctgaggac
     2341 tctgcggcac cccatcatat ggttggttag ccgtctgctt cccttttcct ttcctagtat
     2401 tttctctcta cttcctcttc tccgatttct tcccctctat tcctttttat tagtgtcatg
     2461 acacataggt gcttggagaa aggaaagacc cagagcttgg gccaatccac ttcattctga
     2521 cccagaccat ccctaatatt agcattaata ctgctcatct caggttgagc tacatctcac
     2581 tttctgggct caaactgata tggactggaa gagcaggcta tcgcataggg atgggaatct
     2641 tcaacactac agagttccat gtaccagtca ctgattttga cagattaacc aagaggcctt
     2701 cccagtttcc catccttccc acctgtcaaa tgtgaagaaa ctcttctcat ctcatgaaac
     2761 acaggaggaa agatgtcagt gcactggcat tagaggagat gctacggtta acggtttggg
     2821 gaaggaccaa ctcctccgtc tctcattttt cataagaggt caatatttcc acctgggcca
     2881 ggccaagaaa tgaactgctt taaggaaaaa aaaaaaaaaa acctcattct gtacctggat
     2941 ctccaaatga cataggcaac aactgcacgt aggggttgga taatttcttt tcagaagggg
     3001 aagccaccct agcctttacc acccacccag tctgtccccc attctaggca tcctggacca
     3061 ctctgctgag tgggcattat aggtgccaga aaaagtaggc tctggaccac catcatccct
     3121 ttgaagttgg tgccagatat tttcctacat ccaggctctg ggcaacagtc ttactgaagc
     3181 acattccaag tgcccctggc cagaggcaaa gggcactgcc agcctcgtcc agttgtacgg
     3241 ctcacctcat tagggactca gcctctctcc tccctgtttc tctctctctg tctttgttta
     3301 ttgtgttcct gtaccaacct tttatcatct ttttgccagg catcctggct gttacttgga
     3361 cccaacaata acttgccacc ccaagctagg gtcatcccaa ggccaggaag atgaggttgc
     3421 tctgaggggc tccaaagaat acaatggtcc ccacacatga gtttttccgt tactaacagg
     3481 cagctggggc atagttggcc tctgatgttt cattcaaggc caaagtcctg agcccccctc
     3541 tgctggtccc aatccagctc ttatcaactc cccaaaggaa aacccattgg ttcttggctc
     3601 tgaggacagg aaggggtgga gtcactgtcc tgtcaactca agcatctatg gaacaggaga
     3661 agctgggccc caggagccct gcgactccca ggagaggcca ttgaaaatac tgaagcaaca
     3721 atgcttccac ttccatttct ccttacccca ccccctccag gccacttagg gggtaggggg
     3781 cagaataagt gtgcagggcc tcctttgttg ctcatggctg gacagctcta aagagtcagg
     3841 ctgccactca cttctctcca gatgatggaa agacattcac aggtcccaga tctgcccatt
     3901 caggtgtcac ctaacattgg cagggtgtca atttactttt ttatttttca caaatgcgtg
     3961 tgtgcacgtg tgggcttgtg tgctttccga gagaatgttg tttggccaaa gcagcacagt
     4021 attaatattt agagtaggaa gcagcctctt aggtaccaca gttaaaaact aagagaacga
     4081 acaaaatttc agagcttgag acctgggaca tttaaatcct caaggggttt ggaacaaaat
     4141 aaacagatct aaatgtcaaa aaaaaaaaaa aaaaaaaaaa
//
