LOCUS       NM_207651               4045 bp    mRNA    linear   ROD 07-FEB-2024
DEFINITION  Mus musculus solute carrier family 14 (urea transporter), member 2
            (Slc14a2), transcript variant 1, mRNA.
ACCESSION   NM_207651
VERSION     NM_207651.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4045)
  AUTHORS   Himmel,N.J., Rogers,R.T., Redd,S.K., Wang,Y. and Blount,M.A.
  TITLE     Purinergic signaling is enhanced in the absence of UT-A1 and UT-A3
  JOURNAL   Physiol Rep 9 (1), e14636 (2021)
   PUBMED   33369887
  REMARK    GeneRIF: Purinergic signaling is enhanced in the absence of UT-A1
            and UT-A3.
REFERENCE   2  (bases 1 to 4045)
  AUTHORS   Kabutomori,J., Pina-Lopes,N. and Musa-Aziz,R.
  TITLE     Water transport mediated by murine urea transporters: implications
            for urine concentration mechanisms
  JOURNAL   Biol Open 9 (8) (2020)
   PUBMED   32661130
  REMARK    GeneRIF: Water transport mediated by murine urea transporters:
            implications for urine concentration mechanisms.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4045)
  AUTHORS   Geng,X., Zhang,S., He,J., Ma,A., Li,Y., Li,M., Zhou,H., Chen,G. and
            Yang,B.
  TITLE     The urea transporter UT-A1 plays a predominant role in a
            urea-dependent urine-concentrating mechanism
  JOURNAL   J Biol Chem 295 (29), 9893-9900 (2020)
   PUBMED   32461256
  REMARK    GeneRIF: The urea transporter UT-A1 plays a predominant role in a
            urea-dependent urine-concentrating mechanism.
REFERENCE   4  (bases 1 to 4045)
  AUTHORS   Rianto,F., Kuma,A., Ellis,C.L., Hassounah,F., Rodriguez,E.L.,
            Wang,X.H., Sands,J.M. and Klein,J.D.
  TITLE     UT-A1/A3 knockout mice show reduced fibrosis following unilateral
            ureteral obstruction
  JOURNAL   Am J Physiol Renal Physiol 318 (5), F1160-F1166 (2020)
   PUBMED   32174141
  REMARK    GeneRIF: Reduced UT-A1/A3 activity reduces the severity of renal
            fibrosis following unilateral ureteral obstruction.
REFERENCE   5  (bases 1 to 4045)
  AUTHORS   Rogers,R.T., Sun,M.A., Yue,Q., Bao,H.F., Sands,J.M., Blount,M.A.
            and Eaton,D.C.
  TITLE     Lack of urea transporters, UT-A1 and UT-A3, increases nitric oxide
            accumulation to dampen medullary sodium reabsorption through ENaC
  JOURNAL   Am J Physiol Renal Physiol 316 (3), F539-F549 (2019)
   PUBMED   30539654
  REMARK    GeneRIF: In summary, loss of both UT-A1 and UT-A3 (but not UT-A3
            alone) causes elevated medullary NO production and salt wasting
REFERENCE   6  (bases 1 to 4045)
  AUTHORS   Jung,J.Y., Madsen,K.M., Han,K.H., Yang,C.W., Knepper,M.A.,
            Sands,J.M. and Kim,J.
  TITLE     Expression of urea transporters in potassium-depleted mouse kidney
  JOURNAL   Am J Physiol Renal Physiol 285 (6), F1210-F1224 (2003)
   PUBMED   12952854
  REMARK    GeneRIF: potassium depletion is associated with reduced expression
            of UT-A1, UT-A3, and UT-B but increased expression of UT-A2.
REFERENCE   7  (bases 1 to 4045)
  AUTHORS   Fenton,R.A., Stewart,G.S., Carpenter,B., Howorth,A., Potter,E.A.,
            Cooper,G.J. and Smith,C.P.
  TITLE     Characterization of mouse urea transporters UT-A1 and UT-A2
  JOURNAL   Am J Physiol Renal Physiol 283 (4), F817-F825 (2002)
   PUBMED   12217874
REFERENCE   8  (bases 1 to 4045)
  AUTHORS   Fenton,R.A., Cottingham,C.A., Stewart,G.S., Howorth,A., Hewitt,J.A.
            and Smith,C.P.
  TITLE     Structure and characterization of the mouse UT-A gene (Slc14a2)
  JOURNAL   Am J Physiol Renal Physiol 282 (4), F630-F638 (2002)
   PUBMED   11880324
  REMARK    GeneRIF: Levels of UTA mRNA were increased in thirsted mice
            compared with control animals
REFERENCE   9  (bases 1 to 4045)
  AUTHORS   Fenton,R.A., Howorth,A., Cooper,G.J., Meccariello,R., Morris,I.D.
            and Smith,C.P.
  TITLE     Molecular characterization of a novel UT-A urea transporter isoform
            (UT-A5) in testis
  JOURNAL   Am J Physiol Cell Physiol 279 (5), C1425-C1431 (2000)
   PUBMED   11029290
REFERENCE   10 (bases 1 to 4045)
  AUTHORS   Fenton,R.A., Hewitt,J.E., Howorth,A., Cottingham,C.A. and
            Smith,C.P.
  TITLE     The murine urea transporter genes Slc14a1 and Slc14a2 occur in
            tandem on chromosome 18
  JOURNAL   Cytogenet Cell Genet 87 (1-2), 95-96 (1999)
   PUBMED   10640821
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140455.2, AC145554.2, AC151578.1 and AC112792.4.
            
            [WARNING] On Apr 9, 2024 this sequence was replaced by NM_207651.4.
            
            On Nov 2, 2007 this sequence version replaced NM_207651.2.
            
            Transcript Variant: This variant (1), also known as UT-A1,
            represents the longest transcript and encodes the longest isoform
            (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF366052.2, BC150680.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-248               AC140455.2         50167-50414         c
            249-379             AC145554.2         326-456
            380-445             AC151578.1         115975-116040       c
            446-633             AC112792.4         157307-157494       c
            634-814             AC112792.4         155283-155463       c
            815-1004            AC112792.4         154091-154280       c
            1005-1133           AC112792.4         144115-144243       c
            1134-1326           AC112792.4         140480-140672       c
            1327-1474           AC112792.4         134128-134275       c
            1475-1609           AC112792.4         132935-133069       c
            1610-1659           AC112792.4         132512-132561       c
            1660-1834           AC112792.4         131850-132024       c
            1835-1960           AC112792.4         111485-111610       c
            1961-2043           AC112792.4         109147-109229       c
            2044-2203           AC112792.4         108253-108412       c
            2204-2393           AC112792.4         107366-107555       c
            2394-2522           AC112792.4         106626-106754       c
            2523-2715           AC112792.4         105567-105759       c
            2716-2863           AC112792.4         103896-104043       c
            2864-2998           AC112792.4         102387-102521       c
            2999-3048           AC112792.4         98783-98832         c
            3049-4045           AC112792.4         94533-95529         c
FEATURES             Location/Qualifiers
     source          1..4045
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 52.53 cM"
     gene            1..4045
                     /gene="Slc14a2"
                     /gene_synonym="UT-A1; UT-A3"
                     /note="solute carrier family 14 (urea transporter), member
                     2"
                     /db_xref="GeneID:27411"
                     /db_xref="MGI:MGI:1351653"
     exon            1..248
                     /gene="Slc14a2"
                     /gene_synonym="UT-A1; UT-A3"
                     /inference="alignment:Splign:2.1.0"
     exon            249..379
                     /gene="Slc14a2"
                     /gene_synonym="UT-A1; UT-A3"
                     /inference="alignment:Splign:2.1.0"
     exon            380..445
                     /gene="Slc14a2"
                     /gene_synonym="UT-A1; UT-A3"
                     /inference="alignment:Splign:2.1.0"
     exon            446..633
                     /gene="Slc14a2"
                     /gene_synonym="UT-A1; UT-A3"
                     /inference="alignment:Splign:2.1.0"
     CDS             457..3249
                     /gene="Slc14a2"
                     /gene_synonym="UT-A1; UT-A3"
                     /note="isoform a is encoded by transcript variant 1; urea
                     transporter 2; urea transporter, kidney; solute carrier
                     family 14 member 2"
                     /codon_start=1
                     /product="urea transporter 2 isoform a"
                     /protein_id="NP_997534.2"
                     /db_xref="CCDS:CCDS29361.1"
                     /db_xref="GeneID:27411"
                     /db_xref="MGI:MGI:1351653"
                     /translation="MSDHHPLKEMSDSNSSPLLPEPLSSRYKLYESELSSPTWPSSSQ
                     DTHPALPLLEMPEEKDLRSSDEDSHIVKIEKPNERNKRRESEVSRRASAGRGGFSLFQ
                     AVSYLTGDMKECKNWLKDKPLVLQFLDWVLRGAAQVMFVNNPISGLIIFIGLLIQNPW
                     WTIAGTLGTVASTLAALALSQDRSAIASGLHGYNGMLVGLLMAVFSEKLDYYWWLLFP
                     VTFTSMACPIISSALSTIFAKWDLPVFTLPFNIALTLYLAATGHYNLFFPTTLIKPAS
                     AAPNITWTEIEMPLLLQTIPVGVGQVYGCDNPWTGGMILVALFISSPLICLHAAIGSI
                     VGLLAALTVATPFETIYLGLWSYNCVLSCIAIGGMFYALTWQTHLLALVCALFCAYMG
                     AALSNTMAVVGVPSGTWAFCLSTLTFLLLTSNNTGIYKLPLSKVTYPEANRIYFLTVR
                     RSEEEKSPNGGSGEQSHGSGQWKAEESSETVLPRRRSVFHIEWSSIRRRSKVFGKGEH
                     QERQTKEPLPCPYRKPTVELFDLDTMEESTEIKVEANTARTSWIQSSMVAGGKRVSKA
                     LSYITGEMKECGEGLKDKSPVFQFLDWVLRGMSQVMFVNNPLSGILIVLGLFVQNPWW
                     AILGCLGTVMSTLTALILSQDKSAIAAGLHGYNGVLVGLLMAVFSDKGNYYWWLLLPV
                     IVMSMTCPILSSALSTVFSKWDLPVFTLPFNIAVTLYLAATGHHNLFFPTTLLQPTTT
                     PPNITWSDIQVSLLLRAIPVGIGQVYGCDNPWTGGIFLVALFISSPLICLHAAIGSTI
                     GMLAALSIATPFDSIYFGLCGFNSTLACIAIGGMFYVITWQTHLLAIACALFAAYLGA
                     ALANMLSVFGLPPCTWPFCLSALTFLLLTSNNPAIYKLPLSKVTYPEANRIYFLSQEK
                     NRRASTITKYQAYDVS"
     exon            634..814
                     /gene="Slc14a2"
                     /gene_synonym="UT-A1; UT-A3"
                     /inference="alignment:Splign:2.1.0"
     exon            815..1004
                     /gene="Slc14a2"
                     /gene_synonym="UT-A1; UT-A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1133
                     /gene="Slc14a2"
                     /gene_synonym="UT-A1; UT-A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1326
                     /gene="Slc14a2"
                     /gene_synonym="UT-A1; UT-A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1474
                     /gene="Slc14a2"
                     /gene_synonym="UT-A1; UT-A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1609
                     /gene="Slc14a2"
                     /gene_synonym="UT-A1; UT-A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1659
                     /gene="Slc14a2"
                     /gene_synonym="UT-A1; UT-A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1834
                     /gene="Slc14a2"
                     /gene_synonym="UT-A1; UT-A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..1960
                     /gene="Slc14a2"
                     /gene_synonym="UT-A1; UT-A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2043
                     /gene="Slc14a2"
                     /gene_synonym="UT-A1; UT-A3"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2203
                     /gene="Slc14a2"
                     /gene_synonym="UT-A1; UT-A3"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2393
                     /gene="Slc14a2"
                     /gene_synonym="UT-A1; UT-A3"
                     /inference="alignment:Splign:2.1.0"
     exon            2394..2522
                     /gene="Slc14a2"
                     /gene_synonym="UT-A1; UT-A3"
                     /inference="alignment:Splign:2.1.0"
     exon            2523..2715
                     /gene="Slc14a2"
                     /gene_synonym="UT-A1; UT-A3"
                     /inference="alignment:Splign:2.1.0"
     exon            2716..2863
                     /gene="Slc14a2"
                     /gene_synonym="UT-A1; UT-A3"
                     /inference="alignment:Splign:2.1.0"
     exon            2864..2998
                     /gene="Slc14a2"
                     /gene_synonym="UT-A1; UT-A3"
                     /inference="alignment:Splign:2.1.0"
     exon            2999..3048
                     /gene="Slc14a2"
                     /gene_synonym="UT-A1; UT-A3"
                     /inference="alignment:Splign:2.1.0"
     exon            3049..4045
                     /gene="Slc14a2"
                     /gene_synonym="UT-A1; UT-A3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttgatgaga ttagtacttc aaaagcaggt cttccagaat ggcaaaccca ctgtagttca
       61 gagtagctga agaggaagaa agacacagcc ggccaggaca gcagacattg ggacacccac
      121 ttgtcttcta ggctggctct gttttctgcc ttgaatactc aaggaagact gcaagatcat
      181 atttaaggtg atctctgcaa caacatcagc ttcacaaagt tatcactgca aagtttggga
      241 catgggagat ctttcctgtt tgcttcctga gtgtttccag gtgtgagtgc attgcattga
      301 catcttcctg cctctgttga caagaaggac aaagcttgaa aggccctcca tctacttcat
      361 caaccggacc tgagtgactg gctatttctt accacttgaa gtcatctgaa tagaagtttt
      421 caagaccacc aagaccaagg aaacttcaca tgacaaatga gtgaccacca ccccctgaag
      481 gagatgtctg acagcaacag cagccctctc ttgccagagc ctctttccag cagatacaaa
      541 ttgtatgagt cagagctaag cagccctacc tggccttcaa gctcccagga tacacaccca
      601 gcccttcccc tgctggaaat gccggaagaa aaggatctcc gctcatcaga tgaagacagc
      661 cacatagtga agattgaaaa acccaatgag aggaataaaa ggagagaaag tgaggtgtcc
      721 cgccgggctt ctgcgggccg gggaggcttc agcctcttcc aagccgtgag ctatctcact
      781 ggcgacatga aggaatgcaa gaactggctg aaagataagc ccctggtcct acagttccta
      841 gactgggtcc ttcggggagc agctcaggtg atgtttgtca acaaccccat tagtgggctc
      901 atcatcttca tagggctcct aatccagaat ccctggtgga cgattgctgg gacactgggg
      961 acagtggctt caaccttggc tgcccttgcc ttaagccagg acaggtcagc catcgcctcc
     1021 ggactccatg gctacaacgg gatgctggtg ggactgctga tggctgtctt ctcggagaag
     1081 ttagactact actggtggct tctgtttcct gtgaccttca catccatggc ctgccccatt
     1141 atttctagtg ccttgagtac catcttcgcc aagtgggacc tgcccgtctt cacactgccc
     1201 ttcaacattg ccttaacact gtacctggca gctacgggcc actacaacct tttcttcccc
     1261 accacgctca tcaagcctgc gtctgcagct cccaatatca cctggacaga gattgaaatg
     1321 cctttgctgt tacaaaccat ccctgttggg gtcggccagg tctacggctg tgacaacccc
     1381 tggacaggtg gcatgatcct ggtggctctg tttatctcct ccccactcat ctgcttacat
     1441 gcagccatag ggtcaatcgt ggggctgcta gcagcattga ctgtggccac tccctttgag
     1501 acgatctacc tgggcctttg gagctacaac tgtgtcctct cctgcattgc cattggcggc
     1561 atgttctacg cactcacctg gcagacacac ctgctggcac ttgtctgtgc cctgttctgt
     1621 gcatacatgg gagctgccct ctccaataca atggcagtgg ttggcgtgcc ctcaggcacc
     1681 tgggccttct gtctctccac cctcaccttc ctcctcctca caagcaacaa cactggcatc
     1741 tacaagctcc cactcagcaa agtcacctac ccggaggcca accgcatcta cttcctgaca
     1801 gtgagacgca gtgaagagga gaagtccccc aatggtggca gtggagagca gtcacacgga
     1861 tcaggccagt ggaaggcaga agagagctct gagaccgtgc tccccaggcg taggagtgtg
     1921 ttccacatcg agtggtcatc catccggagg aggagcaaag tgtttggaaa aggcgaacac
     1981 caagagaggc aaaccaaaga gccactgccc tgcccgtatc ggaagcccac agtggagctc
     2041 tttgacctgg acaccatgga ggagagcact gagataaagg tggaagccaa cacagccagg
     2101 acttcctgga ttcagagctc catggtcgct ggggggaaga gagtcagcaa agccctcagc
     2161 tacatcacag gagagatgaa ggaatgcggc gagggactta aagataaatc tccagtgttc
     2221 cagtttcttg actgggtgct ccggggcatg tctcaggtga tgtttgtaaa caaccctctc
     2281 agcggcatcc tcatcgtcct tggcctcttc gtgcagaatc cctggtgggc tatcttgggt
     2341 tgcttgggca ctgtcatgtc caccctgact gccctcatcc tgagccagga caagtcagcc
     2401 attgcagcag gactccatgg ctacaatggg gtgcttgtgg ggctcctgat ggccgtgttc
     2461 tcggacaagg gcaattacta ctggtggctg ctgcttcctg tcattgtcat gtccatgact
     2521 tgccccatcc tttccagtgc cctgagcacc gtcttcagca agtgggacct cccagtcttc
     2581 acactgccct tcaacatcgc cgtgaccctg tacctggcag cgacgggcca ccacaatctc
     2641 ttcttcccca cgacgctgct acagcctaca accactccac ccaacatcac ctggtcagat
     2701 atccaagtgt ctttgcttct gagagccatc ccggttggaa tcggccaagt gtacgggtgt
     2761 gacaacccct ggactggagg catcttcctg gtcgctctgt tcatctcttc gcctctcatt
     2821 tgcttgcatg ctgccattgg atccaccata gggatgttag cagcactcag cattgccaca
     2881 ccatttgact ccatctactt cggcctgtgt ggcttcaaca gcaccctggc ctgcatcgcc
     2941 attggtggca tgttctacgt catcacctgg cagacccacc tgctcgccat tgcctgtgcc
     3001 ctgtttgcag cctacctggg tgctgccctg gccaacatgc tgtctgtgtt tggattacca
     3061 ccctgcacct ggcccttctg cctctcggcg ctcaccttcc tcctcctgac aagcaacaac
     3121 cctgccatct ataagctgcc tctcagcaaa gtcacctacc cagaggccaa ccgcatctac
     3181 ttcctgtccc aggaaaaaaa cagaagggca tcaacgataa ctaagtacca ggcctacgac
     3241 gtctcctaaa ctgccctttc taaagcacac catgtcaagg cagcctctgt ccgggtacat
     3301 ggtctgcacc taagctaaag ctaaggtcac tgaacctccc ttctttctgg ttgggaccct
     3361 cactaaggtg tgcagaactc atcaaagtca tgctagttta gaataaatac ccactgatgg
     3421 ctctttggga actctctttt tttggaagac gggggacgac ttgttagcca cccctttcga
     3481 ttatgcagtg gaacagagca tgatgccagg aaatgctcgt tagcctgcaa ggcaagaggg
     3541 cctggtccct accctgctct gccactaatg agttccaact ctctcaggcc agtcctcccc
     3601 ctaaccccac ccccatctca gcctgggttt tgttgttgtt gttgttgttg ttgccaaaga
     3661 tttctttacg acaaggaggg actccagagt ccttctacct cagaaacatt cttttccatc
     3721 tcctgtaaac taatcaactc accatgacca gcaagtgatt atcctgactt gagatactta
     3781 gggaatggct ctcagaggag agaggaaaat gttaagtgtc ctgtgggagt ttatccttag
     3841 acatgggagg agatgctctc cagacttggg acacctgaat cattgaaaat gccagtgcac
     3901 cttctttgca cagtagaaat acttccagaa atatcatatg gtatgaactg atcttttcca
     3961 acatccaatc atagtgtcaa caaatgtctt tgcttatgta atcttcaaaa tcagtcctgt
     4021 cattaaactt gaaatttgca agttg
//
