LOCUS       NM_011388               4088 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus solute carrier family 10, member 2 (Slc10a2), mRNA.
ACCESSION   NM_011388
VERSION     NM_011388.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4088)
  AUTHORS   Peiper,A.M., Morales Aparicio,J., Hu,Z., Phophi,L., Helm,E.W.,
            Rubinstein,R.J., Phillips,M., Williams,C.G., Subramanian,S.,
            Cross,M., Iyer,N., Nguyen,Q., Newsome,R., Jobin,C., Langel,S.N.,
            Bucardo,F., Becker-Dreps,S., Tan,X.D., Dawson,P.A. and Karst,S.M.
  TITLE     Metabolic immaturity and breastmilk bile acid metabolites are
            central determinants of heightened newborn vulnerability to
            norovirus diarrhea
  JOURNAL   Cell Host Microbe 32 (9), 1488-1501 (2024)
   PUBMED   39214086
REFERENCE   2  (bases 1 to 4088)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4088)
  AUTHORS   Truong,J.K., Li,J., Li,Q., Pachura,K., Rao,A., Gumber,S.,
            Fuchs,C.D., Feranchak,A.P., Karpen,S.J., Trauner,M. and Dawson,P.A.
  TITLE     Active enterohepatic cycling is not required for the choleretic
            actions of 24-norUrsodeoxycholic acid in mice
  JOURNAL   JCI Insight 8 (6), e149360 (2023)
   PUBMED   36787187
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4088)
  AUTHORS   Meadows,V., Marakovits,C., Ekser,B., Kundu,D., Zhou,T., Kyritsi,K.,
            Pham,L., Chen,L., Kennedy,L., Ceci,L., Wu,N., Carpino,G., Zhang,W.,
            Isidan,A., Meyer,A., Owen,T., Gaudio,E., Onori,P., Alpini,G. and
            Francis,H.
  TITLE     Loss of apical sodium bile acid transporter alters bile acid
            circulation and reduces biliary damage in cholangitis
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 324 (1), G60-G77 (2023)
   PUBMED   36410025
  REMARK    GeneRIF: Loss of apical sodium bile acid transporter alters bile
            acid circulation and reduces biliary damage in cholangitis.
REFERENCE   5  (bases 1 to 4088)
  AUTHORS   Zaufel,A., van de Wiel,S.M.W., Yin,L., Fauler,G., Chien,D.,
            Dong,X., Gilmer,J.F., Truong,J.K., Dawson,P.A., van de
            Graaf,S.F.J., Fickert,P. and Moustafa,T.
  TITLE     Secondary (iso)BAs cooperate with endogenous ligands to activate
            FXR under physiological and pathological conditions
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1867 (8), 166153 (2021)
   PUBMED   33895309
REFERENCE   6  (bases 1 to 4088)
  AUTHORS   Dawson,P.A., Haywood,J., Craddock,A.L., Wilson,M., Tietjen,M.,
            Kluckman,K., Maeda,N. and Parks,J.S.
  TITLE     Targeted deletion of the ileal bile acid transporter eliminates
            enterohepatic cycling of bile acids in mice
  JOURNAL   J Biol Chem 278 (36), 33920-33927 (2003)
   PUBMED   12819193
  REMARK    GeneRIF: Slc10a2 is essential for efficient intestinal absorption
            of bile acids
REFERENCE   7  (bases 1 to 4088)
  AUTHORS   Chen,F., Ma,L., Al-Ansari,N. and Shneider,B.
  TITLE     The role of AP-1 in the transcriptional regulation of the rat
            apical sodium-dependent bile acid transporter
  JOURNAL   J Biol Chem 276 (42), 38703-38714 (2001)
   PUBMED   11509565
REFERENCE   8  (bases 1 to 4088)
  AUTHORS   Lammert,F., Carey,M.C. and Paigen,B.
  TITLE     Chromosomal organization of candidate genes involved in cholesterol
            gallstone formation: a murine gallstone map
  JOURNAL   Gastroenterology 120 (1), 221-238 (2001)
   PUBMED   11208732
  REMARK    Review article
REFERENCE   9  (bases 1 to 4088)
  AUTHORS   Saeki,T., Matoba,K., Furukawa,H., Kirifuji,K., Kanamoto,R. and
            Iwami,K.
  TITLE     Characterization, cDNA cloning, and functional expression of mouse
            ileal sodium-dependent bile acid transporter
  JOURNAL   J Biochem 125 (4), 846-851 (1999)
   PUBMED   10101301
REFERENCE   10 (bases 1 to 4088)
  AUTHORS   Lammert,F., Paigen,B. and Carey,M.C.
  TITLE     Localization of the ileal sodium-bile salt cotransporter gene
            (Slc10a2) to mouse chromosome 8
  JOURNAL   Mamm Genome 9 (2), 173-174 (1998)
   PUBMED   9457686
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC110744.6.
            
            On May 24, 2016 this sequence version replaced NM_011388.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY529655.1, AB002693.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-481               AC110744.6         175702-176182       c
            482-600             AC110744.6         169343-169461       c
            601-689             AC110744.6         164156-164244       c
            690-865             AC110744.6         162517-162692       c
            866-1023            AC110744.6         159919-160076       c
            1024-4088           AC110744.6         154114-157178       c
FEATURES             Location/Qualifiers
     source          1..4088
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 2.16 cM"
     gene            1..4088
                     /gene="Slc10a2"
                     /gene_synonym="9130221J18Rik; ASBT; IBAT; ISBT"
                     /note="solute carrier family 10, member 2"
                     /db_xref="GeneID:20494"
                     /db_xref="MGI:MGI:1201406"
     exon            1..481
                     /gene="Slc10a2"
                     /gene_synonym="9130221J18Rik; ASBT; IBAT; ISBT"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..1151
                     /gene="Slc10a2"
                     /gene_synonym="9130221J18Rik; ASBT; IBAT; ISBT"
                     /note="ileal Na(+)/bile acid cotransporter; ileal
                     sodium-dependent bile acid transporter; apical
                     sodium-dependent bile acid transporter;
                     sodium/taurocholate cotransporting polypeptide, ileal;
                     Na(+)-dependent ileal bile acid transporter"
                     /codon_start=1
                     /product="ileal sodium/bile acid cotransporter"
                     /protein_id="NP_035518.1"
                     /db_xref="CCDS:CCDS22089.1"
                     /db_xref="GeneID:20494"
                     /db_xref="MGI:MGI:1201406"
                     /translation="MDNSSVCPPNATVCEGDSCVVPESNFNAILNTVMSTVLTILLAM
                     VMFSMGCNVEVHKFLGHIKRPWGIFVGFLCQFGIMPLTGFILSVASGILPVQAVVVLI
                     MGCCPGGTGSNILAYWIDGDMDLSVSMTTCSTLLALGMMPLCLFVYTKMWVDSGTIVI
                     PYDSIGISLVALVIPVSFGMFVNHKWPQKAKIILKIGSITGVILIVLIAVIGGILYQS
                     AWIIEPKLWIIGTIFPIAGYSLGFFLARLAGQPWYRCRTVALETGMQNTQLCSTIVQL
                     SFSPEDLNLVFTFPLIYTVFQLVFAAVILGIYVTYRKCYGKNDAEFLEKTDNEMDSRP
                     SFDETNKGFQPDEK"
     exon            482..600
                     /gene="Slc10a2"
                     /gene_synonym="9130221J18Rik; ASBT; IBAT; ISBT"
                     /inference="alignment:Splign:2.1.0"
     exon            601..689
                     /gene="Slc10a2"
                     /gene_synonym="9130221J18Rik; ASBT; IBAT; ISBT"
                     /inference="alignment:Splign:2.1.0"
     exon            690..865
                     /gene="Slc10a2"
                     /gene_synonym="9130221J18Rik; ASBT; IBAT; ISBT"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1023
                     /gene="Slc10a2"
                     /gene_synonym="9130221J18Rik; ASBT; IBAT; ISBT"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..4088
                     /gene="Slc10a2"
                     /gene_synonym="9130221J18Rik; ASBT; IBAT; ISBT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2523..2528
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc10a2"
                     /gene_synonym="9130221J18Rik; ASBT; IBAT; ISBT"
                     /note="hexamer: AAGAAA"
     polyA_site      2546
                     /gene="Slc10a2"
                     /gene_synonym="9130221J18Rik; ASBT; IBAT; ISBT"
                     /note="major polyA site"
     regulatory      4064..4069
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc10a2"
                     /gene_synonym="9130221J18Rik; ASBT; IBAT; ISBT"
                     /note="hexamer: AATAAA"
     polyA_site      4086
                     /gene="Slc10a2"
                     /gene_synonym="9130221J18Rik; ASBT; IBAT; ISBT"
                     /note="major polyA site"
ORIGIN      
        1 gagaaagggt ttaaaagttt ggcgtgttga aagcatactc agctggcagt agagacagaa
       61 ctggtgcttc tgtggacttg gccatttgca cagcacaagc agtgatggat aactcctctg
      121 tctgtccccc aaatgcaact gtctgcgaag gcgattcctg cgtagtacct gagagcaact
      181 tcaatgcaat tctcaataca gtgatgagca ctgtgctcac catcctctta gccatggtga
      241 tgttttctat ggggtgcaat gtggaagtcc acaagttcct aggacatata aagagaccat
      301 ggggtatctt cgtgggcttc ctctgtcagt ttggaatcat gcctctcaca ggctttatcc
      361 tgtctgtggc ctctggcatc cttcctgtac aggctgtagt ggtgctaatt atgggttgct
      421 gccctggagg aactggctcc aatatcctgg cctattggat agatggcgac atggacctca
      481 gtgttagcat gaccacttgc tccacactgc ttgcccttgg aatgatgcct ctttgcctct
      541 tcgtctacac caagatgtgg gttgactcgg gaacgattgt gattccctat gatagcattg
      601 gtatttctct ggttgctctt gttattcctg tttcctttgg aatgtttgta aatcacaaat
      661 ggccacaaaa agcgaagatt atacttaaaa ttggatccat cacaggtgta attctcattg
      721 tgctcatagc tgtgattgga ggaatactgt accaaagtgc ctggatcatt gaacccaaac
      781 tgtggattat aggaacaata ttccctatag ctggctacag cctgggtttc ttcctggcta
      841 gactagctgg tcaaccctgg tacaggtgcc gaacagtagc cttggaaact ggaatgcaga
      901 acactcagct gtgctccacc attgtacagc tctccttctc ccccgaggat ctcaacctgg
      961 tgttcacctt cccactcatc tatactgttt tccagctcgt ctttgcagca gtaatattag
     1021 gaatttatgt cacatacagg aaatgttatg gaaaaaatga tgctgagttt ctagagaaaa
     1081 cagacaatga aatggactcc aggccatcat ttgatgagac aaacaaggga tttcaaccag
     1141 atgagaagta gacaagaaag aaaaagaaaa cttcagaaca atattcatta aactaaaact
     1201 gaatttattt cttttggtgg aaaatcatca gaaaaaacaa atttaaaagt taaattcaaa
     1261 ttgaaattat gttttttgta taaagtaatc cattctttag tgtgacaaag atccaaagat
     1321 atgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtac atgagcgtac
     1381 gatcgtacat gagtcagttt tctgtattca tagtcagatt ggtcacaaga tattccttga
     1441 tttcaaattc acagaagctt aagcctcttt ttttaaaaag gcagtgttta tattaatctc
     1501 ttattacttc agatcaatat tatcttacta aaatatttaa catgatgtaa atgtgtaaat
     1561 agttgtttca ctgtattgtt taggaaatga tgttttttaa agtctatgat attttatgtt
     1621 cagtacaggt atcatttttc agatattttt ggccatagtg agttaaaatc atagatgtca
     1681 aacttatcct ttgggggcca aatgcatgta catagaatgt atagatagat gaaagatagg
     1741 tagatagata gatagataga tagatagata gatagataga tagatgaaag atagatagat
     1801 agatagatag atagatagat agatagatga aagatagata gatgatagat agatagatag
     1861 atagatagat agatagatag atagatagat agatagatag atagatagat tagataggtg
     1921 atagatagat agatagatag atagatagat agatagatag attagatagg tgatagatag
     1981 atagatagat agatagatag atagattaga tagatagata gattagatag atagatagat
     2041 agatagatag atagatagat agatagatag atagataaac tgattatcat taatatatta
     2101 tcagaaaata tctatagacc taatttgata taggtcaaat tggaaacttg gtcatatgta
     2161 agctgaactc agagtcaagc acttttgttt gttaaaatat aacatattat tactgtaaaa
     2221 taattatttt cttcagtgtt tatgattgta aaatgattga tgtgaatgaa tgtattcctc
     2281 tgacatttta atcatgagtt tgaagatttg caacatattt atttgtggtt ttgcactata
     2341 ctccgacaaa tatctgtatt tgtattttag aaaagtaggt ccttcaaatg atattccaga
     2401 aatagaaaca agagaaagta ttgctaatca actgaagaac aaactagaat tgaattaact
     2461 catcaacata ttttatatcc attcatatgc ctctagggtc cctgatgccc tttttatctt
     2521 tcaagaaata gagatcattc aatacagttt gaatttgaca attaattttt ggaactctga
     2581 agaggtttgt tcaaatatga tctgtatgaa gcaggtctaa atgggacaat atgatagata
     2641 ttaagcccat atgaagtgcc ataccagtca ccatgagcag gaggtatcag aagttacaaa
     2701 ggaacaatgg tatcagtcta gaaaatgaca taatacaatg aagagataaa taaatgtaag
     2761 gaaaagcaca gataaaagaa atattgaaaa aacttaatat ggcaaatctg atgtgtgaca
     2821 ggaagtagct acaggaagat tcatgtcaga aagtgagatt tgaagaagat aagaagtccc
     2881 caggcaacaa agtaggaaaa tcatttctca gatgtcatag atatagatat atacctgtct
     2941 atatctaaaa tggtagaaac caaataagac ttataaatca gcaagactgt atggctgtca
     3001 tagggatgga atttgtgctt gtctttttcc ttgagaccca acttgattta cttttcttca
     3061 ttttggagga gaaacatgtt tttaactagt ctttggttgt tggtcttatg gcaacttttg
     3121 atattgccaa aggcttgtgg attcctttaa tttataatgt ttttgctcca aagactattc
     3181 tgcatttgaa tgatctgact ttagatcaca atgagggctt ctggttgtag acttaaaata
     3241 ttttggctgg agatattgtc acagtctgta cagtgtttgc tctgacagca tgagggtctg
     3301 aactagacta ccaacactca tataaaaatg ccaggtatga tactgtgcag ctgtaatccc
     3361 agtactagaa agaagaaacc aggaggataa gagccagtct agccaatcag tgagctctga
     3421 gttcagtgaa agaccatgtt gcaaaaacta aaataaagag ctacaaagga agacacttgc
     3481 cattgaccac atgtacatca cacagacaca cacacacaca cacacacaca cacacacatt
     3541 tggagcattt ttccatcact agacaaaagc agaaagttga actcagaatg tcttaaggca
     3601 ttggacattt attggtagac aggagactgg attttcttct tgataatgtc aagaaagtac
     3661 gtccaaacat ggaaaatgaa gtctagttct taagtacctc ttaacattcc tcatcaagaa
     3721 gaaaacagac agatgcatta aagacaccat gtgaatttcg atcaagtttt caacaccccc
     3781 caaattaagg gcctggatgc cagcagctga atcaactggg ttttcatccc taatgattaa
     3841 agaatatgag tgacatagaa cttcattttc ttaccatata tggtggcttg tgaggttatt
     3901 tttcccccta atattctaga agaatagaag aatattctag aaaaagagtt aagcattcta
     3961 aaattacaaa tctctttttt taatgatttt gaaaagctga tgaaatcata tatattattg
     4021 cctctgtttc atattaaatg aatattttta ttttaaaggc ataaataaaa aaatgattgt
     4081 gtactatc
//
