LOCUS       NM_144539               5284 bp    mRNA    linear   ROD 13-MAY-2024
DEFINITION  Mus musculus SLAM family member 7 (Slamf7), transcript variant 1,
            mRNA.
ACCESSION   NM_144539
VERSION     NM_144539.6
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5284)
  AUTHORS   Yuan,F., Wei,J., Cheng,Y., Wang,F., Gu,M., Li,Y., Zhao,X., Sun,H.,
            Ban,R., Zhou,J. and Xia,Z.
  TITLE     SLAMF7 Promotes Foam Cell Formation of Macrophage by Suppressing
            NR4A1 Expression During Carotid Atherosclerosis
  JOURNAL   Inflammation 47 (2), 530-542 (2024)
   PUBMED   37971565
  REMARK    GeneRIF: SLAMF7 Promotes Foam Cell Formation of Macrophage by
            Suppressing NR4A1 Expression During Carotid Atherosclerosis.
REFERENCE   2  (bases 1 to 5284)
  AUTHORS   Wu,Y., Wang,Q., Li,M., Lao,J., Tang,H., Ming,S., Wu,M., Gong,S.,
            Li,L., Liu,L. and Huang,X.
  TITLE     SLAMF7 regulates the inflammatory response in macrophages during
            polymicrobial sepsis
  JOURNAL   J Clin Invest 133 (6), e150224 (2023)
   PUBMED   36749634
  REMARK    GeneRIF: SLAMF7 regulates the inflammatory response in macrophages
            during polymicrobial sepsis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5284)
  AUTHORS   O'Connell,P., Blake,M.K., Godbehere,S., Amalfitano,A. and
            Aldhamen,Y.A.
  TITLE     SLAMF7 modulates B cells and adaptive immunity to regulate
            susceptibility to CNS autoimmunity
  JOURNAL   J Neuroinflammation 19 (1), 241 (2022)
   PUBMED   36199066
  REMARK    GeneRIF: SLAMF7 modulates B cells and adaptive immunity to regulate
            susceptibility to CNS autoimmunity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5284)
  AUTHORS   Tang,Z., Davidson,D., Li,R., Zhong,M.C., Qian,J., Chen,J. and
            Veillette,A.
  TITLE     Inflammatory macrophages exploit unconventional pro-phagocytic
            integrins for phagocytosis and anti-tumor immunity
  JOURNAL   Cell Rep 37 (11), 110111 (2021)
   PUBMED   34910922
REFERENCE   5  (bases 1 to 5284)
  AUTHORS   Loyal,L., Warth,S., Jurchott,K., Molder,F., Nikolaou,C., Babel,N.,
            Nienen,M., Durlanik,S., Stark,R., Kruse,B., Frentsch,M., Sabat,R.,
            Wolk,K. and Thiel,A.
  TITLE     SLAMF7 and IL-6R define distinct cytotoxic versus helper memory
            CD8+ T cells
  JOURNAL   Nat Commun 11 (1), 6357 (2020)
   PUBMED   33311473
  REMARK    GeneRIF: SLAMF7 and IL-6R define distinct cytotoxic versus helper
            memory CD8(+) T cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5284)
  AUTHORS   Dong,Z., Cruz-Munoz,M.E., Zhong,M.C., Chen,R., Latour,S. and
            Veillette,A.
  TITLE     Essential function for SAP family adaptors in the surveillance of
            hematopoietic cells by natural killer cells
  JOURNAL   Nat Immunol 10 (9), 973-980 (2009)
   PUBMED   19648922
REFERENCE   7  (bases 1 to 5284)
  AUTHORS   Cruz-Munoz,M.E., Dong,Z., Shi,X., Zhang,S. and Veillette,A.
  TITLE     Influence of CRACC, a SLAM family receptor coupled to the adaptor
            EAT-2, on natural killer cell function
  JOURNAL   Nat Immunol 10 (3), 297-305 (2009)
   PUBMED   19151721
  REMARK    GeneRIF: CRACC was a critical positive regulator of NK cell
            function mediated by EAT-2.
REFERENCE   8  (bases 1 to 5284)
  AUTHORS   Claus,M., Meinke,S., Bhat,R. and Watzl,C.
  TITLE     Regulation of NK cell activity by 2B4, NTB-A and CRACC
  JOURNAL   Front Biosci 13, 956-965 (2008)
   PUBMED   17981603
  REMARK    GeneRIF: 2B4, NTB-A and CRACC have roles in the regulation of
            Natural Killer cell function [review]
            Review article
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5284)
  AUTHORS   Wandstrat,A.E., Nguyen,C., Limaye,N., Chan,A.Y., Subramanian,S.,
            Tian,X.H., Yim,Y.S., Pertsemlidis,A., Garner,H.R. Jr., Morel,L. and
            Wakeland,E.K.
  TITLE     Association of extensive polymorphisms in the SLAM/CD2 gene cluster
            with murine lupus
  JOURNAL   Immunity 21 (6), 769-780 (2004)
   PUBMED   15589166
REFERENCE   10 (bases 1 to 5284)
  AUTHORS   Tovar,V., del Valle,J., Zapater,N., Martin,M., Romero,X.,
            Pizcueta,P., Bosch,J., Terhorst,C. and Engel,P.
  TITLE     Mouse novel Ly9: a new member of the expanding CD150 (SLAM) family
            of leukocyte cell-surface receptors
  JOURNAL   Immunogenetics 54 (6), 394-402 (2002)
   PUBMED   12242590
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091521.19 and AC083892.19.
            
            On Oct 19, 2022 this sequence version replaced NM_144539.5.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030148.1, AK030135.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849377 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-223               AC091521.19        37993-38215         c
            224-350             AC091521.19        34209-34335         c
            351-662             AC083892.19        6714-7025
            663-935             AC083892.19        8713-8985
            936-1058            AC083892.19        9196-9318
            1059-1162           AC083892.19        10581-10684
            1163-1225           AC083892.19        11607-11669
            1226-5284           AC083892.19        12985-17043
FEATURES             Location/Qualifiers
     source          1..5284
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 79.54 cM"
     gene            1..5284
                     /gene="Slamf7"
                     /gene_synonym="19A; 19A24; 4930560D03Rik; CRACC; CS1"
                     /note="SLAM family member 7"
                     /db_xref="GeneID:75345"
                     /db_xref="MGI:MGI:1922595"
     exon            1..223
                     /gene="Slamf7"
                     /gene_synonym="19A; 19A24; 4930560D03Rik; CRACC; CS1"
                     /inference="alignment:Splign:2.1.0"
     exon            224..350
                     /gene="Slamf7"
                     /gene_synonym="19A; 19A24; 4930560D03Rik; CRACC; CS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             296..1297
                     /gene="Slamf7"
                     /gene_synonym="19A; 19A24; 4930560D03Rik; CRACC; CS1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; leukocyte cell-surface antigen; novel Ly9"
                     /codon_start=1
                     /product="SLAM family member 7 isoform 1 precursor"
                     /protein_id="NP_653122.2"
                     /db_xref="CCDS:CCDS15500.1"
                     /db_xref="GeneID:75345"
                     /db_xref="MGI:MGI:1922595"
                     /translation="MARFSTYIIFTSVLCQLTVTAASGTLKKVAGALDGSVTFTLNIT
                     EIKVDYVVWTFNTFFLAMVKKDGVTSQSSNKERIVFPDGLYSMKLSQLKKNDSGAYRA
                     EIYSTSSQASLIQEYVLHVYKHLSRPKVTIDRQSNKNGTCVINLTCSTDQDGENVTYS
                     WKAVGQGDNQFHDGATLSIAWRSGEKDQALTCMARNPVSNSFSTPVFPQKLCEDAATD
                     LTSLRGILYILCFSAVLILFAVLLTIFHTMWIKKGKGCEEDKKRVDRHQEMPDLCPHL
                     EENADYDTIPYTEKRRPEEDAPNTFYSTVQIPKVVKSPSSLPAKPLVPRSLSFENVI"
     exon            351..662
                     /gene="Slamf7"
                     /gene_synonym="19A; 19A24; 4930560D03Rik; CRACC; CS1"
                     /inference="alignment:Splign:2.1.0"
     exon            663..935
                     /gene="Slamf7"
                     /gene_synonym="19A; 19A24; 4930560D03Rik; CRACC; CS1"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1058
                     /gene="Slamf7"
                     /gene_synonym="19A; 19A24; 4930560D03Rik; CRACC; CS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1162
                     /gene="Slamf7"
                     /gene_synonym="19A; 19A24; 4930560D03Rik; CRACC; CS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1225
                     /gene="Slamf7"
                     /gene_synonym="19A; 19A24; 4930560D03Rik; CRACC; CS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..5284
                     /gene="Slamf7"
                     /gene_synonym="19A; 19A24; 4930560D03Rik; CRACC; CS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3062..3067
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slamf7"
                     /gene_synonym="19A; 19A24; 4930560D03Rik; CRACC; CS1"
                     /note="hexamer: CATAAA"
     polyA_site      3084
                     /gene="Slamf7"
                     /gene_synonym="19A; 19A24; 4930560D03Rik; CRACC; CS1"
                     /note="major polyA site"
     regulatory      4707..4712
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slamf7"
                     /gene_synonym="19A; 19A24; 4930560D03Rik; CRACC; CS1"
                     /note="hexamer: AATAAA"
     polyA_site      4729
                     /gene="Slamf7"
                     /gene_synonym="19A; 19A24; 4930560D03Rik; CRACC; CS1"
     regulatory      5261..5266
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slamf7"
                     /gene_synonym="19A; 19A24; 4930560D03Rik; CRACC; CS1"
                     /note="hexamer: AATAAA"
     polyA_site      5284
                     /gene="Slamf7"
                     /gene_synonym="19A; 19A24; 4930560D03Rik; CRACC; CS1"
ORIGIN      
        1 actcctaccc atgatgaaat gttgaaggcc caagcctggc agagcttctg cagcaaacca
       61 tgaaatgtgt catgatggga agatgtcatt tcacagcaca cctccttgtc tcctagctcc
      121 tacattcttt ccaccccttc ttccacagtg tttcctgagc cctgatacag acgccttgct
      181 taaagctgag tactccatca ctgattctcc ggactttgac cagctgagga caagagagct
      241 aagactacca gagtgctttc tgttcatctt tactgactga cgacctgaaa acgctatggc
      301 tcgtttctca acgtacatca tctttacctc tgtcctctgt cagctaacag tcacagcagc
      361 ttctggaact ctgaagaagg tggccggtgc ccttgatgga tctgtgacat tcactctgaa
      421 tatcactgaa ataaaggttg actatgttgt atggacgttc aacacattct ttcttgccat
      481 ggtaaaaaaa gacggcgtta catcacaaag tagtaacaaa gaaaggatag tctttccaga
      541 tggactctac tccatgaagc tcagccaatt gaagaagaat gactctggag cctaccgtgc
      601 agagatttac agtacatcga gtcaggcttc cttaatccag gagtatgtgc tgcatgtcta
      661 caagcatttg tcaaggccca aggtcaccat agatcggcaa agcaacaaga atggcacctg
      721 cgtaatcaat ctgacatgtt ccacggatca ggacggggag aatgtaacct acagctggaa
      781 agctgtgggg cagggggaca atcagtttca tgatggtgcc accctctcca tcgcctggag
      841 atcaggagag aaagaccagg ccttaacatg catggccagg aatccagtca gcaacagttt
      901 ctcaaccccc gtctttcccc agaagctctg tgaagatgct gccacggatc taacttcact
      961 caggggcatc ctatacatcc tgtgcttctc agcagtgctc atcctatttg ctgtcttgct
     1021 gactattttt catactatgt ggataaagaa aggaaaagga tgtgaggaag acaagaagag
     1081 agtggacagg caccaggaaa tgcccgactt gtgccctcac ttagaggaga acgcagacta
     1141 tgacacaatc ccttacacgg aaaaaagaag accagaagaa gatgcaccaa acacatttta
     1201 ttccactgtg cagatcccca aagtggtaaa gagtcccagc tccctgcctg caaagccact
     1261 cgtgccaagg tcattaagct ttgaaaatgt tatctagatg acagcactcc gtcctctcca
     1321 gaaaaaaaca aaacaaaaca aaactgcaaa acaaacaaaa cctcaccatt ctgagcagaa
     1381 atgaaaactt ctgtcaaaga ctgaatgtaa atgtctcccc gccagaccca catgtttgca
     1441 tccagacaga gaagttcagg ctcaagggct ttcagggtac aatgactctt ggggactggg
     1501 atacagccca ttcagacatt ctgactaaga atctctctat gcccatcctg tctccggtaa
     1561 tgatgaatga ggctgtgctc atagacagtg gactaatttg tctgatgaag aaatttttga
     1621 caaagcacag catttggctg tggcacagcc atgttcgctg tttttattca catttatagc
     1681 tgtatgtaaa taatctcaat cattcagttc ccagataaaa gacacataac cttttatatt
     1741 tattataagc ctttatagac tagagctggg cagatatcta ccctctaagc tatttttgcc
     1801 tacttcccta tcaataaccc caagatataa tttgccatgt tccatctagg ctgctcttac
     1861 tccaattggc ccagccctta tggccatatt ttcatgattc cccaacacaa tggtgtcttc
     1921 tctctccacc gtctctcctc atgaacctcc tgcctcagat cccaagcctg ggaaccaaaa
     1981 cctcacctcc ctctcttctg ccctgctata ggctgccgac atctttattc acccagtagt
     2041 tttaaattaa ggagcaggga aacatggtat cactttgtgt aggtgaggat tctctagtcc
     2101 cagagggcaa ccagaccttg gggaccagtg acaagtatta caatacatag caacagacca
     2161 aacctcagca gaactcaaaa caaagaaaag gaacaggaag atgggaaaag catgcaggtt
     2221 gatagacagc atgaagggtt ttcaaatggg tttttcagct tcgactgtaa tggttaaagg
     2281 gatgagccca gactgtgccc taggacaaga gaaaggggac actgagagct aaaccctgtc
     2341 tttcaaaaac cctattcaaa aaagctttca tttaaaagaa agaatgcctg aacacagagt
     2401 gtcccacatc gcacatcaga ctgtggaagt gtttctctgg gttctcacgg ttctcagagg
     2461 ctgctggagc cctgacccaa gcaggtatgg ctccatcctg gagtgacagc agaactcagc
     2521 aatgtccaca cgtgcagaat gtaaactctg gggagccact gaagcttgca ctaaggttcc
     2581 aggggaggaa aaccaggcaa cgtgtatcga ggttgggctt tctgaatgga cctgccttgt
     2641 aagcctgcat aaaactatga aggcaaagcc taacttgcag tttagactcc aggatgctgg
     2701 agctgcctaa aacataaagg atgctggagc tgcccagaac ataaagcatc tactaagaaa
     2761 attttcaggc actgaaaaca cccgagaaag aggccacgtg tggttttggt tggaaggtca
     2821 tggaaacagg cctcctcaaa cccattggaa catacatgat gataccatgt acccaagatg
     2881 ccagatacgg agcttcaagg cttatacctc tctgctgagt tttctcctat ctttggctct
     2941 ttctttgcca cgccccatcc ctcccttttg gaatgtgaat gtttcctctg ccattgtgca
     3001 ttgaaagtat gtgagttttc tattttttaa gagctcacaa ctaggacttt gccttacatc
     3061 tcataaaaga cattggacat tgaactgtta tggctaggga ctcttgaagt tagatggaat
     3121 gtgttttgca ttgtgtgatg accgtaggca tattgagcca agacctgtga gccaagacgg
     3181 gagtgttatg gattgagtcg aaaagattca aggttgcggg cttgtgtggt tcaacacttg
     3241 gtgttattta agggtgctgt agaccctata gaagatagag tctgtctgca gacggtgagt
     3301 ctccaggagg caggcctaga aagtgacagt cactcctggc tctgggcaag ccttctgctc
     3361 cacctcaggc agaatcctgt ccaccatgtt atgaagaagc agacattgca aactccctcc
     3421 aacacaggcc aagcccctaa agccgccatg cctctgatga caatggatta taacctctag
     3481 aactcaaaat cgaaagcagg cccttcccct gtaagttgct cctgccagga ttttggcagt
     3541 gtggtagctg ataccacttc cttccagaat aagctattct cagcctcttt ggactctgag
     3601 gttcatcgtc caattgctga gaactctcct caaacccaga atctgtattc ctttctgcca
     3661 gtgtgactga atctgtcagt tagcccagag aaaatgactg ggagatgcct gaaattgctc
     3721 caaataagtc tattaattta ttaatggaac cagcagctat gagccaggtg ctgtgttaca
     3781 ctttcatgga ttgttgcaat acactcactc ttgcttgata tctcatgaac cactttatag
     3841 ggcgccacag aaatactaac tacggagtcc cagaagggta tgtaggtacc aatggccaaa
     3901 atgcacaagg acagaaaatc caaacataca cctatgtttg tctggtacca tttgaggtcc
     3961 tttaaagcag atgatggagg acaaggaccc ctcatctgga cttcaactat acctacatgc
     4021 tccaagggaa ccgtgtacgc cctgagccta cagaggagtc catctttaaa aatagagaaa
     4081 tagcctgcat acaaattttt gatctagtct aagacctagc atcacagata gagtctgggg
     4141 tttgatggct tgaaaacctt tacagttgtg tttgtttgtt tgtttgtttg ttcccaatga
     4201 gtctttattg agaacctcta ctaggttagt cttctaggta aaacagacat atatcctccc
     4261 ccaaaaaatc ttattttctt tttctagtgt catggaagag acatgggaac aggtagagta
     4321 agggtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgta
     4381 tttgatgtgc tcccagaaca agaactacat gtcttcatga gaatgctgaa agggaactaa
     4441 ggttccaggg ttgagggata tgaaatcaag gagacaaatc tatgtttaaa agagaagaag
     4501 ccaagatgct gtcttgagct gatgggaggg gaagtgaaag ctaaaaatag gatgtattcc
     4561 ccaacacgtg gcaactctgt cataaccaca aagagctgag ctaggctttg cccagagctg
     4621 cctaggcatc tgtccaaggc acagttgtga atgctactaa gcactgtgtg ctaattactg
     4681 tgtttattac tttactttta tgaataaata aaatattatt taaataaaat cagtacgtat
     4741 taaggaaggg ttccctgaaa ttctctcaaa ggtgagaggt aaggcgcaga gcagcatctg
     4801 aagagaacta tttacagtat ggccggaaga agccagggct tcacattggt ccaggtggtt
     4861 gtgagtttta tctgtagttt agtctgtagt tttatctcca tgacccacgt cctctgtatt
     4921 gatcatttta aaggcactgc agaattcgca tacagaaaac atgtgttgtg ttgctatttg
     4981 cagtagacac actctggaga ctgcctaaaa gtgaggtggg aaatgagggt tacgtgagcg
     5041 caggctttaa gagcacaggc tttaagaatg cagggcagag tgccagagag gcagctcagc
     5101 agttaaaagg actggctggt tttccaaagg actcaggctt aatccccagc actgaggagg
     5161 tggctcacaa ccatctgtaa ctccagttcc agggcatctg gtgccctcct ttggtttcca
     5221 tgggcaccag gcatgtacac ggtacataca tatacatacc aataaaatgt ctatacacat
     5281 aaaa
//
