LOCUS       NM_054055               3224 bp    mRNA    linear   ROD 05-AUG-2024
DEFINITION  Mus musculus solute carrier family 13 (sodium-dependent
            dicarboxylate transporter), member 3 (Slc13a3), mRNA.
ACCESSION   NM_054055
VERSION     NM_054055.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3224)
  AUTHORS   Hull,V.L., Wang,Y., McDonough,J., Zhu,M., Burns,T., Al Ramel,N.,
            Dehghani,A., Guo,F. and Pleasure,D.
  TITLE     Astroglial conditional Slc13a3 knockout is therapeutic in murine
            Canavan leukodystrophy
  JOURNAL   Ann Clin Transl Neurol 11 (4), 1059-1062 (2024)
   PUBMED   38282243
  REMARK    GeneRIF: Astroglial conditional Slc13a3 knockout is therapeutic in
            murine Canavan leukodystrophy.
REFERENCE   2  (bases 1 to 3224)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3224)
  AUTHORS   Wang,Y., Hull,V., Sternbach,S., Popovich,B., Burns,T.,
            McDonough,J., Guo,F. and Pleasure,D.
  TITLE     Ablating the Transporter Sodium-Dependent Dicarboxylate Transporter
            3 Prevents Leukodystrophy in Canavan Disease Mice
  JOURNAL   Ann Neurol 90 (5), 845-850 (2021)
   PUBMED   34498299
REFERENCE   4  (bases 1 to 3224)
  AUTHORS   Zhang,Z., Li,L., Wu,C., Yin,G., Zhu,P., Zhou,Y., Hong,Y., Ni,H.,
            Qian,Z. and Wu,W.S.
  TITLE     Inhibition of Slug effectively targets leukemia stem cells via the
            Slc13a3/ROS signaling pathway
  JOURNAL   Leukemia 34 (2), 380-390 (2020)
   PUBMED   31492896
  REMARK    GeneRIF: Genetic or pharmacological inhibition of SLUG or forced
            expression of Slc13a3 suppresses the growth of human AML cells.
REFERENCE   5  (bases 1 to 3224)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   6  (bases 1 to 3224)
  AUTHORS   Stellmer,F., Keyser,B., Burckhardt,B.C., Koepsell,H.,
            Streichert,T., Glatzel,M., Jabs,S., Thiem,J., Herdering,W.,
            Koeller,D.M., Goodman,S.I., Lukacs,Z., Ullrich,K., Burckhardt,G.,
            Braulke,T. and Muhlhausen,C.
  TITLE     3-Hydroxyglutaric acid is transported via the sodium-dependent
            dicarboxylate transporter NaDC3
  JOURNAL   J Mol Med (Berl) 85 (7), 763-770 (2007)
   PUBMED   17356845
  REMARK    GeneRIF: demonstrate the membrane translocation of 3OH-GA mediated
            by NaDC3 and the cis-inhibitory effect on OCT2-mediated transport
            of cations
REFERENCE   7  (bases 1 to 3224)
  AUTHORS   Fujita,T., Katsukawa,H., Yodoya,E., Wada,M., Shimada,A., Okada,N.,
            Yamamoto,A. and Ganapathy,V.
  TITLE     Transport characteristics of N-acetyl-L-aspartate in rat
            astrocytes: involvement of sodium-coupled high-affinity carboxylate
            transporter NaC3/NaDC3-mediated transport system
  JOURNAL   J Neurochem 93 (3), 706-714 (2005)
   PUBMED   15836629
REFERENCE   8  (bases 1 to 3224)
  AUTHORS   Willnow,T., Antignac,C., Brandli,A., Christensen,E., Cox,R.,
            Davidson,D., Davies,J., Devuyst,O., Eichele,G., Hastie,N.,
            Verroust,P., Schedl,A. and Meij,I.
  TITLE     The European renal genome project: an integrated approach towards
            understanding the genetics of kidney development and disease
  JOURNAL   Organogenesis 2 (2), 42-47 (2005)
   PUBMED   19521566
REFERENCE   9  (bases 1 to 3224)
  AUTHORS   Kelley-Loughnane,N., Sabla,G.E., Ley-Ebert,C., Aronow,B.J. and
            Bezerra,J.A.
  TITLE     Independent and overlapping transcriptional activation during liver
            development and regeneration in mice
  JOURNAL   Hepatology 35 (3), 525-534 (2002)
   PUBMED   11870364
REFERENCE   10 (bases 1 to 3224)
  AUTHORS   Pajor,A.M., Gangula,R. and Yao,X.
  TITLE     Cloning and functional characterization of a high-affinity
            Na(+)/dicarboxylate cotransporter from mouse brain
  JOURNAL   Am J Physiol Cell Physiol 280 (5), C1215-C1223 (2001)
   PUBMED   11287335
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL591064.11.
            
            On Mar 21, 2007 this sequence version replaced NM_054055.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026803.1, AF306491.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               AL591064.11        121780-121926       c
            148-413             AL591064.11        97251-97516         c
            414-577             AL591064.11        94221-94384         c
            578-644             AL591064.11        86011-86077         c
            645-824             AL591064.11        82766-82945         c
            825-950             AL591064.11        78937-79062         c
            951-1046            AL591064.11        75767-75862         c
            1047-1151           AL591064.11        74679-74783         c
            1152-1249           AL591064.11        73259-73356         c
            1250-1362           AL591064.11        68715-68827         c
            1363-1524           AL591064.11        60599-60760         c
            1525-1662           AL591064.11        57551-57688         c
            1663-3224           AL591064.11        54024-55585         c
FEATURES             Location/Qualifiers
     source          1..3224
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 85.54 cM"
     gene            1..3224
                     /gene="Slc13a3"
                     /gene_synonym="NaC3; NaDC-3; NaDC3; SDCT2"
                     /note="solute carrier family 13 (sodium-dependent
                     dicarboxylate transporter), member 3"
                     /db_xref="GeneID:114644"
                     /db_xref="MGI:MGI:2149635"
     exon            1..147
                     /gene="Slc13a3"
                     /gene_synonym="NaC3; NaDC-3; NaDC3; SDCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            148..413
                     /gene="Slc13a3"
                     /gene_synonym="NaC3; NaDC-3; NaDC3; SDCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            414..577
                     /gene="Slc13a3"
                     /gene_synonym="NaC3; NaDC-3; NaDC3; SDCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            578..644
                     /gene="Slc13a3"
                     /gene_synonym="NaC3; NaDC-3; NaDC3; SDCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            645..824
                     /gene="Slc13a3"
                     /gene_synonym="NaC3; NaDC-3; NaDC3; SDCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            825..950
                     /gene="Slc13a3"
                     /gene_synonym="NaC3; NaDC-3; NaDC3; SDCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1046
                     /gene="Slc13a3"
                     /gene_synonym="NaC3; NaDC-3; NaDC3; SDCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1151
                     /gene="Slc13a3"
                     /gene_synonym="NaC3; NaDC-3; NaDC3; SDCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1249
                     /gene="Slc13a3"
                     /gene_synonym="NaC3; NaDC-3; NaDC3; SDCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1362
                     /gene="Slc13a3"
                     /gene_synonym="NaC3; NaDC-3; NaDC3; SDCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1524
                     /gene="Slc13a3"
                     /gene_synonym="NaC3; NaDC-3; NaDC3; SDCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1662
                     /gene="Slc13a3"
                     /gene_synonym="NaC3; NaDC-3; NaDC3; SDCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..3224
                     /gene="Slc13a3"
                     /gene_synonym="NaC3; NaDC-3; NaDC3; SDCT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3199..3204
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc13a3"
                     /gene_synonym="NaC3; NaDC-3; NaDC3; SDCT2"
                     /note="hexamer: AATAAA"
     polyA_site      3224
                     /gene="Slc13a3"
                     /gene_synonym="NaC3; NaDC-3; NaDC3; SDCT2"
                     /note="major polyA site"
ORIGIN      
        1 ggcagtcggg ccgcctggtc tccagcgatc gcgcggatgg cggcgctggc ggcgctggcc
       61 aagaaggtgt ggagcgcgcg gcgcctcctg gtgctgctgc tggtgccgct ggctctgctg
      121 cccattctct tcgccctgcc gcccaaggaa ggccgatgcc tctatgtcat cctgctcatg
      181 gcggtgtact ggtgcacaga ggccctgccc ctgtcagtga cagctcttct gcccatcatc
      241 ctcttcccct tcatgggcat tctgccctcc agcaaggtct gcccccagta cttcctcgac
      301 accaacttcc tcttccttag cggcctgatc atggccagcg ccatagagga atggaacttg
      361 caccggagaa tcgccctcaa ggtcctcatg ctggttgggg tccagcctgc aaggctcatc
      421 ctggggatga tggtgaccac gtcattcctg tctatgtggc tgagcaacac ggcctccacc
      481 gcaatgatgc tacccattgc cagtgccatc ctcaagagcc tctttggcca gcgcgaagct
      541 cggaaggacc ttccccggga aggcgacgag agcacagctg ctgtgcaggg aaatggactg
      601 cgaacagtgc ccacggagat gcagtttctt gccagttcgg aaggaggtca cactgaggat
      661 gcagaggccc cgatggagct gcctgatgac tccaaggagg aggaacaccg cagaaacatc
      721 tggaagggct tcctcatttc cattccttac tctgccagca ttgggggcac tgccaccctc
      781 acgggcaccg cccccaacct catcctgctc ggccagctca agagtttctt cccacagtgt
      841 gatgtggtga attttggctc ctggttcatc ttcgccttcc ctctcatgct gttgttccta
      901 ctggtgggct ggctctggat ctccttcctc tatggtggaa tgagctggag aagttggagg
      961 aagaagaaat ccaagatacg agctgacgca gaggatcagg ctaaagcggt gatccaggag
     1021 gagttccaga acctggggcc catcaagttt gctgaacagg ccgtcttcat cttgttctgc
     1081 acgtttgcca tcctcctctt ctcccgggac cccaagttca tccctggctg ggccagcctc
     1141 ttcgcccctg ggtttgtctc ggatgctgtc accggtgtgg ccattgtcac catcctgttc
     1201 ttcttccctt cccagaagcc ctcactcaag tggtggtttg acttcaaagc tcccaactcg
     1261 gagacggagc ccctgctgag ctggaagaag gcccaggaga cagtgccctg gaacattatc
     1321 cttcttctag gaggtggctt tgccatggcc aagggctgtg aggagtctgg gctatcagca
     1381 tggatcggtg gacagctgca ccccctggag catgtccccc cactgctggc agtgctgctc
     1441 atcaccgtgg tcatcgcctt cttcacggag tttgccagca acacggccac catcatcatc
     1501 ttcctgcccg tcctggcaga gctggccatc cgactgcatg tgcacccctt gtacctgatg
     1561 atcccaggca cggtcggctg ctcctacgcc ttcatgctgc cggtctcaac acccccaaac
     1621 tccattgcct tctctactgg acacttgctg gtcaaagaca tggtgcggac gggcctgctg
     1681 atgaacctga tgggtgtcct gctgctcagc ctggccatga acacctgggc acagaccatc
     1741 ttccagctgg gcaccttccc agactgggcc aacacccatg ctgctaacgc caccgcactg
     1801 ccaccagcct tgaccaacaa cacagttcaa accttctgag ccctgctggg gacttttttt
     1861 taggctgggc cttcttctcc agaaggctgt tgctgtcact tgctgctagg agcctccaag
     1921 ctgatcaagc aattctttcc tgtaatctga taggaggcag caagcaagga catcctccag
     1981 tggtttcctg gagccaccgg ctcactgtct gcagcacctt ctctttcttt ctcatgcatt
     2041 tcaaagccag ctatctcctg cactagctgt ctgtggcctg tagaacaagc ttttttcacc
     2101 aagctggtct ctggccaggg tgcaggaaag tccacttcag ccaccaggag caaagctgaa
     2161 atggcatttg tttttcacac ctggggtcag gggtatcgat agtcacggct gccattggct
     2221 ttaggtctct ggaccagaga caggagaggc tttgcgactc caaagctcta ggccagatgt
     2281 tacagttgtt cgcagcaggc tcgattctgc cctctctttt taaccatctc ccttgtagat
     2341 gatccgggcc actagagatt agcttccatt gcctgaggca gagggaggac acaggtcttc
     2401 ctggagtctc tctgctgctt tccccagcct cccaagcaac acactatggg ggagaggggg
     2461 tgtcaagaaa ctccagctca cacatctacc caagatgctt ggggttctct tttttcatct
     2521 gattatgtta ggccctagct ctaggtcagc cctgctgggc ccttgagagg ggctctgtgg
     2581 ctgcagagct gtttttaccc tgacaactgg gtttgtcctc cctactccca ccccaagtgg
     2641 tcaataagtc ttatttgcaa aagccatgat cttcaagggt gagagaaaaa tctgaaggtc
     2701 agcggagacc tcagagaaaa cgggggcaaa gtgtcttagg ccagaagtac gctgtagcat
     2761 tgtaacattg tgcagatgga gacaccccac ccctctctac cccaccccac ccaagacagc
     2821 cttccactag aggctgaagc caggaagcag acagttgctg tccttattcc tgttaaaagc
     2881 ctctggcact atgaacaacg cagtgtgggg acagtgggtg actcagaact ctgctggtac
     2941 ctgggggtgg agctatcact tcctccagag ggaggacatc ccagggatag cacaagtgag
     3001 tcagagtatt ttcccagagc tggcgtggag ggggccctca gcgagaggtg acaacgtagg
     3061 actgaatcag cttcagcacc ccctggggct ggatggggat atccctcggg ggacaaggac
     3121 ggacatgcac agagagaacc acagccttgg gaccatagga ttcatgattt ctgatactgc
     3181 tgatcaaaaa tgcgcgcaaa taaagaatgt tggtcaatac tgga
//
