LOCUS       NM_011387               1506 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus solute carrier family 10 (sodium/bile acid
            cotransporter family), member 1 (Slc10a1), transcript variant 2,
            mRNA.
ACCESSION   NM_011387
VERSION     NM_011387.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1506)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1506)
  AUTHORS   Yang,F., Xu,W., Wu,L., Yang,L., Zhu,S., Wang,L., Wu,W., Zhang,Y.,
            Chong,Y. and Peng,L.
  TITLE     NTCP Deficiency Affects the Levels of Circulating Bile Acids and
            Induces Osteoporosis
  JOURNAL   Front Endocrinol (Lausanne) 13, 898750 (2022)
   PUBMED   35937832
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1506)
  AUTHORS   Salhab,A., Amer,J., Lu,Y. and Safadi,R.
  TITLE     Sodium+/taurocholate cotransporting polypeptide as target therapy
            for liver fibrosis
  JOURNAL   Gut 71 (7), 1373-1385 (2022)
   PUBMED   34266968
  REMARK    GeneRIF: Sodium(+)/taurocholate cotransporting polypeptide as
            target therapy for liver fibrosis.
REFERENCE   4  (bases 1 to 1506)
  AUTHORS   Mao,F., Wang,M.X., Hou,X., Zhou,Z., Yan,Y.Y., Fang,L.J., Tan,Z.,
            Fang,W.Y., Liu,T., He,W., Li,C., Xie,X.B., Lu,S.Q., Sui,J.,
            Wang,F., Han,J., Wang,J.S. and Li,W.
  TITLE     NTCP Deficiency Causes Gallbladder Abnormalities in Mice and Human
            Beings
  JOURNAL   Cell Mol Gastroenterol Hepatol 11 (3), 831-839 (2021)
   PUBMED   32919083
  REMARK    GeneRIF: NTCP Deficiency Causes Gallbladder Abnormalities in Mice
            and Human Beings.
REFERENCE   5  (bases 1 to 1506)
  AUTHORS   Yang,Y., Liu,L., Zhang,X., Jiang,X. and Wang,L.
  TITLE     Tanshinone IIA prevents rifampicin-induced liver injury by
            regulating BSEP/NTCP expression via epigenetic activation of NRF2
  JOURNAL   Liver Int 40 (1), 141-154 (2020)
   PUBMED   31571363
  REMARK    GeneRIF: Tanshinone IIA prevents rifampicin-induced liver injury by
            regulating BSEP/NTCP expression via epigenetic activation of NRF2.
REFERENCE   6  (bases 1 to 1506)
  AUTHORS   Koopen,N.R., Wolters,H., Voshol,P., Stieger,B., Vonk,R.J.,
            Meier,P.J., Kuipers,F. and Hagenbuch,B.
  TITLE     Decreased Na+-dependent taurocholate uptake and low expression of
            the sinusoidal Na+-taurocholate cotransporting protein (Ntcp) in
            livers of mdr2 P-glycoprotein-deficient mice
  JOURNAL   J Hepatol 30 (1), 14-21 (1999)
   PUBMED   9927146
REFERENCE   7  (bases 1 to 1506)
  AUTHORS   Green,R.M., Ananthanarayanan,M., Suchy,F.J. and Beier,D.R.
  TITLE     Genetic mapping of the Na(+)-taurocholate cotransporting
            polypeptide to mouse chromosome 12
  JOURNAL   Mamm Genome 9 (7), 598 (1998)
   PUBMED   9657862
REFERENCE   8  (bases 1 to 1506)
  AUTHORS   Torchia,E.C., Cheema,S.K. and Agellon,L.B.
  TITLE     Coordinate regulation of bile acid biosynthetic and recovery
            pathways
  JOURNAL   Biochem Biophys Res Commun 225 (1), 128-133 (1996)
   PUBMED   8769105
REFERENCE   9  (bases 1 to 1506)
  AUTHORS   Hagenbuch,B. and Meier,P.J.
  TITLE     Molecular cloning, chromosomal localization, and functional
            characterization of a human liver Na+/bile acid cotransporter
  JOURNAL   J Clin Invest 93 (3), 1326-1331 (1994)
   PUBMED   8132774
REFERENCE   10 (bases 1 to 1506)
  AUTHORS   Hagenbuch,B., Stieger,B., Foguet,M., Lubbert,H. and Meier,P.J.
  TITLE     Functional expression cloning and characterization of the
            hepatocyte Na+/bile acid cotransport system
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10629-10633 (1991)
   PUBMED   1961729
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125092.4.
            
            On Apr 16, 2010 this sequence version replaced NM_011387.1.
            
            Transcript Variant: This variant (2) contains an alternate segment
            in the 3' coding region that results in a frameshift and early stop
            codon compare to variant 1. The resulting protein (isoform 2) has a
            shorter, distinct C-terminus compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U95132.1, BI149148.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-491               AC125092.4         104975-105465       c
            492-702             AC125092.4         97825-98035         c
            703-881             AC125092.4         95407-95585         c
            882-1506            AC125092.4         92878-93502         c
FEATURES             Location/Qualifiers
     source          1..1506
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 37.21 cM"
     gene            1..1506
                     /gene="Slc10a1"
                     /gene_synonym="Ntcp"
                     /note="solute carrier family 10 (sodium/bile acid
                     cotransporter family), member 1"
                     /db_xref="GeneID:20493"
                     /db_xref="MGI:MGI:97379"
     exon            1..491
                     /gene="Slc10a1"
                     /gene_synonym="Ntcp"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..1089
                     /gene="Slc10a1"
                     /gene_synonym="Ntcp"
                     /note="isoform 2 is encoded by transcript variant 2;
                     sodium-taurocholate cotransporting polypeptide; Na(+)/bile
                     acid cotransporter; Na(+)/taurocholate transport protein;
                     sodium bile acid cotransporting polypeptide; hepatic
                     sodium/bile acid cotransporter"
                     /codon_start=1
                     /product="hepatic sodium/bile acid cotransporter isoform
                     2"
                     /protein_id="NP_035517.1"
                     /db_xref="CCDS:CCDS88362.1"
                     /db_xref="GeneID:20493"
                     /db_xref="MGI:MGI:97379"
                     /translation="MEAHNVSAPFNFSLPPGFGHRATDTALSVILVVMLLLIMLSLGC
                     TMEFSKIKAHFWKPKGVIIAIVAQYGIMPLSAFLLGKVFHLTSIEALAILICGCSPGG
                     NLSNLFTLAMKGDMNLSIVMTTCSSFTALGMMPLLLYIYSKGIYDGDLKDKVPYKGIM
                     LSLVMVLIPCAIGIFLKSKRPHYVPYVLKAGMIITFSLSVAVTVLSVINVGNSIMFVM
                     TPHLLATSSLMPFTGFLMGYILSALFRLNPSCRRTISMETGFQNVQLCSTILNVTFPP
                     EVIGPLFFFPLLYMIFQLAEGLLFIIIFRCYLKIKPQKGKY"
     exon            492..702
                     /gene="Slc10a1"
                     /gene_synonym="Ntcp"
                     /inference="alignment:Splign:2.1.0"
     exon            703..881
                     /gene="Slc10a1"
                     /gene_synonym="Ntcp"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1506
                     /gene="Slc10a1"
                     /gene_synonym="Ntcp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ataatctttt atttgcccac agctacattt tgtccagaaa ctctgtcctg aaagaggact
       61 gaagaaaaca tccagccagc actgggcaag gaagggcagg agcagagagt gaggtggtgt
      121 tcactgggtc ggaggatgga ggcgcacaac gtatcagccc ccttcaattt ctccctgccg
      181 cctggctttg gccaccgggc cacagacact gcgctcagcg tcattctggt agttatgttg
      241 ctgctcatca tgctctcgct tggctgcacc atggagttca gcaagatcaa ggctcacttc
      301 tggaagccca aaggggtgat catcgccata gtggcccagt acggtatcat gcccctcagt
      361 gctttccttc tgggcaaggt ctttcatctg accagcattg aggctctggc catcctcatc
      421 tgcggctgct ctcctggggg gaacctgtct aacctcttca ccctggccat gaagggggac
      481 atgaacctca gcattgtgat gaccacctgc tccagcttca ctgccttggg catgatgcct
      541 ctcctcttat acatctacag caaaggaatc tacgacggag atcttaagga caaggtgccc
      601 tacaaaggca ttatgttatc actcgtcatg gttctcattc cttgcgccat agggatcttc
      661 ctgaagtcca aaaggccaca ctatgtaccc tacgtcctca aggcaggcat gatcatcact
      721 ttctccctct ctgtggctgt cacagtcctg tctgtcatca atgtgggcaa cagcatcatg
      781 ttcgtcatga caccacactt actggctacc tcctccctga tgcctttcac tggcttcctg
      841 atgggctaca ttctctctgc tctcttccga ctaaatccaa gctgcagacg caccatcagc
      901 atggaaacag gattccaaaa cgtccaactc tgttctacca tcctcaatgt caccttcccc
      961 cctgaagtca ttggaccact gttcttcttt cctctccttt atatgatttt tcagcttgca
     1021 gaaggacttc tcttcattat tatcttccgg tgctatttga aaatcaaacc tcagaagggt
     1081 aagtattgaa ctcatctcct atgagtattt gctctggacc tgagctacca acaaaagatt
     1141 ccaagtagga actggaacca ggtaaaacag catgccagcg actttgaaga gtaaaggtca
     1201 ttttcaccag taacactact ccaagttaat gcatctggcg ttgttctcat gggcctgact
     1261 ttgtaagaca agcttcaata ttacagagaa cgatcttgaa actaaaacat gtctagggtt
     1321 tctttaattt ggaaagcttc agcattcttt agtgttcagc tttctgcaag gtcagagccc
     1381 agctggtggc gcacgccttt aatcccagca cttgggaggc agaggcaggt ggatttctga
     1441 gttcgaggcc agctggtcta cagagtgagt tccaggacag ccagggctat acagagaccc
     1501 tgtctc
//
