LOCUS       NM_001289724            1861 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus stem-loop binding protein (Slbp), transcript variant
            2, mRNA.
ACCESSION   NM_001289724
VERSION     NM_001289724.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1861)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1861)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1861)
  AUTHORS   Jin,Y., Yang,M., Gao,C., Yue,W., Liang,X., Xie,B., Zhu,X., Fan,S.,
            Li,R. and Li,M.
  TITLE     Fbxo30 regulates chromosome segregation of oocyte meiosis
  JOURNAL   Cell Mol Life Sci 76 (11), 2217-2229 (2019)
   PUBMED   30980108
  REMARK    GeneRIF: SLBP overexpression caused by Fbxo30 depletion results in
            a remarkable overload of histone H3 on chromosomes that excessively
            condenses chromosomes and inhibits chromosome segregation. The
            finding uncovers an unidentified pathway-controlling chromosome
            segregation and cell progress.
REFERENCE   4  (bases 1 to 1861)
  AUTHORS   Jang,C.W., Shibata,Y., Starmer,J., Yee,D. and Magnuson,T.
  TITLE     Histone H3.3 maintains genome integrity during mammalian
            development
  JOURNAL   Genes Dev 29 (13), 1377-1392 (2015)
   PUBMED   26159997
REFERENCE   5  (bases 1 to 1861)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 1861)
  AUTHORS   Allard,P., Yang,Q., Marzluff,W.F. and Clarke,H.J.
  TITLE     The stem-loop binding protein regulates translation of histone mRNA
            during mammalian oogenesis
  JOURNAL   Dev Biol 286 (1), 195-206 (2005)
   PUBMED   16125165
  REMARK    GeneRIF: histone synthesis in immature and maturing oocytes is
            governed by a translational control mechanism that is directly
            regulated by changes in the amount of SLBP
REFERENCE   7  (bases 1 to 1861)
  AUTHORS   Whitfield,M.L., Kaygun,H., Erkmann,J.A., Townley-Tilson,W.H.,
            Dominski,Z. and Marzluff,W.F.
  TITLE     SLBP is associated with histone mRNA on polyribosomes as a
            component of the histone mRNP
  JOURNAL   Nucleic Acids Res 32 (16), 4833-4842 (2004)
   PUBMED   15358832
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1861)
  AUTHORS   Black,D., Bird,M.A., Hayden,M., Schrum,L.W., Lange,P., Samson,C.,
            Hatano,E., Rippe,R.A., Brenner,D.A. and Behrns,K.E.
  TITLE     TNF alpha-induced hepatocyte apoptosis is associated with
            alterations of the cell cycle and decreased stem loop binding
            protein
  JOURNAL   Surgery 135 (6), 619-628 (2004)
   PUBMED   15179368
  REMARK    GeneRIF: Inhibition of NF kappa B in TNF alpha-treated primary
            mouse hepatocytes is associated with increased S-phase cell cycle
            retention and decreased stem loop binding protein.
REFERENCE   9  (bases 1 to 1861)
  AUTHORS   Allard,P., Champigny,M.J., Skoggard,S., Erkmann,J.A.,
            Whitfield,M.L., Marzluff,W.F. and Clarke,H.J.
  TITLE     Stem-loop binding protein accumulates during oocyte maturation and
            is not cell-cycle-regulated in the early mouse embryo
  JOURNAL   J Cell Sci 115 (Pt 23), 4577-4586 (2002)
   PUBMED   12415002
  REMARK    GeneRIF: SLBP expression and activity differ in mouse oocytes and
            early embryos compared with somatic cells.
REFERENCE   10 (bases 1 to 1861)
  AUTHORS   Wang,Z.F., Whitfield,M.L., Ingledue,T.C. 3rd, Dominski,Z. and
            Marzluff,W.F.
  TITLE     The protein that binds the 3' end of histone mRNA: a novel
            RNA-binding protein required for histone pre-mRNA processing
  JOURNAL   Genes Dev 10 (23), 3028-3040 (1996)
   PUBMED   8957003
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162898.10, AK162121.1, AC132233.4 and BE979466.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon, compared to variant 1. The encoded isoform (2) is shorter
            than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029631.1, SRR7345562.571882.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-255               AC162898.10        28661-28915         c
            256-602             AK162121.1         2-348
            603-614             AC132233.4         158769-158780       c
            615-1710            AK162121.1         421-1516
            1711-1861           BE979466.1         1-151               c
FEATURES             Location/Qualifiers
     source          1..1861
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.83 cM"
     gene            1..1861
                     /gene="Slbp"
                     /note="stem-loop binding protein"
                     /db_xref="GeneID:20492"
                     /db_xref="MGI:MGI:108402"
     exon            1..380
                     /gene="Slbp"
                     /inference="alignment:Splign:2.1.0"
     CDS             322..1089
                     /gene="Slbp"
                     /note="isoform 2 is encoded by transcript variant 2;
                     histone RNA hairpin-binding protein; histone
                     stem-loop-binding protein"
                     /codon_start=1
                     /product="histone RNA hairpin-binding protein isoform 2"
                     /protein_id="NP_001276653.1"
                     /db_xref="CCDS:CCDS80257.1"
                     /db_xref="GeneID:20492"
                     /db_xref="MGI:MGI:108402"
                     /translation="MACRPRSPPGYGSRRDGGASPRSPARWSLGRKRRADGRDRKPED
                     SEEGELQTADHRPESFTTPEGHKPRSRCSDWASAVEEDEMRTRVNKEIASSDSKESMS
                     SVPADVETDESVLMRRQKQINYGKNTIAYDRYIKEVPRHLRQPGIHPRTPNKFKKYSR
                     RSWDQQIKLWKVALHFWDPPAEEGCDLQEIQPVDLGEMETEFTESSSESQTSSQDNFD
                     VYAGTPTKVRHVDCQVEDEFDLEACLTEPLKDFSAMS"
     exon            381..497
                     /gene="Slbp"
                     /inference="alignment:Splign:2.1.0"
     exon            498..602
                     /gene="Slbp"
                     /inference="alignment:Splign:2.1.0"
     exon            603..740
                     /gene="Slbp"
                     /inference="alignment:Splign:2.1.0"
     exon            741..890
                     /gene="Slbp"
                     /inference="alignment:Splign:2.1.0"
     exon            891..972
                     /gene="Slbp"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1846
                     /gene="Slbp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1820..1825
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slbp"
                     /note="hexamer: AATAAA"
     polyA_site      1846
                     /gene="Slbp"
                     /note="major polyA site"
ORIGIN      
        1 agttcctttc cgccttagtc gggctgttcc atttctcccg cccttcggac ggccgcatta
       61 ggcgttgtag tttagcgact gcccgcaatc ccaaggcttg ggttggagcc gggtccgtca
      121 ggcgggcgcg cagagctgag agggactccc ctgcaggtgc gcgtctcatg gtttcgccct
      181 tcgccgcgcg cgcgcgggag ttaccgaggg gcggggccgc tgcgcactta agggcggttg
      241 ggcaaggcga gctcagacct cgtcagtgct gttgccgagt gaagtgcttg ccgccgagct
      301 gcccttcaga cttctgccgc catggcctgc agacctagaa gcccacccgg ttatgggagt
      361 cgccgcgacg gtggtgcgag cccgcggtcc cctgcgagat ggagtctcgg acggaagcgc
      421 agagcggacg gaagggaccg gaagcccgag gactccgagg aaggcgagct ccagactgcg
      481 gaccaccgac ctgaaagctt tacaactcct gaaggccata agccccgttc tagatgttct
      541 gactgggcca gtgcagttga agaagatgaa atgaggacca gagttaacaa agagattgca
      601 agttctgatt caaaggagtc tatgtcttca gtgcctgctg atgtggagac ggatgaaagt
      661 gtcttgatga gaaggcagaa gcagatcaac tacgggaaga acactattgc ctatgatcga
      721 tatattaaag aggtgcccag acacctgcga caacctggaa tccatcccag gacccccaac
      781 aaatttaaga agtacagccg gcggtcatgg gaccaacaaa ttaaactctg gaaggtggct
      841 ttgcattttt gggatcctcc tgctgaagaa ggatgtgatt tgcaagaaat acaacctgta
      901 gatcttgggg aaatggagac tgaattcaca gaaagcagct ctgagtctca gacaagttca
      961 caggataact ttgatgtgta tgctggcaca cccaccaaag tcagacacgt ggactgccaa
     1021 gtggaggatg agtttgattt ggaagcttgt ttaactgaac ctttgaaaga cttctctgcc
     1081 atgagttaac tgccacctgg tggttactca gagaaatacg tggctctgcc tggccacctg
     1141 gaaggcctga gttgctctgc atttgttttt gttgtctctg ttaagagttt attttctcat
     1201 gataaattgt ttttcttgcc ttatttttat gtatggtaaa tgtgttaggc atgttttaag
     1261 ttgtaaatga agctaaatgc agtggagact tagccctatt atatttttgc cccccaagtt
     1321 agacaacagg aaacttgagc cttcagttgc cacttttcag atgtgttggc agtggatttt
     1381 aaccatgtgt ctatgggacc aatttagaat cagttgcctt tcaggtaact gataaagaat
     1441 tctcagtcag gcagctgcaa tgactctgta aaaacttatt ttctggtctt ttatcaatgt
     1501 gaatgtagtt ttccctcata cagagctctg gacaaaggat gctaagctat tatattaatg
     1561 ggctgtatgt aagttatata gttttaattt ggaacttgaa atagcattag tgtgaggtaa
     1621 gtatcttagc acatgctcta tgagagttga ggcagaagag agggacttag aaagaacttt
     1681 gtttttttaa tgatcagtta atttaccatg taatattgct gtaaatgata atgtgtacag
     1741 ttactctgtt catgtatcca gttgtaaact tgtcaatatt tgcatttcta ttgcttttgt
     1801 atggaatgat aattgcaaaa ataaagaccc tttaactgac ttgtaaaaaa aaaaaaaaaa
     1861 a
//
