LOCUS       NM_001360694            5194 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus solute carrier family 12, member 7 (Slc12a7),
            transcript variant 2, mRNA.
ACCESSION   NM_001360694 XM_006517172
VERSION     NM_001360694.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5194)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5194)
  AUTHORS   Frenette-Cotton,R., Marcoux,A.A., Garneau,A.P., Noel,M. and
            Isenring,P.
  TITLE     Phosphoregulation of K+ -Cl- cotransporters during cell swelling:
            Novel insights
  JOURNAL   J Cell Physiol 233 (1), 396-408 (2018)
   PUBMED   28276587
  REMARK    GeneRIF: During cell swelling PP1alpha and PP1gamma1 are involved
            in KCC4 regulation by WNK4, but that the kinase acts upon these
            phosphatases to inhibit their activity.
REFERENCE   3  (bases 1 to 5194)
  AUTHORS   Fu,B., Wang,L., Li,S. and Dorf,M.E.
  TITLE     ZMPSTE24 defends against influenza and other pathogenic viruses
  JOURNAL   J Exp Med 214 (4), 919-929 (2017)
   PUBMED   28246125
REFERENCE   4  (bases 1 to 5194)
  AUTHORS   Potter,P.K., Bowl,M.R., Jeyarajan,P., Wisby,L., Blease,A.,
            Goldsworthy,M.E., Simon,M.M., Greenaway,S., Michel,V., Barnard,A.,
            Aguilar,C., Agnew,T., Banks,G., Blake,A., Chessum,L., Dorning,J.,
            Falcone,S., Goosey,L., Harris,S., Haynes,A., Heise,I., Hillier,R.,
            Hough,T., Hoslin,A., Hutchison,M., King,R., Kumar,S., Lad,H.V.,
            Law,G., MacLaren,R.E., Morse,S., Nicol,T., Parker,A., Pickford,K.,
            Sethi,S., Starbuck,B., Stelma,F., Cheeseman,M., Cross,S.H.,
            Foster,R.G., Jackson,I.J., Peirson,S.N., Thakker,R.V., Vincent,T.,
            Scudamore,C., Wells,S., El-Amraoui,A., Petit,C.,
            Acevedo-Arozena,A., Nolan,P.M., Cox,R., Mallon,A.M. and Brown,S.D.
  TITLE     Novel gene function revealed by mouse mutagenesis screens for
            models of age-related disease
  JOURNAL   Nat Commun 7, 12444 (2016)
   PUBMED   27534441
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5194)
  AUTHORS   Melo,Z., Cruz-Rangel,S., Bautista,R., Vazquez,N.,
            Castaneda-Bueno,M., Mount,D.B., Pasantes-Morales,H., Mercado,A. and
            Gamba,G.
  TITLE     Molecular evidence for a role for K(+)-Cl(-) cotransporters in the
            kidney
  JOURNAL   Am J Physiol Renal Physiol 305 (10), F1402-F1411 (2013)
   PUBMED   24089410
  REMARK    GeneRIF: Data are consistent with a role for KCC4 in salt
            reabsorption of the thick ascending loop of Henle's loop and acid
            secretion of the collecting duct.
REFERENCE   6  (bases 1 to 5194)
  AUTHORS   Song,L., Mercado,A., Vazquez,N., Xie,Q., Desai,R., George,A.L. Jr.,
            Gamba,G. and Mount,D.B.
  TITLE     Molecular, functional, and genomic characterization of human KCC2,
            the neuronal K-Cl cotransporter
  JOURNAL   Brain Res Mol Brain Res 103 (1-2), 91-105 (2002)
   PUBMED   12106695
REFERENCE   7  (bases 1 to 5194)
  AUTHORS   Boettger,T., Hubner,C.A., Maier,H., Rust,M.B., Beck,F.X. and
            Jentsch,T.J.
  TITLE     Deafness and renal tubular acidosis in mice lacking the K-Cl
            co-transporter Kcc4
  JOURNAL   Nature 416 (6883), 874-878 (2002)
   PUBMED   11976689
  REMARK    GeneRIF: Deafness and renal tubular acidosis in mice lacking the
            K-Cl co-transporter Kcc4
            GeneRIF: Mice lacking SLC12A7 function suffer from deafness and
            renal metabolic acidosis. The phenotype suggests a function in
            inner ear potassium recycling. A function in the proton secreting
            alpha-intercalating cells of the kidney is shown.
REFERENCE   8  (bases 1 to 5194)
  AUTHORS   Casula,S., Shmukler,B.E., Wilhelm,S., Stuart-Tilley,A.K., Su,W.,
            Chernova,M.N., Brugnara,C. and Alper,S.L.
  TITLE     A dominant negative mutant of the KCC1 K-Cl cotransporter: both N-
            and C-terminal cytoplasmic domains are required for K-Cl
            cotransport activity
  JOURNAL   J Biol Chem 276 (45), 41870-41878 (2001)
   PUBMED   11551954
REFERENCE   9  (bases 1 to 5194)
  AUTHORS   Hubner,C.A., Stein,V., Hermans-Borgmeyer,I., Meyer,T., Ballanyi,K.
            and Jentsch,T.J.
  TITLE     Disruption of KCC2 reveals an essential role of K-Cl cotransport
            already in early synaptic inhibition
  JOURNAL   Neuron 30 (2), 515-524 (2001)
   PUBMED   11395011
REFERENCE   10 (bases 1 to 5194)
  AUTHORS   Mount,D.B., Mercado,A., Song,L., Xu,J., George,A.L. Jr., Delpire,E.
            and Gamba,G.
  TITLE     Cloning and characterization of KCC3 and KCC4, new members of the
            cation-chloride cotransporter gene family
  JOURNAL   J Biol Chem 274 (23), 16355-16362 (1999)
   PUBMED   10347194
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT030152.4.
            
            On Feb 9, 2018 this sequence version replaced XM_006517172.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849376 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-231               CT030152.4         41547-41777
            232-326             CT030152.4         62406-62500
            327-449             CT030152.4         62931-63053
            450-596             CT030152.4         66452-66598
            597-651             CT030152.4         67828-67882
            652-782             CT030152.4         68537-68667
            783-1024            CT030152.4         70437-70678
            1025-1236           CT030152.4         71811-72022
            1237-1404           CT030152.4         72985-73152
            1405-1503           CT030152.4         73491-73589
            1504-1561           CT030152.4         74654-74711
            1562-1736           CT030152.4         75414-75588
            1737-1855           CT030152.4         76306-76424
            1856-1954           CT030152.4         76830-76928
            1955-2074           CT030152.4         77500-77619
            2075-2179           CT030152.4         78272-78376
            2180-2348           CT030152.4         78815-78983
            2349-2544           CT030152.4         83301-83496
            2545-2714           CT030152.4         83916-84085
            2715-2846           CT030152.4         84193-84324
            2847-2954           CT030152.4         86872-86979
            2955-3133           CT030152.4         87793-87971
            3134-3148           CT030152.4         88581-88595
            3149-3282           CT030152.4         91426-91559
            3283-5194           CT030152.4         92730-94641
FEATURES             Location/Qualifiers
     source          1..5194
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 40.15 cM"
     gene            1..5194
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /note="solute carrier family 12, member 7"
                     /db_xref="GeneID:20499"
                     /db_xref="MGI:MGI:1342283"
     exon            1..231
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..3374
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /note="isoform 2 is encoded by transcript variant 2; K-Cl
                     cotransporter 4; electroneutral potassium-chloride
                     cotransporter 4"
                     /codon_start=1
                     /product="solute carrier family 12 member 7 isoform 2"
                     /protein_id="NP_001347623.1"
                     /db_xref="GeneID:20499"
                     /db_xref="MGI:MGI:1342283"
                     /translation="MPTNFTVVPVEARADGAGDEAAERTEEPESPESVDQTSPTPGDG
                     NPRENSPFINNVEVERESYFEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEH
                     EEDEDSRRREVKAPRMGTFIGVYLPCLQNILGVILFLRLTWIVGAAGVMESFLIVAMC
                     CTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYIL
                     GTIEIFLTYISPSAAIFQAETADGEAAALLNNMRVYGSCALALMAVVVFVGVKYVNKL
                     ALVFLACVVLSILAIYAGVIKTAFAPPDIPVCLLGNRTLANRNFDTCAKMQVVSNGTV
                     TTALWRLFCNGSSLGATCDEYFAQNNVTEIQGIPGVASGVFLDNLWSTYSDKGAFVEK
                     KGVSSVPVSEESRPGGLPYVLTDIMTYFTMLVGIYFPSVTGIMAGSNRSGDLKDAQKS
                     IPTGTILAIVTTSFIYLSCIVLFGACIEGVVLRDKFGEALQGNLVIGMLAWPSPWVIV
                     IGSFFSTCGAGLQSLTGAPRLLQAIARDGIIPFLQVFGHGKANGEPTWALLLTALICE
                     TGILIASLDSVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMS
                     LCLALMFICSWYYALFAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLRVEH
                     GPPHTKNWRPQVLVMLNLDSEQCVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHV
                     EAQRAEENIRSLMSAEKTKGFCQLVVSSNLRDGASHLIQSAGLGGMKHNTVLMAWPEA
                     WKEADNPFSWKNFVDTVRDTTAAHQALLVAKNIDLFPQNQERFSDGNIDVWWIVHDGG
                     MLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMFLYHLRISAEVEVVEMV
                     ENDISAFTYEKTLMMEQRSQMLKQMQLSKNEREREAQLIHDRNTASHTTATARTQAPP
                     TPDKVQMTWTKEKLIAEKHRNKDTGPSGFKDLFSLKPEWGNLDQSNVRRMHTAVKLNG
                     VVLNKSQDAQLVLLNMPGPPKSRQGDENYMEFLEVLTEGLNRVLLVRGGGREVITIYS
                     "
     exon            232..326
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            327..449
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            450..596
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            597..651
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            652..782
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            783..1024
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1236
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1404
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1503
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1561
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1736
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1855
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..1954
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..2074
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2179
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2348
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2544
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2545..2714
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2715..2846
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2847..2954
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2955..3133
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            3134..3148
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            3149..3282
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            3283..5194
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5161..5166
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /note="hexamer: AGTAAA"
     regulatory      5178..5183
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /note="hexamer: TATAAA"
     polyA_site      5183
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /note="major polyA site"
     polyA_site      5194
                     /gene="Slc12a7"
                     /gene_synonym="D13Ertd261e; Kcc4"
                     /note="major polyA site"
ORIGIN      
        1 acgtggcggg caagggcggg ccgggcggac cccgccccta cgccggagtc cggcggctgc
       61 tctggagcag cgtgtggctg cgagggacag cagagtctaa cggagccatg cccacgaact
      121 ttacggtggt gccggtggag gcgcgcgccg acggcgccgg ggacgaagct gctgagcgca
      181 cggaagaacc cgagtctccc gagagcgtgg atcaaacctc ccctacgccg ggagatggaa
      241 accccaggga aaacagccct ttcatcaata atgtggaggt ggaaagagag agctacttcg
      301 aggggaagaa catggcactt tttgaggaag agatggacag caaccccatg gtgtcatcac
      361 tgctgaacaa gctggccaac tataccaacc tgagccaggg tgtggtagag catgaggaag
      421 atgaggacag ccggaggcga gaggtcaagg ccccacgcat gggcaccttc atcggagtct
      481 acctgccgtg cctgcagaac atcttgggtg ttatcctttt cctgcgtctg acctggattg
      541 tgggggcagc tggtgttatg gagtccttcc tcattgtggc catgtgctgc acctgtacaa
      601 tgctgacagc catctccatg agcgccatcg ctaccaacgg cgtggtccca gcgggaggct
      661 cgtactacat gatctcccgt tcgctggggc ctgagtttgg aggtgctgtt ggcctctgct
      721 tctacttggg cacgacattt gcaggcgcca tgtacatcct gggtaccatc gagatcttcc
      781 tgacctacat ctctccaagt gcggccatct tccaggcaga gacggcggat ggcgaggcgg
      841 ccgcactgtt gaacaacatg cgtgtgtatg gcagctgtgc cctggcactc atggcggtgg
      901 tggtctttgt tggtgtcaaa tatgtcaaca agctggcact ggtcttctta gcctgtgttg
      961 tgctttctat cctggccatc tatgctggtg tcatcaagac agcctttgcc ccacctgaca
     1021 tcccggtctg ccttctaggg aaccgcacgc tggcaaatcg caactttgat acctgtgcca
     1081 agatgcaggt tgtcagcaac ggtacagtga ccactgcact ctggcgcctc ttctgcaatg
     1141 gctccagctt gggtgccacc tgtgatgagt actttgcaca gaacaacgtt actgagatac
     1201 agggcatccc tggtgtggcc agtggtgtct tcctggataa cctgtggagc acatattcag
     1261 acaagggggc atttgtggaa aagaaaggtg tgtcctcagt gcctgtgtcc gaggagagcc
     1321 ggcctggtgg attgccatac gtcctcacag acatcatgac ctacttcacc atgctagttg
     1381 gcatctactt cccgtctgta actgggatca tggcaggatc caaccgctcc ggggacctca
     1441 aagacgccca gaagtctatt ccaacaggga ccattctggc catcgtgact acatctttca
     1501 tttatctttc ctgcatagtg ctgtttgggg cctgcattga aggtgtagtc ctgcgagata
     1561 agtttgggga ggccttgcaa gggaacctgg tcattggcat gctggcctgg ccatctccct
     1621 gggtcattgt gattggctcc ttcttctcca cctgtggtgc tggcctgcag agcctgactg
     1681 gggcaccccg cctactgcag gccattgcgc gtgacggaat catccccttc ctacaggtgt
     1741 ttggtcatgg aaaggccaac ggggagccca catgggccct gctgctcacg gctctcatct
     1801 gtgagaccgg tatcctcatc gcctccctgg acagtgtggc ccccatcctg tccatgttct
     1861 tcctcatgtg ctacatgttc gtcaatctgg cctgtgccgt acagaccctg ctacgcacac
     1921 ccaactggcg tccacgcttc aagttctacc actggaccct ctccttcctt gggatgagtc
     1981 tctgcctcgc gctgatgttc atctgctcct ggtactacgc ccttttcgcc atgctcattg
     2041 ccggctgcat ctacaagtac atcgagtacc gcggggctga gaaggagtgg ggggatggca
     2101 tcaggggcct gtcactgaat gctgcccgct acgccctgct gcgtgtggaa catgggcccc
     2161 cacataccaa gaactggagg ccccaggtgt tggtgatgct gaacctggac tcggagcagt
     2221 gtgtaaagca cccccgcctg ctgtccttca cctctcagct gaaggctggc aagggcctga
     2281 ccatcgtggg atctgtgcta gagggcacct acttagacaa gcatgtggag gcccagaggg
     2341 ctgaagagaa tatccggtct ctgatgagtg cagagaagac gaagggcttc tgccagctgg
     2401 tggtgtcctc caacctgcga gatggtgcgt cccacctgat ccagtcggct ggcctcggtg
     2461 gcatgaaaca caacactgtc ctcatggcct ggccagaggc ttggaaggag gcagataatc
     2521 ctttctcctg gaagaacttt gtagacacag tccgtgacac tacagcagca catcaggcct
     2581 tgttggtggc caagaacatt gacttattcc cacaaaacca agagcgcttc agcgacggga
     2641 acattgatgt gtggtggatc gtgcatgacg ggggcatgct catgcttctg ccctttctgc
     2701 tgcgccagca caaggtgtgg cgaaagtgcc ggatgcgcat cttcactgtg gcccaggtgg
     2761 atgataacag catccagatg aagaaggacc tgcagatgtt cctgtaccac ctcaggatca
     2821 gtgccgaggt ggaggtggtg gagatggttg aaaatgatat ttccgcattc acctatgaga
     2881 agacgctaat gatggagcag aggtcacaga tgctgaaaca gatgcagttg tcaaagaatg
     2941 agcgggagag agaggcccag ctgattcatg acaggaacac tgcatcccat accacagcaa
     3001 ctgctagaac ccaagcccca ccaacacccg acaaagtgca gatgacatgg acgaaagaga
     3061 aactcattgc agagaaacac aggaacaagg acactggccc atcaggcttc aaagacctct
     3121 tcagcctaaa gccagagtgg ggaaacctgg accagtccaa cgtcaggagg atgcatactg
     3181 ctgtgaagct caacggcgta gttctcaaca agtcccagga tgcccaactg gtcctgctga
     3241 atatgccagg ccccccaaaa agtcggcagg gggacgagaa ctacatggag ttcctcgagg
     3301 tcctgacgga agggctgaac agggtcctcc tggtcagggg tggtggccga gaagtcatca
     3361 ccatctactc ctaacacctg caacctggac acacctggat ggggtcagga ctgtgcaagc
     3421 tgcctgtggc caggctggga ctcgccagca tgccactgtg atagccactg ctctggcact
     3481 cattgcctgg cctaccaaca tgttgcagtg attctggtca ccctgacaca cacggcttcc
     3541 cacagacata acagctccta ggcttcctcc aaacagaaga tgctatatgg cggggagtat
     3601 ctagagctgt tctggtagga acggctcctt acattgttgt cggcaatggt aggtataccc
     3661 aggagatctg gggcagctct tcctattact ggcagggcct cgcctcctga cactaggatc
     3721 acctttctgc agatggctgt ccagcatttt gtggcagtta tattttactt ccaccagaga
     3781 acagtacaaa ggcgcctctg tacttttcat gaacctgaca gataaaccag aactcgtgaa
     3841 caagcacaca gttccttggg tctagaatgt cactgagttg ttccccattg gcttctttgt
     3901 tcctttgagt atccttgctg tgctttctgt acagtaagca cactgaggac tgtccaccct
     3961 cacctcctca ttctctcccc caccctcctc agacatggct cagggtacca ctggaaagtg
     4021 agatagtgtt tacagggtag gagtgggtca ccattggaac cagtggtacc tgacagctgt
     4081 gttcccatct gagtcgatgc cctaggagct cctgcagaga gaacctttgt tctgcagggc
     4141 tatctgcagc tagcctgctt tctcttctca tgggaactca gccactttat ttcatacgca
     4201 ccgagctggg aacttcaagc aggtgactac ggagagccac agtgtaacaa gcaaacggca
     4261 ggaactctga gaattctgca catagtccac cacagcaggc agcatccaga gtgtgaacca
     4321 tgatgtgtct cagcatacag ctttgcacat gaaatgccgt cccatccctc accctcctgg
     4381 agagaaaagc caggcccagc ccaacaccct cagcctcagc agccacagcc ctgggtgtgt
     4441 gtctttctgg ctgagtgtct cctgccatag atccttactc agccgggggc cataggcgcc
     4501 tctgcacttt tcaagaacct gacagatgat ttgcacttta cccttgggca ttctgctctg
     4561 taggtcatgg tttgttcaca ggctgtaggc aacagcactg atccgttcct cacgttctgt
     4621 atggcgtatt tatttattta accctccccg gggaagcttg atagaggtgg cttctatgtg
     4681 gatggcccgt ggtgccaggc tctgggcatc tccgacttcc tccaagagaa tcagccctgt
     4741 ccacattcac gacgttccag ttagggtaga ggccacgttt gcacctgcac aggttcttca
     4801 ggctttgtta ggcacccagg taagctcgcc agagtgactg ctgcccagtg tgtgtccctg
     4861 tcagcatagt gatttccaca cctgcttttg cctcaattct gaacttggct cagactcctg
     4921 agccctggat gtctagagca gagcaggtgg ctcgcctcgc ctctcccagc tgttaggaat
     4981 gccctgggca gctggccttt gcaggttctg ggtcgctgct tacaagagat gcctgtcaag
     5041 agcgtccagc ctcctttctg ttgcaatctc catgttcctg gtaactgtgg ccgttcagat
     5101 cagtttcatg ttttttcctt tttatagact tttgtctttg tatgactttg ttagtagcag
     5161 agtaaagttc tataaaatat aaatgtttaa ggaa
//
