LOCUS       NM_022411               2240 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus solute carrier family 13 (sodium-dependent
            dicarboxylate transporter), member 2 (Slc13a2), mRNA.
ACCESSION   NM_022411
VERSION     NM_022411.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2240)
  AUTHORS   Osis,G., Webster,K.L., Harris,A.N., Lee,H.W., Chen,C., Fang,L.,
            Romero,M.F., Khattri,R.B., Merritt,M.E., Verlander,J.W. and
            Weiner,I.D.
  TITLE     Regulation of renal NaDC1 expression and citrate excretion by
            NBCe1-A
  JOURNAL   Am J Physiol Renal Physiol 317 (2), F489-F501 (2019)
   PUBMED   31188034
  REMARK    GeneRIF: NaDC1 expression increased only in the proximal convoluted
            tubules and proximal straight tubules in knockout mice blocked both
            the citrate and NaDC1 changes
REFERENCE   2  (bases 1 to 2240)
  AUTHORS   Osis,G., Handlogten,M.E., Lee,H.W., Hering-Smith,K.S., Huang,W.,
            Romero,M.F., Verlander,J.W. and Weiner,I.D.
  TITLE     Effect of NBCe1 deletion on renal citrate and 2-oxoglutarate
            handling
  JOURNAL   Physiol Rep 4 (8) (2016)
   PUBMED   27117802
REFERENCE   3  (bases 1 to 2240)
  AUTHORS   Colas,C., Pajor,A.M. and Schlessinger,A.
  TITLE     Structure-Based Identification of Inhibitors for the SLC13 Family
            of Na(+)/Dicarboxylate Cotransporters
  JOURNAL   Biochemistry 54 (31), 4900-4908 (2015)
   PUBMED   26176240
REFERENCE   4  (bases 1 to 2240)
  AUTHORS   Ohana,E., Shcheynikov,N., Moe,O.W. and Muallem,S.
  TITLE     SLC26A6 and NaDC-1 transporters interact to regulate oxalate and
            citrate homeostasis
  JOURNAL   J Am Soc Nephrol 24 (10), 1617-1626 (2013)
   PUBMED   23833257
  REMARK    GeneRIF: Slc26a6-null mice exhibit increased renal and intestinal
            sodium-dependent succinate uptake, as well as urinary hyperoxaluria
            and hypocitraturia, but no change in urinary pH, indicating
            enhanced transport activity of NaDC-1.
REFERENCE   5  (bases 1 to 2240)
  AUTHORS   Tang,F., Barbacioru,C., Nordman,E., Bao,S., Lee,C., Wang,X.,
            Tuch,B.B., Heard,E., Lao,K. and Surani,M.A.
  TITLE     Deterministic and stochastic allele specific gene expression in
            single mouse blastomeres
  JOURNAL   PLoS One 6 (6), e21208 (2011)
   PUBMED   21731673
REFERENCE   6  (bases 1 to 2240)
  AUTHORS   Oshiro,N. and Pajor,A.M.
  TITLE     Ala-504 is a determinant of substrate binding affinity in the mouse
            Na(+)/dicarboxylate cotransporter
  JOURNAL   Biochim Biophys Acta 1758 (6), 781-788 (2006)
   PUBMED   16787639
REFERENCE   7  (bases 1 to 2240)
  AUTHORS   Oshiro,N., King,S.C. and Pajor,A.M.
  TITLE     Transmembrane helices 3 and 4 are involved in substrate recognition
            by the Na+/dicarboxylate cotransporter, NaDC1
  JOURNAL   Biochemistry 45 (7), 2302-2310 (2006)
   PUBMED   16475819
  REMARK    GeneRIF: Substrate-dependent inward currents, measured using
            two-electrode voltage clamp, were similar for glutarate & succinate
            in Xenopus oocytes expressing mouse NaDC1. Currents evoked by
            glutarate in rabbit NaDC1 were about 5% of succinate-dependent
            currents.
REFERENCE   8  (bases 1 to 2240)
  AUTHORS   Mink,M., Fogelgren,B., Olszewski,K., Maroy,P. and Csiszar,K.
  TITLE     A novel human gene (SARM) at chromosome 17q11 encodes a protein
            with a SAM motif and structural similarity to
            Armadillo/beta-catenin that is conserved in mouse, Drosophila, and
            Caenorhabditis elegans
  JOURNAL   Genomics 74 (2), 234-244 (2001)
   PUBMED   11386760
REFERENCE   9  (bases 1 to 2240)
  AUTHORS   Pajor,A.M. and Sun,N.N.
  TITLE     Molecular cloning, chromosomal organization, and functional
            characterization of a sodium-dicarboxylate cotransporter from mouse
            kidney
  JOURNAL   Am J Physiol Renal Physiol 279 (3), F482-F490 (2000)
   PUBMED   10966927
REFERENCE   10 (bases 1 to 2240)
  AUTHORS   Schorpp,M., Hofmann,M., Dear,T.N. and Boehm,T.
  TITLE     Characterization of mouse and human nude genes
  JOURNAL   Immunogenetics 46 (6), 509-515 (1997)
   PUBMED   9321431
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591131.9.
            
            On Feb 23, 2018 this sequence version replaced NM_022411.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF201903.1, AK140972.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-169               AL591131.9         74077-74245         c
            170-298             AL591131.9         58821-58949         c
            299-435             AL591131.9         56682-56818         c
            436-635             AL591131.9         56389-56588         c
            636-807             AL591131.9         55325-55496         c
            808-930             AL591131.9         55083-55205         c
            931-1149            AL591131.9         52755-52973         c
            1150-1238           AL591131.9         52487-52575         c
            1239-1360           AL591131.9         52095-52216         c
            1361-1522           AL591131.9         51043-51204         c
            1523-1660           AL591131.9         50302-50439         c
            1661-2240           AL591131.9         49287-49866         c
FEATURES             Location/Qualifiers
     source          1..2240
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.74 cM"
     gene            1..2240
                     /gene="Slc13a2"
                     /gene_synonym="mNaDC-1; Nadc-1; Nadc1"
                     /note="solute carrier family 13 (sodium-dependent
                     dicarboxylate transporter), member 2"
                     /db_xref="GeneID:20500"
                     /db_xref="MGI:MGI:1276558"
     exon            1..169
                     /gene="Slc13a2"
                     /gene_synonym="mNaDC-1; Nadc-1; Nadc1"
                     /inference="alignment:Splign:2.1.0"
     exon            170..298
                     /gene="Slc13a2"
                     /gene_synonym="mNaDC-1; Nadc-1; Nadc1"
                     /inference="alignment:Splign:2.1.0"
     exon            299..435
                     /gene="Slc13a2"
                     /gene_synonym="mNaDC-1; Nadc-1; Nadc1"
                     /inference="alignment:Splign:2.1.0"
     exon            436..635
                     /gene="Slc13a2"
                     /gene_synonym="mNaDC-1; Nadc-1; Nadc1"
                     /inference="alignment:Splign:2.1.0"
     exon            636..807
                     /gene="Slc13a2"
                     /gene_synonym="mNaDC-1; Nadc-1; Nadc1"
                     /inference="alignment:Splign:2.1.0"
     exon            808..930
                     /gene="Slc13a2"
                     /gene_synonym="mNaDC-1; Nadc-1; Nadc1"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1149
                     /gene="Slc13a2"
                     /gene_synonym="mNaDC-1; Nadc-1; Nadc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1238
                     /gene="Slc13a2"
                     /gene_synonym="mNaDC-1; Nadc-1; Nadc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1360
                     /gene="Slc13a2"
                     /gene_synonym="mNaDC-1; Nadc-1; Nadc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1522
                     /gene="Slc13a2"
                     /gene_synonym="mNaDC-1; Nadc-1; Nadc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1660
                     /gene="Slc13a2"
                     /gene_synonym="mNaDC-1; Nadc-1; Nadc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..2240
                     /gene="Slc13a2"
                     /gene_synonym="mNaDC-1; Nadc-1; Nadc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2194..2199
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc13a2"
                     /gene_synonym="mNaDC-1; Nadc-1; Nadc1"
                     /note="hexamer: ATTAAA"
     polyA_site      2214
                     /gene="Slc13a2"
                     /gene_synonym="mNaDC-1; Nadc-1; Nadc1"
                     /note="major polyA site"
ORIGIN      
        1 gtgcgctaca ccttcagtct ttttcgtagc tcctggaagc agctgccggg acaggctggt
       61 cctcaccatg gccacctgct ggcaggcact atgggcctat cgctcctacc tgattgtgct
      121 atgtctgccc attttcctgt tgcctctgcc actcattgtc caaactaagg aagcctactg
      181 tgcttactcc atcatcctca tggcgctgct gtggtgtaca gaggccctgc ccttggctgt
      241 caccgccctc ttccccatca tcctcttccc tttgatgggt atcatggaag cctccaaggt
      301 ctgcttagag tacttcaagg acaccaacat attgttcgtc gggggtctga tggtggccat
      361 cgccgtggag cactggaacc tgcacaagcg cattgccctt ggagtgctcc ttatcatagg
      421 agtgcggccc gccctgctgc ttctgggctt catgttggtc acagccttcc tctccatgtg
      481 gatcagcaac acagccacca cagccatgat gctgcccatc gggtatgcag tcctggagca
      541 gctgcagggc tcacaaaagg atgtggagga aggcaatagt aacccttcct ttgagctcca
      601 ggaagcaagt ccccagaagg aggagaccaa gcttgataac ggtcaggctg tatctgtttc
      661 ttcggagcca agagctcaga agaccaaaga gcatcaccgc ttcagccagg gcctgagtct
      721 ctgcatctgc tactcagcca gcattggggg cattgccacc ctgacgggta ccacacccaa
      781 cctggtgctc caaggccagg tcaactcgat cttccctgaa aatagtaacg tggtgaactt
      841 tgcttcatgg tttggttttg ccttccccac catggtgatc ttgctgctac tggcttggct
      901 atggctacag gtcctcttcc tgggtgtcaa cttccggaag aactttggct ttggggaagg
      961 ggaagaggaa cggaagcagg ctgccttcca ggtcatcaag acccagcaca ggctgctggg
     1021 ccccatgagt tttgcagaga aggctgtcac tttcctgttt gtcctgctag tggtgctctg
     1081 gttcacgagg gagccgggct tcttcccagg ctggggtgac acagctttcg ccaataaaaa
     1141 agggcaaagc atggtatcag atgggacagt ggccatcttt atcagcctga ttatgttcat
     1201 cataccctcc aagattccag gactaaccga ggacccaaaa aaaccaggga agctgaaggc
     1261 tcctcctgcc atcctcacct ggaagacagt gaacgataag atgccctgga atatcctgat
     1321 cttgctgggt gggggctttg ccctggccaa aggcagtgag gaatcaggtt tgtctaagtg
     1381 gctgggagac aaactgaccc cgctgcagca cgtaccgcca tcagccaccg tgctcatcct
     1441 ctctctattg gtggccatct tcactgagtg caccagcaac gtggccacca ctacactatt
     1501 tctgcccatc ctggcctcca tggcacaggc catctgcctt cacccgctct atgtcatgct
     1561 tccctgcacc ctggctgcct ccctagcttt catgctaccc gtggccactc cacccaacgc
     1621 cattgtcttc tcttttggag gcctcaaagt gtctgatatg gcccgtgcag gattcctgct
     1681 caatatcatc ggagtgctga ctatcacatt atccataaac agctggagta tccctatctt
     1741 caagctggac acatttccca cctgggccta ctccaacaca agccagtgcc ttctcaatcc
     1801 gcctaattcc actgtaccag gccactagac tatggtacaa cctagctctg ctaggggaaa
     1861 agccgctggt gccactcctc ggagccagga gagggcgctc caaactccaa gtcccgggac
     1921 agaggtgcag aatcggctgg cgcatgcgaa atcatgtatt cgtgtgtttg cctacatcct
     1981 gtatgtgtgc tctccggtga agaggaagat gctcgtgtct ccgtgtggtg tgcgtggacg
     2041 cttgcgtgtg gtgtggcctg agggctcctc agtagttgta tgcatggcaa ccgcgcccgc
     2101 cctctgactc ccagctaggc ctccagatct ctttgccctg tatttattga aactctgggc
     2161 aggaggcccc tgggagcagg aactccaagg ttcattaaag gctttttcag tagagtccgg
     2221 gtgtgtttcc cggtgttcag
//
