LOCUS       NM_013612               2304 bp    mRNA    linear   ROD 17-JUL-2024
DEFINITION  Mus musculus solute carrier family 11 (proton-coupled divalent
            metal ion transporters), member 1 (Slc11a1), mRNA.
ACCESSION   NM_013612
VERSION     NM_013612.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2304)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2304)
  AUTHORS   Zigdon,M., Sawaed,J., Zelik,L., Binyamin,D., Ben-Simon,S.,
            Asulin,N., Levin,R., Modilevsky,S., Naama,M., Telpaz,S., Rubin,E.,
            Awad,A., Sawaed,W., Harshuk-Shabso,S., Nuriel-Ohayon,M.,
            Krishnamohan,M., Werbner,M., Koren,O., Winter,S.E., Apte,R.N.,
            Voronov,E. and Bel,S.
  TITLE     Salmonella manipulates the host to drive pathogenicity via
            induction of interleukin 1beta
  JOURNAL   PLoS Biol 22 (1), e3002486 (2024)
   PUBMED   38236896
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2304)
  AUTHORS   de Andrade,S.T.Q., Guidugli,T.I., Borrego,A., Rodrigues,B.L.C.,
            Fernandes,N.C.C.A., Guerra,J.M., de Sousa,J.G., Starobinas,N.,
            Jensen,J.R., Cabrera,W.H.K., De Franco,M., Ibanez,O.M., Massa,S.
            and Ribeiro,O.G.
  TITLE     Slc11a1 gene polymorphism influences dextran sulfate sodium
            (DSS)-induced colitis in a murine model of acute inflammation
  JOURNAL   Genes Immun 24 (2), 71-80 (2023)
   PUBMED   36792680
  REMARK    GeneRIF: Slc11a1 gene polymorphism influences dextran sulfate
            sodium (DSS)-induced colitis in a murine model of acute
            inflammation.
REFERENCE   4  (bases 1 to 2304)
  AUTHORS   Bettke,J.A., Tam,J.W., Montoya,V., Butler,B.P. and van der
            Velden,A.W.M.
  TITLE     Inflammatory Monocytes Promote Granuloma-Mediated Control of
            Persistent Salmonella Infection
  JOURNAL   Infect Immun 90 (4), e0007022 (2022)
   PUBMED   35311578
REFERENCE   5  (bases 1 to 2304)
  AUTHORS   Brigo,N., Pfeifhofer-Obermair,C., Tymoszuk,P., Demetz,E., Engl,S.,
            Barros-Pinkelnig,M., Dichtl,S., Fischer,C., Valente De Souza,L.,
            Petzer,V., von Raffay,L., Hilbe,R., Berger,S., Seifert,M.,
            Schleicher,U., Bogdan,C. and Weiss,G.
  TITLE     Cytokine-Mediated Regulation of ARG1 in Macrophages and Its Impact
            on the Control of Salmonella enterica Serovar Typhimurium Infection
  JOURNAL   Cells 10 (7), 1823 (2021)
   PUBMED   34359992
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2304)
  AUTHORS   Barton,C.H., Ajioka,J.W., Roach,T.I. and Blackwell,J.M.
  TITLE     Mapping Creb-1 to chromosome 1 in the mouse
  JOURNAL   Genomics 14 (3), 790-792 (1992)
   PUBMED   1358811
REFERENCE   7  (bases 1 to 2304)
  AUTHORS   Plant,J. and Glynn,A.A.
  TITLE     Locating salmonella resistance gene on mouse chromosome 1
  JOURNAL   Clin Exp Immunol 37 (1), 1-6 (1979)
   PUBMED   385184
REFERENCE   8  (bases 1 to 2304)
  AUTHORS   Bradley,D.J., Taylor,B.A., Blackwell,J., Evans,E.P. and Freeman,J.
  TITLE     Regulation of Leishmania populations within the host. III. Mapping
            of the locus controlling susceptibility to visceral leishmaniasis
            in the mouse
  JOURNAL   Clin Exp Immunol 37 (1), 7-14 (1979)
   PUBMED   290436
REFERENCE   9  (bases 1 to 2304)
  AUTHORS   Bradley,D.J.
  TITLE     Regulation of Leishmania populations within the host. II. genetic
            control of acute susceptibility of mice to Leishmania donovani
            infection
  JOURNAL   Clin Exp Immunol 30 (1), 130-140 (1977)
   PUBMED   606434
REFERENCE   10 (bases 1 to 2304)
  AUTHORS   Plant,J. and Glynn,A.A.
  TITLE     Genetics of resistance to infection with Salmonella typhimurium in
            mice
  JOURNAL   J Infect Dis 133 (1), 72-78 (1976)
   PUBMED   1107437
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB873183.1 and AK171393.1.
            
            [WARNING] On Jul 25, 2024 this sequence was replaced by
            NM_013612.3.
            
            On Jun 20, 2008 this sequence version replaced NM_013612.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK171393.1, AK144237.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                BB873183.1         2-21
            21-2304             AK171393.1         2-2285
FEATURES             Location/Qualifiers
     source          1..2304
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 38.54 cM"
     gene            1..2304
                     /gene="Slc11a1"
                     /gene_synonym="Bcg; ity; Ity; Ity1; Lsh; Nramp; Nramp1"
                     /note="solute carrier family 11 (proton-coupled divalent
                     metal ion transporters), member 1"
                     /db_xref="GeneID:18173"
                     /db_xref="MGI:MGI:1345275"
     exon            1..119
                     /gene="Slc11a1"
                     /gene_synonym="Bcg; ity; Ity; Ity1; Lsh; Nramp; Nramp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..1759
                     /gene="Slc11a1"
                     /gene_synonym="Bcg; ity; Ity; Ity1; Lsh; Nramp; Nramp1"
                     /note="NRAMP 1; host resistance locus Bcg/Ity/Lsh; solute
                     carrier family 11 member 1"
                     /codon_start=1
                     /product="natural resistance-associated macrophage protein
                     1"
                     /protein_id="NP_038640.2"
                     /db_xref="CCDS:CCDS15047.1"
                     /db_xref="GeneID:18173"
                     /db_xref="MGI:MGI:1345275"
                     /translation="MISDKSPPRLSRPSYGSISSLPGPAPQPAPCRETYLSEKIPIPS
                     ADQGTFSLRKLWAFTGPGFLMSIAFLDPGNIESDLQAGAVAGFKLLWVLLWATVLGLL
                     CQRLAARLGVVTGKDLGEVCHLYYPKVPRILLWLTIELAIVGSDMQEVIGTAISFNLL
                     SAGRIPLWDGVLITIVDTFFFLFLDNYGLRKLEAFFGLLITIMALTFGYEYVVAHPSQ
                     GALLKGLVLPTCPGCGQPELLQAVGIVGAIIMPHNIYLHSALVKSREVDRTRRVDVRE
                     ANMYFLIEATIALSVSFIINLFVMAVFGQAFYQQTNEEAFNICANSSLQNYAKIFPRD
                     NNTVSVDIYQGGVILGCLFGPAALYIWAVGLLAAGQSSTMTGTYAGQFVMEGFLKLRW
                     SRFARVLLTRSCAILPTVLVAVFRDLKDLSGLNDLLNVLQSLLLPFAVLPILTFTSMP
                     AVMQEFANGRMSKAITSCIMALVCAINLYFVISYLPSLPHPAYFGLVALFAIGYLGLT
                     AYLAWTCCIAHGATFLTHSSHKHFLYGLPNEEQGGVQGSG"
     exon            120..253
                     /gene="Slc11a1"
                     /gene_synonym="Bcg; ity; Ity; Ity1; Lsh; Nramp; Nramp1"
                     /inference="alignment:Splign:2.1.0"
     exon            254..376
                     /gene="Slc11a1"
                     /gene_synonym="Bcg; ity; Ity; Ity1; Lsh; Nramp; Nramp1"
                     /inference="alignment:Splign:2.1.0"
     exon            377..496
                     /gene="Slc11a1"
                     /gene_synonym="Bcg; ity; Ity; Ity1; Lsh; Nramp; Nramp1"
                     /inference="alignment:Splign:2.1.0"
     exon            497..603
                     /gene="Slc11a1"
                     /gene_synonym="Bcg; ity; Ity; Ity1; Lsh; Nramp; Nramp1"
                     /inference="alignment:Splign:2.1.0"
     exon            604..674
                     /gene="Slc11a1"
                     /gene_synonym="Bcg; ity; Ity; Ity1; Lsh; Nramp; Nramp1"
                     /inference="alignment:Splign:2.1.0"
     exon            675..742
                     /gene="Slc11a1"
                     /gene_synonym="Bcg; ity; Ity; Ity1; Lsh; Nramp; Nramp1"
                     /inference="alignment:Splign:2.1.0"
     exon            743..898
                     /gene="Slc11a1"
                     /gene_synonym="Bcg; ity; Ity; Ity1; Lsh; Nramp; Nramp1"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1057
                     /gene="Slc11a1"
                     /gene_synonym="Bcg; ity; Ity; Ity1; Lsh; Nramp; Nramp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1147
                     /gene="Slc11a1"
                     /gene_synonym="Bcg; ity; Ity; Ity1; Lsh; Nramp; Nramp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1267
                     /gene="Slc11a1"
                     /gene_synonym="Bcg; ity; Ity; Ity1; Lsh; Nramp; Nramp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1417
                     /gene="Slc11a1"
                     /gene_synonym="Bcg; ity; Ity; Ity1; Lsh; Nramp; Nramp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1491
                     /gene="Slc11a1"
                     /gene_synonym="Bcg; ity; Ity; Ity1; Lsh; Nramp; Nramp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1645
                     /gene="Slc11a1"
                     /gene_synonym="Bcg; ity; Ity; Ity1; Lsh; Nramp; Nramp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..2304
                     /gene="Slc11a1"
                     /gene_synonym="Bcg; ity; Ity; Ity1; Lsh; Nramp; Nramp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2292..2297
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc11a1"
                     /gene_synonym="Bcg; ity; Ity; Ity1; Lsh; Nramp; Nramp1"
                     /note="putative"
ORIGIN      
        1 gtgggttccc actcttactc actcggacca gcacccacag aaggggacag attgaggagc
       61 tagttgccag gcctggtgac cacacacaga gtatcctgcc gcctgcgtcc tcatgattag
      121 tgacaagagc cccccgaggc tgagcaggcc cagttatggc tccatttcca gcctgcctgg
      181 cccagcacct cagccagcgc cttgccggga gacctacctg agtgagaaga tccccattcc
      241 cagcgcagac cagggtacat tcagcctgag gaagctgtgg gcgttcacgg ggcctggttt
      301 cctcatgagc atcgctttcc ttgacccggg aaacattgag tccgaccttc aagctggcgc
      361 tgtggctggg ttcaaactcc tctgggtgct gctctgggcg actgtgctag gtttgctgtg
      421 ccagcggctg gctgcccggc tgggcgtggt gacaggcaag gacttgggtg aagtctgcca
      481 tctctactac cccaaggtgc cccgcatcct cctctggctg accattgagc tggccattgt
      541 gggctcagat atgcaggaag tcatcgggac ggctatctcc ttcaatctgc tctccgctgg
      601 acgcatcccg ctgtgggacg gtgtactgat caccattgtg gacaccttct tcttcctctt
      661 cttggataac tatggtttgc gcaagctgga agctttcttc ggtctcctca ttaccataat
      721 ggctttgacc ttcggctatg agtatgtggt agcacaccct tcccagggag cgctccttaa
      781 gggcctggtg ctgcccacct gtccgggctg tgggcagccc gagctgctgc aggcagtggg
      841 catcgtcggt gccatcatca tgccccataa catctacctg cactcagcct tggtcaagtc
      901 tagagaagta gacagaaccc gccgggtgga tgttcgagaa gccaacatgt acttcctgat
      961 tgaggccacc atcgccctat cggtgtcctt catcatcaac ctcttcgtca tggctgtttt
     1021 tggtcaggcc ttctaccagc aaaccaatga ggaagcgttc aacatctgtg ccaacagcag
     1081 cctccagaac tatgctaaga tcttccccag ggacaataac actgtgtcag tggatattta
     1141 tcaaggaggt gtgatcctag gctgtctctt tggccctgcg gccctctaca tctgggcagt
     1201 aggtctcctg gcagcggggc agagttctac tatgaccggc acctatgcag gacagttcgt
     1261 gatggagggt ttccttaagc tgcggtggtc ccgcttcgct cgggtccttc tcacgcgctc
     1321 ttgcgccatc ctgcccactg tgttggtggc tgtcttccga gacctgaagg acctgtccgg
     1381 cctcaacgat ctactcaatg ttctgcagag tctactgctg cccttcgctg tactgcccat
     1441 tttgactttc accagcatgc cagctgtcat gcaggagttt gccaacggcc ggatgagcaa
     1501 agccatcact tcgtgcatca tggcgctagt ctgcgccatc aacctgtact ttgtgatcag
     1561 ctacctgccc agcctcccgc accctgccta ctttggcctt gtggctctgt tcgcaatagg
     1621 ttacttgggc ctgactgctt atctggcctg gacctgttgc atcgcccacg gagccacctt
     1681 cctgacccac agctcccaca agcacttctt atatgggctc cctaacgagg agcagggagg
     1741 cgtgcagggt tccgggtgac cgcggcatcc agcaagcaaa gaggcaacag ggcagacaca
     1801 gcagagcaat tggaggtccc ctactggctt tctggattac cggtttccag tttggacaag
     1861 tgctttacct cggaataatg acaccattct tatcaccaca acctaagaga cttaaaaaac
     1921 acagtgcctg gggcgagaga tggctcaggt gtgaagaaca ctagccacca ccctttcaga
     1981 agatggggat tcaattccca gcatcaacgt ggtggctttc aactgaaggt gactccagtt
     2041 cccagaacac ctcaaacaga actgccacaa ctccattgtc tcactccagc tcgtggaaga
     2101 tgaagggagg agtcctaaag agttctaggt cgggtctctg gagagacggc tcagctgtta
     2161 agagcaccgg actgctcttc cagaggtcct gagttcaatt cccagcaacc acatggtggc
     2221 tcacaaccat ccataatggg atccctcttc tggtgtgtct gaagacaaca acagtgtcct
     2281 cacatatata aaataaataa atct
//
