LOCUS       NP_033219                275 aa            linear   ROD 03-JUN-2024
DEFINITION  histone RNA hairpin-binding protein isoform 1 [Mus musculus].
ACCESSION   NP_033219
VERSION     NP_033219.1
DBSOURCE    REFSEQ: accession NM_009193.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 275)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 275)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 275)
  AUTHORS   Jin,Y., Yang,M., Gao,C., Yue,W., Liang,X., Xie,B., Zhu,X., Fan,S.,
            Li,R. and Li,M.
  TITLE     Fbxo30 regulates chromosome segregation of oocyte meiosis
  JOURNAL   Cell Mol Life Sci 76 (11), 2217-2229 (2019)
   PUBMED   30980108
  REMARK    GeneRIF: SLBP overexpression caused by Fbxo30 depletion results in
            a remarkable overload of histone H3 on chromosomes that excessively
            condenses chromosomes and inhibits chromosome segregation. The
            finding uncovers an unidentified pathway-controlling chromosome
            segregation and cell progress.
REFERENCE   4  (residues 1 to 275)
  AUTHORS   Jang,C.W., Shibata,Y., Starmer,J., Yee,D. and Magnuson,T.
  TITLE     Histone H3.3 maintains genome integrity during mammalian
            development
  JOURNAL   Genes Dev 29 (13), 1377-1392 (2015)
   PUBMED   26159997
REFERENCE   5  (residues 1 to 275)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (residues 1 to 275)
  AUTHORS   Allard,P., Yang,Q., Marzluff,W.F. and Clarke,H.J.
  TITLE     The stem-loop binding protein regulates translation of histone mRNA
            during mammalian oogenesis
  JOURNAL   Dev Biol 286 (1), 195-206 (2005)
   PUBMED   16125165
  REMARK    GeneRIF: histone synthesis in immature and maturing oocytes is
            governed by a translational control mechanism that is directly
            regulated by changes in the amount of SLBP
REFERENCE   7  (residues 1 to 275)
  AUTHORS   Whitfield,M.L., Kaygun,H., Erkmann,J.A., Townley-Tilson,W.H.,
            Dominski,Z. and Marzluff,W.F.
  TITLE     SLBP is associated with histone mRNA on polyribosomes as a
            component of the histone mRNP
  JOURNAL   Nucleic Acids Res 32 (16), 4833-4842 (2004)
   PUBMED   15358832
  REMARK    Publication Status: Online-Only
REFERENCE   8  (residues 1 to 275)
  AUTHORS   Black,D., Bird,M.A., Hayden,M., Schrum,L.W., Lange,P., Samson,C.,
            Hatano,E., Rippe,R.A., Brenner,D.A. and Behrns,K.E.
  TITLE     TNF alpha-induced hepatocyte apoptosis is associated with
            alterations of the cell cycle and decreased stem loop binding
            protein
  JOURNAL   Surgery 135 (6), 619-628 (2004)
   PUBMED   15179368
  REMARK    GeneRIF: Inhibition of NF kappa B in TNF alpha-treated primary
            mouse hepatocytes is associated with increased S-phase cell cycle
            retention and decreased stem loop binding protein.
REFERENCE   9  (residues 1 to 275)
  AUTHORS   Allard,P., Champigny,M.J., Skoggard,S., Erkmann,J.A.,
            Whitfield,M.L., Marzluff,W.F. and Clarke,H.J.
  TITLE     Stem-loop binding protein accumulates during oocyte maturation and
            is not cell-cycle-regulated in the early mouse embryo
  JOURNAL   J Cell Sci 115 (Pt 23), 4577-4586 (2002)
   PUBMED   12415002
  REMARK    GeneRIF: SLBP expression and activity differ in mouse oocytes and
            early embryos compared with somatic cells.
REFERENCE   10 (residues 1 to 275)
  AUTHORS   Wang,Z.F., Whitfield,M.L., Ingledue,T.C. 3rd, Dominski,Z. and
            Marzluff,W.F.
  TITLE     The protein that binds the 3' end of histone mRNA: a novel
            RNA-binding protein required for histone pre-mRNA processing
  JOURNAL   Genes Dev 10 (23), 3028-3040 (1996)
   PUBMED   8957003
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162898.10, AK162121.1, AC132233.4 and BE979466.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025113.1, AK154053.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..275
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.83 cM"
     Protein         1..275
                     /product="histone RNA hairpin-binding protein isoform 1"
                     /note="histone RNA hairpin-binding protein; histone
                     stem-loop-binding protein"
                     /calculated_mol_wt=31472
     Region          1..88
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P97440.1)"
     Site            20
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14493; propagated from
                     UniProtKB/Swiss-Prot (P97440.1)"
     Site            23
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14493; propagated from
                     UniProtKB/Swiss-Prot (P97440.1)"
     Region          31..34
                     /region_name="Nuclear localization signal NLS1.
                     /evidence=ECO:0000250|UniProtKB:Q14493"
                     /note="propagated from UniProtKB/Swiss-Prot (P97440.1)"
     Site            59
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14493; propagated from
                     UniProtKB/Swiss-Prot (P97440.1)"
     Site            61
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q14493; propagated from
                     UniProtKB/Swiss-Prot (P97440.1)"
     Site            62
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by CDK1.
                     /evidence=ECO:0000250|UniProtKB:Q14493; propagated from
                     UniProtKB/Swiss-Prot (P97440.1)"
     Region          96..99
                     /region_name="Nuclear localization signal NLS2.
                     /evidence=ECO:0000250|UniProtKB:Q14493"
                     /note="propagated from UniProtKB/Swiss-Prot (P97440.1)"
     Region          103..133
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P97440.1)"
     Region          129..198
                     /region_name="RNA-binding.
                     /evidence=ECO:0000250|UniProtKB:Q14493"
                     /note="propagated from UniProtKB/Swiss-Prot (P97440.1)"
     Region          130..199
                     /region_name="SLBP_RNA_bind"
                     /note="Histone RNA hairpin-binding protein RNA-binding
                     domain; pfam15247"
                     /db_xref="CDD:464587"
     Site            171
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q14493; propagated from
                     UniProtKB/Swiss-Prot (P97440.1)"
     Site            182
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14493; propagated from
                     UniProtKB/Swiss-Prot (P97440.1)"
     Region          219..240
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P97440.1)"
     CDS             1..275
                     /gene="Slbp"
                     /coded_by="NM_009193.2:322..1149"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS19205.1"
                     /db_xref="GeneID:20492"
                     /db_xref="MGI:MGI:108402"
ORIGIN      
        1 macrprsppg ygsrrdggas prsparwslg rkrradgrdr kpedseegel qtadhrpesf
       61 ttpeghkprs rcsdwasave edemrtrvnk eiarykrkll indfgrerks ssgssdskes
      121 mssvpadvet desvlmrrqk qinygkntia ydryikevpr hlrqpgihpr tpnkfkkysr
      181 rswdqqiklw kvalhfwdpp aeegcdlqei qpvdlgemet eftesssesq tssqdnfdvy
      241 agtptkvrhv dcqvedefdl eaclteplkd fsams
//
