LOCUS       NM_001114332            5394 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus solute carrier family 16 (monocarboxylic acid
            transporters), member 10 (Slc16a10), transcript variant 1, mRNA.
ACCESSION   NM_001114332
VERSION     NM_001114332.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5394)
  AUTHORS   Hoen,E., Goossens,F.M., Falize,K., Mayerl,S., van der Spek,A.H. and
            Boelen,A.
  TITLE     The Differential Effect of a Shortage of Thyroid Hormone Compared
            with Knockout of Thyroid Hormone Transporters Mct8 and Mct10 on
            Murine Macrophage Polarization
  JOURNAL   Int J Mol Sci 25 (4), 2111 (2024)
   PUBMED   38396788
  REMARK    GeneRIF: The Differential Effect of a Shortage of Thyroid Hormone
            Compared with Knockout of Thyroid Hormone Transporters Mct8 and
            Mct10 on Murine Macrophage Polarization.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5394)
  AUTHORS   Lademann,F., Mayerl,S., Tsourdi,E., Verrey,F., Leitch,V.D.,
            Williams,G.R., Bassett,J.H.D., Hofbauer,L.C., Heuer,H. and
            Rauner,M.
  TITLE     The Thyroid Hormone Transporter MCT10 Is a Novel Regulator of
            Trabecular Bone Mass and Bone Turnover in Male Mice
  JOURNAL   Endocrinology 163 (1) (2022)
   PUBMED   34669927
  REMARK    GeneRIF: The Thyroid Hormone Transporter MCT10 Is a Novel Regulator
            of Trabecular Bone Mass and Bone Turnover in Male Mice.
REFERENCE   3  (bases 1 to 5394)
  AUTHORS   Venugopalan,V., Al-Hashimi,A., Weber,J., Rehders,M., Qatato,M.,
            Wirth,E.K., Schweizer,U., Heuer,H., Verrey,F. and Brix,K.
  TITLE     The Amino Acid Transporter Mct10/Tat1 Is Important to Maintain the
            TSH Receptor at Its Canonical Basolateral Localization and Assures
            Regular Turnover of Thyroid Follicle Cells in Male Mice
  JOURNAL   Int J Mol Sci 22 (11), 5776 (2021)
   PUBMED   34071318
  REMARK    GeneRIF: The Amino Acid Transporter Mct10/Tat1 Is Important to
            Maintain the TSH Receptor at Its Canonical Basolateral Localization
            and Assures Regular Turnover of Thyroid Follicle Cells in Male
            Mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5394)
  AUTHORS   Venugopalan,V., Al-Hashimi,A., Rehders,M., Golchert,J.,
            Reinecke,V., Homuth,G., Volker,U., Manirajah,M., Touzani,A.,
            Weber,J., Bogyo,M.S., Verrey,F., Wirth,E.K., Schweizer,U.,
            Heuer,H., Kirstein,J. and Brix,K.
  TITLE     The Thyroid Hormone Transporter Mct8 Restricts Cathepsin-Mediated
            Thyroglobulin Processing in Male Mice through Thyroid
            Auto-Regulatory Mechanisms That Encompass Autophagy
  JOURNAL   Int J Mol Sci 22 (1), 462 (2021)
   PUBMED   33466458
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5394)
  AUTHORS   Rajendran,A., Poncet,N., Oparija-Rogenmozere,L., Herzog,B. and
            Verrey,F.
  TITLE     Tissue-specific deletion of mouse basolateral uniporter LAT4
            (Slc43a2) reveals its crucial role in small intestine and kidney
            amino acid transport
  JOURNAL   J Physiol 598 (22), 5109-5132 (2020)
   PUBMED   32841365
REFERENCE   6  (bases 1 to 5394)
  AUTHORS   Wirth,E.K., Roth,S., Blechschmidt,C., Holter,S.M., Becker,L.,
            Racz,I., Zimmer,A., Klopstock,T., Gailus-Durner,V., Fuchs,H.,
            Wurst,W., Naumann,T., Brauer,A., de Angelis,M.H., Kohrle,J.,
            Gruters,A. and Schweizer,U.
  TITLE     Neuronal 3',3,5-triiodothyronine (T3) uptake and behavioral
            phenotype of mice deficient in Mct8, the neuronal T3 transporter
            mutated in Allan-Herndon-Dudley syndrome
  JOURNAL   J Neurosci 29 (30), 9439-9449 (2009)
   PUBMED   19641107
REFERENCE   7  (bases 1 to 5394)
  AUTHORS   Ramadan,T., Camargo,S.M., Herzog,B., Bordin,M., Pos,K.M. and
            Verrey,F.
  TITLE     Recycling of aromatic amino acids via TAT1 allows efflux of neutral
            amino acids via LAT2-4F2hc exchanger
  JOURNAL   Pflugers Arch 454 (3), 507-516 (2007)
   PUBMED   17273864
  REMARK    GeneRIF: the aromatic amino acid diffusion pathway TAT1 can control
            neutral amino acid efflux via neighboring exchanger LAT2-4F2hc, by
            recycling its aromatic influx substrates
REFERENCE   8  (bases 1 to 5394)
  AUTHORS   Ramadan,T., Camargo,S.M., Summa,V., Hunziker,P., Chesnov,S.,
            Pos,K.M. and Verrey,F.
  TITLE     Basolateral aromatic amino acid transporter TAT1 (Slc16a10)
            functions as an efflux pathway
  JOURNAL   J Cell Physiol 206 (3), 771-779 (2006)
   PUBMED   16245314
  REMARK    GeneRIF: TAT1 is a basolateral epithelial transporter and can
            function as a net efflux pathway for aromatic amino acids. We
            propose that it may supply parallel exchangers with recycling
            uptake substrates that could drive the efflux of other amino acids.
REFERENCE   9  (bases 1 to 5394)
  AUTHORS   Augustin,M., Sedlmeier,R., Peters,T., Huffstadt,U., Kochmann,E.,
            Simon,D., Schoniger,M., Garke-Mayerthaler,S., Laufs,J., Mayhaus,M.,
            Franke,S., Klose,M., Graupner,A., Kurzmann,M., Zinser,C., Wolf,A.,
            Voelkel,M., Kellner,M., Kilian,M., Seelig,S., Koppius,A.,
            Teubner,A., Korthaus,D., Nehls,M. and Wattler,S.
  TITLE     Efficient and fast targeted production of murine models based on
            ENU mutagenesis
  JOURNAL   Mamm Genome 16 (6), 405-413 (2005)
   PUBMED   16075367
REFERENCE   10 (bases 1 to 5394)
  AUTHORS   Willnow,T., Antignac,C., Brandli,A., Christensen,E., Cox,R.,
            Davidson,D., Davies,J., Devuyst,O., Eichele,G., Hastie,N.,
            Verroust,P., Schedl,A. and Meij,I.
  TITLE     The European renal genome project: an integrated approach towards
            understanding the genetics of kidney development and disease
  JOURNAL   Organogenesis 2 (2), 42-47 (2005)
   PUBMED   19521566
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK165240.1 and AK151290.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK165240.1, AK144135.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1844              AK165240.1         2-1845
            1845-2394           AK151290.1         1846-2395
            2395-5394           AK165240.1         2395-5394
FEATURES             Location/Qualifiers
     source          1..5394
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 21.48 cM"
     gene            1..5394
                     /gene="Slc16a10"
                     /gene_synonym="2610103N14Rik; 9830169E08; Mct10; PRO0813;
                     TAT1"
                     /note="solute carrier family 16 (monocarboxylic acid
                     transporters), member 10"
                     /db_xref="GeneID:72472"
                     /db_xref="MGI:MGI:1919722"
     exon            1..552
                     /gene="Slc16a10"
                     /gene_synonym="2610103N14Rik; 9830169E08; Mct10; PRO0813;
                     TAT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..1757
                     /gene="Slc16a10"
                     /gene_synonym="2610103N14Rik; 9830169E08; Mct10; PRO0813;
                     TAT1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     monocarboxylate transporter 10; MCT 10; T-type amino acid
                     transporter 1; aromatic amino acid transporter 1; solute
                     carrier family 16 member 10"
                     /codon_start=1
                     /product="monocarboxylate transporter 10 isoform 1"
                     /protein_id="NP_001107804.1"
                     /db_xref="CCDS:CCDS48543.1"
                     /db_xref="GeneID:72472"
                     /db_xref="MGI:MGI:1919722"
                     /translation="MVPSQEEPAAERETNEAQPPGPAPSDDAPLPGPGPSDVSDVAAE
                     KVEVELTRSAGSEPPVPPEGGWGWLVMLAAMWCNGSVFGIQNAYGVLFVSMLDTFKAK
                     DDDNMAFKTAWVGSLSMGMIFFCCPIVSVFTDMFGCRRTAVVGAAVGFIGLMSSSFVS
                     SIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLL
                     GNLISSVKLFNTLRILCIFMFVLFLAGFTYRPLVPSTKEKESGGSRSSFFSRRKLSPP
                     KKVFNFALFKETTYAVWAAGIPLALFGYFVPYVHLMNHVKERFQDVNNKEVLFMCIGI
                     TSGVGRLLFGRIADYLPGVKKVYLQVLSFFFIGLMSMMIPLCSAFGALIAVCLAMGLF
                     DGCFISIMAPIAFELVGPQDASQAIGFLLGFMSIPMTVGPPIAGLLHDKLGTYDVAFY
                     LAGIPPFVGGVVLCLIPWIHSKKQRKISKNAGGEKMEKMLENQSSLLSGSSGIFKKDS
                     ASII"
     exon            553..697
                     /gene="Slc16a10"
                     /gene_synonym="2610103N14Rik; 9830169E08; Mct10; PRO0813;
                     TAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            698..1151
                     /gene="Slc16a10"
                     /gene_synonym="2610103N14Rik; 9830169E08; Mct10; PRO0813;
                     TAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1295
                     /gene="Slc16a10"
                     /gene_synonym="2610103N14Rik; 9830169E08; Mct10; PRO0813;
                     TAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1524
                     /gene="Slc16a10"
                     /gene_synonym="2610103N14Rik; 9830169E08; Mct10; PRO0813;
                     TAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..5394
                     /gene="Slc16a10"
                     /gene_synonym="2610103N14Rik; 9830169E08; Mct10; PRO0813;
                     TAT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2439..2444
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc16a10"
                     /gene_synonym="2610103N14Rik; 9830169E08; Mct10; PRO0813;
                     TAT1"
                     /note="hexamer: AATAAA"
     polyA_site      2459
                     /gene="Slc16a10"
                     /gene_synonym="2610103N14Rik; 9830169E08; Mct10; PRO0813;
                     TAT1"
                     /note="major polyA site"
ORIGIN      
        1 aggcgcgagg ggcagccggt gtgtcaagtc ctctggccgc cttaggcggt gtctgcggtg
       61 tgcgcctctc gcccgcccgc ccgcccgcct gcccgcggct ccagtgtcct cgcctcggcc
      121 tccctcctcc gtccgcgcgg ctgtcccagg ctccgcgagc caccccggga ccttgcgccc
      181 gcaagctttc tcggtgcccg acggggccgc ctcgggacat ggtgccgtcc caggaggagc
      241 ccgccgccga gcgggagacg aacgaggcgc agccgcccgg gcccgcgccc tcggatgacg
      301 ctccgctgcc cggcccggga ccctcggatg tctccgacgt ggccgcagag aaagtggagg
      361 tggagctgac gaggtcagcg ggcagtgagc cccccgttcc ccccgagggc ggctggggct
      421 ggttggtgat gctggcggcc atgtggtgca acgggtcggt gtttggcatc cagaacgcct
      481 acggggtgct cttcgtgtcc atgctggaca ccttcaaggc caaggacgat gacaacatgg
      541 ccttcaagac agcgtgggtg ggctcgctgt ccatgggcat gatcttcttc tgctgcccca
      601 tcgtgagtgt cttcacggac atgttcggct gccggagaac agctgttgtg ggggcagctg
      661 tgggattcat tggactcatg tccagttctt ttgtaagctc catcgagcct ctgtacctca
      721 cctatggaat catatttgcc tgcggctgct cctttgccta ccagccgtca ctggtcattt
      781 tgggacacta cttcaagaag cgccttggac tagtcaacgg catcgtcacg gccggcagca
      841 gcgtcttcac aatcctgctc cctttgctgt taggaaatct aatcagcagt gtgaagctct
      901 ttaacacgct gcggatcctc tgcatcttca tgtttgttct ctttctggct ggctttacct
      961 accgacctct tgttcccagc accaaagaga aagagagtgg gggcagcaga agctcattct
     1021 tctccaggag aaagcttagt cctccaaaaa aagtctttaa ctttgccctc ttcaaggaga
     1081 caacctatgc agtgtgggct gctgggatac cacttgcact ttttggctac tttgtgcctt
     1141 acgttcactt gatgaaccat gtaaaggaaa ggtttcaaga tgtaaacaac aaagaggtgc
     1201 tcttcatgtg cattggcatc acttcaggag ttggacggct tctctttggc cgcattgctg
     1261 actatttgcc cggtgtgaag aaggtctacc tccaggttct ctccttcttc ttcattggcc
     1321 tgatgtccat gatgattccc ctgtgcagcg ccttcggagc cctcattgct gtctgccttg
     1381 ccatgggtct cttcgatgga tgcttcattt ctatcatggc gcccattgcc tttgaactag
     1441 ttggtcctca ggatgcttcc caagcaattg gatttctact tggattcatg tcgataccca
     1501 tgactgtagg ccctcctatt gcagggttac ttcatgacaa gctgggcacc tacgacgtgg
     1561 ccttttacct tgctggaatc cctcccttcg ttgggggtgt tgtgctctgt ttaatcccgt
     1621 ggatccatag caagaagcaa agaaagatca gtaagaacgc cggaggggag aagatggaga
     1681 aaatgctgga gaaccagagc tctctactgt caggctcatc aggaatcttc aaaaaagact
     1741 ccgcctcgat tatttaatgc cgtacatacc tcacctcacg ggatttgctt ttgaatttta
     1801 agccagtttt cctttttata tgaattgcag atttcttatt tttttaatca tccttggaat
     1861 agcacaaatg ggacatgagc cctttattat gacaagagcc atctctctcc caagcagctt
     1921 tggtattccc acgagtaagg gggagactgt cacaggcaag cacgtctgga aatccagcgt
     1981 gagcgttcag agctccgagg aaggagcagc cttggcagcc tcagatgctg tcagctgctg
     2041 cgtgctttga acgtgcttgg agctgcgctg ggtgggcagc tccgggctcc tccgcaccgg
     2101 aaacattttg tcagtccctc ttggtatctt ttgttccact gtgttacttt ctccttcatt
     2161 tttggaattt aagcctagat cctagataat aagaggccaa cctaaacctt gagtctgtta
     2221 aatgacttaa gctatgaaat taggaggttc ttacatgctg tagtcaaggg acctcctggg
     2281 agcagatgct actgctacca cagtggacat gggggagaga aaggccctct tgtaggcggc
     2341 aatcaggtgt ttcttccacc aacctttgtt ccctttggtt tgtagtgtgt tttactccag
     2401 tagccagaaa caccccaaat ttctgatttt atataaacaa taaagtgaag tagaatgtat
     2461 aaaagatatc ctggcaattt tatcagagtt tttctgactt ctgggtttat tagcactatg
     2521 tttgagtgtt ttgttgagcg tattatcagc tggtggagtg gacacagatt ggaagttctg
     2581 tccattagaa aatgtctgat agaaataatt gcttaaactg atttatggaa ctaatgattt
     2641 ttttggaact aatgatttta aaatgttaaa tatatttata agaagcccaa tttctaattt
     2701 ttccaaattt ttttttttta gcaaaacttt gcatttgtat gtacagtctt gtgatatgcc
     2761 aaggagcctg acggccggtg ctttcccagc ctgcctcttg tggagtttac gtacacagac
     2821 tgagagactc cattgtaact aggtgataca atctttctgc acagcatcga gtatgctcct
     2881 tcctcttctt tggccagaaa attagtgtag tatttattta ttgattacct ccattgtccc
     2941 ccgtttatgt cccaactgta agaaagcttt gaggatctaa aattaaaacc aaagttgggc
     3001 cgtgacccat tactcattta tcaaagcagg aacacactgt tatatctttg aaattgtatg
     3061 ttagacttta aaggttaaaa tgccaagtat tcttaaatca ttagcctcga tgactgttag
     3121 agtggaacgt agcttgcttg ttcatgggag aagaatgcta tcttttccta agcacttgca
     3181 gggtccttct gtttctaagt tatctggaag gtgagactta attttatcat ctccctactc
     3241 agcattccct ttctgttgca tataaaaggc cgacctccct ctctccatct gtcaagggcg
     3301 ggctgcctgg agacagtata gactcatttt tgttgggagt gggggtagag gtctggaggg
     3361 aagaggggct aggagttgaa agatggaagc tcttcctctt aattacagct tgcttaccta
     3421 ttgtcttgta agagctcaca gcctaaatgc taagtgtaca cgttctttta atgggttttg
     3481 aataattgta atttatttat tatttattta ttgtgatgcg gagcctaagt agatctgact
     3541 ggccttcagc tcctgtctgt tgcttcagac ctgtgttagg atgcagcggt gtgctaccat
     3601 gtgtgtcaaa aagtttgatt ttgaagaccc aagctggcat ggaactcacc atgtagccca
     3661 ggctagcctc aaacaaactc acaaagctct tttaggtgtt tttgaagcag gcttggttgt
     3721 ggcccagcag ggagttggaa cttgaggtcc tcctgcttca gcttcttaca cagagggatc
     3781 ccagagtgtg ccaccaccgc cagcgtcacc gccagcgtca ctcactgccg acaggtgctt
     3841 ctgttttaaa ttgacaaagg ggttttagca atttgtttgc agtaagatct ctttcaggag
     3901 ggaaaatatt ttaaccatat tggcctttct tgttcttttc tttcttgttt tagataaagt
     3961 tttactaagt agacctggca ggcctggagc tcacagagac atgccagcct cagcctccca
     4021 agtgctgggg ttcaagggcg ggcacaccac catgtgggct ctcttccatg ggcttatatt
     4081 gtacatctga gaagttttgc ctatgaagtt attactgagt tcgaatatat ggaagtgtct
     4141 gattgttgct aatgcttaat gatttaaggt ttatttacaa gaaaatgatc atcaaatcca
     4201 gtcttgtgat gaacatggcc tcccaacaga gtaactttaa aaaaaaagtc ccttctcagg
     4261 gtatctagca cagagtggat gtttaaaatc actcatgggt gaggatatgg catagaggta
     4321 gggagctctc ccaacagtcc gaagccccag ccagccagac tcacttcaag gagtaaaaat
     4381 gaacaacaac aaaaagggca tatagaaact ttaactggat ttgattaagg ggatattttg
     4441 aacatttgag ctatttgttt ttcagttttt ggagtcattg gtcttaacat tttagatctt
     4501 gatacagatt aaaactgctg tgagtgacag tgtcagtctc ctgtcaggtc ctctcaggac
     4561 catgctgtga cagtatcaga ttcccctccc cacaaaacaa aacatgaaaa cagtgccacc
     4621 aagaagtgca cccttgtccc aggtcccggg ccccagcctg cgtgcttctg tcagtgggac
     4681 ccagatacct ggaggtcaca gacttaggtc agtcctgctt tccttcatag actttgcctc
     4741 ggccatttta taagaatgag acagtaactc acagccgctg ttgcctttct agagagacgg
     4801 tgtactcagg ctgaggatgc tgggttcgct gtagactacc ctgagcgttg tgtgccgggg
     4861 tctcactgac tgctgtacag ctcctttgac agcagcttct acgtagtgga gcagtgagag
     4921 tgtcagataa cagaaggctg gagaggcgcc tcaccgcacc cagcacctat gtatttcaaa
     4981 agttcagact ctgttagcaa aacctaatat tccaaatata cctagtgctc caggtgtgag
     5041 ctccctcctt ccatccatca ttcccttcct ccctcctctc tctccccacc tctctccctc
     5101 ctacagaagg tgccagctta ctccatagct gtataaataa aatatagctg actgtgtgaa
     5161 agagtcatgc tgggttcgac caacataggt attttcctag ttttgagaaa tcctgttctt
     5221 ttaaaataat ataatttata attgattttt ttaaaaatgt gatttatata tttaatatag
     5281 acaaccaaaa cctttttaat gaagagtgct ttgtactttg gagaatacag tcattttact
     5341 gtggggaaat gtgatattct cagtaaatgc aataaaattt ttagcaaatt cctg
//
