LOCUS       NM_031406               3315 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus solute carrier family 12 (potassium/chloride
            transporters), member 9 (Slc12a9), transcript variant 2, mRNA.
ACCESSION   NM_031406
VERSION     NM_031406.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3315)
  AUTHORS   Wenz,M., Hartmann,A.M., Friauf,E. and Nothwang,H.G.
  TITLE     CIP1 is an activator of the K+-Cl- cotransporter KCC2
  JOURNAL   Biochem Biophys Res Commun 381 (3), 388-392 (2009)
   PUBMED   19232517
REFERENCE   2  (bases 1 to 3315)
  AUTHORS   Blaesse,P., Airaksinen,M.S., Rivera,C. and Kaila,K.
  TITLE     Cation-chloride cotransporters and neuronal function
  JOURNAL   Neuron 61 (6), 820-838 (2009)
   PUBMED   19323993
  REMARK    Review article
REFERENCE   3  (bases 1 to 3315)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   4  (bases 1 to 3315)
  AUTHORS   Wilson,M.D., Riemer,C., Martindale,D.W., Schnupf,P., Boright,A.P.,
            Cheung,T.L., Hardy,D.M., Schwartz,S., Scherer,S.W., Tsui,L.C.,
            Miller,W. and Koop,B.F.
  TITLE     Comparative analysis of the gene-dense ACHE/TFR2 region on human
            chromosome 7q22 with the orthologous region on mouse chromosome 5
  JOURNAL   Nucleic Acids Res 29 (6), 1352-1365 (2001)
   PUBMED   11239002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC150682.2.
            
            On Dec 18, 2009 this sequence version replaced NM_031406.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046982.1, AK154118.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               AC150682.2         61371-61505         c
            136-358             AC150682.2         60379-60601         c
            359-493             AC150682.2         60049-60183         c
            494-625             AC150682.2         58866-58997         c
            626-934             AC150682.2         56360-56668         c
            935-1042            AC150682.2         55520-55627         c
            1043-1154           AC150682.2         55294-55405         c
            1155-1312           AC150682.2         53440-53597         c
            1313-1395           AC150682.2         53246-53328         c
            1396-1520           AC150682.2         50970-51094         c
            1521-1713           AC150682.2         50639-50831         c
            1714-1888           AC150682.2         50319-50493         c
            1889-2035           AC150682.2         49317-49463         c
            2036-3315           AC150682.2         42481-43760         c
FEATURES             Location/Qualifiers
     source          1..3315
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 76.35 cM"
     gene            1..3315
                     /gene="Slc12a9"
                     /gene_synonym="CIP1"
                     /note="solute carrier family 12 (potassium/chloride
                     transporters), member 9"
                     /db_xref="GeneID:83704"
                     /db_xref="MGI:MGI:1933532"
     exon            1..135
                     /gene="Slc12a9"
                     /gene_synonym="CIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            136..358
                     /gene="Slc12a9"
                     /gene_synonym="CIP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..2922
                     /gene="Slc12a9"
                     /gene_synonym="CIP1"
                     /note="potassium-chloride transporter 9; cation-chloride
                     cotransporter-interacting protein 1"
                     /codon_start=1
                     /product="solute carrier family 12 member 9"
                     /protein_id="NP_113583.2"
                     /db_xref="CCDS:CCDS19766.1"
                     /db_xref="GeneID:83704"
                     /db_xref="MGI:MGI:1933532"
                     /translation="MASESSPLLAYRLLGEEGAAFPPNGAGVSGVPSSRKLSTFLGVV
                     VPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYIILALTVLSVCAIATNGAVRGG
                     GAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESILDVFGADATGSSGIQVL
                     PQGYGWNLLYGSLLLGLVGGVCTLGAGLYARASFLTFLLVSGSLASVLVSFVAVGPRN
                     IPLAPRPGTNASSVPHRHGHFTGFNGSTLRDNLGAGYAEDYTTGAMMTFASVFAVLFN
                     GCTGIMAGANMSGELKDPSRAIPLGTIIAVAYTFFIYILLFFLSSFTCDRALLQEDYG
                     FFRDISLWPPLVLIGIYATALSASMSSLIGASRILHALAQDDLFGVILAPAKVVSGGG
                     NPWGAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPT
                     FSLFSWHTCLLGVASCLLMMFLISPGAAGGSLLLMGLLSALLTARGGPSSWGYVSQAL
                     LFHQVRKYLLRLDVRKEHVKFWRPQLLLLVGNPRGALPLLRLANQLKKGGLYVLGHVT
                     LGDLDSLPSDPVQPQYGAWLSLVDLAQVKAFVDLTLSPSVRQGAQHLLRISGLGGMKP
                     NTLVLGFYDDAPPQDHFLTDPAFSEPAEGTREGGSPALSTLFPPPRAPGSPRALSPQD
                     YVATVADALKMNKNVVLARACGALPPERLSRGSSSSAQLHHVDVWPLNLLRPRGGPGY
                     VDVCGLFLLQMATILSMVPAWHSARLRIFLCLGPREAPGAAEGRLRALLSQLRIRAEV
                     QEVVWGEGAETGEPEEEEGDFVNGGRGDEEAEALACSANALVRAQQGRGTVGGPGGPE
                     GRDGEEGPTTALTFLYLPRPPADPARYPRYLALLETLSRDLGPTLLIHGVTPVTCTDL
                     "
     exon            359..493
                     /gene="Slc12a9"
                     /gene_synonym="CIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            494..625
                     /gene="Slc12a9"
                     /gene_synonym="CIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            626..934
                     /gene="Slc12a9"
                     /gene_synonym="CIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1042
                     /gene="Slc12a9"
                     /gene_synonym="CIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1154
                     /gene="Slc12a9"
                     /gene_synonym="CIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1312
                     /gene="Slc12a9"
                     /gene_synonym="CIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1395
                     /gene="Slc12a9"
                     /gene_synonym="CIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1520
                     /gene="Slc12a9"
                     /gene_synonym="CIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1713
                     /gene="Slc12a9"
                     /gene_synonym="CIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1888
                     /gene="Slc12a9"
                     /gene_synonym="CIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..2035
                     /gene="Slc12a9"
                     /gene_synonym="CIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..3315
                     /gene="Slc12a9"
                     /gene_synonym="CIP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3296..3301
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc12a9"
                     /gene_synonym="CIP1"
                     /note="hexamer: AATAAA"
     polyA_site      3315
                     /gene="Slc12a9"
                     /gene_synonym="CIP1"
                     /note="major polyA site"
ORIGIN      
        1 ttgctgggga gggcaggctc cgggcctgac atcccggtag cccgcttgct ttttccggct
       61 ccctcgcccc ctcggtttat agcggagccc cacaggcgcg ctgggatcac accggagcag
      121 cttcattcct aggtggtctc ctagcccttt tgtggcttcc tctgctggcg ttcagcaatg
      181 gccagcgaga gctcccctct tttggcctac cggcttctgg gggaagaggg ggctgccttc
      241 cctcccaatg gagctggagt atctggagtg ccatcatccc gcaagctctc caccttcctg
      301 ggtgtggtgg tgcccacggt tctgtccatg tttagcatag tcgtgtttct gaggattggg
      361 ttcgtggtgg gccacgctgg gctgttgcag gccttggcga tgctactggt tgcctacatc
      421 attctggcac taacagtcct ctcagtgtgt gccattgcca ccaatggagc tgtgagaggg
      481 ggcggagcct acttcatgat cagcaggact ctggggccgg aggttggtgg cagcattggc
      541 ctcatgttct acctggctaa cgtctgtggc tgtgccgtat ccctgctggg actggtggag
      601 tctatactgg acgtcttcgg ggctgatgcc acaggctcca gtgggatcca ggttctaccc
      661 cagggttatg gctggaatct gctctatggc tcccttctgc tgggcctcgt gggtggtgtg
      721 tgcactttgg gagctgggct ctatgcccga gcctcctttc ttacattcct gctggtttct
      781 ggctccctgg cctccgtgct ggtcagtttt gtggcagtgg gacccaggaa catcccgtta
      841 gctcctcgac cgggcaccaa tgcttcctcc gtgccacacc ggcatggcca cttcactggg
      901 ttcaacggaa gcaccctaag ggacaactta ggtgctggct acgccgagga ctacaccaca
      961 ggggccatga tgactttcgc cagtgttttt gctgtcctct tcaacggctg cacgggcatc
     1021 atggctgggg ccaacatgtc aggggagctg aaggacccca gccgggcaat tcctctgggc
     1081 accatcattg cagtcgccta taccttcttc atctacatcc tgctgttctt cctctccagc
     1141 ttcacttgtg acagagccct gcttcaagaa gactatggct tcttccgtga catcagcttg
     1201 tggcccccgc tcgtgttgat cggcatctat gccacggccc tctcagcctc catgagctct
     1261 ctcatcggtg cctcccggat cctgcatgcg ctggcccaag atgacctttt cggggtcatc
     1321 ttggcaccag ccaaggtggt atctggaggg ggcaacccct ggggtgctgt cctgtattcc
     1381 tggggcctgg tgcagctggt gctgctggct gggaagctca acacattggc tgctgtggtc
     1441 accgtcttct acttggtggc ttatgctgcg gtggacctgt cttgcctgag tctggagtgg
     1501 gcttcggccc ctaacttccg ccccaccttc agcctgttct cctggcacac ctgcctgctt
     1561 ggggtggcct cctgcctgct gatgatgttt ctcattagtc ctggggccgc cggcgggtcc
     1621 cttcttctca tgggcctgct ttccgctctt ctcaccgcac gaggaggacc cagcagttgg
     1681 ggttatgtca gccaagcctt gcttttccac caggttcgga agtacttgct ccgcctggat
     1741 gtccgcaagg agcacgtaaa gttctggcgg ccccagctgc tgctcctggt gggaaaccca
     1801 cggggtgccc tgcctctgct tcgcctggcc aaccagctaa agaagggggg actctatgtg
     1861 ctgggccatg tcactctggg agaccttgac tccttaccat cagatcctgt gcagccgcag
     1921 tatggtgcat ggctgagcct ggtggacctt gcccaagtga aggcctttgt ggatctcacc
     1981 ctatcaccct ccgtgcgtca gggggctcag catctgctcc ggatctctgg tcttggcggc
     2041 atgaagccca acacattggt gctgggtttt tacgacgatg ccccacccca ggaccatttt
     2101 ctaacagacc cagccttctc tgaacctgca gagggcacca gagagggcgg gtcgccagcc
     2161 ctgagcacgc tgttccctcc acctcgggct cctgggagcc ccagggctct cagtccccaa
     2221 gactacgtgg ccacggtggc agatgctctc aagatgaaca agaatgtggt tctcgcacga
     2281 gcatgtgggg ctttgccccc ggagcggcta agccgggggt ccagtagcag cgctcagcta
     2341 catcatgtgg acgtgtggcc cttaaacctg ctgaggcccc ggggtggacc tggctacgtg
     2401 gacgtctgtg gcctttttct gttgcagatg gctaccatct taagcatggt gcctgcctgg
     2461 cacagtgccc ggctccggat cttcctgtgc ttggggccca gggaggctcc tggggcagca
     2521 gagggaaggc ttcgggccct gttgagtcaa ctcaggatcc gggcagaggt gcaagaggtg
     2581 gtgtggggtg aaggggcaga gactggcgag cctgaggagg aggaagggga ctttgtgaat
     2641 ggtggtcgag gagacgaaga ggctgaggct ctagcttgca gtgccaatgc cctggtgcga
     2701 gcacagcagg ggcgaggcac cgtaggaggc cctgggggac ccgaaggaag ggatggggag
     2761 gagggaccca ccacagccct taccttcctg tacctgcctc gaccgcctgc tgatcctgct
     2821 cgctacccca gatacctggc actgctggag accctgagcc gtgatctggg tcccaccctt
     2881 cttattcacg gggtcactcc ggtaacctgc actgatctct gatgcctgtt catacagggt
     2941 tggatagagc gggcccaggc tcattctgag caatggacgc ccctcccccc gccccaagtg
     3001 ggccctgccc tttggatgat gtgttaaggg gaccatggtc tcctttgggc gggggaacgg
     3061 acatagtaca ctaattctag gtggctgccc cattgtaggg gaggacattg cggccctgtc
     3121 cctggtcttc ctccgcttcc ttcactggtg ccttgaccag aggggctggc ctcttctgtg
     3181 actctaggct acctcagtgt ccccatcctg gccacagacg caccgcctcc ctctccccga
     3241 cttccttggg tggtgatgtt tgtgttttgt tttatttttc taactactga ccataaataa
     3301 aagaccgaaa cacta
//
