LOCUS       NM_172892               3426 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus solute carrier family 13 (sodium/sulfate symporters),
            member 4 (Slc13a4), mRNA.
ACCESSION   NM_172892
VERSION     NM_172892.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3426)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3426)
  AUTHORS   Sharmin,S., Pradhan,J., Zhang,Z., Bellingham,M., Simmons,D. and
            Piper,M.
  TITLE     Perineuronal net abnormalities in Slc13a4+/- mice are rescued by
            postnatal administration of N-acetylcysteine
  JOURNAL   Exp Neurol 342, 113734 (2021)
   PUBMED   33945789
  REMARK    GeneRIF: Perineuronal net abnormalities in Slc13a4(+/-) mice are
            rescued by postnatal administration of N-acetylcysteine.
REFERENCE   3  (bases 1 to 3426)
  AUTHORS   Zhang,Z., Jhaveri,D., Sharmin,S., Harvey,T.J., Dawson,P.A.,
            Piper,M. and Simmons,D.G.
  TITLE     Cell-extrinsic requirement for sulfate in regulating hippocampal
            neurogenesis
  JOURNAL   Biol Open 9 (7) (2020)
   PUBMED   32661132
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3426)
  AUTHORS   Zhang,Z., Dawson,P.A., Piper,M. and Simmons,D.G.
  TITLE     Postnatal N-acetylcysteine administration rescues impaired social
            behaviors and neurogenesis in Slc13a4 haploinsufficient mice
  JOURNAL   EBioMedicine 43, 435-446 (2019)
   PUBMED   30956169
  REMARK    GeneRIF: Our study identifies SLC13A4 as a critical regulator of
            early postnatal brain development. Haploinsufficiency of Slc13a4
            leads to atypical phenotypes in mice that display a developmental
            origin similar to the onset of neurodevelopmental disorders in
            humans such as ASD.
REFERENCE   5  (bases 1 to 3426)
  AUTHORS   Rakoczy,J., Zhang,Z., Bowling,F.G., Dawson,P.A. and Simmons,D.G.
  TITLE     Loss of the sulfate transporter Slc13a4 in placenta causes severe
            fetal abnormalities and death in mice
  JOURNAL   Cell Res 25 (11), 1273-1276 (2015)
   PUBMED   26292834
  REMARK    GeneRIF: Study describes the critical requirement of placental
            Slc13a4 activity for normal fetal development in mice.
REFERENCE   6  (bases 1 to 3426)
  AUTHORS   Moreno-Moya,J.M., Franchi,N.A., Martinez-Escribano,S.,
            Martinez-Conejero,J.A., Bocca,S., Oehninger,S. and Horcajadas,J.A.
  TITLE     Transcriptome of early embryonic invasion at implantation sites in
            a murine model
  JOURNAL   Reprod Fertil Dev (2015) In press
   PUBMED   25940376
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   7  (bases 1 to 3426)
  AUTHORS   Shalom-Barak,T., Zhang,X., Chu,T., Timothy Schaiff,W., Reddy,J.K.,
            Xu,J., Sadovsky,Y. and Barak,Y.
  TITLE     Placental PPARgamma regulates spatiotemporally diverse genes and a
            unique metabolic network
  JOURNAL   Dev Biol 372 (1), 143-155 (2012)
   PUBMED   22967998
REFERENCE   8  (bases 1 to 3426)
  AUTHORS   Dawson,P.A., Rakoczy,J. and Simmons,D.G.
  TITLE     Placental, renal, and ileal sulfate transporter gene expression in
            mouse gestation
  JOURNAL   Biol Reprod 87 (2), 43 (2012)
   PUBMED   22674389
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3426)
  AUTHORS   Dawson,P.A., Sim,P., Simmons,D.G. and Markovich,D.
  TITLE     Fetal loss and hyposulfataemia in pregnant NaS1 transporter null
            mice
  JOURNAL   J Reprod Dev 57 (4), 444-449 (2011)
   PUBMED   21403420
REFERENCE   10 (bases 1 to 3426)
  AUTHORS   Dawson,P.A., Pirlo,K.J., Steane,S.E., Kunzelmann,K., Chien,Y.J. and
            Markovich,D.
  TITLE     Molecular cloning and characterization of the mouse Na+ sulfate
            cotransporter gene (Slc13a4): Structure and expression
  JOURNAL   Genes Genet Syst 81 (4), 265-272 (2006)
   PUBMED   17038798
  REMARK    GeneRIF: Tissue distribution of mNaS2 and its cDNA and gene
            structures.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK036354.1 and AW536922.1.
            
            On Dec 8, 2009 this sequence version replaced NM_172892.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036354.1, BC089161.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               AK036354.1         2-180
            180-3421            AK036354.1         182-3423
            3422-3426           AW536922.1         1-5                 c
FEATURES             Location/Qualifiers
     source          1..3426
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 15.26 cM"
     gene            1..3426
                     /gene="Slc13a4"
                     /gene_synonym="9630060C05Rik; SUT-1; SUT1"
                     /note="solute carrier family 13 (sodium/sulfate
                     symporters), member 4"
                     /db_xref="GeneID:243755"
                     /db_xref="MGI:MGI:2442367"
     exon            1..769
                     /gene="Slc13a4"
                     /gene_synonym="9630060C05Rik; SUT-1; SUT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             671..2548
                     /gene="Slc13a4"
                     /gene_synonym="9630060C05Rik; SUT-1; SUT1"
                     /codon_start=1
                     /product="solute carrier family 13 member 4"
                     /protein_id="NP_766480.1"
                     /db_xref="CCDS:CCDS20000.1"
                     /db_xref="GeneID:243755"
                     /db_xref="MGI:MGI:2442367"
                     /translation="MGLLQGLLQARKLLLVICVPLLLLPLPTIYPTSEAACAYVLLVT
                     AVYWVSEAVPLGAAALVPAFLYPFFGVLRSSEVAAEYFKNTTLLLVGVICVAAAVEKW
                     NLHKRIALRMVLMAGAKPGMLLLCFMCCTTMLSMWLSNTSTTAMVMPIVEAVLQELIN
                     AEEEQLAAGTEEAELMGLDVNNRQTSMELIFVNEDTSAADFTSLMQSKNLNGVPMVTK
                     SINTANQQQQKKQQPSQEKPGVPTPSSKTQELNKKKYRSHHDQMICKCLSLSISYAAT
                     IGGLTTIIGTSTSLIFLEHFNNQYPAAEVVNFGTWFLFSFPISLIMLVVSWFWIHWLF
                     LGCNFKETCSLSKKKKTRREELSEKRIREEYEKLGDISYPEMVTAFFFILMTVLWFTR
                     EPGFVPGWDSFFEKKGYRTDATVSVFLGFLLFLIPAKKPCFGKKSDGTGQEASKGIEP
                     IITWKDFQKTMPWEIVILVGGGYALASGSKSSGLSTWIGHQMLSLSSLPPWAITLLAC
                     VLVSIVTEFVSNPATITIFLPILCTLSETLHINPLYTLVPVTMSISFAVMLPVGNPPN
                     AIVFSYGHCQIKDMVKAGLGVNVIGLVIVMVAINTWGVSLFHLDAFPAWAKVSNITDQ
                     T"
     exon            770..898
                     /gene="Slc13a4"
                     /gene_synonym="9630060C05Rik; SUT-1; SUT1"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1035
                     /gene="Slc13a4"
                     /gene_synonym="9630060C05Rik; SUT-1; SUT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1199
                     /gene="Slc13a4"
                     /gene_synonym="9630060C05Rik; SUT-1; SUT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1254
                     /gene="Slc13a4"
                     /gene_synonym="9630060C05Rik; SUT-1; SUT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1294
                     /gene="Slc13a4"
                     /gene_synonym="9630060C05Rik; SUT-1; SUT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1375
                     /gene="Slc13a4"
                     /gene_synonym="9630060C05Rik; SUT-1; SUT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1563
                     /gene="Slc13a4"
                     /gene_synonym="9630060C05Rik; SUT-1; SUT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1683
                     /gene="Slc13a4"
                     /gene_synonym="9630060C05Rik; SUT-1; SUT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1785
                     /gene="Slc13a4"
                     /gene_synonym="9630060C05Rik; SUT-1; SUT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1887
                     /gene="Slc13a4"
                     /gene_synonym="9630060C05Rik; SUT-1; SUT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..1985
                     /gene="Slc13a4"
                     /gene_synonym="9630060C05Rik; SUT-1; SUT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2110
                     /gene="Slc13a4"
                     /gene_synonym="9630060C05Rik; SUT-1; SUT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2272
                     /gene="Slc13a4"
                     /gene_synonym="9630060C05Rik; SUT-1; SUT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2410
                     /gene="Slc13a4"
                     /gene_synonym="9630060C05Rik; SUT-1; SUT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2411..3426
                     /gene="Slc13a4"
                     /gene_synonym="9630060C05Rik; SUT-1; SUT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3402..3407
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc13a4"
                     /gene_synonym="9630060C05Rik; SUT-1; SUT1"
                     /note="hexamer: AATAAA"
     polyA_site      3422
                     /gene="Slc13a4"
                     /gene_synonym="9630060C05Rik; SUT-1; SUT1"
                     /note="major polyA site"
ORIGIN      
        1 gattcttcac ggctgctttg gaagtccata cttcaggaaa agtataagta ggagcccaat
       61 ttgaagggaa gaaatctaaa cagaattaag gtgtcaggta ctgagagaga gagagtgcac
      121 cctcagactg acaccagtgc tggctttaag ggaaggggcc aacagatttt ttttttttta
      181 ccaacagtca gccaggtcgg aggtaagaca aaacaggtca ccagaaagaa gaaaagctac
      241 tgtggttttg gggtttttgt tttgttttgt tttgttttgt tttgttttta agctttaaat
      301 gattcttcaa tactgaccag tagccgcaag ctcattgctc ccgaggactc tttctggcgt
      361 ctagcatgaa gccaccctct tgttaaccag agagaaaacc cagcgctcag gtgtgtaagc
      421 ctttcccggc tcttcttcga tggccataac actatgctgc tcaacctcac ctaaggcaaa
      481 agtcaagcag cccagctttc tgtggaaact gggtgcagcc accctgcttc tctgctcccg
      541 agaccaaaga ggactaactc ttggaagcca gggaaggtgt gtgaagtctt cctggacgga
      601 gaggggagcg tagcgcagaa cagaagagga cgccattgag gactcgatcc aggatccaga
      661 caggtccacc atgggcttgc tgcagggcct tctccaagcg aggaagctgc tattggtcat
      721 ctgtgtgccg ctgctgctgc tgcctctgcc caccatctac cccaccagcg aagctgcgtg
      781 tgcttacgtg ttgcttgtga ccgctgtgta ctgggtgtct gaggccgtgc ctctcggagc
      841 tgcagccctc gtgcctgcct tcctctaccc gttcttcggt gttctccgat ccagtgaggt
      901 ggcggctgag tacttcaaga acaccacgct gctgttggtg ggcgtcatct gtgtggcagc
      961 agctgtggag aagtggaatt tacacaagcg catcgccctg cgcatggtct tgatggcggg
     1021 agccaagcct ggcatgctcc tgctgtgttt catgtgctgt accaccatgc tgtccatgtg
     1081 gctctccaac acctccacca ccgccatggt gatgcccatc gtggaggcgg tgctgcagga
     1141 gctcatcaac gctgaggagg aacagctggc agccggcact gaggaggctg agctcatggg
     1201 tcttgatgta aacaacagac agacgtccat ggaactcatc tttgtcaatg aagacacgtc
     1261 ggctgcagac ttcacttctc tgatgcagag caagaatctg aatggtgtgc ccatggtcac
     1321 caaatccatc aacacagcaa accaacagca acagaagaag cagcagccgt cacaggaaaa
     1381 gccaggagtc ccaaccccca gctccaagac ccaagaactg aacaagaaga agtacagatc
     1441 ccaccatgac caaatgatct gcaagtgcct ttctctgagc atttcctatg ctgccaccat
     1501 tggtggcctg accaccatca taggcacctc caccagcctc attttcttag agcatttcaa
     1561 caaccagtac ccggcggcag aggtggtgaa cttcggaacc tggttcctct tcagcttccc
     1621 catctcgctc atcatgctgg tggtcagctg gttctggatc cactggctct tcctgggctg
     1681 caacttcaaa gagacctgct ctctgagcaa gaagaagaag accaggaggg aggagctatc
     1741 agagaagagg atccgggagg aatatgagaa gctaggagac attagctacc ctgagatggt
     1801 gaccgccttt ttcttcattc tgatgacggt gctgtggttt acccgggagc ccggctttgt
     1861 ccctggctgg gattctttct ttgaaaagaa aggctaccgc actgatgcca cagtctctgt
     1921 attccttggc ttcctgcttt tcctcattcc agcaaagaag ccctgctttg ggaaaaagag
     1981 tgatggaaca ggccaggaag cctccaaagg gatagagccc atcatcacgt ggaaggactt
     2041 ccagaaaact atgccctggg agattgtcat tctggtggga ggaggctacg ccctggcttc
     2101 tggcagcaag agctctggcc tctccacatg gatcgggcac cagatgctgt ccctgagcag
     2161 cctcccgcca tgggctatca ccctgctggc gtgtgtcctg gtgtccattg tcacggagtt
     2221 tgtcagcaat ccagccacca tcaccatctt cctgcccatc ctttgtaccc tgtccgaaac
     2281 gctgcacatc aatccactgt acaccctggt ccccgttacc atgtcaatct ccttcgctgt
     2341 gatgctgccc gtgggcaacc cccccaacgc catcgtcttc agctacgggc actgccagat
     2401 caaagacatg gtgaaagccg gtctgggagt caatgtcatc ggtctggtga tcgtgatggt
     2461 ggccatcaat acttggggag ttagcctctt ccacttggat gctttcccag cctgggctaa
     2521 ggtcagcaac atcactgatc agacctaacg cgagcggaca gttaccaagc acagccagag
     2581 ctaagccttg ggccgagaaa accaccagaa gcataaaccc cagacccaca tggaggctat
     2641 tcccgccgcc agatcccgcc aaccgccacc gggcgcattg gctgtgtctc cctcccagcc
     2701 tgcctgcttt tcttaccacc aactctcaag aaagcctaca gctgctctct cttcctgtgt
     2761 ccagctctct ctttttgaag accagaaaac actgtaagcc ttggtgccct gagaggaaac
     2821 ctcacaaact gaccggcatc actaggtttt gtgtcacctt cctaggaatc agagctagcc
     2881 agagcactct gcctgtcaga ccatgagacc tgtgacctct cttctgggag aaaacctcac
     2941 ccatgttctc aagcatttct gtcctatctc tagaaaaggt aacctgtctc tcttcagtgg
     3001 tccccctacc tcggcaccaa attcctgaaa agaaataata ttctccttca gaaggaggct
     3061 ggcctgattc caccaaagga aagagatgga aacaaaccaa ccaaccatcc tgaggtcagc
     3121 ttctctatgc actgtcatta acaggagatt ctattgtgtt gtgtgtggtg agaggaaaaa
     3181 ggttcatacc tgtcttatta ggaagaccac aactacaatt aagaccacag tattaactga
     3241 tattacatct acttctccat ttaataacta gcttgtttct gagaaaacca agttctaagt
     3301 ggtacccaaa ggtgttgcca gtccttccta tgcatccacg agccctttga ggggagagat
     3361 gtgccttggg ttctttacaa tgtattaaac tctaactgct caataaatgt ctctgatgac
     3421 tactgc
//
