LOCUS       NM_001205311            3300 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus solute carrier family 12, member 3 (Slc12a3),
            transcript variant 1, mRNA.
ACCESSION   NM_001205311
VERSION     NM_001205311.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3300)
  AUTHORS   Mertens,R.T., Misra,A., Xiao,P., Baek,S., Rone,J.M., Mangani,D.,
            Sivanathan,K.N., Arojojoye,A.S., Awuah,S.G., Lee,I., Shi,G.P.,
            Petrova,B., Brook,J.R., Anderson,A.C., Flavell,R.A., Kanarek,N.,
            Hemberg,M. and Nowarski,R.
  TITLE     A metabolic switch orchestrated by IL-18 and the cyclic
            dinucleotide cGAMP programs intestinal tolerance
  JOURNAL   Immunity 57 (9), 2077-2094 (2024)
   PUBMED   38906145
REFERENCE   2  (bases 1 to 3300)
  AUTHORS   Song,L., Li,Q., Xia,L., Sahay,A.E., Qiu,Q., Li,Y., Li,H.,
            Sasaki,K., Susztak,K., Wu,H. and Wan,L.
  TITLE     Single-cell multiomics reveals ENL mutation perturbs kidney
            developmental trajectory by rewiring gene regulatory landscape
  JOURNAL   Nat Commun 15 (1), 5937 (2024)
   PUBMED   39009564
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3300)
  AUTHORS   Huang,B., Zeng,Z., Kim,S., Fausto,C.C., Koppitch,K., Li,H., Li,Z.,
            Chen,X., Guo,J., Zhang,C.C., Ma,T., Medina,P., Schreiber,M.E.,
            Xia,M.W., Vonk,A.C., Xiang,T., Patel,T., Li,Y., Parvez,R.K.,
            Der,B., Chen,J.H., Liu,Z., Thornton,M.E., Grubbs,B.H., Diao,Y.,
            Dou,Y., Gnedeva,K., Ying,Q., Pastor-Soler,N.M., Fei,T.,
            Hallows,K.R., Lindstrom,N.O., McMahon,A.P. and Li,Z.
  TITLE     Long-term expandable mouse and human-induced nephron progenitor
            cells enable kidney organoid maturation and modeling of plasticity
            and disease
  JOURNAL   Cell Stem Cell 31 (6), 921-939 (2024)
   PUBMED   38692273
REFERENCE   4  (bases 1 to 3300)
  AUTHORS   Naillat,F., Deshar,G., Hankkila,A., Rak-Raszewska,A., Sharma,A.,
            Prunskaite-Hyyrylainen,R., Railo,A., Shan,J. and Vainio,S.J.
  TITLE     Calcium signaling induces partial EMT and renal fibrosis in a
            Wnt4mCherry knock-in mouse model
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167180 (2024)
   PUBMED   38653356
REFERENCE   5  (bases 1 to 3300)
  AUTHORS   Xu,J., Zhou,X., Zhang,T., Zhang,B. and Xu,P.X.
  TITLE     Smarca4 deficiency induces Pttg1 oncogene upregulation and
            hyperproliferation of tubular and interstitial cells during kidney
            development
  JOURNAL   Front Cell Dev Biol 11, 1233317 (2023)
   PUBMED   37727504
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3300)
  AUTHORS   Brooks,H.L., Sorensen,A.M., Terris,J., Schultheis,P.J.,
            Lorenz,J.N., Shull,G.E. and Knepper,M.A.
  TITLE     Profiling of renal tubule Na+ transporter abundances in NHE3 and
            NCC null mice using targeted proteomics
  JOURNAL   J Physiol 530 (Pt 3), 359-366 (2001)
   PUBMED   11158268
REFERENCE   7  (bases 1 to 3300)
  AUTHORS   Kunchaparty,S., Palcso,M., Berkman,J., Velazquez,H., Desir,G.V.,
            Bernstein,P., Reilly,R.F. and Ellison,D.H.
  TITLE     Defective processing and expression of thiazide-sensitive Na-Cl
            cotransporter as a cause of Gitelman's syndrome
  JOURNAL   Am J Physiol 277 (4), F643-F649 (1999)
   PUBMED   10516289
REFERENCE   8  (bases 1 to 3300)
  AUTHORS   Schultheis,P.J., Lorenz,J.N., Meneton,P., Nieman,M.L., Riddle,T.M.,
            Flagella,M., Duffy,J.J., Doetschman,T., Miller,M.L. and Shull,G.E.
  TITLE     Phenotype resembling Gitelman's syndrome in mice lacking the apical
            Na+-Cl- cotransporter of the distal convoluted tubule
  JOURNAL   J Biol Chem 273 (44), 29150-29155 (1998)
   PUBMED   9786924
REFERENCE   9  (bases 1 to 3300)
  AUTHORS   Pathak,B.G., Shaughnessy,J.D. Jr., Meneton,P., Greeb,J.,
            Shull,G.E., Jenkins,N.A. and Copeland,N.G.
  TITLE     Mouse chromosomal location of three epithelial sodium channel
            subunit genes and an apical sodium chloride cotransporter gene
  JOURNAL   Genomics 33 (1), 124-127 (1996)
   PUBMED   8617496
REFERENCE   10 (bases 1 to 3300)
  AUTHORS   Gamba,G., Miyanoshita,A., Lombardi,M., Lytton,J., Lee,W.S.,
            Hediger,M.A. and Hebert,S.C.
  TITLE     Molecular cloning, primary structure, and characterization of two
            members of the mammalian electroneutral sodium-(potassium)-chloride
            cotransporter family expressed in kidney
  JOURNAL   J Biol Chem 269 (26), 17713-17722 (1994)
   PUBMED   8021284
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK052691.1 and AC128663.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK052691.1, BC038612.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3102              AK052691.1         2-3103
            3103-3300           AC128663.4         74000-74197         c
FEATURES             Location/Qualifiers
     source          1..3300
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 46.46 cM"
     gene            1..3300
                     /gene="Slc12a3"
                     /gene_synonym="NCC; NCCT; TSC"
                     /note="solute carrier family 12, member 3"
                     /db_xref="GeneID:20497"
                     /db_xref="MGI:MGI:108114"
     exon            1..306
                     /gene="Slc12a3"
                     /gene_synonym="NCC; NCCT; TSC"
                     /inference="alignment:Splign:2.1.0"
     exon            307..453
                     /gene="Slc12a3"
                     /gene_synonym="NCC; NCCT; TSC"
                     /inference="alignment:Splign:2.1.0"
     exon            454..529
                     /gene="Slc12a3"
                     /gene_synonym="NCC; NCCT; TSC"
                     /inference="alignment:Splign:2.1.0"
     exon            530..625
                     /gene="Slc12a3"
                     /gene_synonym="NCC; NCCT; TSC"
                     /inference="alignment:Splign:2.1.0"
     exon            626..765
                     /gene="Slc12a3"
                     /gene_synonym="NCC; NCCT; TSC"
                     /inference="alignment:Splign:2.1.0"
     exon            766..876
                     /gene="Slc12a3"
                     /gene_synonym="NCC; NCCT; TSC"
                     /inference="alignment:Splign:2.1.0"
     exon            877..988
                     /gene="Slc12a3"
                     /gene_synonym="NCC; NCCT; TSC"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1119
                     /gene="Slc12a3"
                     /gene_synonym="NCC; NCCT; TSC"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1204
                     /gene="Slc12a3"
                     /gene_synonym="NCC; NCCT; TSC"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1359
                     /gene="Slc12a3"
                     /gene_synonym="NCC; NCCT; TSC"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1467
                     /gene="Slc12a3"
                     /gene_synonym="NCC; NCCT; TSC"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1591
                     /gene="Slc12a3"
                     /gene_synonym="NCC; NCCT; TSC"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1693
                     /gene="Slc12a3"
                     /gene_synonym="NCC; NCCT; TSC"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1849
                     /gene="Slc12a3"
                     /gene_synonym="NCC; NCCT; TSC"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1949
                     /gene="Slc12a3"
                     /gene_synonym="NCC; NCCT; TSC"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2061
                     /gene="Slc12a3"
                     /gene_synonym="NCC; NCCT; TSC"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2202
                     /gene="Slc12a3"
                     /gene_synonym="NCC; NCCT; TSC"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2309
                     /gene="Slc12a3"
                     /gene_synonym="NCC; NCCT; TSC"
                     /inference="alignment:Splign:2.1.0"
     exon            2310..2392
                     /gene="Slc12a3"
                     /gene_synonym="NCC; NCCT; TSC"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2494
                     /gene="Slc12a3"
                     /gene_synonym="NCC; NCCT; TSC"
                     /inference="alignment:Splign:2.1.0"
     exon            2495..2606
                     /gene="Slc12a3"
                     /gene_synonym="NCC; NCCT; TSC"
                     /inference="alignment:Splign:2.1.0"
     exon            2607..2693
                     /gene="Slc12a3"
                     /gene_synonym="NCC; NCCT; TSC"
                     /inference="alignment:Splign:2.1.0"
     exon            2694..2829
                     /gene="Slc12a3"
                     /gene_synonym="NCC; NCCT; TSC"
                     /inference="alignment:Splign:2.1.0"
     exon            2830..2897
                     /gene="Slc12a3"
                     /gene_synonym="NCC; NCCT; TSC"
                     /inference="alignment:Splign:2.1.0"
     exon            2898..3300
                     /gene="Slc12a3"
                     /gene_synonym="NCC; NCCT; TSC"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3300
                     /gene="Slc12a3"
                     /gene_synonym="NCC; NCCT; TSC"
                     /note="major polyA site"
ORIGIN      
        1 ttgtcccctc ctttgatacc cagagccata atggcagagc tccccgtgac agagctgcct
       61 ggcgatgctc tgtgcagtgg gcgcttcacc atcagcacac tgatgggagg cgatgagccc
      121 ccaccagctg cctgtgacag cagccagccc agccacttaa cacacggcag caccttatac
      181 atgcgcacct tcggttacaa caccatagac gtggtgccgg cctacgaaca ctatgctaac
      241 agcgctctgc ccggtgagcc ccggaaggtg cggcccaccc tggctgacct gcattcattc
      301 ctcaagcagg aaggtagcca cctgcatgcc ctggcctttg atggacggca aggtcgtgag
      361 ctgactgatg gacttgtgga agatgagaca ggcaccaaca gtgagaagag ccctggagaa
      421 cctgttcgct tcggctgggt caagggggtg atgatccgtt gcatgctcaa catctgggga
      481 gtgatcctct acctgcgact cccctggatt acggcgcagg cgggcatcgt gctgacttgg
      541 ctcatcatcc tgctgtcggt catggtgaca tccatcaccg gcctctccat ctccgccatc
      601 tctaccaatg gcaaggtcaa gtcgggtggc acctatttcc ttatttcccg gagtctggga
      661 ccagagctgg gaggctccat tggcctcatc ttcgcctttg ccaatgctgt gggtgtggcc
      721 atgcacactg tgggctttgc agaaaccgta agggacctac tgcaggagta tggcacaccc
      781 atcgtagacc ccatcaatga catccgcatc atcggtgtgg tcacggtcac tgtgctgctg
      841 gccatctcgc tggctgggat ggagtgggag tccaaggccc aggtgctatt ctttcttgtc
      901 atcatggtct cctttgccaa ctacctggtg ggcacactga tcccagcatc tgaagacaaa
      961 gcctctaaag gcttctacag ctaccatggg gacatttttg ttcagaacct ggtacccgac
     1021 tggagaggca ttgatggtag cttctttggc atgttctcca tcttcttccc ttcggccact
     1081 ggcattctgg caggggccaa catctccggg gacctcaagg atcctgctgt agccatcccc
     1141 aagggaacac tcatggccat tttctggacc accatctcct accttgccat ctcagctacc
     1201 atcggctcct gtgtggtgag agatgcctct ggggatgtga acgacaccat gactcctggt
     1261 ccaggcccct gcgaagggct agcctgtggc tatggctgga acttcacaga atgctcccag
     1321 cagcgcagtt gccgctatgg cctcatcaac tactaccaga ccatgagcat ggtgtctgcc
     1381 ttcgcacccc tgatcacagc cggcatcttt ggcgccaccc tgtcttctgc cttggcctgt
     1441 cttgtctcgg ctgctaaggt cttccagtgc ctgtgtgaag accagctgta ccctctgatt
     1501 ggcttttttg gcaaaggcta tggcaagaac agggagcctg tgcgtggcta cctgctggcc
     1561 tatgccattg ctgtggcctt catcatcatt gctgaactta acaccatcgc ccccatcatt
     1621 tccaacttct tcctctgctc ctacgccctc atcaatttca gctgcttcca tgcctccatc
     1681 accaactcac ctggatggag accctccttc cgatactaca gcaagtgggc ggcgctgttt
     1741 ggggcagtga tctcggtggt catcatgttc ctgcttacct ggtgggctgc tctcattgcc
     1801 atcggagtcg tcctcttcct cctgctctat gtgatctaca agaagccaga ggtgaactgg
     1861 ggttcctcag tacaggctgg ctcctacaat ctggccctga gctactccgt gggcctcaac
     1921 gaggtggaag accacatcaa gaactaccgc ccccagtgcc tggtgcttac agggcccccc
     1981 aacttccgcc cagcccttgt ggactttgtg agcacattta cccagaacct aagcctaatg
     2041 atttgtggtc atgtgctcat tggacctggc aagcagagag tgcccgagct ccggctcatc
     2101 gccagtggac acaccaagtg gctgaacaag aggaagatca aggccttcta ctctgacgtc
     2161 atcgctgagg acttgcgcag tggcgtccag attctcatgc aggcctcagg gcttgggaga
     2221 atgaagccga acattctggt ggttggattc aagaggaact ggcagtctgc ccacccagcc
     2281 acagtggagg actacattgg tgtcctgcat gatgcctttg acttcaacta cggggtttgt
     2341 gtcatgagga tgcgcgaggg gctcaatgtc tccgaggctc tgcagaccca cacaacccca
     2401 gaggcattga tacaagagga gcaggctagc accatcttcc agtcggagca aggcaagaag
     2461 accattgaca tctactggct gttcgatgat ggaggtctca ccctcctcat cccctatctc
     2521 ctgcaccgca agaagagatg gggcaaatgc aagatccgag tgtttgttgg gggccagatc
     2581 aacaggatgg acgaagagag aaaggcgatc atctctctgt tgagcaagtt cagactggga
     2641 ttccatgaag ttcacgtcct tcccgacatc aaccagaagc cccaggccga gcacaccaag
     2701 cggtttgagg acatgattgc acccttccgc ctcaatgatg gcttcaagga cgaggccacc
     2761 gtcactgaga tgaggaggga ctgtccctgg aagatctcag atgaagagat taacaagaac
     2821 agaattaagt cccttcggca ggtgagactg agtgagatac tgctggatta ctctcgggat
     2881 gctgctctga tcatccttac cctgcccatt ggaaggaagg ggaagtgccc cagttcgctg
     2941 tacatggcct ggctggagac cctgtcccag gacctcagac ctcccgtcct cctcatccga
     3001 ggcaaccagg agaatgtgct caccttttac tgccagtgat gcctggggtg acgggaaccg
     3061 ccacccagaa ccccaaagct gagggcttgg gatagagtca gaacgcaccc tctccagctg
     3121 gagaagaggc ttcaagttct actgtatcat cccatccatc agcgcctatg cagaagatgg
     3181 ggtttcccgg ctgactgaac ccccatcaga cacactttct ggaccttgaa gttgcatgga
     3241 aaagtctctg gaagagtcta tctcttttta aaaaagcttt tatttgtctt gatgaccaaa
//
