LOCUS       NM_029084               2040 bp    mRNA    linear   ROD 07-OCT-2024
DEFINITION  Mus musculus SLAM family member 8 (Slamf8), mRNA.
ACCESSION   NM_029084 XM_993718
VERSION     NM_029084.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2040)
  AUTHORS   Romero-Pinedo,S., Barros,D.I.R., Ruiz-Magana,M.J.,
            Maganto-Garcia,E., Moreno de Lara,L., Abadia-Molina,F., Terhorst,C.
            and Abadia-Molina,A.C.
  TITLE     SLAMF8 Downregulates Mouse Macrophage Microbicidal Mechanisms via
            PI3K Pathways
  JOURNAL   Front Immunol 13, 910112 (2022)
   PUBMED   35837407
  REMARK    GeneRIF: SLAMF8 Downregulates Mouse Macrophage Microbicidal
            Mechanisms via PI3K Pathways.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2040)
  AUTHORS   Qin,W., Rong,X., Yu,C., Jia,P., Yang,J. and Zhou,G.
  TITLE     Knockout of SLAMF8 attenuates collagen-induced rheumatoid arthritis
            in mice through inhibiting TLR4/NF-kappaB signaling pathway
  JOURNAL   Int Immunopharmacol 107, 108644 (2022)
   PUBMED   35259711
  REMARK    GeneRIF: Knockout of SLAMF8 attenuates collagen-induced rheumatoid
            arthritis in mice through inhibiting TLR4/NF-kappaB signaling
            pathway.
REFERENCE   3  (bases 1 to 2040)
  AUTHORS   Zeng,X., Liu,G., Peng,W., He,J., Cai,C., Xiong,W., Chen,S., Yang,M.
            and Dong,Z.
  TITLE     Combined deficiency of SLAMF8 and SLAMF9 prevents endotoxin-induced
            liver inflammation by downregulating TLR4 expression on macrophages
  JOURNAL   Cell Mol Immunol 17 (2), 153-162 (2020)
   PUBMED   30552382
  REMARK    GeneRIF: Combined deficiency of SLAMF8 and SLAMF9 prevents
            endotoxin-induced liver inflammation by downregulating TLR4
            expression on macrophages.
REFERENCE   4  (bases 1 to 2040)
  AUTHORS   Wang,G., van Driel,B.J., Liao,G., O'Keeffe,M.S., Halibozek,P.J.,
            Flipse,J., Yigit,B., Azcutia,V., Luscinskas,F.W., Wang,N. and
            Terhorst,C.
  TITLE     Migration of myeloid cells during inflammation is differentially
            regulated by the cell surface receptors Slamf1 and Slamf8
  JOURNAL   PLoS One 10 (3), e0121968 (2015)
   PUBMED   25799045
  REMARK    GeneRIF: Slamf1 and Slamf8 govern ROS-dependent innate immune
            responses of myeloid cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2040)
  AUTHORS   De Calisto,J., Wang,N., Wang,G., Yigit,B., Engel,P. and Terhorst,C.
  TITLE     SAP-Dependent and -Independent Regulation of Innate T Cell
            Development Involving SLAMF Receptors
  JOURNAL   Front Immunol 5, 186 (2014)
   PUBMED   24795728
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2040)
  AUTHORS   Wang,G., Abadia-Molina,A.C., Berger,S.B., Romero,X., O'Keeffe,M.S.,
            Rojas-Barros,D.I., Aleman,M., Liao,G., Maganto-Garcia,E.,
            Fresno,M., Wang,N., Detre,C. and Terhorst,C.
  TITLE     Cutting edge: Slamf8 is a negative regulator of Nox2 activity in
            macrophages
  JOURNAL   J Immunol 188 (12), 5829-5832 (2012)
   PUBMED   22593622
  REMARK    GeneRIF: Slamf8 was found to be a negative regulator of Nox2
            activity in bacterial phagosomes.
REFERENCE   7  (bases 1 to 2040)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   8  (bases 1 to 2040)
  AUTHORS   Kingsbury,G.A., Feeney,L.A., Nong,Y., Calandra,S.A., Murphy,C.J.,
            Corcoran,J.M., Wang,Y., Prabhu Das,M.R., Busfield,S.J., Fraser,C.C.
            and Villeval,J.L.
  TITLE     Cloning, expression, and function of BLAME, a novel member of the
            CD2 family
  JOURNAL   J Immunol 166 (9), 5675-5680 (2001)
   PUBMED   11313408
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK142633.1.
            
            [WARNING] On Oct 18, 2024 this sequence was replaced by
            NM_029084.4.
            
            On Apr 6, 2007 this sequence version replaced NM_029084.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142633.1, BC024587.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2040              AK142633.1         2-2041
FEATURES             Location/Qualifiers
     source          1..2040
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 79.99 cM"
     gene            1..2040
                     /gene="Slamf8"
                     /gene_synonym="5830408F06Rik; Blame; SBBI42"
                     /note="SLAM family member 8"
                     /db_xref="GeneID:74748"
                     /db_xref="MGI:MGI:1921998"
     exon            1..170
                     /gene="Slamf8"
                     /gene_synonym="5830408F06Rik; Blame; SBBI42"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..973
                     /gene="Slamf8"
                     /gene_synonym="5830408F06Rik; Blame; SBBI42"
                     /note="B lymphocyte activator macrophage expressed"
                     /codon_start=1
                     /product="SLAM family member 8 precursor"
                     /protein_id="NP_083360.2"
                     /db_xref="CCDS:CCDS15517.1"
                     /db_xref="GeneID:74748"
                     /db_xref="MGI:MGI:1921998"
                     /translation="MWSLWSLLLFEALLPVVVVSVQVLSKVGDSELLVAECPPGFQVR
                     EAIWRSLWPSEELLATFFRGSLETLYHSRFLGRVQLYDNLSLELGPLKPGDSGNFSVL
                     MVDTRGQTWTQTLYLKVYDAVPKPEVQVFTAAAEETQPLNTCQVFLSCWAPNISDITY
                     SWRREGTVDFNGEVHSHFSNGQVLSVSLGLGDKDVAFTCIASNPVSWDMTTVTPWESC
                     HHEAASGKASYKDVLLVVVPITLFLILAGLFGAWHHGLCSGKKKDACTDGVLPETENA
                     LV"
     exon            171..497
                     /gene="Slamf8"
                     /gene_synonym="5830408F06Rik; Blame; SBBI42"
                     /inference="alignment:Splign:2.1.0"
     exon            498..803
                     /gene="Slamf8"
                     /gene_synonym="5830408F06Rik; Blame; SBBI42"
                     /inference="alignment:Splign:2.1.0"
     exon            804..911
                     /gene="Slamf8"
                     /gene_synonym="5830408F06Rik; Blame; SBBI42"
                     /inference="alignment:Splign:2.1.0"
     exon            912..2040
                     /gene="Slamf8"
                     /gene_synonym="5830408F06Rik; Blame; SBBI42"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1636..1641
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slamf8"
                     /gene_synonym="5830408F06Rik; Blame; SBBI42"
                     /note="hexamer: AATAGA"
     polyA_site      1659
                     /gene="Slamf8"
                     /gene_synonym="5830408F06Rik; Blame; SBBI42"
                     /note="major polyA site"
ORIGIN      
        1 atcttgtttt gagtcaagat tcctccttct gaacatggga ctttccagca ggaccacagc
       61 tccttccgtg cactcgtctg gcctaggatg gatatcctag tttgctgagg gaatcttcca
      121 agggaggaca acggccatgt ggtccctctg gagtcttctt ctctttgaag ctctccttcc
      181 cgttgtggtt gtcagtgtcc aagtgctaag caaggtaggg gactcagagc tgctggtggc
      241 cgagtgtcct ccgggcttcc aagtgcgtga ggctatctgg cgatctctgt ggccatcgga
      301 ggagctcctg gccacatttt tccgaggttc cttggagact ctgtaccact ctcgtttcct
      361 gggccgagtc cagctatatg acaacctcag cctggagctt ggacccctga aacctggaga
      421 cagcggcaat ttctctgtgc tgatggtgga tacaaggggt caaacctgga cccagaccct
      481 gtatctcaag gtgtacgatg cagtacccaa gcccgaggtt caagtgttca ctgctgcagc
      541 agaggagacc caacccctca atacctgtca ggtcttcttg tcctgctggg cccccaacat
      601 cagtgacata acctacagct ggcgacggga ggggacagtg gacttcaatg gtgaagtgca
      661 cagccatttc tcaaatggac aggtgttaag tgtctcactg ggactggggg acaaggatgt
      721 ggcctttacc tgcattgcct ccaatcctgt cagctgggat atgaccacag tcaccccctg
      781 ggagagctgc catcacgagg cagcctccgg gaaggcctcc tacaaggacg tgctactggt
      841 agtagtgcca attacactgt tcctgatcct ggctggtctc tttggggcat ggcaccatgg
      901 cctctgctca gggaagaaga aggatgcttg cactgacggg gtgcttccag agacagagaa
      961 tgccctcgta tagaggatgt catgagggac aacataaact ggtgcttgga ccatgatgag
     1021 atgccctgct cagccacgtg atgctccaca cctggacacc tccaggatcc tcataactgc
     1081 cacaagtcgg cctgcctcta gcggacagcc aagaaaacca ccatcctgga acgtcaccct
     1141 ggcccaaact tcctccttcc tccatcctgt tcgcacatgc cggatcctct ctgggcaagg
     1201 tgaactagta ggatgcttcc ttcagaacac aggactttct ctaggatcca cagagacatt
     1261 gattatccaa ggcatccatt cttctatcac tgtacataag gtcttgccca acagccacca
     1321 agggacggcc tccaggccag gaccttggct caaagagaga tgagatgttt gaactaacat
     1381 ggaaattgag ctaaccattg ccaactccaa ctccagcccc tggggtctga gttccttgtg
     1441 ttcaagatgt tattataaga aaaggcaaag aacaggaaat gatggagggt ggggcattct
     1501 ctttctggtc tgaaggactt taagattatc tgagttcaag ggccatcaaa agtaaattga
     1561 gattacagat gatgaggggt tggtagctaa tgtgccatgt tgggatcaaa gccatttttc
     1621 tggtagcact atattaatag acacctttgt tgccattaat tcttgtgtct cctgcatatc
     1681 tggggtggtg tttcaagctt tttccataca ttctacatag ttgtcagaaa aaacaaaaac
     1741 aaagagtttg acccagccag taggaaattc ttccacaact tcaagagaaa cagctaagtt
     1801 cagaataagt ctgtcttcct aaaactggga gaatgaagag ccataaaaag ctacacaagg
     1861 gactggagag atggcttagc agttcagagc actgaccgct cctccagagg tcctgagttc
     1921 aactcccagc aaccacatgg tggctcacaa ccatctgtaa tgggattcaa tgccctcttc
     1981 tgatgtgact gaggacagct acagtgtact catatacaga aaataaataa accttttttt
//
