LOCUS       NM_023044               2345 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus solute carrier family 15, member 3 (Slc15a3), mRNA.
ACCESSION   NM_023044
VERSION     NM_023044.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2345)
  AUTHORS   Luo,J., Li,P., Dong,M., Zhang,Y., Lu,S., Chen,M., Zhou,H., Lin,N.,
            Jiang,H. and Wang,Y.
  TITLE     SLC15A3 plays a crucial role in pulmonary fibrosis by regulating
            macrophage oxidative stress
  JOURNAL   Cell Death Differ 31 (4), 417-430 (2024)
   PUBMED   38374230
  REMARK    GeneRIF: SLC15A3 plays a crucial role in pulmonary fibrosis by
            regulating macrophage oxidative stress.
REFERENCE   2  (bases 1 to 2345)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2345)
  AUTHORS   Rimann,I., Gonzalez-Quintial,R., Baccala,R., Kiosses,W.B.,
            Teijaro,J.R., Parker,C.G., Li,X., Beutler,B., Kono,D.H. and
            Theofilopoulos,A.N.
  TITLE     The solute carrier SLC15A4 is required for optimal trafficking of
            nucleic acid-sensing TLRs and ligands to endolysosomes
  JOURNAL   Proc Natl Acad Sci U S A 119 (14), e2200544119 (2022)
   PUBMED   35349343
REFERENCE   4  (bases 1 to 2345)
  AUTHORS   Kitakaze,T., Sakamoto,T., Kitano,T., Inoue,N., Sugihara,F.,
            Harada,N. and Yamaji,R.
  TITLE     The collagen derived dipeptide hydroxyprolyl-glycine promotes C2C12
            myoblast differentiation and myotube hypertrophy
  JOURNAL   Biochem Biophys Res Commun 478 (3), 1292-1297 (2016)
   PUBMED   27553280
REFERENCE   5  (bases 1 to 2345)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 2345)
  AUTHORS   Nakamura,N., Lill,J.R., Phung,Q., Jiang,Z., Bakalarski,C., de
            Maziere,A., Klumperman,J., Schlatter,M., Delamarre,L. and
            Mellman,I.
  TITLE     Endosomes are specialized platforms for bacterial sensing and NOD2
            signalling
  JOURNAL   Nature 509 (7499), 240-244 (2014)
   PUBMED   24695226
REFERENCE   7  (bases 1 to 2345)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 2345)
  AUTHORS   Takahashi,Y., Miyata,M., Zheng,P., Imazato,T., Horwitz,A. and
            Smith,J.D.
  TITLE     Identification of cAMP analogue inducible genes in RAW264
            macrophages
  JOURNAL   Biochim Biophys Acta 1492 (2-3), 385-394 (2000)
   PUBMED   11004510
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132402.3.
            
            On Mar 17, 2009 this sequence version replaced NM_023044.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF121080.1, BC051940.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1035              AC132402.3         97621-98655         c
            1036-1319           AC132402.3         92411-92694         c
            1320-1467           AC132402.3         87923-88070         c
            1468-1575           AC132402.3         86838-86945         c
            1576-1744           AC132402.3         86122-86290         c
            1745-1903           AC132402.3         85153-85311         c
            1904-2059           AC132402.3         83861-84016         c
            2060-2345           AC132402.3         83284-83569         c
FEATURES             Location/Qualifiers
     source          1..2345
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 7.23 cM"
     gene            1..2345
                     /gene="Slc15a3"
                     /gene_synonym="cI-1; Ci1"
                     /note="solute carrier family 15, member 3"
                     /db_xref="GeneID:65221"
                     /db_xref="MGI:MGI:1929691"
     exon            1..1035
                     /gene="Slc15a3"
                     /gene_synonym="cI-1; Ci1"
                     /inference="alignment:Splign:2.1.0"
     CDS             478..2214
                     /gene="Slc15a3"
                     /gene_synonym="cI-1; Ci1"
                     /note="peptide transporter 3; cAMP-inducible gene 1
                     protein; peptide/histidine transporter 2; cAMP inducible
                     gene 1"
                     /codon_start=1
                     /product="solute carrier family 15 member 3"
                     /protein_id="NP_075531.2"
                     /db_xref="CCDS:CCDS29588.1"
                     /db_xref="GeneID:65221"
                     /db_xref="MGI:MGI:1929691"
                     /translation="MSAPRAEEQPSRSGERQPLVARGPRGPRRWRRTAAAAVLLVQML
                     ERAAFFGVTSNLVLYLNSLNFNWDGQQASRATLLFLGASYLLAPVGGWLADVYLGRFL
                     TISLSLLLYLAASGLLLTTITNDGRRSFCGEMPELPLEPACPSSSCQGSWSSPYCATT
                     LYLVLLLLALAASSVRSTLTSFGADQVMDLGRDATRRFFNWFYWSINLGAILSLLVVA
                     FIEQNISFLWGYSIIVGLVGLAFFIFLFATPVFITKPPTGSQVSSMLKLAFQNCCPCR
                     RSSSRDSESAHLLPDQRSNQPGPSPQEDMANFQVLVKILPVMVTLVPYWMVYFQMQST
                     YVLQGLHLHIPNIFRTNPNISLLLRSDSSNYRIPEAWLLLANVAVILILIPVKDHLID
                     PLLLRCKLLPSSLQKMALGMFFGFTSIIVAGVLEKERLQYIAANQTVPQLIGKDLYYA
                     APLSIWWQIPQYLLIGVSEIFASIPGLEFAYSEAPRSMQGAIMGIFFCLSGVGSLLGS
                     GLVALLSFPGGWMYCPKDFGNINNCQMDRYFFLLAGIEAVTAVLFLWIAGRYERTRQD
                     PASQRSSSRVRG"
     exon            1036..1319
                     /gene="Slc15a3"
                     /gene_synonym="cI-1; Ci1"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1467
                     /gene="Slc15a3"
                     /gene_synonym="cI-1; Ci1"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1575
                     /gene="Slc15a3"
                     /gene_synonym="cI-1; Ci1"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1744
                     /gene="Slc15a3"
                     /gene_synonym="cI-1; Ci1"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1903
                     /gene="Slc15a3"
                     /gene_synonym="cI-1; Ci1"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..2059
                     /gene="Slc15a3"
                     /gene_synonym="cI-1; Ci1"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2345
                     /gene="Slc15a3"
                     /gene_synonym="cI-1; Ci1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2300..2305
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc15a3"
                     /gene_synonym="cI-1; Ci1"
                     /note="hexamer: AATGAA"
     regulatory      2314..2319
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc15a3"
                     /gene_synonym="cI-1; Ci1"
                     /note="hexamer: CATAAA"
     polyA_site      2315
                     /gene="Slc15a3"
                     /gene_synonym="cI-1; Ci1"
     polyA_site      2319
                     /gene="Slc15a3"
                     /gene_synonym="cI-1; Ci1"
                     /note="major polyA site"
     polyA_site      2345
                     /gene="Slc15a3"
                     /gene_synonym="cI-1; Ci1"
ORIGIN      
        1 gagaggaaga gccagagggg actaaggaag gaagagaagc agtcaagcaa aaaggagtgt
       61 gtagaggagg tggccgggcc aggggagaca ttgaggccca ggtatcataa gagaagggga
      121 caattagaaa aggcagttaa ccggggacac tagaggaaag gggggccggg aggataaggt
      181 agtggagcaa gcaggatgat ggggtagggt tggggggggg ggggtagact aggccagagc
      241 agaggaagga aaggagacga tttgatagaa gcacagggga gatgaacaag aagaactggg
      301 aggggaagga gtgagtggag agttcaagtg gagatagaaa ctaggtagca aggagaggga
      361 cctgagggaa aaagagagag agaacgacac ggggtgagaa aagagggcga tcagggttag
      421 gggagaggag gggaggacag aggagagagt ctgggtcacg gagacaggaa ggccaggatg
      481 tctgcccctc gcgcggaaga gcaaccaagc aggtccggag agcgacaacc gctggtggcc
      541 cgaggcccgc ggggaccacg acggtggaga cggacagctg ctgctgcggt gctgctagtg
      601 cagatgctgg aacgcgctgc cttctttggt gtcacctcca acctcgtgct ctacctcaac
      661 agcttgaact tcaattggga cggccaacag gcatcacggg ccacactcct cttcctaggc
      721 gcctcctacc tgctggctcc agtggggggc tggctggcag acgtgtacct gggacgcttc
      781 ctcactatct cgctcagcct gctgctctat ctggctgcct ctggcttgtt gctcaccacc
      841 atcaccaatg atggccgcag atccttctgt ggagagatgc ccgagttgcc actggaacct
      901 gcctgcccat cctcaagctg ccaaggctcc tggtccagcc cctactgcgc gaccaccctc
      961 tacttggtgt tgctgctcct ggccctggct gccagctccg tcaggagcac cctcacctcg
     1021 ttcggggctg accaggtgat ggatctcggg cgcgatgcca cccgccgctt cttcaactgg
     1081 ttctattgga gcatcaacct gggtgccata ttgtccctgt tggtggtggc tttcatcgag
     1141 cagaacatca gcttcctatg gggctacagc atcatcgtgg gcctcgtggg cctggcattc
     1201 ttcatttttc tctttgccac accagtcttc atcaccaagc ccccaacagg cagccaagtg
     1261 tcatctatgc tgaagcttgc gttccaaaac tgctgtccct gccggaggtc ctcttccagg
     1321 gactctgaaa gtgcccacct gttgcctgac cagaggtcta accagcctgg accttctcca
     1381 caagaagata tggccaactt ccaggtgctg gtgaagatcc tgcctgtgat ggtgaccctt
     1441 gtgccttatt ggatggtata tttccagatg cagtccacct atgtcctcca aggtctccac
     1501 ctccatatcc ccaacatctt caggaccaac cctaacatct ctttgttgct gagatcagat
     1561 agcagtaact acaggatccc agaagcctgg ctcctactgg ccaatgttgc ggtgatcctg
     1621 attctgatcc ctgtcaagga tcacttgatt gatcctctgc tgctgcggtg caagctgctg
     1681 ccctcatctc tgcagaaaat ggccctgggc atgttctttg ggttcacctc catcattgtg
     1741 gcaggagtcc tggagaaaga acgcttacag tacattgctg ccaaccagac agtgcctcag
     1801 ctgattggga aggacttata ctatgcagcg ccactgtcta tctggtggca gatcccccag
     1861 tacctgctca tcggggtcag tgagatcttt gccagcatcc caggtctgga gttcgcttac
     1921 tcagaagccc cacgctccat gcagggtgca attatgggca tcttcttctg cctttccggg
     1981 gtgggctcac tgctaggctc tggcttggtg gccctactgt cttttcctgg gggctggatg
     2041 tactgcccca aggactttgg gaacatcaac aactgtcaga tggaccgtta cttcttcctg
     2101 ctggccggca ttgaggctgt cacagccgtc ctgtttctct ggattgctgg tcgctatgag
     2161 aggactcgcc aggacccagc ctcccagcgc tcgtccagca gggtcagagg ctaatggtct
     2221 ccacccaccc tgacagagag tgtcacagca gtaccagcta tgcccattct tttctcattt
     2281 attctgtacc caacagtaga atgaagtggt tcccataaat aaggggcatg cgccctccct
     2341 cttga
//
