LOCUS       NM_013730               2688 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus signaling lymphocytic activation molecule family
            member 1 (Slamf1), transcript variant 1, mRNA.
ACCESSION   NM_013730
VERSION     NM_013730.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2688)
  AUTHORS   Li,A., Zhang,Z., Ru,X., Yi,Y., Li,X., Qian,J., Wang,J., Yang,X. and
            Yao,Y.
  TITLE     Identification of SLAMF1 as an immune-related key gene associated
            with rheumatoid arthritis and verified in mice collagen-induced
            arthritis model
  JOURNAL   Front Immunol 13, 961129 (2022)
   PUBMED   36110846
  REMARK    GeneRIF: Identification of SLAMF1 as an immune-related key gene
            associated with rheumatoid arthritis and verified in mice
            collagen-induced arthritis model.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2688)
  AUTHORS   Kohn,E.M., Dos Santos Dias,L., Dobson,H.E., He,X., Wang,H.,
            Klein,B.S. and Wuthrich,M.
  TITLE     SLAMF1 Is Dispensable for Vaccine-Induced T Cell Development but
            Required for Resistance to Fungal Infection
  JOURNAL   J Immunol 208 (6), 1417-1423 (2022)
   PUBMED   35217584
  REMARK    GeneRIF: SLAMF1 Is Dispensable for Vaccine-Induced T Cell
            Development but Required for Resistance to Fungal Infection.
REFERENCE   3  (bases 1 to 2688)
  AUTHORS   Zhong,M.C., Lu,Y., Qian,J., Zhu,Y., Dong,L., Zahn,A., Di Noia,J.M.,
            Karo-Atar,D., King,I.L. and Veillette,A.
  TITLE     SLAM family receptors control pro-survival effectors in germinal
            center B cells to promote humoral immunity
  JOURNAL   J Exp Med 218 (3) (2021)
   PUBMED   33237304
REFERENCE   4  (bases 1 to 2688)
  AUTHORS   Poveda,C., Herreros-Cabello,A., Callejas-Hernandez,F.,
            Osuna-Perez,J., Maza,M.C., Chillon-Marinas,C., Calderon,J.,
            Stamatakis,K., Fresno,M. and Girones,N.
  TITLE     Interaction of Signaling Lymphocytic Activation Molecule Family 1
            (SLAMF1) receptor with Trypanosoma cruzi is strain-dependent and
            affects NADPH oxidase expression and activity
  JOURNAL   PLoS Negl Trop Dis 14 (9), e0008608 (2020)
   PUBMED   32925918
  REMARK    GeneRIF: Interaction of Signaling Lymphocytic Activation Molecule
            Family 1 (SLAMF1) receptor with Trypanosoma cruzi is
            strain-dependent and affects NADPH oxidase expression and activity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2688)
  AUTHORS   Dienz,O., DeVault,V.L., Musial,S.C., Mistri,S.K., Mei,L.,
            Baraev,A., Dragon,J.A., Krementsov,D., Veillette,A. and Boyson,J.E.
  TITLE     Critical Role for SLAM/SAP Signaling in the Thymic Developmental
            Programming of IL-17- and IFN-gamma-Producing gammadelta T Cells
  JOURNAL   J Immunol 204 (6), 1521-1534 (2020)
   PUBMED   32024701
  REMARK    GeneRIF: Critical Role for SLAM/SAP Signaling in the Thymic
            Developmental Programming of IL-17- and IFN-gamma-Producing
            gammadelta T Cells.
REFERENCE   6  (bases 1 to 2688)
  AUTHORS   Wu,C., Sayos,J., Wang,N., Howie,D., Coyle,A. and Terhorst,C.
  TITLE     Genomic organization and characterization of mouse SAP, the gene
            that is altered in X-linked lymphoproliferative disease
  JOURNAL   Immunogenetics 51 (10), 805-815 (2000)
   PUBMED   10970095
REFERENCE   7  (bases 1 to 2688)
  AUTHORS   Castro,A.G., Hauser,T.M., Cocks,B.G., Abrams,J., Zurawski,S.,
            Churakova,T., Zonin,F., Robinson,D., Tangye,S.G., Aversa,G.,
            Nichols,K.E., de Vries,J.E., Lanier,L.L. and O'Garra,A.
  TITLE     Molecular and functional characterization of mouse signaling
            lymphocytic activation molecule (SLAM): differential expression and
            responsiveness in Th1 and Th2 cells
  JOURNAL   J Immunol 163 (11), 5860-5870 (1999)
   PUBMED   10570270
REFERENCE   8  (bases 1 to 2688)
  AUTHORS   Eddleston,J., Murdoch,J.N., Copp,A.J. and Stanier,P.
  TITLE     Physical and transcriptional map of a 3-Mb region of mouse
            chromosome 1 containing the gene for the neural tube defect mutant
            loop-tail (Lp)
  JOURNAL   Genomics 56 (2), 149-159 (1999)
   PUBMED   10051400
REFERENCE   9  (bases 1 to 2688)
  AUTHORS   Sayos,J., Wu,C., Morra,M., Wang,N., Zhang,X., Allen,D., van
            Schaik,S., Notarangelo,L., Geha,R., Roncarolo,M.G., Oettgen,H., De
            Vries,J.E., Aversa,G. and Terhorst,C.
  TITLE     The X-linked lymphoproliferative-disease gene product SAP regulates
            signals induced through the co-receptor SLAM
  JOURNAL   Nature 395 (6701), 462-469 (1998)
   PUBMED   9774102
REFERENCE   10 (bases 1 to 2688)
  AUTHORS   Aversa,G., Chang,C.C., Carballido,J.M., Cocks,B.G. and de
            Vries,J.E.
  TITLE     Engagement of the signaling lymphocytic activation molecule (SLAM)
            on activated T cells results in IL-2-independent, cyclosporin
            A-sensitive T cell proliferation and IFN-gamma production
  JOURNAL   J Immunol 158 (9), 4036-4044 (1997)
   PUBMED   9126961
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091521.19.
            
            On Apr 9, 2007 this sequence version replaced NM_013730.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156445.1, AK020012.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               AC091521.19        152468-152638
            172-513             AC091521.19        160119-160460
            514-810             AC091521.19        162418-162714
            811-906             AC091521.19        173276-173371
            907-980             AC091521.19        177631-177704
            981-1076            AC091521.19        183479-183574
            1077-2688           AC091521.19        184909-186520
FEATURES             Location/Qualifiers
     source          1..2688
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 79.54 cM"
     gene            1..2688
                     /gene="Slamf1"
                     /gene_synonym="4933415F16; CD150; CDw150; ESTM51; IPO-3;
                     Slam"
                     /note="signaling lymphocytic activation molecule family
                     member 1"
                     /db_xref="GeneID:27218"
                     /db_xref="MGI:MGI:1351314"
     exon            1..171
                     /gene="Slamf1"
                     /gene_synonym="4933415F16; CD150; CDw150; ESTM51; IPO-3;
                     Slam"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1127
                     /gene="Slamf1"
                     /gene_synonym="4933415F16; CD150; CDw150; ESTM51; IPO-3;
                     Slam"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; signaling lymphocyte activation molecule; SLAM
                     family member 1"
                     /codon_start=1
                     /product="signaling lymphocytic activation molecule
                     isoform 1 precursor"
                     /protein_id="NP_038758.2"
                     /db_xref="CCDS:CCDS15502.1"
                     /db_xref="GeneID:27218"
                     /db_xref="MGI:MGI:1351314"
                     /translation="MDPKGSLSWRILLFLSLAFELSYGTGGGVMDCPVILQKLGQDTW
                     LPLTNEHQINKSVNKSVRILVTMATSPGSKSNKKIVSFDLSKGSYPDHLEDGYHFQSK
                     NLSLKILGNRRESEGWYLVSVEENVSVQQFCKQLKLYEQVSPPEIKVLNKTQENENGT
                     CSLLLACTVKKGDHVTYSWSDEAGTHLLSRANRSHLLHITLSNQHQDSIYNCTASNPV
                     SSISRTFNLSSQACKQESSSESSPWMQYTLVPLGVVIIFILVFTAIIMMKRQGKSNHC
                     QPPVEEKSLTIYAQVQKSGPQEKKLHDALTDQDPCTTIYVAATEPAPESVQEPNPTTV
                     YASVTLPES"
     exon            172..513
                     /gene="Slamf1"
                     /gene_synonym="4933415F16; CD150; CDw150; ESTM51; IPO-3;
                     Slam"
                     /inference="alignment:Splign:2.1.0"
     exon            514..810
                     /gene="Slamf1"
                     /gene_synonym="4933415F16; CD150; CDw150; ESTM51; IPO-3;
                     Slam"
                     /inference="alignment:Splign:2.1.0"
     exon            811..906
                     /gene="Slamf1"
                     /gene_synonym="4933415F16; CD150; CDw150; ESTM51; IPO-3;
                     Slam"
                     /inference="alignment:Splign:2.1.0"
     exon            907..980
                     /gene="Slamf1"
                     /gene_synonym="4933415F16; CD150; CDw150; ESTM51; IPO-3;
                     Slam"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1076
                     /gene="Slamf1"
                     /gene_synonym="4933415F16; CD150; CDw150; ESTM51; IPO-3;
                     Slam"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..2688
                     /gene="Slamf1"
                     /gene_synonym="4933415F16; CD150; CDw150; ESTM51; IPO-3;
                     Slam"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2067..2072
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slamf1"
                     /gene_synonym="4933415F16; CD150; CDw150; ESTM51; IPO-3;
                     Slam"
                     /note="hexamer: ATTAAA"
     polyA_site      2096
                     /gene="Slamf1"
                     /gene_synonym="4933415F16; CD150; CDw150; ESTM51; IPO-3;
                     Slam"
                     /note="major polyA site"
     regulatory      2142..2147
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slamf1"
                     /gene_synonym="4933415F16; CD150; CDw150; ESTM51; IPO-3;
                     Slam"
                     /note="hexamer: TATAAA"
     polyA_site      2162
                     /gene="Slamf1"
                     /gene_synonym="4933415F16; CD150; CDw150; ESTM51; IPO-3;
                     Slam"
     regulatory      2663..2668
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slamf1"
                     /gene_synonym="4933415F16; CD150; CDw150; ESTM51; IPO-3;
                     Slam"
                     /note="hexamer: ATTATA"
     polyA_site      2683
                     /gene="Slamf1"
                     /gene_synonym="4933415F16; CD150; CDw150; ESTM51; IPO-3;
                     Slam"
                     /note="major polyA site"
ORIGIN      
        1 gagcttcttc cttgggggta acagtaagca gctgtcctgc cgagctgagc tgagctgagc
       61 tcacagctgg ggaccctgtc tgcgattgct ggctaatgga tcccaaagga tccctttcct
      121 ggagaatact tctgtttctc tccctggctt ttgagttgag ctacggaaca ggtggaggtg
      181 tgatggattg cccagtgatt ctccagaagc tgggacagga cacgtggctg cccctgacga
      241 atgaacatca gataaataag agcgtgaaca aaagtgtccg catcctcgtc accatggcga
      301 cgtccccagg aagcaaatcc aacaagaaaa ttgtgtcttt tgatctctct aaagggagct
      361 atccagatca cctggaggat ggctaccact ttcaatcaaa aaacctgagc ctgaagatcc
      421 tcgggaacag gcgggagagt gaaggatggt acttggtgag cgtggaggag aacgtttctg
      481 ttcagcaatt ctgcaagcag ctgaagcttt atgaacaggt ctcccctcca gagattaaag
      541 tgctaaacaa aacccaggag aacgagaatg ggacctgcag cttgctgttg gcctgcacag
      601 tgaagaaagg ggaccatgtg acttacagct ggagtgatga ggcaggcacc cacctgctga
      661 gccgagccaa ccgctcccac ctcctgcaca tcactcttag caaccagcat caagacagca
      721 tctacaactg caccgcaagc aaccctgtca gcagtatctc taggaccttc aacctatcat
      781 cgcaagcatg caagcaggaa tcctcctcag aatcgagtcc atggatgcaa tatactcttg
      841 taccactggg ggtcgttata atcttcatcc tggttttcac ggcaataata atgatgaaaa
      901 gacaaggtaa atcaaatcac tgccagccac cagtggaaga aaaaagcctt actatttatg
      961 cccaagtaca gaaatcaggg cctcaagaga agaaacttca tgatgcccta acagatcagg
     1021 acccctgcac aaccatttat gtggctgcca cagagcctgc cccagagtct gtccaggaac
     1081 caaaccccac cacagtttat gccagtgtga cactgccaga gagctgaccc atatacccag
     1141 tgaaaggact ttttgaagga ggatagaaga accaaaatcc acactgaact ggaccccggg
     1201 tcccaagttc tctgtgacag aaactgcaca tctgtaacct tctccaatca gttccctggt
     1261 gacggatctg cacaggcgtg cttatgaagt agatgagaag tgaggcttcc tgggcatgca
     1321 acctgctctg ctgctgacac agatatgaag cagagatccc gtggtacagt gtaccatctt
     1381 tgctgtagca gataatgtgg gtttaggcat ctcactcttt gctggactgg ataacagaac
     1441 tcaaaaaaaa accaacaagc caaagacata gactccatct cagatggctg agcacaaagt
     1501 ataaaagcca ttttggctct ctggacttta ttctggaagc tgatcctgat cacctcaagg
     1561 ccaagggctc catgcctcag tttctctctc accctctaga tgaagaggga acaaagcata
     1621 aagagtgaaa tccttgttgt ctgagatcat tctataaacg aactgacatt ttatttgcaa
     1681 aactcaagct agtaattcag tagacttgaa gatgatttta gagcctctta tgcttcaaac
     1741 aacagaatga aatccatcca atgttcttca aagtgtggtt ctctgattaa gtcaaagcaa
     1801 cactgtttgg caatgctgct gtaaagttgc ctggaatact cagaggaact tgtcccaggg
     1861 aggttttttt cacttcttca aagaactttt gaatttaagt tctctgttta ttcccttgag
     1921 caaaactctg gaacctcaag agtctctctc cgttggttct gaggccattt tatagcctag
     1981 gcctcctgtg gatctacatg tgtatcaccc acttcctatc tcactgcata cctctgtgta
     2041 gtagtaaatt taacctcaag tagaaaatta aattattttg gatgatcagt tccaaatgat
     2101 tagatgttta gtctcttata ataggatgta ggtagagtct atataaagtc ctatattctt
     2161 cacgttgtct gtcctcagag agaccatctt tcaacctatc ttccttcttg cacaactttg
     2221 gcaaatactt taaaaataac cattgtggag atggggagag gtctaaatgg ataatagtac
     2281 ttgctttgca aacatgaaga tctgggttca aactcccagt gtccatgtaa aaagataagt
     2341 gtggttgagt gtgccagtaa catagacaca gataggtcct gagactttgc tccctagcct
     2401 tcccagccag gcataaatgt caagtcccct gagagtgaca gaggaagata ctccccccac
     2461 acacacacac atacacgcac agtgatacac atatacatgc atacaaaaaa aaaacttatt
     2521 gtaacaaaga acaccaactg cctggctcaa aactctcatg tcccattact ctgtaccttt
     2581 ctgtatttag ataatttaca gtgtgagttc tgctgttcca tgtatcctat ttgtgttact
     2641 aacttatgtc aaagtatttc taattataat caacaaaagc taactttg
//
