LOCUS       NM_001113423            4787 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus SLAIN motif family, member 2 (Slain2), transcript
            variant 2, mRNA.
ACCESSION   NM_001113423
VERSION     NM_001113423.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4787)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4787)
  AUTHORS   Pan,X., Zhao,Z., Huang,X. and Cen,X.
  TITLE     Circ-Slain2 Alleviates Cartilage Degradation and Inflammation of
            TMJOA
  JOURNAL   J Dent Res 102 (13), 1498-1506 (2023)
   PUBMED   37817544
  REMARK    GeneRIF: Circ-Slain2 Alleviates Cartilage Degradation and
            Inflammation of TMJOA.
REFERENCE   3  (bases 1 to 4787)
  AUTHORS   Liu,T., Liu,Y., Peng,M., Liu,Q. and Si,G.
  TITLE     Slain2 attenuates brain injury following subarachnoid hemorrhage by
            controlling axonal microtubule structure in mice
  JOURNAL   Neurosci Lett 816, 137495 (2023)
   PUBMED   37741612
  REMARK    GeneRIF: Slain2 attenuates brain injury following subarachnoid
            hemorrhage by controlling axonal microtubule structure in mice.
REFERENCE   4  (bases 1 to 4787)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4787)
  AUTHORS   Hooper,J.E., Jones,K.L., Smith,F.J., Williams,T. and Li,H.
  TITLE     An Alternative Splicing Program for Mouse Craniofacial Development
  JOURNAL   Front Physiol 11, 1099 (2020)
   PUBMED   33013468
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4787)
  AUTHORS   van der Vaart,B., Franker,M.A., Kuijpers,M., Hua,S., Bouchet,B.P.,
            Jiang,K., Grigoriev,I., Hoogenraad,C.C. and Akhmanova,A.
  TITLE     Microtubule plus-end tracking proteins SLAIN1/2 and ch-TOG promote
            axonal development
  JOURNAL   J Neurosci 32 (42), 14722-14728 (2012)
   PUBMED   23077057
  REMARK    GeneRIF: SLAIN2 is expressed throughout development and is highly
            enriched in brain.
REFERENCE   7  (bases 1 to 4787)
  AUTHORS   van der Vaart,B., Manatschal,C., Grigoriev,I., Olieric,V.,
            Gouveia,S.M., Bjelic,S., Demmers,J., Vorobjev,I., Hoogenraad,C.C.,
            Steinmetz,M.O. and Akhmanova,A.
  TITLE     SLAIN2 links microtubule plus end-tracking proteins and controls
            microtubule growth in interphase
  JOURNAL   J Cell Biol 193 (6), 1083-1099 (2011)
   PUBMED   21646404
  REMARK    GeneRIF: Results identify SLAIN2 as a key component of microtubule
            plus end interaction networks.
REFERENCE   8  (bases 1 to 4787)
  AUTHORS   Trivieri,M.G., Oudit,G.Y., Sah,R., Kerfant,B.G., Sun,H.,
            Gramolini,A.O., Pan,Y., Wickenden,A.D., Croteau,W., Morreale de
            Escobar,G., Pekhletski,R., St Germain,D., Maclennan,D.H. and
            Backx,P.H.
  TITLE     Cardiac-specific elevations in thyroid hormone enhance
            contractility and prevent pressure overload-induced cardiac
            dysfunction
  JOURNAL   Proc Natl Acad Sci U S A 103 (15), 6043-6048 (2006)
   PUBMED   16595628
REFERENCE   9  (bases 1 to 4787)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (bases 1 to 4787)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB618957.1, BY736933.1, BC076573.1, AK029260.1 and BY423831.1.
            
            On Nov 16, 2013 this sequence version replaced NM_001113423.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 3' coding region, compared to variant1. It encodes
            isoform b, which lacks an internal segment and is shorter, compared
            to isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146432.1, SRR1660811.58442.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 BB618957.1         2-8
            8-67                BY736933.1         3-62
            68-4351             BC076573.1         1-4284
            4352-4774           AK029260.1         1689-2111
            4775-4787           BY423831.1         379-391
FEATURES             Location/Qualifiers
     source          1..4787
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 38.44 cM"
     gene            1..4787
                     /gene="Slain2"
                     /gene_synonym="5033405K12Rik; 8030444K12Rik"
                     /note="SLAIN motif family, member 2"
                     /db_xref="GeneID:75991"
                     /db_xref="MGI:MGI:1923241"
     exon            1..652
                     /gene="Slain2"
                     /gene_synonym="5033405K12Rik; 8030444K12Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..2009
                     /gene="Slain2"
                     /gene_synonym="5033405K12Rik; 8030444K12Rik"
                     /note="isoform b is encoded by transcript variant 2; SLAIN
                     motif-containing protein 2"
                     /codon_start=1
                     /product="SLAIN motif-containing protein 2 isoform b"
                     /protein_id="NP_001106894.1"
                     /db_xref="CCDS:CCDS51517.1"
                     /db_xref="GeneID:75991"
                     /db_xref="MGI:MGI:1923241"
                     /translation="MEDVNSNVNADQEVRKLQELVKKLEKQNEQLRSRSGAVQGAGLL
                     GPGSPARVGVSTPSSGAASPRGFPLGLGAKASGGAGSGPRRTSSEDLRDATSLLAAGE
                     GGLLDEVEPLRPDELERLSGWEEEEESWLYSSPKKKLTPMQKSVSPLVWCRQVLDYPS
                     PDVECAKKSLIHKLDQTMSALKRQNLYNNPFNSVSYSNSYSPNASSPYSSGFNSPSST
                     PVRPPIVKQLILPGNSGNFKSSSDRNPPLSPQSSIDSELSASELDEDSIGSNYKLNDV
                     TDVQILARMQEESLRQEYAASTSRRSSGSSCNSTRRGTFSDQELDAQSLDDEDDSLQH
                     AVHPALNRFSPSPRNSPRPSPKQSPRNSPRSRSPARGIEYSRASPQPMISRLQQPRLS
                     LQGHPTDLQTSNVKNEEKLRRSLPNLSRTSSTQVDSVKSSRSDSNFQVPNGGIPRMQP
                     QASAIPSPGKFRSPAAPSPLALRQPVKAFSNHGSGSGSQETTQFTQTTSSPGPPVVQN
                     SAPANPSSNINSATLTRPAGTTAMRSGLPRPSAPSAGGIPVPRSKLVQPVRRSLPAPK
                     SYGSMKDDSWKDGCY"
     exon            653..801
                     /gene="Slain2"
                     /gene_synonym="5033405K12Rik; 8030444K12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            802..966
                     /gene="Slain2"
                     /gene_synonym="5033405K12Rik; 8030444K12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1128
                     /gene="Slain2"
                     /gene_synonym="5033405K12Rik; 8030444K12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1488
                     /gene="Slain2"
                     /gene_synonym="5033405K12Rik; 8030444K12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1626
                     /gene="Slain2"
                     /gene_synonym="5033405K12Rik; 8030444K12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1942
                     /gene="Slain2"
                     /gene_synonym="5033405K12Rik; 8030444K12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..4787
                     /gene="Slain2"
                     /gene_synonym="5033405K12Rik; 8030444K12Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2409..2414
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slain2"
                     /gene_synonym="5033405K12Rik; 8030444K12Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2435
                     /gene="Slain2"
                     /gene_synonym="5033405K12Rik; 8030444K12Rik"
                     /note="major polyA site"
     regulatory      4332..4337
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slain2"
                     /gene_synonym="5033405K12Rik; 8030444K12Rik"
                     /note="hexamer: TATAAA"
     polyA_site      4351
                     /gene="Slain2"
                     /gene_synonym="5033405K12Rik; 8030444K12Rik"
                     /note="major polyA site"
     regulatory      4738..4743
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slain2"
                     /gene_synonym="5033405K12Rik; 8030444K12Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4775
                     /gene="Slain2"
                     /gene_synonym="5033405K12Rik; 8030444K12Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggcggaggga cggagggaag atggctgccg aggccggata ttggcgccgc ctcccccagt
       61 cgcggagccg gcgcagatga ggcggttcgg ctggggccag cggcgcttcg caacccgagc
      121 cggggagacc ctggcggtgg ggcctggccc tgctctatgc cggcgcctcg gctagcgtga
      181 gcggtggcgg taacgcctct ctttcccccc gaccccgcgc ttcccctgcg gcttggggag
      241 tcggagcggg cggcgcggcc ggcatggagg acgttaactc caatgtgaac gcggaccagg
      301 aggtgcggaa gctgcaggag ctggtgaaga agctggagaa gcagaacgag cagctgagga
      361 gccgctcggg agccgtgcag ggtgcaggcc tcctcgggcc cggcagccca gctcgggtcg
      421 gcgtgtccac cccttcgtcg ggcgcggcgt cccctcgggg cttcccgctg ggcctgggcg
      481 ccaaggccag cggcggggcg ggctccggcc cgcgacggac cagcagcgag gacctgcggg
      541 acgccacctc cttgctggcg gccggcgagg gaggcttgct ggacgaggta gagccgctgc
      601 ggcccgacga gctggagcgc ttgtcaggct gggaggagga agaggagagc tggttgtact
      661 catcaccaaa gaaaaaactc acaccaatgc agaaatctgt cagtccatta gtttggtgca
      721 ggcaagtttt ggattaccca agtcctgatg tggagtgtgc taaaaagtcc cttatccaca
      781 aacttgatca aactatgtca gctctcaaga ggcaaaattt atacaataat cctttcaact
      841 ctgtgagtta ctcaaattct tatagtccaa atgccagtag cccatacagc agtggcttca
      901 actctccatc ctcaacacca gtgcgacctc ccatagtcaa gcagcttata cttcctggaa
      961 attcaggtaa cttcaaaagt tcatcagata gaaaccctcc actcagccct cagtcctcta
     1021 tagatagtga gttaagtgct tcagaattag atgaagattc aattggatcc aactataagc
     1081 taaatgatgt aactgatgtg cagattctag cgcggatgca ggaagaaagt ctccggcaag
     1141 aatatgcagc cagcacctct cgccgcagct ctggttcatc ttgcaattct acgaggcggg
     1201 gcacttttag tgatcaggag ctggacgccc agagcttgga tgatgaagat gacagtctgc
     1261 agcatgcagt acaccctgcc cttaataggt tttctccatc cccacggaat tcaccacgac
     1321 catctcctaa gcagtcgcct cgaaattcac ctcgttcacg gtctcctgcc cggggaatag
     1381 aatacagtag agcgtcccca cagcctatga ttagccgctt gcagcagcct cgcctttccc
     1441 tccaaggcca tcccacagat ttacagacga gcaatgttaa aaatgaagaa aaacttagac
     1501 gcagtcttcc aaacctatcc cgaacatcga gcacacaggt tgactctgtg aaaagcagta
     1561 gaagtgactc caattttcaa gtgccaaatg gaggaatacc tcgaatgcag cctcaggctt
     1621 cagccatacc ttctccaggc aaattccgct cccctgcagc accgtctcca ttggctcttc
     1681 ggcaaccagt gaaagcgttt agtaaccatg gctctggttc tggtagccaa gaaactaccc
     1741 agttcacaca aaccacctcc tcacctgggc ctcctgtggt gcagaactca gccccagcaa
     1801 acccttccag caatatcaac agtgccactc taaccagacc tgcagggaca actgcaatga
     1861 ggagtggcct gccccggcca agcgcccctt ctgcgggggg catcccagtg cctcgcagca
     1921 agcttgtaca gcctgttcga agatcattgc cagctcctaa aagttatggt agcatgaaag
     1981 atgacagttg gaaagacggc tgttactgac cagcagagat gaggacacag atgtccacag
     2041 cttcatggac accgtcacca aactgaaacc aacttttata tgcagactct tcagatgaga
     2101 ctcttggggt ttgcaaactc ccagcctctc tgtcttaata gcacaactga cggagacgag
     2161 gaagcagcac tttaaagcca cgtgacatca gatgtatttg gtaatcatgc agtcactctc
     2221 catgggctcc ttagcttgtt cactagaaac acggttcatt ttattatttg acagaggcca
     2281 atatctgggc aaatacctac tggatgccaa agagaaatgc ccatttgtaa agagagtaca
     2341 tgggaagatg gtgaacctag gctatccaaa acctcacgtt caacctactt tactgtacaa
     2401 atagtatcaa taaatattgt gttaacaaga actaatattc tgactaatta aattgtttta
     2461 ttagtccttc aggatacagt aaattataaa gattgggaga gaggaaagaa gggcctgagc
     2521 taaagacttc aaacatgctt ctacctatgt ttagggaagt tttatacagt acttttgcag
     2581 gctcattggg aaaactatct tatgttttaa acatagctca cacgtagcca tgtccaactg
     2641 gtgtcacagg gcacgcccac accttgcatc aacatcacag acttgtgtgt acttgttttt
     2701 gattgccaga agggctcact gtcagttaca gtctttctaa ctgtctagtt cctggctcag
     2761 gaaagacggc ctttgctgtt gaagccacct tactcacatg ctgtttctgt cacacaacta
     2821 aaagatctcg tttccattcc caggtttcta tgatatgatg tgtctttgtt cttgacaaaa
     2881 taacacctca gcacttacaa cctggaataa aaccatgtca caggaggagg ggaaatctat
     2941 gcactgaact ataaaatctc tggtgatgac agttgtattg ttgctcgtga tcggcagaat
     3001 gctctattat gtgggagtcg atccacttta aactgaatta ctgtatgaag tatcttttta
     3061 aaatactgtc ccctttaact tagattctgc cttacatcag cgttttcatg gtttgtaaca
     3121 agtcatccga ctctactttg ctgagtactt gctttctaat ggcatatgtg tgtatatacc
     3181 ccttgaaatc agctggttta tttctatcgg attattagca aactataact ctagctgact
     3241 tctcattttt tataatgagg tctgtttttt aaatacttaa tctagacagt tttaaatatt
     3301 ggcagttggg tcacataaag gtggggattt gaactcattt cctgtaagta gaggtgttct
     3361 gtaaggtgca agtagaaatg cagagagaaa gggaaggaaa gtttcccgct caggaaagca
     3421 tgagttaata acagagaccc agtctgccac tgctgacgct ggaccagcag cagggagaca
     3481 tagagctcgc tagcacaaac agcgccagtg ccagtgccgg aactagagtg tagagtgaaa
     3541 gaccttgtgt ccttgcattg gaagggatga gagggaaagg aggggctcac ggttatccat
     3601 aatgatgaac taaaaaactg ttgtttttcc aagaaagatg gaacgtatac tttggtgcgg
     3661 tgtgtctcat aaatgacaaa ggagtagccg ctgtctctgt agagtcacat gtgcacacag
     3721 caagcaggtc tctgttcagt gtaacagttg aaaagaaata ataaatgctg caatctaata
     3781 atttaaaaga actttaatga accatctatt acatttttta agttagataa tcagtttcaa
     3841 aaggaatatt caggttattt aacattgttt ttaaatggct gtatcagaaa aaatatctat
     3901 ttttttttaa ttaaactatt tcatcacttg tttaaaaatg tattttggat ctgagtttgg
     3961 tgatattatt tcagctgctg ctgtactacc acagattatt ggcttttagt ttcctaaaga
     4021 gaaaaattgc cttcttacta gaaagccttt gtgtattgcc ggtttttctg tttgggaaaa
     4081 tctaaggatt tactgtggtt agtagtacag aagaaatgtg gatttgatga actagtgcct
     4141 atgattttaa cttatgtttg atatatagta gtagggttat aaatgttgat tattttgtgc
     4201 caacagccca gaattgtcac ttgtatgtca gcagaagcta tgacctctgc ttccaaagtt
     4261 atttaatttt ctcagtgttt ggatgttatt ttttgtaagt gtgttaataa aagtgtaaag
     4321 aattggaaaa atataaatat tcttaactca agcatttgct gaatcatttt tctacaaaac
     4381 ttgtttgtat aaaactctct gaagagttga cttttctcag ttttcatacc ctggaaatca
     4441 cattttgtaa aactggggac cattcataaa tgtcagatac ttttttaaat tatctcagaa
     4501 catcactttt atatatagat ataaaaaatt tttttgaaag caaagaagat taaatacata
     4561 tgtggcccag atgtttgtat acctctagga tgatctagac tatgtatgtt cagattgacg
     4621 taactcactg tacaggtgtc cggttttgac agtatgatgc atggtccttt tagatcacat
     4681 gaagtttgat ttgcaaacat ttctatagct gaacttgtaa tatgtggttg cctccttaat
     4741 aaacagcctg accataatgt ttattattaa atctatattt atcttcc
//
