LOCUS       NM_172838               4092 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus solute carrier family 16 (monocarboxylic acid
            transporters), member 12 (Slc16a12), mRNA.
ACCESSION   NM_172838
VERSION     NM_172838.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4092)
  AUTHORS   Dhayat,N., Simonin,A., Anderegg,M., Pathare,G., Luscher,B.P.,
            Deisl,C., Albano,G., Mordasini,D., Hediger,M.A., Surbek,D.V.,
            Vogt,B., Sass,J.O., Kloeckener-Gruissem,B. and Fuster,D.G.
  TITLE     Mutation in the Monocarboxylate Transporter 12 Gene Affects
            Guanidinoacetate Excretion but Does Not Cause Glucosuria
  JOURNAL   J Am Soc Nephrol 27 (5), 1426-1436 (2016)
   PUBMED   26376857
REFERENCE   2  (bases 1 to 4092)
  AUTHORS   Castorino,J.J., Gallagher-Colombo,S.M., Levin,A.V.,
            Fitzgerald,P.G., Polishook,J., Kloeckener-Gruissem,B., Ostertag,E.
            and Philp,N.J.
  TITLE     Juvenile cataract-associated mutation of solute carrier SLC16A12
            impairs trafficking of the protein to the plasma membrane
  JOURNAL   Invest Ophthalmol Vis Sci 52 (9), 6774-6784 (2011)
   PUBMED   21778275
  REMARK    GeneRIF: a model whereby the SLC16A12 (c.643C>T) mutation causes
            juvenile cataract by a defect in protein trafficking rather than by
            haploinsufficiency.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125259.8 and AC016791.23.
            
            On Jul 25, 2018 this sequence version replaced NM_172838.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029076.1, AK028284.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-263               AC125259.8         65874-66136
            264-511             AC016791.23        139274-139521       c
            512-615             AC016791.23        128918-129021       c
            616-759             AC016791.23        125914-126057       c
            760-1339            AC016791.23        123437-124016       c
            1340-1599           AC016791.23        121066-121325       c
            1600-4092           AC016791.23        117031-119523       c
FEATURES             Location/Qualifiers
     source          1..4092
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 29.79 cM"
     gene            1..4092
                     /gene="Slc16a12"
                     /gene_synonym="3230401A21; MCT 12"
                     /note="solute carrier family 16 (monocarboxylic acid
                     transporters), member 12"
                     /db_xref="GeneID:240638"
                     /db_xref="MGI:MGI:2147716"
     exon            1..263
                     /gene="Slc16a12"
                     /gene_synonym="3230401A21; MCT 12"
                     /inference="alignment:Splign:2.1.0"
     exon            264..511
                     /gene="Slc16a12"
                     /gene_synonym="3230401A21; MCT 12"
                     /inference="alignment:Splign:2.1.0"
     CDS             402..1862
                     /gene="Slc16a12"
                     /gene_synonym="3230401A21; MCT 12"
                     /codon_start=1
                     /product="monocarboxylate transporter 12"
                     /protein_id="NP_766426.1"
                     /db_xref="CCDS:CCDS29767.1"
                     /db_xref="GeneID:240638"
                     /db_xref="MGI:MGI:2147716"
                     /translation="MTKITRVSLASPPDGGWGWMIVAGCFLVTICTRAVTRCISIFFV
                     EFQTYFAQDYSQTAWIHSIVDCMTMLCAPLGSVVSNQLSCQAGIMLGGLLASTGFILG
                     SFATSLKHLYLSLGVLTGLGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFIL
                     APVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRPITLKEDRSVPEKNHNRESQRED
                     CKQASPYSPLTKECTETRLCCSLQQEYGFLLMSDFVVLAVSVLFMAYGCSPLFVYLVP
                     YALSVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKNYRYVCYLFAVALDGLCY
                     LCLPMLQTFPLLVPFSCTFGYFDGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPY
                     LVSPPIAGWLVDTTGSYTAAFLLCGFAMIFSSILLGFVRIVKRMKRTQVPFPVKDSDP
                     KLQLWTNGSVAYSVARELDQKDEEPLPKARSGCNLT"
     exon            512..615
                     /gene="Slc16a12"
                     /gene_synonym="3230401A21; MCT 12"
                     /inference="alignment:Splign:2.1.0"
     exon            616..759
                     /gene="Slc16a12"
                     /gene_synonym="3230401A21; MCT 12"
                     /inference="alignment:Splign:2.1.0"
     exon            760..1339
                     /gene="Slc16a12"
                     /gene_synonym="3230401A21; MCT 12"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1599
                     /gene="Slc16a12"
                     /gene_synonym="3230401A21; MCT 12"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..4092
                     /gene="Slc16a12"
                     /gene_synonym="3230401A21; MCT 12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4068..4073
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc16a12"
                     /gene_synonym="3230401A21; MCT 12"
                     /note="hexamer: AATAAA"
     polyA_site      4092
                     /gene="Slc16a12"
                     /gene_synonym="3230401A21; MCT 12"
                     /note="major polyA site"
ORIGIN      
        1 gacaaagccc gtccgccggc agggcagagt caccctcggg gctgcggtga ctgagagctt
       61 tgcttctccg gggcggggcg gtgggatctc cctagtgaca gtgtccggcg ggcgctgcct
      121 gcgggccccg gcccctacgg cgcctccgcc ctgtgcgctc ctccgcccct cagccgggac
      181 cggactccag agccgtggga aggggccgcc gcgaagggga catgtgggct cgccgtcgcc
      241 agcgttgcag ctgtccccgc gagatgggca gtaaccccta tgccaggtag catcctgcac
      301 caactttgac tatcaacagg aagttactgg gtagcgaaca ctcaagatca caacttactg
      361 ctgcagtaac ttggaaagag aagaaaacca gaattgaaac catgacgaag ataactagag
      421 tcagcttggc atcccctcca gatggaggct ggggctggat gatagtggcc ggctgcttcc
      481 ttgttaccat ctgcacccgg gcagtcacca gatgtatctc catatttttt gtggagtttc
      541 agacatactt tgctcaggat tactcccaaa cagcatggat ccattccatt gtagactgta
      601 tgacaatgct ctgtgctccg cttgggagtg ttgtcagtaa ccagttatcc tgtcaagcgg
      661 ggatcatgct gggtggcttg ctggcatcta ctggtttcat cctgggctca tttgccacca
      721 gcttgaagca cctctacctc agcctgggag ttcttacagg tcttggattt gcactttgtt
      781 actctccggc aattgccatg gtgggcaagt atttcagcag acggaaagcc ctggcttatg
      841 ggattgccat gtcaggcagt ggcattggta ccttcatcct ggctcctgtc gttcagctcc
      901 tcatcgaaca gttttcctgg cgaggagcac tgctcattct tggcgggttc gttctgaatc
      961 tctgcgtctg cggcgctctg atgcgtccaa ttacccttaa agaggaccga tcagtcccag
     1021 aaaagaatca caaccgtgaa tctcagcgag aagactgtaa gcaagcatct ccctattcac
     1081 ctttgaccaa agaatgtaca gagacccgtc tttgctgctc cttgcagcag gaatacggtt
     1141 ttttactgat gtcagacttc gtcgtgttgg ccgtctctgt tctgttcatg gcctacggct
     1201 gcagccctct ctttgtgtac ctagtgcctt atgctttgag tgtcggagtg agccaccatc
     1261 aagctgcttt cctcatgtcc atcctcgggg taatcgatat tgttggcaat atcacatttg
     1321 gctggctaac tgacagaagg tgtctgaaga attaccgata tgtttgctac ctctttgccg
     1381 tggcactaga tgggctgtgc tatctgtgtc ttccaatgct tcaaaccttc ccccttcttg
     1441 tgcctttctc ttgtaccttt ggctactttg atggagccta cgttaccttg atcccggtcg
     1501 tgactgcaga gatagtaggg accacctctt tgtcttcagc acttggcgtg gtctacttcc
     1561 ttcatgcagt gccatacttg gtgagcccac ccattgcagg atggctggtg gacacgacgg
     1621 gcagctacac tgcagccttc cttctctgtg gatttgccat gatatttagt tccatcctgc
     1681 ttggcttcgt tagaattgtc aagaggatga agagaacaca agtgcctttc ccggtcaaag
     1741 actcagatcc caagctacaa ctgtggacca atggatcagt ggcctactct gtagcaaggg
     1801 agttagatca gaaagatgag gaacccctgc ctaaagccag gtctggttgc aacctcacgt
     1861 gacatccctg ggaatcttca aggctggtgg accccaggcc accaggttgt tcatggtctg
     1921 gaaatatttt attttgacag agtatcacct cccaagtaaa ttattaatac tgttttgcta
     1981 acatatttat atgggggaaa ataacgagca acgaagaaat ctggagtagc ctggagtttt
     2041 ctcatttggg atttgtactt acttagctcc aggggaaagt cagggcatag tttatgggat
     2101 tagctgtatt tcaaggcaac tccaaggcag aggccattga gaatgggttt tgtcataaca
     2161 aaattgaccc ccaccacctc attctgaatg gaagcagtga gtatgctggc agtggagatg
     2221 cagaggtggc ttgagggcag agtgcctcaa tttttagagt ggcaaagaag ttcttgagac
     2281 tctttgaatg ataatgatta gtgtacaaca gatgttctct catcagttcc ctgcctcttc
     2341 caatgggcat cactttgaga gacccaagaa tcatcaaaca ccatggctgg aatggacttt
     2401 agagggtggc tggtgataat atttgatttg aaactgtctt gttgaaacag gaagctcttt
     2461 tcttcagact gtgcccccaa catgcacctc ggtcactacc gcatactgac tctaaatgta
     2521 acataactca ttcaatggtg gaataactgc tccatctttt ctgaagggat tgtaacacac
     2581 cagaaatcct catctttttt tttttttctt cagaaaaaaa aagttctagt ttgaactgta
     2641 gacacattcc ttttaggaac agaaaaatgt tgacagtatt cccattgagc agtaattgaa
     2701 ttcttgagtc agcaggtatc tggtgggagt cttccttaca aagcagtcgt tagattcagc
     2761 attatccaaa agagggcttg ggggttttct tatcatacag atgttctaaa catggccttc
     2821 ggagatcact gtgtctcttg ctagatgata gttataaatc tgactcattg gcttggaagc
     2881 atctgctcct tcttgaaagc cagactttct tggtacttgg aatcctttct gaatttttag
     2941 atcagaggag aggacaagga gaagaaaaaa aaagaagagt gggtccccca tcttatctcc
     3001 agctgttttc aaatccacac aatgaagatt cctgaatccc cagtcatgtt ccatctgcaa
     3061 agaaggacaa gttacataat taaaggactt ttttttagtt gttcaagagg ttaaatacaa
     3121 gtcacaagga acattttgat ctcaaaggcc atgtaaccta ctgtcaccaa gaggtcccag
     3181 cgtggcttta gccagacaca gtgctgggag aaatgaccaa gttttgagga atggctgaag
     3241 tggctgaatc ctcgttgaac tgaatatctt taggttacta tattgctttc ataacgagac
     3301 tctggcttga tccgatggag aaattgatac tagtccattg tagcttttca cagaaaaatt
     3361 tgaatgttct gtctttactc agcctgggac tttagttttg aatccattca cttagtgatt
     3421 tgcaatttta aaaatacttt gggtacaact ttaaaaaact caaagttaaa ataaaatact
     3481 tgttttggaa tagcacttta ccttaagaga cattttttta atcataaaaa tgatttttta
     3541 aaaatataat tactcttatt tgtatgtttt aaagcattga ttataaattt tgtgggattc
     3601 tataatataa tttctctatt gtgcttatga aaaaaatagg atagtgatca agggttttaa
     3661 aatttatata aaaacatttt agatcttttg actttataca tgcaataaat ttgccttcta
     3721 actatcttgg gacaacattt ttgaagaacc agtaagaaac actgtagatc ttagagttta
     3781 cagtttggtc atctgtacaa catgttacta aaacaatatc tccgtgtatt taaacagttg
     3841 gttccaaagc taagggaatg ggatattttg tggaatggag aataaacctg tagaggaatg
     3901 attctatgcc ttaaatattt tttcacccaa ctgtaagttc tcctttgtaa ctaagtagga
     3961 aaacgacaat atctaacgtt tcaatgtgcc attctttctt ttgcttaaat tagaatttta
     4021 tgaatgaatc agatgtgtag gctaatattt tcctagttca aaggcaaaat aaaatggatt
     4081 tatagacatg ta
//
