LOCUS       NM_001347186            1570 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus SLAM family member 6 (Slamf6), transcript variant 2,
            mRNA.
ACCESSION   NM_001347186 XM_006496885
VERSION     NM_001347186.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1570)
  AUTHORS   Rietdijk,S., Keszei,M., Castro,W., Terhorst,C. and
            Abadia-Molina,A.C.
  TITLE     Characterization of Ly108-H1 Signaling Reveals Ly108-3 Expression
            and Additional Strain-Specific Differences in Lupus Prone Mice
  JOURNAL   Int J Mol Sci 24 (5), 5024 (2023)
   PUBMED   36902453
  REMARK    GeneRIF: Characterization of Ly108-H1 Signaling Reveals Ly108-3
            Expression and Additional Strain-Specific Differences in Lupus
            Prone Mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1570)
  AUTHORS   Hasim,M.S., Marotel,M., Hodgins,J.J., Vulpis,E., Makinson,O.J.,
            Asif,S., Shih,H.Y., Scheer,A.K., MacMillan,O., Alonso,F.G.,
            Burke,K.P., Cook,D.P., Li,R., Petrucci,M.T., Santoni,A.,
            Fallon,P.G., Sharpe,A.H., Sciume,G., Veillette,A., Zingoni,A.,
            Gray,D.A., McCurdy,A. and Ardolino,M.
  TITLE     When killers become thieves: Trogocytosed PD-1 inhibits NK cells in
            cancer
  JOURNAL   Sci Adv 8 (15), eabj3286 (2022)
   PUBMED   35417234
REFERENCE   3  (bases 1 to 1570)
  AUTHORS   Hajaj,E., Zisman,E., Tzaban,S., Merims,S., Cohen,J., Klein,S.,
            Frankenburg,S., Sade-Feldman,M., Tabach,Y., Yizhak,K., Navon,A.,
            Stepensky,P., Hacohen,N., Peretz,T., Veillette,A., Karni,R.,
            Eisenberg,G. and Lotem,M.
  TITLE     Alternative Splicing of the Inhibitory Immune Checkpoint Receptor
            SLAMF6 Generates a Dominant Positive Form, Boosting T-cell Effector
            Functions
  JOURNAL   Cancer Immunol Res 9 (6), 637-650 (2021)
   PUBMED   33762352
  REMARK    GeneRIF: Alternative Splicing of the Inhibitory Immune Checkpoint
            Receptor SLAMF6 Generates a Dominant Positive Form, Boosting T-cell
            Effector Functions.
REFERENCE   4  (bases 1 to 1570)
  AUTHORS   Dienz,O., DeVault,V.L., Musial,S.C., Mistri,S.K., Mei,L.,
            Baraev,A., Dragon,J.A., Krementsov,D., Veillette,A. and Boyson,J.E.
  TITLE     Critical Role for SLAM/SAP Signaling in the Thymic Developmental
            Programming of IL-17- and IFN-gamma-Producing gammadelta T Cells
  JOURNAL   J Immunol 204 (6), 1521-1534 (2020)
   PUBMED   32024701
  REMARK    GeneRIF: Critical Role for SLAM/SAP Signaling in the Thymic
            Developmental Programming of IL-17- and IFN-gamma-Producing
            gammadelta T Cells.
REFERENCE   5  (bases 1 to 1570)
  AUTHORS   Hajaj,E., Eisenberg,G., Klein,S., Frankenburg,S., Merims,S., Ben
            David,I., Eisenhaure,T., Henrickson,S.E., Villani,A.C., Hacohen,N.,
            Abudi,N., Abramovich,R., Cohen,J.E., Peretz,T., Veillette,A. and
            Lotem,M.
  TITLE     SLAMF6 deficiency augments tumor killing and skews toward an
            effector phenotype revealing it as a novel T cell checkpoint
  JOURNAL   Elife 9, e52539 (2020)
   PUBMED   32122464
  REMARK    GeneRIF: SLAMF6 deficiency augments tumor killing and skews toward
            an effector phenotype revealing it as a novel T cell checkpoint.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1570)
  AUTHORS   Norkina,O. and De Lisle,R.C.
  TITLE     Potential genetic modifiers of the cystic fibrosis intestinal
            inflammatory phenotype on mouse chromosomes 1, 9, and 10
  JOURNAL   BMC Genet 6, 29 (2005)
   PUBMED   15921521
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1570)
  AUTHORS   Howie,D., Laroux,F.S., Morra,M., Satoskar,A.R., Rosas,L.E.,
            Faubion,W.A., Julien,A., Rietdijk,S., Coyle,A.J., Fraser,C. and
            Terhorst,C.
  TITLE     Cutting edge: the SLAM family receptor Ly108 controls T cell and
            neutrophil functions
  JOURNAL   J Immunol 174 (10), 5931-5935 (2005)
   PUBMED   15879084
  REMARK    GeneRIF: Following targeted disruption of the LY108 gene, CD4+ T
            cell and innate responses are defective; a surprising role for
            Ly108 is revealed in the control of responses to bacteria by
            neutrophils, while macrophage functions are intact.
REFERENCE   8  (bases 1 to 1570)
  AUTHORS   Wandstrat,A.E., Nguyen,C., Limaye,N., Chan,A.Y., Subramanian,S.,
            Tian,X.H., Yim,Y.S., Pertsemlidis,A., Garner,H.R. Jr., Morel,L. and
            Wakeland,E.K.
  TITLE     Association of extensive polymorphisms in the SLAM/CD2 gene cluster
            with murine lupus
  JOURNAL   Immunity 21 (6), 769-780 (2004)
   PUBMED   15589166
REFERENCE   9  (bases 1 to 1570)
  AUTHORS   Fraser,C.C., Howie,D., Morra,M., Qiu,Y., Murphy,C., Shen,Q.,
            Gutierrez-Ramos,J.C., Coyle,A., Kingsbury,G.A. and Terhorst,C.
  TITLE     Identification and characterization of SF2000 and SF2001, two new
            members of the immune receptor SLAM/CD2 family
  JOURNAL   Immunogenetics 53 (10-11), 843-850 (2002)
   PUBMED   11862385
REFERENCE   10 (bases 1 to 1570)
  AUTHORS   Peck,S.R. and Ruley,H.E.
  TITLE     Ly108: a new member of the mouse CD2 family of cell surface
            proteins
  JOURNAL   Immunogenetics 52 (1-2), 63-72 (2000)
   PUBMED   11132158
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091523.23 and BC030031.1.
            
            On Nov 17, 2016 this sequence version replaced XM_006496885.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030031.1, AF248636.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                AC091523.23        159809-159902
            95-1570             BC030031.1         1-1476
FEATURES             Location/Qualifiers
     source          1..1570
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 79.54 cM"
     gene            1..1570
                     /gene="Slamf6"
                     /gene_synonym="KAL1; KAL1b; Ly108; NTB-A; NTBA; SF2000"
                     /note="SLAM family member 6"
                     /db_xref="GeneID:30925"
                     /db_xref="MGI:MGI:1353620"
     exon            1..331
                     /gene="Slamf6"
                     /gene_synonym="KAL1; KAL1b; Ly108; NTB-A; NTBA; SF2000"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..1302
                     /gene="Slamf6"
                     /gene_synonym="KAL1; KAL1b; Ly108; NTB-A; NTBA; SF2000"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; lymphocyte antigen 108"
                     /codon_start=1
                     /product="SLAM family member 6 isoform 2 precursor"
                     /protein_id="NP_001334115.1"
                     /db_xref="CCDS:CCDS83638.1"
                     /db_xref="GeneID:30925"
                     /db_xref="MGI:MGI:1353620"
                     /translation="MAVSRAPAPDSACQRMVWLFPLVFCLGSGSEVSQSSSDPQLMNG
                     VLGESAVLPLKLPAGKIANIIIWNYEWEASQVTALVINLSNPESPQIMNTDVKKRLNI
                     TQSYSLQISNLTMADTGSYTAQITTKDSEVITFKYILRVFERLGNLETTNYTLLLENG
                     TCQIHLACVLKNQSQTVSVEWQATGNISLGGPNVTIFWDPRNSGDQTYVCRAKNAVSN
                     LSVSVSTQSLCKGVLTNPPWNAVWFMTTISIISAVILIFVCWSIHVWKRRGSLPLTSQ
                     HPESSQSTDGPGSPGNTVYAQVTRPMQEMKIPKPIKNDSMTIYSIVNHSREETVALTG
                     YNQPITLKVNTLINYNS"
     exon            332..673
                     /gene="Slamf6"
                     /gene_synonym="KAL1; KAL1b; Ly108; NTB-A; NTBA; SF2000"
                     /inference="alignment:Splign:2.1.0"
     exon            674..937
                     /gene="Slamf6"
                     /gene_synonym="KAL1; KAL1b; Ly108; NTB-A; NTBA; SF2000"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1051
                     /gene="Slamf6"
                     /gene_synonym="KAL1; KAL1b; Ly108; NTB-A; NTBA; SF2000"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1081
                     /gene="Slamf6"
                     /gene_synonym="KAL1; KAL1b; Ly108; NTB-A; NTBA; SF2000"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1155
                     /gene="Slamf6"
                     /gene_synonym="KAL1; KAL1b; Ly108; NTB-A; NTBA; SF2000"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1227
                     /gene="Slamf6"
                     /gene_synonym="KAL1; KAL1b; Ly108; NTB-A; NTBA; SF2000"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1304
                     /gene="Slamf6"
                     /gene_synonym="KAL1; KAL1b; Ly108; NTB-A; NTBA; SF2000"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1570
                     /gene="Slamf6"
                     /gene_synonym="KAL1; KAL1b; Ly108; NTB-A; NTBA; SF2000"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1551..1556
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slamf6"
                     /gene_synonym="KAL1; KAL1b; Ly108; NTB-A; NTBA; SF2000"
                     /note="hexamer: AATAAA"
     polyA_site      1570
                     /gene="Slamf6"
                     /gene_synonym="KAL1; KAL1b; Ly108; NTB-A; NTBA; SF2000"
                     /note="major polyA site"
ORIGIN      
        1 aaatcataag tagaaggttt ttgtggctgg gttggtgtcc cagtccctcc accagaagtc
       61 ttgcctggtt acagaagatg gcccgttcaa gttccacgtt ccctactgct aagagtctta
      121 gcttacaaaa gatattcttg taagccaagt gtgaagttaa tcacgacaac caaaggtttg
      181 ctaacataga ggaagagctc tcatcaatag gggaacagaa agtctcagcg acaagcttat
      241 gaaagaatgg ctgtctcaag ggctccagca cccgactccg cctgtcagag gatggtctgg
      301 ctctttccac ttgtcttctg cctcggctca gggagtgaag tttcacagag cagctcagac
      361 ccccagctaa tgaatggcgt tctaggagag tctgcagttc ttcctctaaa gcttcctgca
      421 gggaagatag ccaatatcat catctggaat tatgaatggg aagcgtcaca agtcactgcc
      481 ctcgttatca acctaagtaa tcctgaaagt ccacaaatca tgaacactga tgtaaagaag
      541 agactgaaca tcacccagtc ctactccctg caaatcagca accttaccat ggcagacaca
      601 ggatcataca ctgcgcagat aaccacaaag gactctgaag tgatcacctt caaatatatt
      661 ctgagggtct ttgaacgact gggtaactta gaaactacca actatactct cctgctagag
      721 aatgggacct gccagataca cctggcctgt gttttgaaga atcaaagtca aactgtctca
      781 gttgagtggc aagccacagg aaacatctct ttaggaggac caaatgtcac tatcttttgg
      841 gacccgagga attctggtga ccagacttac gtctgcagag ccaagaatgc tgtcagcaat
      901 ttgtcagtct ctgtttcgac ccagagtctc tgcaaagggg ttctaactaa tccaccctgg
      961 aatgcagtat ggtttatgac tacaatttca ataatcagtg ctgtcatact catctttgtg
     1021 tgctggagca tacatgtttg gaagagaaga ggttctcttc ctttgactag ccaacatcca
     1081 gagtcctccc agagcacaga tggcccaggc tctccaggga acactgtgta tgcacaagtc
     1141 actcgtccaa tgcaggaaat gaaaatccca aaacctatca aaaatgactc catgacaatt
     1201 tactccatag ttaatcattc cagagaggaa acagtggctt taaccggcta taaccaaccc
     1261 attaccctga aggttaacac tttaatcaac tataactcct gaaggaagag cactgcagtg
     1321 acttgaggaa attaaacaat gctgtcacca cagctctggc ttagattaat gaagtcagca
     1381 tctctggaga ttgagcgctg ccatttgcat tgttcaaacg ctttctaggt ggtatggtga
     1441 gatgccagag ggctaagggc cattatagca gggtagtttg actaggaata cataagatag
     1501 aaagcctaga atcatatcat tgaaagggac aatggaccta agagaagtgg aataaaattg
     1561 tgtcacgctg
//
