LOCUS       NM_011390               5131 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus solute carrier family 12, member 7 (Slc12a7),
            transcript variant 1, mRNA.
ACCESSION   NM_011390
VERSION     NM_011390.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5131)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5131)
  AUTHORS   Frenette-Cotton,R., Marcoux,A.A., Garneau,A.P., Noel,M. and
            Isenring,P.
  TITLE     Phosphoregulation of K+ -Cl- cotransporters during cell swelling:
            Novel insights
  JOURNAL   J Cell Physiol 233 (1), 396-408 (2018)
   PUBMED   28276587
  REMARK    GeneRIF: During cell swelling PP1alpha and PP1gamma1 are involved
            in KCC4 regulation by WNK4, but that the kinase acts upon these
            phosphatases to inhibit their activity.
REFERENCE   3  (bases 1 to 5131)
  AUTHORS   Fu,B., Wang,L., Li,S. and Dorf,M.E.
  TITLE     ZMPSTE24 defends against influenza and other pathogenic viruses
  JOURNAL   J Exp Med 214 (4), 919-929 (2017)
   PUBMED   28246125
REFERENCE   4  (bases 1 to 5131)
  AUTHORS   Potter,P.K., Bowl,M.R., Jeyarajan,P., Wisby,L., Blease,A.,
            Goldsworthy,M.E., Simon,M.M., Greenaway,S., Michel,V., Barnard,A.,
            Aguilar,C., Agnew,T., Banks,G., Blake,A., Chessum,L., Dorning,J.,
            Falcone,S., Goosey,L., Harris,S., Haynes,A., Heise,I., Hillier,R.,
            Hough,T., Hoslin,A., Hutchison,M., King,R., Kumar,S., Lad,H.V.,
            Law,G., MacLaren,R.E., Morse,S., Nicol,T., Parker,A., Pickford,K.,
            Sethi,S., Starbuck,B., Stelma,F., Cheeseman,M., Cross,S.H.,
            Foster,R.G., Jackson,I.J., Peirson,S.N., Thakker,R.V., Vincent,T.,
            Scudamore,C., Wells,S., El-Amraoui,A., Petit,C.,
            Acevedo-Arozena,A., Nolan,P.M., Cox,R., Mallon,A.M. and Brown,S.D.
  TITLE     Novel gene function revealed by mouse mutagenesis screens for
            models of age-related disease
  JOURNAL   Nat Commun 7, 12444 (2016)
   PUBMED   27534441
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5131)
  AUTHORS   Melo,Z., Cruz-Rangel,S., Bautista,R., Vazquez,N.,
            Castaneda-Bueno,M., Mount,D.B., Pasantes-Morales,H., Mercado,A. and
            Gamba,G.
  TITLE     Molecular evidence for a role for K(+)-Cl(-) cotransporters in the
            kidney
  JOURNAL   Am J Physiol Renal Physiol 305 (10), F1402-F1411 (2013)
   PUBMED   24089410
  REMARK    GeneRIF: Data are consistent with a role for KCC4 in salt
            reabsorption of the thick ascending loop of Henle's loop and acid
            secretion of the collecting duct.
REFERENCE   6  (bases 1 to 5131)
  AUTHORS   Song,L., Mercado,A., Vazquez,N., Xie,Q., Desai,R., George,A.L. Jr.,
            Gamba,G. and Mount,D.B.
  TITLE     Molecular, functional, and genomic characterization of human KCC2,
            the neuronal K-Cl cotransporter
  JOURNAL   Brain Res Mol Brain Res 103 (1-2), 91-105 (2002)
   PUBMED   12106695
REFERENCE   7  (bases 1 to 5131)
  AUTHORS   Boettger,T., Hubner,C.A., Maier,H., Rust,M.B., Beck,F.X. and
            Jentsch,T.J.
  TITLE     Deafness and renal tubular acidosis in mice lacking the K-Cl
            co-transporter Kcc4
  JOURNAL   Nature 416 (6883), 874-878 (2002)
   PUBMED   11976689
  REMARK    GeneRIF: Deafness and renal tubular acidosis in mice lacking the
            K-Cl co-transporter Kcc4
            GeneRIF: Mice lacking SLC12A7 function suffer from deafness and
            renal metabolic acidosis. The phenotype suggests a function in
            inner ear potassium recycling. A function in the proton secreting
            alpha-intercalating cells of the kidney is shown.
REFERENCE   8  (bases 1 to 5131)
  AUTHORS   Casula,S., Shmukler,B.E., Wilhelm,S., Stuart-Tilley,A.K., Su,W.,
            Chernova,M.N., Brugnara,C. and Alper,S.L.
  TITLE     A dominant negative mutant of the KCC1 K-Cl cotransporter: both N-
            and C-terminal cytoplasmic domains are required for K-Cl
            cotransport activity
  JOURNAL   J Biol Chem 276 (45), 41870-41878 (2001)
   PUBMED   11551954
REFERENCE   9  (bases 1 to 5131)
  AUTHORS   Hubner,C.A., Stein,V., Hermans-Borgmeyer,I., Meyer,T., Ballanyi,K.
            and Jentsch,T.J.
  TITLE     Disruption of KCC2 reveals an essential role of K-Cl cotransport
            already in early synaptic inhibition
  JOURNAL   Neuron 30 (2), 515-524 (2001)
   PUBMED   11395011
REFERENCE   10 (bases 1 to 5131)
  AUTHORS   Mount,D.B., Mercado,A., Song,L., Xu,J., George,A.L. Jr., Delpire,E.
            and Gamba,G.
  TITLE     Cloning and characterization of KCC3 and KCC4, new members of the
            cation-chloride cotransporter gene family
  JOURNAL   J Biol Chem 274 (23), 16355-16362 (1999)
   PUBMED   10347194
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT030152.4.
            
            On Nov 17, 2006 this sequence version replaced NM_011390.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF087436.1, AK131129.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-194               CT030152.4         41584-41777
            195-289             CT030152.4         62406-62500
            290-412             CT030152.4         62931-63053
            413-559             CT030152.4         66452-66598
            560-614             CT030152.4         67828-67882
            615-745             CT030152.4         68537-68667
            746-987             CT030152.4         70437-70678
            988-1199            CT030152.4         71811-72022
            1200-1367           CT030152.4         72985-73152
            1368-1466           CT030152.4         73491-73589
            1467-1524           CT030152.4         74654-74711
            1525-1699           CT030152.4         75414-75588
            1700-1818           CT030152.4         76306-76424
            1819-1917           CT030152.4         76830-76928
            1918-2037           CT030152.4         77500-77619
            2038-2142           CT030152.4         78272-78376
            2143-2311           CT030152.4         78815-78983
            2312-2507           CT030152.4         83301-83496
            2508-2677           CT030152.4         83916-84085
            2678-2809           CT030152.4         84193-84324
            2810-2917           CT030152.4         86872-86979
            2918-3096           CT030152.4         87793-87971
            3097-3230           CT030152.4         91426-91559
            3231-5131           CT030152.4         92730-94630
FEATURES             Location/Qualifiers
     source          1..5131
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 40.15 cM"
     gene            1..5131
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /note="solute carrier family 12, member 7"
                     /db_xref="GeneID:20499"
                     /db_xref="MGI:MGI:1342283"
     exon            1..194
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..3322
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /note="isoform 1 is encoded by transcript variant 1; K-Cl
                     cotransporter 4; electroneutral potassium-chloride
                     cotransporter 4"
                     /codon_start=1
                     /product="solute carrier family 12 member 7 isoform 1"
                     /protein_id="NP_035520.1"
                     /db_xref="CCDS:CCDS26635.1"
                     /db_xref="GeneID:20499"
                     /db_xref="MGI:MGI:1342283"
                     /translation="MPTNFTVVPVEARADGAGDEAAERTEEPESPESVDQTSPTPGDG
                     NPRENSPFINNVEVERESYFEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEH
                     EEDEDSRRREVKAPRMGTFIGVYLPCLQNILGVILFLRLTWIVGAAGVMESFLIVAMC
                     CTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYIL
                     GTIEIFLTYISPSAAIFQAETADGEAAALLNNMRVYGSCALALMAVVVFVGVKYVNKL
                     ALVFLACVVLSILAIYAGVIKTAFAPPDIPVCLLGNRTLANRNFDTCAKMQVVSNGTV
                     TTALWRLFCNGSSLGATCDEYFAQNNVTEIQGIPGVASGVFLDNLWSTYSDKGAFVEK
                     KGVSSVPVSEESRPGGLPYVLTDIMTYFTMLVGIYFPSVTGIMAGSNRSGDLKDAQKS
                     IPTGTILAIVTTSFIYLSCIVLFGACIEGVVLRDKFGEALQGNLVIGMLAWPSPWVIV
                     IGSFFSTCGAGLQSLTGAPRLLQAIARDGIIPFLQVFGHGKANGEPTWALLLTALICE
                     TGILIASLDSVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMS
                     LCLALMFICSWYYALFAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLRVEH
                     GPPHTKNWRPQVLVMLNLDSEQCVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHV
                     EAQRAEENIRSLMSAEKTKGFCQLVVSSNLRDGASHLIQSAGLGGMKHNTVLMAWPEA
                     WKEADNPFSWKNFVDTVRDTTAAHQALLVAKNIDLFPQNQERFSDGNIDVWWIVHDGG
                     MLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMFLYHLRISAEVEVVEMV
                     ENDISAFTYEKTLMMEQRSQMLKQMQLSKNEREREAQLIHDRNTASHTTATARTQAPP
                     TPDKVQMTWTKEKLIAEKHRNKDTGPSGFKDLFSLKPDQSNVRRMHTAVKLNGVVLNK
                     SQDAQLVLLNMPGPPKSRQGDENYMEFLEVLTEGLNRVLLVRGGGREVITIYS"
     exon            195..289
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            290..412
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            413..559
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            560..614
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            615..745
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            746..987
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1199
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1367
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1466
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1524
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1699
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1818
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1917
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2037
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2142
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2311
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2507
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2508..2677
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2678..2809
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2810..2917
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2918..3096
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            3097..3230
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            3231..5131
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5109..5114
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /note="hexamer: AGTAAA"
     polyA_site      5131
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /note="major polyA site"
ORIGIN      
        1 ctacgccgga gtccggcggc tgctctggag cagcgtgtgg ctgcgaggga cagcagagtc
       61 taacggagcc atgcccacga actttacggt ggtgccggtg gaggcgcgcg ccgacggcgc
      121 cggggacgaa gctgctgagc gcacggaaga acccgagtct cccgagagcg tggatcaaac
      181 ctcccctacg ccgggagatg gaaaccccag ggaaaacagc cctttcatca ataatgtgga
      241 ggtggaaaga gagagctact tcgaggggaa gaacatggca ctttttgagg aagagatgga
      301 cagcaacccc atggtgtcat cactgctgaa caagctggcc aactatacca acctgagcca
      361 gggtgtggta gagcatgagg aagatgagga cagccggagg cgagaggtca aggccccacg
      421 catgggcacc ttcatcggag tctacctgcc gtgcctgcag aacatcttgg gtgttatcct
      481 tttcctgcgt ctgacctgga ttgtgggggc agctggtgtt atggagtcct tcctcattgt
      541 ggccatgtgc tgcacctgta caatgctgac agccatctcc atgagcgcca tcgctaccaa
      601 cggcgtggtc ccagcgggag gctcgtacta catgatctcc cgttcgctgg ggcctgagtt
      661 tggaggtgct gttggcctct gcttctactt gggcacgaca tttgcaggcg ccatgtacat
      721 cctgggtacc atcgagatct tcctgaccta catctctcca agtgcggcca tcttccaggc
      781 agagacggcg gatggcgagg cggccgcact gttgaacaac atgcgtgtgt atggcagctg
      841 tgccctggca ctcatggcgg tggtggtctt tgttggtgtc aaatatgtca acaagctggc
      901 actggtcttc ttagcctgtg ttgtgctttc tatcctggcc atctatgctg gtgtcatcaa
      961 gacagccttt gccccacctg acatcccggt ctgccttcta gggaaccgca cgctggcaaa
     1021 tcgcaacttt gatacctgtg ccaagatgca ggttgtcagc aacggtacag tgaccactgc
     1081 actctggcgc ctcttctgca atggctccag cttgggtgcc acctgtgatg agtactttgc
     1141 acagaacaac gttactgaga tacagggcat ccctggtgtg gccagtggtg tcttcctgga
     1201 taacctgtgg agcacatatt cagacaaggg ggcatttgtg gaaaagaaag gtgtgtcctc
     1261 agtgcctgtg tccgaggaga gccggcctgg tggattgcca tacgtcctca cagacatcat
     1321 gacctacttc accatgctag ttggcatcta cttcccgtct gtaactggga tcatggcagg
     1381 atccaaccgc tccggggacc tcaaagacgc ccagaagtct attccaacag ggaccattct
     1441 ggccatcgtg actacatctt tcatttatct ttcctgcata gtgctgtttg gggcctgcat
     1501 tgaaggtgta gtcctgcgag ataagtttgg ggaggccttg caagggaacc tggtcattgg
     1561 catgctggcc tggccatctc cctgggtcat tgtgattggc tccttcttct ccacctgtgg
     1621 tgctggcctg cagagcctga ctggggcacc ccgcctactg caggccattg cgcgtgacgg
     1681 aatcatcccc ttcctacagg tgtttggtca tggaaaggcc aacggggagc ccacatgggc
     1741 cctgctgctc acggctctca tctgtgagac cggtatcctc atcgcctccc tggacagtgt
     1801 ggcccccatc ctgtccatgt tcttcctcat gtgctacatg ttcgtcaatc tggcctgtgc
     1861 cgtacagacc ctgctacgca cacccaactg gcgtccacgc ttcaagttct accactggac
     1921 cctctccttc cttgggatga gtctctgcct cgcgctgatg ttcatctgct cctggtacta
     1981 cgcccttttc gccatgctca ttgccggctg catctacaag tacatcgagt accgcggggc
     2041 tgagaaggag tggggggatg gcatcagggg cctgtcactg aatgctgccc gctacgccct
     2101 gctgcgtgtg gaacatgggc ccccacatac caagaactgg aggccccagg tgttggtgat
     2161 gctgaacctg gactcggagc agtgtgtaaa gcacccccgc ctgctgtcct tcacctctca
     2221 gctgaaggct ggcaagggcc tgaccatcgt gggatctgtg ctagagggca cctacttaga
     2281 caagcatgtg gaggcccaga gggctgaaga gaatatccgg tctctgatga gtgcagagaa
     2341 gacgaagggc ttctgccagc tggtggtgtc ctccaacctg cgagatggtg cgtcccacct
     2401 gatccagtcg gctggcctcg gtggcatgaa acacaacact gtcctcatgg cctggccaga
     2461 ggcttggaag gaggcagata atcctttctc ctggaagaac tttgtagaca cagtccgtga
     2521 cactacagca gcacatcagg ccttgttggt ggccaagaac attgacttat tcccacaaaa
     2581 ccaagagcgc ttcagcgacg ggaacattga tgtgtggtgg atcgtgcatg acgggggcat
     2641 gctcatgctt ctgccctttc tgctgcgcca gcacaaggtg tggcgaaagt gccggatgcg
     2701 catcttcact gtggcccagg tggatgataa cagcatccag atgaagaagg acctgcagat
     2761 gttcctgtac cacctcagga tcagtgccga ggtggaggtg gtggagatgg ttgaaaatga
     2821 tatttccgca ttcacctatg agaagacgct aatgatggag cagaggtcac agatgctgaa
     2881 acagatgcag ttgtcaaaga atgagcggga gagagaggcc cagctgattc atgacaggaa
     2941 cactgcatcc cataccacag caactgctag aacccaagcc ccaccaacac ccgacaaagt
     3001 gcagatgaca tggacgaaag agaaactcat tgcagagaaa cacaggaaca aggacactgg
     3061 cccatcaggc ttcaaagacc tcttcagcct aaagccggac cagtccaacg tcaggaggat
     3121 gcatactgct gtgaagctca acggcgtagt tctcaacaag tcccaggatg cccaactggt
     3181 cctgctgaat atgccaggcc ccccaaaaag tcggcagggg gacgagaact acatggagtt
     3241 cctcgaggtc ctgacggaag ggctgaacag ggtcctcctg gtcaggggtg gtggccgaga
     3301 agtcatcacc atctactcct aacacctgca acctggacac acctggatgg ggtcaggact
     3361 gtgcaagctg cctgtggcca ggctgggact cgccagcatg ccactgtgat agccactgct
     3421 ctggcactca ttgcctggcc taccaacatg ttgcagtgat tctggtcacc ctgacacaca
     3481 cggcttccca cagacataac agctcctagg cttcctccaa acagaagatg ctatatggcg
     3541 gggagtatct agagctgttc tggtaggaac ggctccttac attgttgtcg gcaatggtag
     3601 gtatacccag gagatctggg gcagctcttc ctattactgg cagggcctcg cctcctgaca
     3661 ctaggatcac ctttctgcag atggctgtcc agcattttgt ggcagttata ttttacttcc
     3721 accagagaac agtacaaagg cgcctctgta cttttcatga acctgacaga taaaccagaa
     3781 ctcgtgaaca agcacacagt tccttgggtc tagaatgtca ctgagttgtt ccccattggc
     3841 ttctttgttc ctttgagtat ccttgctgtg ctttctgtac agtaagcaca ctgaggactg
     3901 tccaccctca cctcctcatt ctctccccca ccctcctcag acatggctca gggtaccact
     3961 ggaaagtgag atagtgttta cagggtagga gtgggtcacc attggaacca gtggtacctg
     4021 acagctgtgt tcccatctga gtcgatgccc taggagctcc tgcagagaga acctttgttc
     4081 tgcagggcta tctgcagcta gcctgctttc tcttctcatg ggaactcagc cactttattt
     4141 catacgcacc gagctgggaa cttcaagcag gtgactacgg agagccacag tgtaacaagc
     4201 aaacggcagg aactctgaga attctgcaca tagtccacca cagcaggcag catccagagt
     4261 gtgaaccatg atgtgtctca gcatacagct ttgcacatga aatgccgtcc catccctcac
     4321 cctcctggag agaaaagcca ggcccagccc aacaccctca gcctcagcag ccacagccct
     4381 gggtgtgtgt ctttctggct gagtgtctcc tgccatagat ccttactcag ccgggggcca
     4441 taggcgcctc tgcacttttc aagaacctga cagatgattt gcactttacc cttgggcatt
     4501 ctgctctgta ggtcatggtt tgttcacagg ctgtaggcaa cagcactgat ccgttcctca
     4561 cgttctgtat ggcgtattta tttatttaac cctccccggg gaagcttgat agaggtggct
     4621 tctatgtgga tggcccgtgg tgccaggctc tgggcatctc cgacttcctc caagagaatc
     4681 agccctgtcc acattcacga cgttccagtt agggtagagg ccacgtttgc acctgcacag
     4741 gttcttcagg ctttgttagg cacccaggta agctcgccag agtgactgct gcccagtgtg
     4801 tgtccctgtc agcatagtga tttccacacc tgcttttgcc tcaattctga acttggctca
     4861 gactcctgag ccctggatgt ctagagcaga gcaggtggct cgcctcgcct ctcccagctg
     4921 ttaggaatgc cctgggcagc tggcctttgc aggttctggg tcgctgctta caagagatgc
     4981 ctgtcaagag cgtccagcct cctttctgtt gcaatctcca tgttcctggt aactgtggcc
     5041 gttcagatca gtttcatgtt ttttcctttt tatagacttt tgtctttgta tgactttgtt
     5101 agtagcagag taaagttcta taaaatataa a
//
