LOCUS       NM_001356495            1434 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus Src-like-adaptor 2 (Sla2), transcript variant 1, mRNA.
ACCESSION   NM_001356495 XM_006500405
VERSION     NM_001356495.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1434)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1434)
  AUTHORS   Wybenga-Groot,L.E. and McGlade,C.J.
  TITLE     Sleuthing biochemical evidence to elucidate unassigned electron
            density in a CBL-SLAP2 crystal complex
  JOURNAL   Acta Crystallogr F Struct Biol Commun 77 (Pt 2), 37-46 (2021)
   PUBMED   33620036
  REMARK    GeneRIF: Sleuthing biochemical evidence to elucidate unassigned
            electron density in a CBL-SLAP2 crystal complex.
REFERENCE   3  (bases 1 to 1434)
  AUTHORS   Moharram,S.A., Chougule,R.A., Su,X., Li,T., Sun,J., Zhao,H.,
            Ronnstrand,L. and Kazi,J.U.
  TITLE     Src-like adaptor protein 2 (SLAP2) binds to and inhibits FLT3
            signaling
  JOURNAL   Oncotarget 7 (36), 57770-57782 (2016)
   PUBMED   27458164
  REMARK    GeneRIF: SLAP2 acts as a negative regulator of FLT3 signaling and
            therefore, modulation of SLAP2 expression levels may provide an
            alternative therapeutic approach for FLT3-ITD positive acute
            myeloid leukemia
REFERENCE   4  (bases 1 to 1434)
  AUTHORS   Cherpokova,D., Bender,M., Morowski,M., Kraft,P., Schuhmann,M.K.,
            Akbar,S.M., Sultan,C.S., Hughes,C.E., Kleinschnitz,C., Stoll,G.,
            Dragone,L.L., Watson,S.P., Tomlinson,M.G. and Nieswandt,B.
  TITLE     SLAP/SLAP2 prevent excessive platelet (hem)ITAM signaling in
            thrombosis and ischemic stroke in mice
  JOURNAL   Blood 125 (1), 185-194 (2015)
   PUBMED   25301707
  REMARK    GeneRIF: SLAP and SLAP2 are critical inhibitors of platelet
            (hem)ITAM signaling in the setting of arterial thrombosis and
            ischemic stroke
REFERENCE   5  (bases 1 to 1434)
  AUTHORS   Liontos,L.M., Dissanayake,D., Ohashi,P.S., Weiss,A., Dragone,L.L.
            and McGlade,C.J.
  TITLE     The Src-like adaptor protein regulates GM-CSFR signaling and
            monocytic dendritic cell maturation
  JOURNAL   J Immunol 186 (4), 1923-1933 (2011)
   PUBMED   21220694
  REMARK    GeneRIF: In bone marrow-derived dendritic cells lacking SLAP and
            closely related SLAP2, downregulation of the granulocyte-macrophage
            colony-stimulating factor (GM-CSF)beta receptor is impaired.
REFERENCE   6  (bases 1 to 1434)
  AUTHORS   Pakuts,B., Debonneville,C., Liontos,L.M., Loreto,M.P. and
            McGlade,C.J.
  TITLE     The Src-like adaptor protein 2 regulates colony-stimulating
            factor-1 receptor signaling and down-regulation
  JOURNAL   J Biol Chem 282 (25), 17953-17963 (2007)
   PUBMED   17353186
  REMARK    GeneRIF: SLAP-2 plays a role in c-Cbl-dependent down-regulation of
            CSF-1R signaling
REFERENCE   7  (bases 1 to 1434)
  AUTHORS   Loreto,M.P. and McGlade,C.J.
  TITLE     Cloning and characterization of human Src-like adaptor protein 2
            and a novel splice isoform, SLAP-2-v
  JOURNAL   Oncogene 22 (2), 266-273 (2003)
   PUBMED   12527895
REFERENCE   8  (bases 1 to 1434)
  AUTHORS   Loreto,M.P., Berry,D.M. and McGlade,C.J.
  TITLE     Functional cooperation between c-Cbl and Src-like adaptor protein 2
            in the negative regulation of T-cell receptor signaling
  JOURNAL   Mol Cell Biol 22 (12), 4241-4255 (2002)
   PUBMED   12024036
REFERENCE   9  (bases 1 to 1434)
  AUTHORS   Pandey,A., Ibarrola,N., Kratchmarova,I., Fernandez,M.M.,
            Constantinescu,S.N., Ohara,O., Sawasdikosol,S., Lodish,H.F. and
            Mann,M.
  TITLE     A novel Src homology 2 domain-containing molecule, Src-like adapter
            protein-2 (SLAP-2), which negatively regulates T cell receptor
            signaling
  JOURNAL   J Biol Chem 277 (21), 19131-19138 (2002)
   PUBMED   11891219
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL935150.10 and BC052655.1.
            
            On Oct 5, 2017 this sequence version replaced XM_006500405.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088672.1, AF287467.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AL935150.10        112946-113057       c
            113-479             BC052655.1         57-423
            480-480             AL935150.10        105775-105775       c
            481-1427            BC052655.1         425-1371
            1428-1434           AL935150.10        99987-99993         c
FEATURES             Location/Qualifiers
     source          1..1434
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 77.89 cM"
     gene            1..1434
                     /gene="Sla2"
                     /gene_synonym="A930009E21Rik; SLAP-2; SLAP2"
                     /note="Src-like-adaptor 2"
                     /db_xref="GeneID:77799"
                     /db_xref="MGI:MGI:1925049"
     exon            1..342
                     /gene="Sla2"
                     /gene_synonym="A930009E21Rik; SLAP-2; SLAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            343..473
                     /gene="Sla2"
                     /gene_synonym="A930009E21Rik; SLAP-2; SLAP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             386..1165
                     /gene="Sla2"
                     /gene_synonym="A930009E21Rik; SLAP-2; SLAP2"
                     /note="modulator of antigen receptor signaling MARS;
                     src-like adapter protein 2"
                     /codon_start=1
                     /product="src-like-adapter 2"
                     /protein_id="NP_001343424.1"
                     /db_xref="CCDS:CCDS38302.1"
                     /db_xref="GeneID:77799"
                     /db_xref="MGI:MGI:1925049"
                     /translation="MGSLSSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPA
                     GEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREK
                     AEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYIS
                     PRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKK
                     LDRSLLFLEAPASGEASLLSEGLRESLSSYISLAEDPLDDA"
     exon            474..573
                     /gene="Sla2"
                     /gene_synonym="A930009E21Rik; SLAP-2; SLAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            574..660
                     /gene="Sla2"
                     /gene_synonym="A930009E21Rik; SLAP-2; SLAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            661..764
                     /gene="Sla2"
                     /gene_synonym="A930009E21Rik; SLAP-2; SLAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            765..914
                     /gene="Sla2"
                     /gene_synonym="A930009E21Rik; SLAP-2; SLAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1047
                     /gene="Sla2"
                     /gene_synonym="A930009E21Rik; SLAP-2; SLAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1434
                     /gene="Sla2"
                     /gene_synonym="A930009E21Rik; SLAP-2; SLAP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1405..1410
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sla2"
                     /gene_synonym="A930009E21Rik; SLAP-2; SLAP2"
                     /note="hexamer: AATAAA"
     polyA_site      1434
                     /gene="Sla2"
                     /gene_synonym="A930009E21Rik; SLAP-2; SLAP2"
                     /note="major polyA site"
ORIGIN      
        1 tgcagctggg agctagagct ctgaggagca gtagcacctg ggtctgtcta cacgggctca
       61 ggtccctagg ccacgctctt tgtccctgct gtgctgggtg ggagggccca atctggtttc
      121 tctgagaagc aaaggactgc tgtactagtt tcgtggagat tgtctgctga caaagaagct
      181 tgatcacagt acctcagcct actctgactc ctttctggtg accgatcctc caggctgctg
      241 gggcctgaga tgccgactac cttaggacct gcaaaggcct gacctgtcgg gtcagtgtgc
      301 acattggctg actaccctca tcaaacgtct gatggcaaac ctttcccttt ccaggttcag
      361 tgtgcttgtg agcgtctgct gagtgatggg aagtttgtcc agcagaggga aaacctccag
      421 ccccagcccc agctcctctg gtccagacca ggaacccgtg tccatgcaac cagaaagaca
      481 caaggtcaca gctgtggccc tgggcagttt cccagcaggt gaacaggcca gactatctct
      541 gagactcggg gagccgctga ccatcatctc tgaggatgga gattggtgga cagtccagtc
      601 ggaagtctca ggcagagagt accacatgcc cagtgtgtat gtggctaaag tcgcccacgg
      661 gtggctgtac gagggcctga gccgggagaa agccgaggaa ctactcctgt tacctgggaa
      721 ccccggaggg gccttcctca tccgggagag ccagaccagg agaggctgct attccctgtc
      781 cgtccgactc agccgccctg catcttggga ccggatcaga cactacagga tacagcgtct
      841 tgacaatggc tggctgtaca tctcacctcg cctcaccttc ccctcactcc acgccttggt
      901 ggagcattac tctgagctag cagatggcat ctgctgtccc ctcagggagc cgtgtgtcct
      961 gcagaagctt gggccactac ctggcaaaga tacacctcca cctgtgactg tgccaacatc
     1021 atcactaaat tggaaaaagc tggaccgcag cctcctgttt ctggaagcac ctgcgagtgg
     1081 ggaggcatct ctgctcagtg aggggctccg agagtccctc agttcctaca tcagcctggc
     1141 tgaggacccc ttggatgatg cttagccctg gagcacaaag agaaagggaa ccaagactgt
     1201 ggcaccgaga gctccaactc cgctgaccct gacaaagctc caggaggcaa ggctgggaga
     1261 acagagacgg ctggggtggg gcacagacac tcggggcctc acctgggctt tctgataagt
     1321 catgtatctc ctaaggcctc acccctacct actacttcta gtccatgtgc agtgcagttc
     1381 aaagcagggc tggcctctac agagaataaa atacttctga ggtctgataa gtca
//
