LOCUS       NM_173403               2085 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus solute carrier family 10 (sodium/bile acid
            cotransporter family), member 4 (Slc10a4), mRNA.
ACCESSION   NM_173403
VERSION     NM_173403.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2085)
  AUTHORS   Ciralli,B., Malfatti,T., Hilscher,M.M., Leao,R.N., Cederroth,C.R.,
            Leao,K.E. and Kullander,K.
  TITLE     Unraveling the role of Slc10a4 in auditory processing and sensory
            motor gating: Implications for neuropsychiatric disorders?
  JOURNAL   Prog Neuropsychopharmacol Biol Psychiatry 131, 110930 (2024)
   PUBMED   38160852
  REMARK    GeneRIF: Unraveling the role of Slc10a4 in auditory processing and
            sensory motor gating: Implications for neuropsychiatric disorders?
REFERENCE   2  (bases 1 to 2085)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2085)
  AUTHORS   Vieira,J.R., Shah,B., Dupraz,S., Paredes,I., Himmels,P.,
            Schermann,G., Adler,H., Motta,A., Gartner,L., Navarro-Aragall,A.,
            Ioannou,E., Dyukova,E., Bonnavion,R., Fischer,A., Bonanomi,D.,
            Bradke,F., Ruhrberg,C. and Ruiz de Almodovar,C.
  TITLE     Endothelial PlexinD1 signaling instructs spinal cord
            vascularization and motor neuron development
  JOURNAL   Neuron 110 (24), 4074-4089 (2022)
   PUBMED   36549270
REFERENCE   4  (bases 1 to 2085)
  AUTHORS   Catela,C., Chen,Y., Weng,Y., Wen,K. and Kratsios,P.
  TITLE     Control of spinal motor neuron terminal differentiation through
            sustained Hoxc8 gene activity
  JOURNAL   Elife 11, e70766 (2022)
   PUBMED   35315772
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2085)
  AUTHORS   Perry,S., Larhammar,M., Vieillard,J., Nagaraja,C., Hilscher,M.M.,
            Tafreshiha,A., Rofo,F., Caixeta,F.V. and Kullander,K.
  TITLE     Characterization of Dmrt3-Derived Neurons Suggest a Role within
            Locomotor Circuits
  JOURNAL   J Neurosci 39 (10), 1771-1782 (2019)
   PUBMED   30578339
REFERENCE   6  (bases 1 to 2085)
  AUTHORS   Larhammar,M., Patra,K., Blunder,M., Emilsson,L., Peuckert,C.,
            Arvidsson,E., Ronnlund,D., Preobraschenski,J., Birgner,C.,
            Limbach,C., Widengren,J., Blom,H., Jahn,R., Wallen-Mackenzie,A. and
            Kullander,K.
  TITLE     SLC10A4 is a vesicular amine-associated transporter modulating
            dopamine homeostasis
  JOURNAL   Biol Psychiatry 77 (6), 526-536 (2015)
   PUBMED   25176177
  REMARK    GeneRIF: Results demonstrate that SLC10A4 is a vesicular
            monoaminergic and cholinergic associated transporter that is
            important for dopamine homeostasis and neuromodulation in vivo
REFERENCE   7  (bases 1 to 2085)
  AUTHORS   Patra,K., Lyons,D.J., Bauer,P., Hilscher,M.M., Sharma,S., Leao,R.N.
            and Kullander,K.
  TITLE     A role for solute carrier family 10 member 4, or vesicular
            aminergic-associated transporter, in structural remodelling and
            transmitter release at the mouse neuromuscular junction
  JOURNAL   Eur J Neurosci 41 (3), 316-327 (2015)
   PUBMED   25410831
  REMARK    GeneRIF: Results suggest that VAAT modulates neuromuscular junction
            transmission efficiency and, as such, may represent a novel target
            for treatment of disorders affecting motor neurons
REFERENCE   8  (bases 1 to 2085)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   9  (bases 1 to 2085)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   10 (bases 1 to 2085)
  AUTHORS   Zelano,J., Mikulovic,S., Patra,K., Kuhnemund,M., Larhammar,M.,
            Emilsson,L., Leao,R.N. and Kullander,K.
  TITLE     The synaptic protein encoded by the gene Slc10A4 suppresses
            epileptiform activity and regulates sensitivity to cholinergic
            chemoconvulsants
  JOURNAL   Exp Neurol 239, 73-81 (2013)
   PUBMED   23022458
  REMARK    GeneRIF: absence of the recently discovered synaptic vesicle
            protein Slc10a4 results in increased sensitivity to cholinergic
            stimulation
            Erratum:[Exp Neurol. 2013 Sep;247:750. Leao, R [corrected to Leao,
            R N]]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK087479.1 and AK149202.1.
            
            On Feb 8, 2006 this sequence version replaced NM_173403.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149202.1, AK087479.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1425              AK087479.1         2-1426
            1426-2085           AK149202.1         1427-2086
FEATURES             Location/Qualifiers
     source          1..2085
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 38.44 cM"
     gene            1..2085
                     /gene="Slc10a4"
                     /gene_synonym="E130304D01"
                     /note="solute carrier family 10 (sodium/bile acid
                     cotransporter family), member 4"
                     /db_xref="GeneID:231290"
                     /db_xref="MGI:MGI:3606480"
     exon            1..753
                     /gene="Slc10a4"
                     /gene_synonym="E130304D01"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..1477
                     /gene="Slc10a4"
                     /gene_synonym="E130304D01"
                     /note="solute carrier family 10 member 4; Na(+)/bile acid
                     cotransporter 4"
                     /codon_start=1
                     /product="sodium/bile acid cotransporter 4"
                     /protein_id="NP_775579.2"
                     /db_xref="CCDS:CCDS19336.1"
                     /db_xref="GeneID:231290"
                     /db_xref="MGI:MGI:3606480"
                     /translation="MDSLDNTTLLLAPSSLLPDNLTLSPNAGSPSASTLSPLAVTSSP
                     GPGLSLAPSPSIGFSPEATPTPEPTSSSLTVGVAGQGSSAFPRPWIPHEPPFWDTPLN
                     HGLNVFVGAALCITMLGLGCTVDVNHFGAHVRRPVGALLAALCQFGFLPLLAFLLALI
                     FKLDEVAAVAVLLCGCCPGGNLSNLMSLLVDGDMNLSIIMTISSTLLALVLMPLCLWI
                     YSRAWINTPLVQLLPLGAVTLTLCSTLIPIGLGVFIRYKYNRVADYIVKVSLWSLLVT
                     LVVLFIMTGTMLGPELLASIPATVYVVAIFMPLAGYASGYGLATLFHLPPNCKRTVCL
                     ETGSQNVQLCTAILKLAFPPRFIGSMYMFPLLYALFQSAEAGVFVLIYKMYGSEILHK
                     REALDEDEDTDISYKKLKEEEMADTSYGTVGTDDLVMMETTQTAL"
     exon            754..964
                     /gene="Slc10a4"
                     /gene_synonym="E130304D01"
                     /inference="alignment:Splign:2.1.0"
     exon            965..2085
                     /gene="Slc10a4"
                     /gene_synonym="E130304D01"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2065..2070
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc10a4"
                     /gene_synonym="E130304D01"
                     /note="hexamer: TATAAA"
     polyA_site      2085
                     /gene="Slc10a4"
                     /gene_synonym="E130304D01"
                     /note="major polyA site"
ORIGIN      
        1 agtgccagct gtggggcagc atgcacacca cagcgacgac cggcccgccg caccgacgcc
       61 gcggggacgc ttgaccagac agacaggtaa aagggaccac aggaccgagg gaggaggtgt
      121 ggccagggac agcccctgca gaccgtgcct cggcgacaga gccatggaca gcctggacaa
      181 caccaccctg ctccttgccc cgtcctcgct gctgcctgac aacctcaccc tgtctcccaa
      241 cgccggcagc ccgagcgcca gcaccctttc gcctctcgct gtcacctcta gtcccggtcc
      301 ggggctcagc ctcgctccaa gtccaagcat cggctttagc cccgaggcaa ccccgactcc
      361 agagcccacg agcagcagcc tcacggtcgg cgtggctggc cagggctcct ccgctttccc
      421 ccggccctgg atcccccacg agcccccatt ctgggacacg ccgctcaacc acgggctgaa
      481 tgtgtttgtg ggcgccgcct tgtgcatcac catgctgggt ctaggctgta ccgtggacgt
      541 gaaccacttc ggggcgcacg tccggcggcc cgtgggcgct ctgctggctg cgctctgcca
      601 gttcggcttc ttgccgctgc tagccttctt gctggccctc atcttcaagc tggatgaggt
      661 ggccgcggtg gctgtactcc tatgtggctg ctgtcctggt ggaaatctct ccaatctcat
      721 gtccctgctg gtagacggcg acatgaacct cagcatcatc atgaccattt cctccacact
      781 cctggccctg gtgttgatgc ccctctgcct ctggatctac agccgtgcct ggatcaatac
      841 ccctctggtg caattgctcc ccctaggggc agtcaccctg actctctgca gcactctcat
      901 tcctattggg ctaggcgtct tcattcgcta caaatacaac cgcgtggctg actacatcgt
      961 gaaggtttcc ctgtggtctc tgcttgtgac cctggtggtt cttttcataa tgactggcac
     1021 catgctggga cctgaactgc tggcaagcat tcccgcaact gtttacgtgg tcgccatttt
     1081 tatgcctctg gcgggctacg cctcgggtta tggcttagct accctcttcc acctcccgcc
     1141 caactgcaag cggactgtgt gtctggaaac aggaagtcag aacgtgcagc tctgcactgc
     1201 gattctcaaa ctggccttcc cgcctcgctt tataggtagc atgtacatgt tccctctgct
     1261 ctacgccctc ttccagtctg ccgaggcagg ggtcttcgtg ttgatctaca aaatgtacgg
     1321 aagtgagata ctgcacaagc gagaggccct agacgaagac gaagacaccg atatttctta
     1381 taagaaactg aaagaagagg aaatggcaga cacctcctat ggcaccgtgg ggacggatga
     1441 cttagtgatg atggagacca cccagaccgc cctctgaccg aggagataca cgggagctga
     1501 aacatcactt cctatttgtg accattggta gcgagtatgg ttcgcatccg ggataaagat
     1561 gggttgacat ttcctgtaac agatttgctc ttcccactgt aatgttgtat ctcagtatta
     1621 cccatgtgtt tttctaactc aacagagtcc cagtattgct tacacctgga tcagctaaag
     1681 tgccggtcct ctgcttaagt agtgtgctgt ttgtttgttt gttttttgtt ttgttttgtt
     1741 ttcccggttt ttgtttgttt tgccatttcc accagcatcg ctacagatag gaaatggggt
     1801 tggaaatgtt tgtaaatgtt tgtaaaacag aaccatgggt ttgctcaact tacaaacaac
     1861 cgattctgtt cagggcgagc ctgtattgag aaaagtccaa aacgggtcag tgaaacgaca
     1921 ggatagcatt gcatcgtcaa accactctca agccagagaa aatcatatta atgtgtgtga
     1981 ctacttgatc tagtatctat tgttaatggc catcaacatt gtccaggggt gaaaggcatt
     2041 ttccccatat gtttcctgta tttgtataaa cgcatctcag ctcca
//
