LOCUS       NM_053079               3123 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus solute carrier family 15 (oligopeptide transporter),
            member 1 (Slc15a1), mRNA.
ACCESSION   NM_053079
VERSION     NM_053079.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3123)
  AUTHORS   Sung,J., Wang,L., Long,D., Yang,C. and Merlin,D.
  TITLE     PepT1-knockout mice harbor a protective metabolome beneficial for
            intestinal wound healing
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 320 (5), G888-G896 (2021)
   PUBMED   33759563
  REMARK    GeneRIF: PepT1-knockout mice harbor a protective metabolome
            beneficial for intestinal wound healing.
REFERENCE   2  (bases 1 to 3123)
  AUTHORS   Viennois,E., Pujada,A., Sung,J., Yang,C., Gewirtz,A.T.,
            Chassaing,B. and Merlin,D.
  TITLE     Impact of PepT1 deletion on microbiota composition and colitis
            requires multiple generations
  JOURNAL   NPJ Biofilms Microbiomes 6 (1), 27 (2020)
   PUBMED   32694535
  REMARK    GeneRIF: Impact of PepT1 deletion on microbiota composition and
            colitis requires multiple generations.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3123)
  AUTHORS   Epling,D., Hu,Y. and Smith,D.E.
  TITLE     Evaluating the intestinal and oral absorption of the prodrug
            valacyclovir in wildtype and huPepT1 transgenic mice
  JOURNAL   Biochem Pharmacol 155, 1-7 (2018)
   PUBMED   29935147
REFERENCE   4  (bases 1 to 3123)
  AUTHORS   Timmermans,S. and Libert,C.
  TITLE     Overview of inactivating mutations in the protein-coding genome of
            the mouse reference strain C57BL/6J
  JOURNAL   JCI Insight 3 (13), 121758 (2018)
   PUBMED   29997285
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3123)
  AUTHORS   Stelzl,T., Geillinger-Kastle,K.E., Stolz,J. and Daniel,H.
  TITLE     Glycans in the intestinal peptide transporter PEPT1 contribute to
            function and protect from proteolysis
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 312 (6), G580-G591 (2017)
   PUBMED   28336547
  REMARK    GeneRIF: Glycosylation of PEPT1 confers resistance against
            proteolytic cleavage by proteinase K, whereas a remarkable
            intrinsic stability against trypsin, even in the absence of
            N-linked glycans, was detected.
REFERENCE   6  (bases 1 to 3123)
  AUTHORS   Sugiura,T., Kato,Y., Wakayama,T., Silver,D.L., Kubo,Y., Iseki,S.
            and Tsuji,A.
  TITLE     PDZK1 regulates two intestinal solute carriers (Slc15a1 and
            Slc22a5) in mice
  JOURNAL   Drug Metab Dispos 36 (6), 1181-1188 (2008)
   PUBMED   18322073
  REMARK    GeneRIF: PDZK1 regulates two intestinal transporters, Slc15a1 and
            Slc22a5, as an adaptor protein for these transporters and affects
            oral absorption of their substrates.
REFERENCE   7  (bases 1 to 3123)
  AUTHORS   Nguyen,H.T., Charrier-Hisamuddin,L., Dalmasso,G., Hiol,A.,
            Sitaraman,S. and Merlin,D.
  TITLE     Association of PepT1 with lipid rafts differently modulates its
            transport activity in polarized and nonpolarized cells
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 293 (6), G1155-G1165 (2007)
   PUBMED   17932227
  REMARK    GeneRIF: In conclusion, the association of PepT1 with lipid rafts
            differently modulates its transport activity in polarized and
            nonpolarized cells.
REFERENCE   8  (bases 1 to 3123)
  AUTHORS   Vavricka,S.R., Musch,M.W., Fujiya,M., Kles,K., Chang,L.,
            Eloranta,J.J., Kullak-Ublick,G.A., Drabik,K., Merlin,D. and
            Chang,E.B.
  TITLE     Tumor necrosis factor-alpha and interferon-gamma increase PepT1
            expression and activity in the human colon carcinoma cell line
            Caco-2/bbe and in mouse intestine
  JOURNAL   Pflugers Arch 452 (1), 71-80 (2006)
   PUBMED   16328452
  REMARK    GeneRIF: Treatment with interleukin-1beta increased PepT1 mRNA
            expression in mouse proximal and distal colon and decreased PepT1
            mRNA expression in jejunum and ileum.
REFERENCE   9  (bases 1 to 3123)
  AUTHORS   Lu,H. and Klaassen,C.
  TITLE     Tissue distribution and thyroid hormone regulation of Pept1 and
            Pept2 mRNA in rodents
  JOURNAL   Peptides 27 (4), 850-857 (2006)
   PUBMED   16202478
  REMARK    GeneRIF: Pept1 mRNA was not only highly expressed in small
            intestine, but also detectable in gonads and large intestine of
            mice
REFERENCE   10 (bases 1 to 3123)
  AUTHORS   Fei,Y.J., Sugawara,M., Liu,J.C., Li,H.W., Ganapathy,V.,
            Ganapathy,M.E. and Leibach,F.H.
  TITLE     cDNA structure, genomic organization, and promoter analysis of the
            mouse intestinal peptide transporter PEPT1
  JOURNAL   Biochim Biophys Acta 1492 (1), 145-154 (2000)
   PUBMED   11004485
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK136428.1, BC116248.1 and AV237408.1.
            
            On Dec 14, 2006 this sequence version replaced NM_053079.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136428.1, AF205540.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-734               AK136428.1         2-735
            735-735             BC116248.1         725-725
            736-2610            AK136428.1         737-2611
            2611-3073           AK136428.1         2613-3075
            3074-3074           AV237408.1         204-204
            3075-3123           AK136428.1         3077-3125
FEATURES             Location/Qualifiers
     source          1..3123
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 65.26 cM"
     gene            1..3123
                     /gene="Slc15a1"
                     /gene_synonym="D630032F02; PECT1; PEPT1"
                     /note="solute carrier family 15 (oligopeptide
                     transporter), member 1"
                     /db_xref="GeneID:56643"
                     /db_xref="MGI:MGI:1861376"
     exon            1..36
                     /gene="Slc15a1"
                     /gene_synonym="D630032F02; PECT1; PEPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            37..53
                     /gene="Slc15a1"
                     /gene_synonym="D630032F02; PECT1; PEPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            54..135
                     /gene="Slc15a1"
                     /gene_synonym="D630032F02; PECT1; PEPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            136..277
                     /gene="Slc15a1"
                     /gene_synonym="D630032F02; PECT1; PEPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            278..397
                     /gene="Slc15a1"
                     /gene_synonym="D630032F02; PECT1; PEPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            398..497
                     /gene="Slc15a1"
                     /gene_synonym="D630032F02; PECT1; PEPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            498..588
                     /gene="Slc15a1"
                     /gene_synonym="D630032F02; PECT1; PEPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            589..672
                     /gene="Slc15a1"
                     /gene_synonym="D630032F02; PECT1; PEPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            673..755
                     /gene="Slc15a1"
                     /gene_synonym="D630032F02; PECT1; PEPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            756..842
                     /gene="Slc15a1"
                     /gene_synonym="D630032F02; PECT1; PEPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            843..932
                     /gene="Slc15a1"
                     /gene_synonym="D630032F02; PECT1; PEPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            933..977
                     /gene="Slc15a1"
                     /gene_synonym="D630032F02; PECT1; PEPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1010
                     /gene="Slc15a1"
                     /gene_synonym="D630032F02; PECT1; PEPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1099
                     /gene="Slc15a1"
                     /gene_synonym="D630032F02; PECT1; PEPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1181
                     /gene="Slc15a1"
                     /gene_synonym="D630032F02; PECT1; PEPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1301
                     /gene="Slc15a1"
                     /gene_synonym="D630032F02; PECT1; PEPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1451
                     /gene="Slc15a1"
                     /gene_synonym="D630032F02; PECT1; PEPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1501
                     /gene="Slc15a1"
                     /gene_synonym="D630032F02; PECT1; PEPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1609
                     /gene="Slc15a1"
                     /gene_synonym="D630032F02; PECT1; PEPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1718
                     /gene="Slc15a1"
                     /gene_synonym="D630032F02; PECT1; PEPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1862
                     /gene="Slc15a1"
                     /gene_synonym="D630032F02; PECT1; PEPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..1970
                     /gene="Slc15a1"
                     /gene_synonym="D630032F02; PECT1; PEPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..3123
                     /gene="Slc15a1"
                     /gene_synonym="D630032F02; PECT1; PEPT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3107..3112
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc15a1"
                     /gene_synonym="D630032F02; PECT1; PEPT1"
                     /note="putative"
     polyA_site      3123
                     /gene="Slc15a1"
                     /gene_synonym="D630032F02; PECT1; PEPT1"
                     /note="putative"
ORIGIN      
        1 agtcgcccgt ccggagcctt ggagccacca caatggggat gtccaagtct cggggttgct
       61 tcggttaccc gttgagcatc ttcttcatcg tggtcaatga attctgtgaa agattctcct
      121 actatggcat gcgagcactc ctggttctgt acttcaggaa cttcctcggc tgggacgaca
      181 atctctccac ggccatttac catacgttcg ttgccctctg ctacctgact ccaattcttg
      241 gagctctgat cgcagactcg tggctgggga agttcaagac aattgtttca ctatccatcg
      301 tctacacgat tggacaagca gtcatctcgg tgagctcaat taatgacctc acagaccacg
      361 accacaatgg cagtcctgac agccttcccg tgcacgtagc actgtccatg gttggcctgg
      421 ccctgatagc ccttggtaca ggaggaatca agccctgtgt gtctgcgttt ggtggcgatc
      481 agtttgaaga gggtcaggaa aaacagcgaa accggttctt ttccatcttt tatttggcta
      541 tcaacggggg aagcctgctc tccacgatca tcactcccat actcagagtt caacagtgcg
      601 gaatccacag tcaacaagct tgttacccac tggccttcgg ggttccagcg gctctcatgg
      661 ctgttgccct aattgtgttt gtccttggca gtggaatgta caagaagttc cagccccagg
      721 gcaacatcat gggcaaagtg gccaagtgca ttggttttgc catcaaaaac aggtttcggc
      781 accgaagtaa ggcatatccc aagagggagc actggctgga ctgggctaaa gagaaatacg
      841 acgagcggct catctcacag attaagatgg tcacgaaggt gatgttcctg tacatcccac
      901 tccccatgtt ctgggccttg tttgaccagc agggttccag atggacactg caagcaacga
      961 ccatgaatgg gaaaattgga gcaattgaaa ttcagccgga ccagatgcag acggtgaatg
     1021 ccatcttgat tgtcatcatg gtccccattg tggacgctgt ggtgtacccg ctcattgcaa
     1081 aatgtggttt caacttcaca tccctgaaga agatgactgt tgggatgttc ctggcgtcca
     1141 tggcctttgt ggtggctgca attgtgcagg tggaaatcga taaaactctt ccagtcttcc
     1201 ctggtggaaa tcaagtccaa attaaggtct tgaacatcgg aaacaataac atgaccgtgc
     1261 attttcctgg aaatagtgtg acgcttgccc aaatgtctca gacagacacg ttcatgactt
     1321 tcgatataga caagctgaca agcataaaca tatcttcctc tggatcccca ggagtcacca
     1381 cagtagctca tgattttgag cagggtcacc ggcacaccct tctagtgtgg aaccccagtc
     1441 aataccgtgt ggtaaaagat ggtcttaacc aaaagccaga gaaaggggag aacggaatca
     1501 ggtttgtcaa cacccttaac gagatggtca ccatcaaaat gagtgggaaa gtatatgaaa
     1561 atgtcaccag tcacaacgcc agcggctacc agttcttccc ttctggcgaa aagcagtaca
     1621 caataaacac cacggcggtg gcaccaacct gtctaactga ttttaaatct tccaaccttg
     1681 actttggcag cgcgtatacc tacgtgatcc gaagggcgag tgatggctgc ctggaagtga
     1741 aggaatttga agacatccca cccaacactg tgaacatggc tctgcagatc ccacagtact
     1801 tccttctcac ctgcggcgag gtggtcttct ctgtcacagg actggagttc tcttattccc
     1861 aggctccgtc taacatgaag tccgtgcttc aggcaggctg gcttctaact gtggcggtcg
     1921 gcaatatcat tgtgctcatc gtggcagggg cggggcactt ccccaaacag tgggctgagt
     1981 acattctgtt tgcctcattg cttctggttg tctgcgtgat attcgccatc atggctcgat
     2041 tctacaccta catcaaccca gcagagattg aagcacagtt tgatgaggat gagaagaaaa
     2101 agggcatagg aaaggaaaac ccgtattctt cattggaacc agtctcacag acaaatatgt
     2161 gaagggcaga aggcaagtgg agaaagatcc aagtacaaca tgagccctga cctctgtcca
     2221 agggacagga cactccacca cagagccctg atggagaaga cctcagaagt gtgagccaga
     2281 ataataacaa agcagttttc taaccaacag ctgtgaacct gaaactctag gggagccttt
     2341 tttatttaaa aaaatttttt ttttaatttt ttaaattttt tttatttttt attttttttg
     2401 cttgtttgtt tgtttcgaga cagggtttct ctgtgtagcc ctggttgtcc tggaactcac
     2461 tctgtagacc agactggcct caaactcaga aatccacctg cccctgcccc tgcccctgcc
     2521 cctgcccctg cccctgcctc tgcctctgcc tcccaagtgc tgggatttag aggcatgcac
     2581 caccatgccc agctataatt tttttttttt aagacaggga ttctctgtat aagcctgact
     2641 gccctggaac ttgctctata gaccaggctg gccttgaact cacagagatc tgcctgcctc
     2701 ttcctcctaa gtactgggat ttcaggcatg caccacaact gcccagctaa aatattattt
     2761 ataatatgca ctttctggtt tgtttttgtt tttcttttaa actgggctgt atcttacatt
     2821 tctgccacag aaatgaactt agctcagatt aacttaattt tgaaaaggca atagtattgt
     2881 tttttctaac agttttatga aaacaatatt gaatttacag agggcttttt taatagtgtg
     2941 taatgagtat caactgattc aagctaattg ctttaccttg gggttttttt gtttgtttgt
     3001 ttgtttgttt gtttgtttgt ttttctagtc tcctttgcct tacctctttt taaattatgt
     3061 gtaattcaaa agactagtca tgagttgtga agtttcactg gtctgaaata aattctagtt
     3121 ctt
//
