LOCUS       NM_009196               4430 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus solute carrier family 16 (monocarboxylic acid
            transporters), member 1 (Slc16a1), mRNA.
ACCESSION   NM_009196
VERSION     NM_009196.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4430)
  AUTHORS   Ballasy,N., Apantaku,I., Dean,W. and Hemberger,M.
  TITLE     Off to a good start: The importance of the placental exchange
            surface - Lessons from the mouse
  JOURNAL   Dev Biol 517, 248-264 (2025)
   PUBMED   39491740
REFERENCE   2  (bases 1 to 4430)
  AUTHORS   Fan,W., Li,Z., He,X., Wang,X., Sun,M. and Yang,Z.
  TITLE     SLC25A1 regulates placental development to ensure embryonic heart
            morphogenesis
  JOURNAL   Development 151 (22) (2024)
   PUBMED   39591637
REFERENCE   3  (bases 1 to 4430)
  AUTHORS   Jeyarajah,M.J., Patterson,V.S., Jaju Bhattad,G., Zhao,L.,
            Whitehead,S.N. and Renaud,S.J.
  TITLE     Placental extracellular vesicles promote cardiomyocyte maturation
            and fetal heart development
  JOURNAL   Commun Biol 7 (1), 1254 (2024)
   PUBMED   39363116
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4430)
  AUTHORS   Li,H., Liu,C., Li,R., Zhou,L., Ran,Y., Yang,Q., Huang,H., Lu,H.,
            Song,H., Yang,B., Ru,H., Lin,S. and Zhang,L.
  TITLE     AARS1 and AARS2 sense L-lactate to regulate cGAS as global lysine
            lactyltransferases
  JOURNAL   Nature 634 (8036), 1229-1237 (2024)
   PUBMED   39322678
REFERENCE   5  (bases 1 to 4430)
  AUTHORS   Braga,A., Chiacchiaretta,M., Pellerin,L., Kong,D. and Haydon,P.G.
  TITLE     Astrocytic metabolic control of orexinergic activity in the lateral
            hypothalamus regulates sleep and wake architecture
  JOURNAL   Nat Commun 15 (1), 5979 (2024)
   PUBMED   39013907
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4430)
  AUTHORS   Thut,C.J., Rountree,R.B., Hwa,M. and Kingsley,D.M.
  TITLE     A large-scale in situ screen provides molecular evidence for the
            induction of eye anterior segment structures by the developing lens
  JOURNAL   Dev Biol 231 (1), 63-76 (2001)
   PUBMED   11180952
REFERENCE   7  (bases 1 to 4430)
  AUTHORS   Koehler-Stec,E.M., Simpson,I.A., Vannucci,S.J., Landschulz,K.T. and
            Landschulz,W.H.
  TITLE     Monocarboxylate transporter expression in mouse brain
  JOURNAL   Am J Physiol 275 (3), E516-E524 (1998)
   PUBMED   9725820
REFERENCE   8  (bases 1 to 4430)
  AUTHORS   Pellerin,L., Pellegri,G., Martin,J.L. and Magistretti,P.J.
  TITLE     Expression of monocarboxylate transporter mRNAs in mouse brain:
            support for a distinct role of lactate as an energy substrate for
            the neonatal vs. adult brain
  JOURNAL   Proc Natl Acad Sci U S A 95 (7), 3990-3995 (1998)
   PUBMED   9520480
REFERENCE   9  (bases 1 to 4430)
  AUTHORS   Carpenter,L., Poole,R.C. and Halestrap,A.P.
  TITLE     Cloning and sequencing of the monocarboxylate transporter from
            mouse Ehrlich Lettre tumour cell confirms its identity as MCT1 and
            demonstrates that glycosylation is not required for MCT1 function
  JOURNAL   Biochim Biophys Acta 1279 (2), 157-163 (1996)
   PUBMED   8603082
REFERENCE   10 (bases 1 to 4430)
  AUTHORS   Garcia,C.K., Li,X., Luna,J. and Francke,U.
  TITLE     cDNA cloning of the human monocarboxylate transporter 1 and
            chromosomal localization of the SLC16A1 locus to 1p13.2-p12
  JOURNAL   Genomics 23 (2), 500-503 (1994)
   PUBMED   7835905
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY729217.1 and AK033516.1.
            
            On Aug 14, 2013 this sequence version replaced NM_009196.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033516.1, AK161701.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 BY729217.1         5-8
            5-4430              AK033516.1         3-4428
FEATURES             Location/Qualifiers
     source          1..4430
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 45.7 cM"
     gene            1..4430
                     /gene="Slc16a1"
                     /gene_synonym="Mct1"
                     /note="solute carrier family 16 (monocarboxylic acid
                     transporters), member 1"
                     /db_xref="GeneID:20501"
                     /db_xref="MGI:MGI:106013"
     exon            1..165
                     /gene="Slc16a1"
                     /gene_synonym="Mct1"
                     /inference="alignment:Splign:2.1.0"
     exon            166..425
                     /gene="Slc16a1"
                     /gene_synonym="Mct1"
                     /inference="alignment:Splign:2.1.0"
     exon            426..569
                     /gene="Slc16a1"
                     /gene_synonym="Mct1"
                     /inference="alignment:Splign:2.1.0"
     exon            570..1415
                     /gene="Slc16a1"
                     /gene_synonym="Mct1"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..4430
                     /gene="Slc16a1"
                     /gene_synonym="Mct1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3198..3203
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc16a1"
                     /gene_synonym="Mct1"
                     /note="hexamer: AATAAA"
     polyA_site      3226
                     /gene="Slc16a1"
                     /gene_synonym="Mct1"
                     /note="major polyA site"
     regulatory      3608..3613
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc16a1"
                     /gene_synonym="Mct1"
                     /note="hexamer: AATGAA"
     polyA_site      3633
                     /gene="Slc16a1"
                     /gene_synonym="Mct1"
     regulatory      3782..3787
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc16a1"
                     /gene_synonym="Mct1"
                     /note="hexamer: AATAAA"
     regulatory      3801..3806
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc16a1"
                     /gene_synonym="Mct1"
                     /note="hexamer: ATTAAA"
     polyA_site      3806
                     /gene="Slc16a1"
                     /gene_synonym="Mct1"
     polyA_site      3824
                     /gene="Slc16a1"
                     /gene_synonym="Mct1"
ORIGIN      
        1 agacaaagtg gcgagctgcg acgtgactgg tcggtcgtgt aggtgcagca gccaaggagc
       61 ccggcggcgg gcaggggaca cgagcgggac ccccccggct ccgaggaact gcggcccgcg
      121 ccgccgcgtc acgcatactc cgggcgccgc gagacacaca taacgatact agatttgcgc
      181 tgcatcttgg aattcatcta cacttaaaat gccacctgcg attggagggc cagtgggata
      241 caccccccca gatggaggct gggggtgggc agtgttagtc ggagccttca tttctattgg
      301 cttctcctat gcatttccca aatccatcac tgtcttcttt aaagagatag aagttatatt
      361 cagtgcaacg accagtgaag tatcatggat atcatctata atgttggctg tcatgtatgc
      421 tggaggtcct atcagcagta tcttggtgaa taaatacggc agccgtccag taatgatcgc
      481 tggtggttgt ctgtctggtt gcggcttgat cgcagcttct ttctgtaaca cagtacagga
      541 actttacttg tgcattggtg ttattggagg tcttgggctt gctttcaact tgaacccagc
      601 tctgactatg attggcaagt atttctacaa gaagcgacca ctggccaacg gactggccat
      661 ggcaggcagc cctgtgttcc tctctaccct ggctccactt aatcaggctt tctttgatat
      721 ttttgactgg agaggaagct tcctaattct tgggggcctc ctcctaaatt gttgtgtagc
      781 tggatccctg atgagaccaa tagggcctga gcaagtcaag ctagaaaaac tcaagtccaa
      841 agaatctcta caggaagctg gaaaatctga tgcaaataca gatctcattg gaggaagtcc
      901 caaaggagaa aagctgtccg tcttccaaac aattaacaaa ttcctggact tgtcgctgtt
      961 tacccatagg ggctttttac tgtacctgtc tggaaatgtg gtcatgtttt ttggactctt
     1021 tacccctttg gtctttctta gtagttatgg taagagtaag gatttttcca gtgagaaatc
     1081 agccttcctt ctttccattt tggcttttgt tgatatggta gccagaccgt ccatgggact
     1141 tgcagccaac accaagtgga tcagacctcg gatccagtac ttttttgctg cttctgttgt
     1201 tgcaaatgga gtgtgccatt tgcttgcccc tttgtctaca acctacgttg ggttctgtgt
     1261 ctacgccgga gtctttggat ttgcctttgg ttggctcagc tctgtattat ttgaaacatt
     1321 gatggacctc attggacccc agaggttctc cagtgctgtg ggcttggtga ccattgtgga
     1381 atgctgccct gtcctcctag ggccaccact tttaggccgc ctcaatgaca tgtatggaga
     1441 ctacaaatac acgtactggg cttgtggcgt gatcctcatc atcgcgggta tctatctctt
     1501 cattggcatg ggcatcaact atcgacttct tgccaaagaa cagaaagcgg aggagaagca
     1561 gaaaagggaa ggaaaagagg acgaggccag caccgatgtc gacgagaagc caaaggagac
     1621 gatgaaagct gcacagtcgc cgcagcagca cagctccggg gaccccacag aggaggagag
     1681 ccctgtctga cctgtgaagc ctggagagag cagcgtgtga cccacgacat ccaaaaccat
     1741 cctgctggcc tctagtctac cagtggtgct cagtgcagac agtggacatt tgtgtggaaa
     1801 acctaccggg tgttcattgg tgggattttt tttttcactc cttaccaatg cctgaattta
     1861 aaatatacta tgctttaggt agggagtggt tggcaaagga tatgggaaag aagtagtgat
     1921 tttctttttg tttgtttgtt ttgttttaat cttagctttt aacagtgtca tgaagattat
     1981 aatatgtgcc ttaagtttta gtttttagaa ctctttagag agccttaact tttaaaacca
     2041 ttctgctgaa ttcatttgtt ttaaatgtca ttttaaaagg aaaaataaca actagcttgc
     2101 ttgaggtaac taaccttaat cttgttttgt tgttgtttgt aatgctttgt cagacattgt
     2161 tactggaaca tttatgaata gaggtattgg ttaaaagtcg caggtttata aaatactgac
     2221 taaagtattt ttctagcatt atagttgcct ggcatatcca cctgctaggt atatatttaa
     2281 gaaatttgaa acataaaatt ttgggaacat cttggcagtt ccagccacag cctgtcacct
     2341 gctgggcact tctcaaatgc ttactacagc ctcgtgctga agtgttatca ctaaactgtc
     2401 acctttgctc ctattcagag acactgaaat caactgcaaa aggttagtat taacatctac
     2461 aaaacaactc tttaacacgt ctgatttaat gtatgcagta tttcaagcag cagctgaatt
     2521 cagtgtaggt ttccccaaac cttagttacg gtatgagaat cttaggtatg tgtgggtttg
     2581 aggggctctg aggtgttggt tcttaggttt gaacccaggg ccacaagcat gctaagtgca
     2641 tgctgtacca ctgagccaca acccacaggc accctggaat ccttctcctt gacccctgaa
     2701 accttttctc ttggtttttg atagttccat ttataccact actagtttag agctgtatgt
     2761 gggatgattc agtaccgact gaatggatgt gcttttgttt tttttacatt gtttttcagt
     2821 atttgcaaaa ccacgagggt tagagtttgg cctcagggaa gccaataaag ataaaatggg
     2881 aggaagtttg ctgagaactt gtatcatgct ttacgattat ttgacatagt cttacctcca
     2941 caccttaact ttcatgaccc tttcactcac ctgaaatgta gaaaaatggg ttcagtgtaa
     3001 ggataagagg aaagatggac cagattggaa ctacagtgtt ttgggttttt ttttttttta
     3061 acctgatgtc ttctgaatag aggcagaaaa aaataagaca tatgacactg aattgtactc
     3121 aatgtgttta aaataccatt gtaattgaca gggtgaatat agatttaaaa ccttgtgtaa
     3181 gaagctgact ttttccaaat aaaacattta ttttattttt agaaaacagt tcttccgcat
     3241 gtttatttgt gagacatgtt atttttgtct tcattcttac taatttttat tttattttaa
     3301 cctttctaat attgaatcgt ccatttatat accttgactc gtacatatgg ttcattttat
     3361 gttgattttc ctcctttagt taagacaagc agggaaggat tttaagaccg catcttgagc
     3421 tgagatcccc tgatgctgtt agccttaaga cactgtggga accaccttgc aatataaagt
     3481 gttgtggtga gaatgtggtg agaatttaga gaggaaacct tgaaagttta cacagacatc
     3541 aactggtttg gactcttatc ttctgtgaag ccatgtcata cttctgtgaa cctttctctt
     3601 ctataaaaat gaaagtctct gttgatggtg gaattttgag ctctgtgtgt gtgcgagcgc
     3661 gcgaagctgc atttgctggg caggtgtgtc tgcgctcagg gttgagccca ggatttatga
     3721 tacagggtca ccaacactct tcagaaagga ttcttagttt ataatcaaaa gccaaaactg
     3781 caataaaact ggaacttgct attaaacttt ttgttagctg cttagtcttg aggtttttcc
     3841 cattaaagga acattgggtc cagcaattgc tctgtcactg ggctaaagcc acagtccata
     3901 ggatttacat aaggtcagtg ttagtgaagc ctgtgtggca cttagcagag gccttctctg
     3961 tcccttcctc attctctatc gtggctatca gctgtgctgt aaagcgggcc tgggagcagt
     4021 gggcactctg agccttgtcc gtcactcctt tgaatgctga ttttgtctca agtcctttca
     4081 gttcacatag ccgtggctgc tgggtaatag atgtgagctg ggcatgaact gtcacatata
     4141 gcagagtggg aaaattactg aatgagtttc aaatcagtac acttaaacta cactgatcag
     4201 gaacgtgtcc agtcaagtct gaaaattaag aacatcttca ccatctgaga tgaacagtat
     4261 gtacaaaatt atattttgat ttttttagtt tataattaaa tcatttttcc ccttttctct
     4321 ttcaaacccc tcccatgttt tccttattct catacaaatt catggcctct ttataattgt
     4381 tagatgtgta tatgtgttgc taaatctata aaaaacaatc ttcttggtcc
//
