LOCUS       NM_133895               2720 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus solute carrier family 15, member 4 (Slc15a4), mRNA.
ACCESSION   NM_133895
VERSION     NM_133895.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2720)
  AUTHORS   Drobek,A., Bernaleau,L., Delacretaz,M., Calderon Copete,S.,
            Royer-Chardon,C., Longepierre,M., Monguio-Tortajada,M.,
            Korzeniowski,J., Rotman,S., Marquis,J. and Rebsamen,M.
  TITLE     The TLR7/9 adaptors TASL and TASL2 mediate IRF5-dependent antiviral
            responses and autoimmunity in mouse
  JOURNAL   Nat Commun 16 (1), 967 (2025)
   PUBMED   39856058
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2720)
  AUTHORS   Lopez-Haber,C., Netting,D.J., Hutchins,Z., Ma,X., Hamilton,K.E. and
            Mantegazza,A.R.
  TITLE     The phagosomal solute transporter SLC15A4 promotes inflammasome
            activity via mTORC1 signaling and autophagy restraint in dendritic
            cells
  JOURNAL   EMBO J 41 (20), e111161 (2022)
   PUBMED   36031853
  REMARK    GeneRIF: The phagosomal solute transporter SLC15A4 promotes
            inflammasome activity via mTORC1 signaling and autophagy restraint
            in dendritic cells.
REFERENCE   3  (bases 1 to 2720)
  AUTHORS   Rimann,I., Gonzalez-Quintial,R., Baccala,R., Kiosses,W.B.,
            Teijaro,J.R., Parker,C.G., Li,X., Beutler,B., Kono,D.H. and
            Theofilopoulos,A.N.
  TITLE     The solute carrier SLC15A4 is required for optimal trafficking of
            nucleic acid-sensing TLRs and ligands to endolysosomes
  JOURNAL   Proc Natl Acad Sci U S A 119 (14), e2200544119 (2022)
   PUBMED   35349343
  REMARK    GeneRIF: The solute carrier SLC15A4 is required for optimal
            trafficking of nucleic acid-sensing TLRs and ligands to
            endolysosomes.
REFERENCE   4  (bases 1 to 2720)
  AUTHORS   Katewa,A., Suto,E., Hui,J., Heredia,J., Liang,J., Hackney,J.,
            Anderson,K., Alcantar,T.M., Bacarro,N., Dunlap,D., Eastham,J.,
            Paler-Martinez,A., Rairdan,X.Y., Modrusan,Z., Lee,W.P.,
            Austin,C.D., Lafkas,D. and Ghilardi,N.
  TITLE     The peptide symporter SLC15a4 is essential for the development of
            systemic lupus erythematosus in murine models
  JOURNAL   PLoS One 16 (1), e0244439 (2021)
   PUBMED   33444326
  REMARK    GeneRIF: The peptide symporter SLC15a4 is essential for the
            development of systemic lupus erythematosus in murine models.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2720)
  AUTHORS   Griffith,A.D., Zaidi,A.K., Pietro,A., Hadiono,M., Yang,J.S.,
            Davis,R. and Popkin,D.L.
  TITLE     A requirement for slc15a4 in imiquimod-induced systemic
            inflammation and psoriasiform inflammation in mice
  JOURNAL   Sci Rep 8 (1), 14451 (2018)
   PUBMED   30262916
  REMARK    GeneRIF: A requirement for slc15a4 in imiquimod-induced systemic
            inflammation and psoriasiform inflammation in mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2720)
  AUTHORS   Sasawatari,S., Okamura,T., Kasumi,E., Tanaka-Furuyama,K.,
            Yanobu-Takanashi,R., Shirasawa,S., Kato,N. and Toyama-Sorimachi,N.
  TITLE     The solute carrier family 15A4 regulates TLR9 and NOD1 functions in
            the innate immune system and promotes colitis in mice
  JOURNAL   Gastroenterology 140 (5), 1513-1525 (2011)
   PUBMED   21277849
  REMARK    GeneRIF: SLC15A4 promotes colitis through Toll-like receptor 9 and
            NOD1-dependent innate immune responses.
REFERENCE   7  (bases 1 to 2720)
  AUTHORS   Blasius,A.L., Arnold,C.N., Georgel,P., Rutschmann,S., Xia,Y.,
            Lin,P., Ross,C., Li,X., Smart,N.G. and Beutler,B.
  TITLE     Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required
            for Toll-like receptor signaling in plasmacytoid dendritic cells
  JOURNAL   Proc Natl Acad Sci U S A 107 (46), 19973-19978 (2010)
   PUBMED   21045126
  REMARK    GeneRIF: The identification of the feeble mutation led to our
            subsequent observations that AP-3, as well as the BLOC-1 and BLOC-2
            are essential for plasmacytoid dendritic cells signaling through
            TLR7 and TLR9.
REFERENCE   8  (bases 1 to 2720)
  AUTHORS   Lee,J., Tattoli,I., Wojtal,K.A., Vavricka,S.R., Philpott,D.J. and
            Girardin,S.E.
  TITLE     pH-dependent internalization of muramyl peptides from early
            endosomes enables Nod1 and Nod2 signaling
  JOURNAL   J Biol Chem 284 (35), 23818-23829 (2009)
   PUBMED   19570976
REFERENCE   9  (bases 1 to 2720)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2720)
  AUTHORS   Hoebe,K., Du,X., Goode,J., Mann,N. and Beutler,B.
  TITLE     Lps2: a new locus required for responses to lipopolysaccharide,
            revealed by germline mutagenesis and phenotypic screening
  JOURNAL   J Endotoxin Res 9 (4), 250-255 (2003)
   PUBMED   12935356
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC016233.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016233.1, AY050630.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2720
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 66.0 cM"
     gene            1..2720
                     /gene="Slc15a4"
                     /gene_synonym="C130069N12Rik; PHT1; PTR4"
                     /note="solute carrier family 15, member 4"
                     /db_xref="GeneID:100561"
                     /db_xref="MGI:MGI:2140796"
     exon            1..578
                     /gene="Slc15a4"
                     /gene_synonym="C130069N12Rik; PHT1; PTR4"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..1748
                     /gene="Slc15a4"
                     /gene_synonym="C130069N12Rik; PHT1; PTR4"
                     /note="peptide-histidine transporter 4; peptide
                     transporter 4; peptide/histidine transporter 1"
                     /codon_start=1
                     /product="solute carrier family 15 member 4"
                     /protein_id="NP_598656.1"
                     /db_xref="CCDS:CCDS19688.1"
                     /db_xref="GeneID:100561"
                     /db_xref="MGI:MGI:2140796"
                     /translation="MEGERAPLLGSRRPAVSAASAVFAGRRAACGAVLLAELLERAAF
                     YGVTANLVLFLNGAPFDWEGAQASQALLLFMGLTYLGSPFGGWLADARLGRARAILLS
                     LALYLLGLLAFPLLAAPRSRSFLCGDPRPELVRNCSAPFPNGSASCPENAARRCAPAT
                     FAGLVLVGLGVATVKANITPFGADQVKDRGPEATRRFFNWFYWSINLGAILSLGGIAY
                     IQQNVSFFTGYLIPTVCVAIAFLVFLCGQSVFITKPPDGSAFTDMFRILTYSCCSQRG
                     GQRRSGEGLGVFQQSSKHSLFDSCKMSRGGPFTEDKVEDVKALVKIVPVFLALIPYWT
                     VYFQMQTTYALQSLHLKIPEISSITTTHHTLPAAWLTMFDAVLILLLIPLKDKLVDPV
                     LRRHGLLPSSLKRIAVGMFFVMCSAFAAGILESKRLDLVKEKTINQTIGGVVYHAADL
                     PIWWQIPQYVLIGISEIFASIAGLEFAYSAAPKSMQSAIMGLFFFFSGIGSFVGSGLL
                     ALVSLKAIGWMSSHTDFGNINSCHLHYYFFLLAAIQGATLLLFLIVSVKYDRQRARTD
                     GGPASTRT"
     exon            579..868
                     /gene="Slc15a4"
                     /gene_synonym="C130069N12Rik; PHT1; PTR4"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1037
                     /gene="Slc15a4"
                     /gene_synonym="C130069N12Rik; PHT1; PTR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1115
                     /gene="Slc15a4"
                     /gene_synonym="C130069N12Rik; PHT1; PTR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1284
                     /gene="Slc15a4"
                     /gene_synonym="C130069N12Rik; PHT1; PTR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1440
                     /gene="Slc15a4"
                     /gene_synonym="C130069N12Rik; PHT1; PTR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1599
                     /gene="Slc15a4"
                     /gene_synonym="C130069N12Rik; PHT1; PTR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..2706
                     /gene="Slc15a4"
                     /gene_synonym="C130069N12Rik; PHT1; PTR4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accgagtcct cagtgaaccg gccatggagg gcgagcgggc gccgctgttg ggttcgcggc
       61 gtccggcagt gtcggcggcg tccgcggtgt tcgcggggcg gcgtgcggcg tgcggggcgg
      121 tgctgttggc cgagctgctg gagcgcgcgg ccttctacgg cgtcacggcc aacctggtgc
      181 tgttcctgaa tggcgcgccg ttcgactggg agggcgcgca ggccagccag gcgctgctgc
      241 tcttcatggg cctcacctat ctgggctcgc cgttcggggg ctggctcgcc gacgcccgcc
      301 tcggccgggc ccgcgccatc ctgctcagcc tggccctcta cctgctgggc ctgctggcct
      361 tcccgctgct ggccgcgccc cgctcgcgct ccttcctctg cggggacccg cggcccgagc
      421 tcgtgcgcaa ctgctcggcg cccttcccca acgggtcagc gtcgtgtccc gagaacgccg
      481 cgcgccgctg tgcccccgcc accttcgcgg ggctcgtgct cgtgggtctc ggggtggcca
      541 cggtcaaggc caacatcacg cccttcggcg ccgatcaggt taaagatcga ggtccagaag
      601 ccactcggag atttttcaat tggttttact ggagcattaa tttgggagca atcctgtcat
      661 taggaggtat tgcctatatt cagcagaatg tgagcttttt cacaggctac ctgattccca
      721 cagtctgtgt ggccattgct ttcctggtct tcctctgtgg ccagagtgtc ttcatcacca
      781 agcctcctga cggcagtgcc ttcactgaca tgttcagaat tctgacctac agttgctgct
      841 cccagagagg agggcagcgg agaagtggtg aaggccttgg agtctttcag caatcttcta
      901 aacacagtct gtttgattca tgtaagatgt cgcgtggagg gccgttcaca gaggacaaag
      961 tggaagacgt gaaagccctg gtcaagattg tgcccgtgtt cttggctctg attccttact
     1021 ggacagtgta tttccaaatg cagaccacat atgctttaca gagtcttcat ttgaagattc
     1081 cagaaatctc aagtatcacc accacccatc acacgctgcc tgcagcttgg ctcaccatgt
     1141 ttgatgcggt gctcatcctc ctgctcatcc cactgaagga caagctggtg gacccggtgc
     1201 tgaggagaca tggcctgctc ccatcctccc tgaagaggat tgctgtgggg atgttcttcg
     1261 tcatgtgctc tgcctttgct gcaggaatcc tggagagtaa aaggctggac ctggtaaagg
     1321 agaagaccat taaccagacc attggtggtg tggtgtacca tgctgctgac ttgcccatct
     1381 ggtggcagat cccacagtat gtgctcattg gcatcagtga gatatttgca agtatagcag
     1441 gtctggaatt tgcatactca gctgccccca agtccatgca gagcgccatc atgggactct
     1501 tcttcttctt ctctggcatt gggtcctttg tgggctcagg actgttggcc ctggtgtctc
     1561 tcaaggccat tgggtggatg agcagtcata cagattttgg gaacatcaac agctgccacc
     1621 tgcattacta cttcttcctg ctggccgcca tccagggagc tacgctgctg ctcttcctca
     1681 ttgtgtctgt gaagtacgac cgccagcgag ccaggacaga tggggggcca gccagcacga
     1741 ggacctgatg cagccagcca gcatgctcac aggttctgca gactctaagg cctcagggct
     1801 tgctaactac cagggcactg ccagcaagca gactgaggct agattgttgg tgtcccaact
     1861 tctgaacttg catgttgtct ggactggctt ctccctccct atgcccggat gatggtggtg
     1921 agtgccttac tatggcccgt ctcatgtgca ctgggcctgc caggagatga ggatgtggct
     1981 tctctcactg aaggtctctg ccagtcctga gccagccatg ctctcctggg cagccaccgt
     2041 tctgctgctg ccatccttat tccttacaaa tattgttact tcctcatagc atctccttta
     2101 cgattagcaa gcacttccat caaggcatag gaggattctc tttagaggtg aaagtgtggt
     2161 tgatgtcaag agagccctag gagctgtgtc tactccatca tggactcttg tcacaggcct
     2221 ggctgatgcc aaggcctttg tgggtcagtc atgtaggctc atctgctcag aaagtaggtt
     2281 ttgttgactg agataaagaa gtttttatta gactaggctg gcctcaaact tggggctgcc
     2341 tcatgtctgc ttctcaagtg ctgagatctc agatgtctgt cactatggtc agcaggactt
     2401 aggtcatgaa caactgatct gctttaagca catgtgtccg tggtgattga ggacaccatg
     2461 tcctcactga aaccagacag cagctggcag gagattggca gttacaccac gcagatcttt
     2521 tctgagaact tgactttgtg tagcagtaag gatggaggca ggtggtgagt ggggaaaaca
     2581 tgggagctgc tgggctattg gcccagcttt gtaccgttac tgacatctgg ggttctgagt
     2641 ttgtcaactg aactgttgtg tgtgttgctg tgttttgtat aattttataa aagcttctca
     2701 gactgaaaaa aaaaaaaaaa
//
