LOCUS       NM_019481               2495 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus solute carrier family 13 (sodium/sulfate symporters),
            member 1 (Slc13a1), mRNA.
ACCESSION   NM_019481
VERSION     NM_019481.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2495)
  AUTHORS   Yorgan,T.A., Peters,S., Amling,M. and Schinke,T.
  TITLE     Osteoblast-specific expression of Panx3 is dispensable for
            postnatal bone remodeling
  JOURNAL   Bone 127, 155-163 (2019)
   PUBMED   31202927
REFERENCE   2  (bases 1 to 2495)
  AUTHORS   Hasnain,S.Z., Dawson,P.A., Lourie,R., Hutson,P., Tong,H.,
            Grencis,R.K., McGuckin,M.A. and Thornton,D.J.
  TITLE     Immune-driven alterations in mucin sulphation is an important
            mediator of Trichuris muris helminth expulsion
  JOURNAL   PLoS Pathog 13 (2), e1006218 (2017)
   PUBMED   28192541
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2495)
  AUTHORS   Barrett,K.G., Fang,H., Gargano,M.D., Markovich,D., Kocarek,T.A. and
            Runge-Morris,M.
  TITLE     Regulation of murine hepatic hydroxysteroid sulfotransferase
            expression in hyposulfatemic mice and in a cell model of
            3'-phosphoadenosine-5'-phosphosulfate deficiency
  JOURNAL   Drug Metab Dispos 41 (8), 1505-1513 (2013)
   PUBMED   23674610
REFERENCE   4  (bases 1 to 2495)
  AUTHORS   Dawson,P.A., Rakoczy,J. and Simmons,D.G.
  TITLE     Placental, renal, and ileal sulfate transporter gene expression in
            mouse gestation
  JOURNAL   Biol Reprod 87 (2), 43 (2012)
   PUBMED   22674389
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2495)
  AUTHORS   Markovich,D., Ku,M.C. and Muslim,D.
  TITLE     Increased lifespan in hyposulfatemic NaS1 null mice
  JOURNAL   Exp Gerontol 46 (10), 833-835 (2011)
   PUBMED   21651971
REFERENCE   6  (bases 1 to 2495)
  AUTHORS   Dawson,P.A., Beck,L. and Markovich,D.
  TITLE     Hyposulfatemia, growth retardation, reduced fertility, and seizures
            in mice lacking a functional NaSi-1 gene
  JOURNAL   Proc Natl Acad Sci U S A 100 (23), 13704-13709 (2003)
   PUBMED   14578452
  REMARK    GeneRIF: NaSi-1 is essential for maintaining sulfate homeostasis,
            and its expression is necessary for a wide range of physiological
            functions
REFERENCE   7  (bases 1 to 2495)
  AUTHORS   Dawson,P.A. and Markovich,D.
  TITLE     Regulation of the mouse Nas1 promoter by vitamin D and thyroid
            hormone
  JOURNAL   Pflugers Arch 444 (3), 353-359 (2002)
   PUBMED   12111243
  REMARK    GeneRIF: 1,25-(OH)(2)D(3)- and T(3)-responsive element was
            identified within the Nas1 promoter.
REFERENCE   8  (bases 1 to 2495)
  AUTHORS   Dawson,P.A. and Markovich,D.
  TITLE     Transcriptional regulation of the sodium-sulfate cotransporter
            NaS(i)-1 gene
  JOURNAL   Cell Biochem Biophys 36 (2-3), 175-182 (2002)
   PUBMED   12139403
  REMARK    GeneRIF: This protein is a functional sulfate transporter in the
            kidney and intestine
            Review article
REFERENCE   9  (bases 1 to 2495)
  AUTHORS   Lee,A., Beck,L. and Markovich,D.
  TITLE     The human renal sodium sulfate cotransporter (SLC13A1; hNaSi-1)
            cDNA and gene: organization, chromosomal localization, and
            functional characterization
  JOURNAL   Genomics 70 (3), 354-363 (2000)
   PUBMED   11161786
REFERENCE   10 (bases 1 to 2495)
  AUTHORS   Beck,L. and Markovich,D.
  TITLE     The mouse Na(+)-sulfate cotransporter gene Nas1. Cloning, tissue
            distribution, gene structure, chromosomal assignment, and
            transcriptional regulation by vitamin D
  JOURNAL   J Biol Chem 275 (16), 11880-11890 (2000)
   PUBMED   10766815
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK128899.1, AK005153.1 and BB502145.2.
            
            On Apr 1, 2008 this sequence version replaced NM_019481.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049981.1, AF199366.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849377 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-960               AK128899.1         1-960
            961-1158            AK005153.1         296-493
            1159-1537           AK128899.1         1159-1537
            1538-2228           AK005153.1         872-1562
            2229-2495           BB502145.2         191-457
FEATURES             Location/Qualifiers
     source          1..2495
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 11.22 cM"
     gene            1..2495
                     /gene="Slc13a1"
                     /gene_synonym="Nas1; NaSi-1"
                     /note="solute carrier family 13 (sodium/sulfate
                     symporters), member 1"
                     /db_xref="GeneID:55961"
                     /db_xref="MGI:MGI:1859937"
     exon            1..127
                     /gene="Slc13a1"
                     /gene_synonym="Nas1; NaSi-1"
                     /inference="alignment:Splign:2.1.0"
     exon            128..256
                     /gene="Slc13a1"
                     /gene_synonym="Nas1; NaSi-1"
                     /inference="alignment:Splign:2.1.0"
     exon            257..393
                     /gene="Slc13a1"
                     /gene_synonym="Nas1; NaSi-1"
                     /inference="alignment:Splign:2.1.0"
     exon            394..581
                     /gene="Slc13a1"
                     /gene_synonym="Nas1; NaSi-1"
                     /inference="alignment:Splign:2.1.0"
     exon            582..639
                     /gene="Slc13a1"
                     /gene_synonym="Nas1; NaSi-1"
                     /inference="alignment:Splign:2.1.0"
     exon            640..688
                     /gene="Slc13a1"
                     /gene_synonym="Nas1; NaSi-1"
                     /inference="alignment:Splign:2.1.0"
     exon            689..840
                     /gene="Slc13a1"
                     /gene_synonym="Nas1; NaSi-1"
                     /inference="alignment:Splign:2.1.0"
     exon            841..960
                     /gene="Slc13a1"
                     /gene_synonym="Nas1; NaSi-1"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1056
                     /gene="Slc13a1"
                     /gene_synonym="Nas1; NaSi-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1158
                     /gene="Slc13a1"
                     /gene_synonym="Nas1; NaSi-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1265
                     /gene="Slc13a1"
                     /gene_synonym="Nas1; NaSi-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1375
                     /gene="Slc13a1"
                     /gene_synonym="Nas1; NaSi-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1537
                     /gene="Slc13a1"
                     /gene_synonym="Nas1; NaSi-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1675
                     /gene="Slc13a1"
                     /gene_synonym="Nas1; NaSi-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..2495
                     /gene="Slc13a1"
                     /gene_synonym="Nas1; NaSi-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2208..2213
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc13a1"
                     /gene_synonym="Nas1; NaSi-1"
                     /note="hexamer: AATAAA"
     polyA_site      2231
                     /gene="Slc13a1"
                     /gene_synonym="Nas1; NaSi-1"
                     /note="major polyA site"
     regulatory      2465..2470
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc13a1"
                     /gene_synonym="Nas1; NaSi-1"
                     /note="hexamer: AATAAA"
     polyA_site      2484
                     /gene="Slc13a1"
                     /gene_synonym="Nas1; NaSi-1"
                     /note="major polyA site"
ORIGIN      
        1 atactgttga aggcacctgc tcaggacaat gaagctcctc aattatgctt tggtctatcg
       61 ccgctttctc cttgtggttt tcactatttt ggttttcttg ccactccctc tcatcatccg
      121 caccaaggaa gcacaatgtg cctacatcct ctttgttatt gccatatttt ggatcacaga
      181 agccttgccc ctgtcaatca cagctctact gcctgggtta atgttcccca tgtttgggat
      241 catgcgttct tcacaggtgg cttctgctta tttcaaagac tttcaccttc tgctaattgg
      301 agtcatctgt ttagcaacat caatagaaaa atggaatttg cacaagagga tcgctctgag
      361 gatggtgatg atggtggggg tgaatccagc ctggctgacg ttggggttca tgagcagcac
      421 tgccttctta tctatgtggc ttagcaacac ctctactgct gccatggtga tgcccatcgt
      481 ggaggctgtg gcgcagcaga tcatcagtgc tgaagcagag gccgaggcca ctcagatgac
      541 ttatttcaat gaatctgccg cccacggact ggacattgat gaaactgtta ttggacaaga
      601 aacaaatgag aaaaaagaga aaacaaaacc agctccagga agcagtcatg acaaagggaa
      661 agtgtcaaga aagatggaga cagaaaagaa tgcagtcaca ggagcaaaat atcggtcaag
      721 gaaggaccac atgatgtgta agctcatgtg tttatctgtt gcttactctt caaccattgg
      781 tgggctgaca acaatcacgg gtacctccac caacctgatc ttctctgagc atttcaatac
      841 gcgctaccct gattgtcgct gcctcaactt tggttcctgg tttttgtttt ccttcccggt
      901 tgctctaatt cttctacttt tgtcttggat ttggctccag tggctctacc taggattcga
      961 ctttaagatg ttcaagtgtg gcaaaaccaa aacactcaaa gaaaaagctt gtgcaaaggt
     1021 gatcaaacaa gaatatgaaa aacttgggcc aatgaggtat caagaaatcg tgaccttggt
     1081 gatcttcatt gtaatggcct tgctctggtt cagtcgggac ccaggctttg tcactggttg
     1141 gtcggtcctg ttttcagagt acccgggtta tgttacagat tcaacggttg ctttagtagc
     1201 aggaatcctt ttctttctaa ttccagctaa gaaagtgaca aaaatgacat ctgcaggaga
     1261 aattattgct tttgattaca ctcctctgat tacttggaaa gaattccagt cattcatgcc
     1321 ctgggacata gccattcttg ttggtggagg ctttgccctg gcagatggct gtcaggtatc
     1381 aggactatct aactggatag ggagtaaatt atctcctcta ggttcattac cagtttggct
     1441 aataattctg atatcttcct tgattgtcac atctttgaca gaggtagcca gcaacccagc
     1501 taccattacc attctgttcc caatattatc tcctttggct gaagccattc aagtgaaccc
     1561 tcttcagatt ttgctgcctt ccactctctg tacctcattt gcatttcttc tgccagttgc
     1621 aaatccaccc aatgctattg ttttttccta tggccacctg aaagtcattg acatggttaa
     1681 agctggactt ggagtgaata ttttgggtgt tgctgtggtg atgctaggca tgttcacctg
     1741 gatcgagccg atgtttaacc tccacgagta tccctcctgg gcttctaact ttgttaatca
     1801 gaccatgcca tgacaaacac acaagagcta ccagttcatg gtgactttag gacttgctaa
     1861 gaattgactg tacaatgtag ctgtatagga ctggcacatg caaatcatcg atacagctac
     1921 ggcaatcgca gaacatgcct cacacatgcc ccttgtcagc atcttaatac agagtccgta
     1981 tcttttcaaa cccaatcaaa gagcatctac ccgccttcgt ccagaaacta aggtggagac
     2041 tgcactggca gaccatctat gtgcttgctc tttctccata aaaatgatgc ttaaggacct
     2101 tcaaagaagt taggccattc accgcatctt aaacttggag ttcagtgtaa cattgcaaac
     2161 atcaacttat tatttgaaaa tattttctta tgaaactaaa agcagaaaat aaagtgtgaa
     2221 agtaaatgag acacttggat aagttatttt ctatagtgtt tgtcaaggga atttgctaaa
     2281 gtctcaagct atggctattc tgtgtaatgt aaaaagaagt gtgtatttat ttattgaaaa
     2341 gtctaactgc attattactg aggtacagac aggacaagtt taaattacaa tagctacaag
     2401 ttccaaaatt catgaatcca tttgatagta aaaaaattta taatgattaa tttctacttg
     2461 ttcaaataaa caggctaata tttatgcttc tatga
//
