LOCUS       NP_001343424             259 aa            linear   ROD 02-MAY-2024
DEFINITION  src-like-adapter 2 [Mus musculus].
ACCESSION   NP_001343424 XP_006500468
VERSION     NP_001343424.1
DBSOURCE    REFSEQ: accession NM_001356495.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 259)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 259)
  AUTHORS   Wybenga-Groot,L.E. and McGlade,C.J.
  TITLE     Sleuthing biochemical evidence to elucidate unassigned electron
            density in a CBL-SLAP2 crystal complex
  JOURNAL   Acta Crystallogr F Struct Biol Commun 77 (Pt 2), 37-46 (2021)
   PUBMED   33620036
  REMARK    GeneRIF: Sleuthing biochemical evidence to elucidate unassigned
            electron density in a CBL-SLAP2 crystal complex.
REFERENCE   3  (residues 1 to 259)
  AUTHORS   Moharram,S.A., Chougule,R.A., Su,X., Li,T., Sun,J., Zhao,H.,
            Ronnstrand,L. and Kazi,J.U.
  TITLE     Src-like adaptor protein 2 (SLAP2) binds to and inhibits FLT3
            signaling
  JOURNAL   Oncotarget 7 (36), 57770-57782 (2016)
   PUBMED   27458164
  REMARK    GeneRIF: SLAP2 acts as a negative regulator of FLT3 signaling and
            therefore, modulation of SLAP2 expression levels may provide an
            alternative therapeutic approach for FLT3-ITD positive acute
            myeloid leukemia
REFERENCE   4  (residues 1 to 259)
  AUTHORS   Cherpokova,D., Bender,M., Morowski,M., Kraft,P., Schuhmann,M.K.,
            Akbar,S.M., Sultan,C.S., Hughes,C.E., Kleinschnitz,C., Stoll,G.,
            Dragone,L.L., Watson,S.P., Tomlinson,M.G. and Nieswandt,B.
  TITLE     SLAP/SLAP2 prevent excessive platelet (hem)ITAM signaling in
            thrombosis and ischemic stroke in mice
  JOURNAL   Blood 125 (1), 185-194 (2015)
   PUBMED   25301707
  REMARK    GeneRIF: SLAP and SLAP2 are critical inhibitors of platelet
            (hem)ITAM signaling in the setting of arterial thrombosis and
            ischemic stroke
REFERENCE   5  (residues 1 to 259)
  AUTHORS   Liontos,L.M., Dissanayake,D., Ohashi,P.S., Weiss,A., Dragone,L.L.
            and McGlade,C.J.
  TITLE     The Src-like adaptor protein regulates GM-CSFR signaling and
            monocytic dendritic cell maturation
  JOURNAL   J Immunol 186 (4), 1923-1933 (2011)
   PUBMED   21220694
  REMARK    GeneRIF: In bone marrow-derived dendritic cells lacking SLAP and
            closely related SLAP2, downregulation of the granulocyte-macrophage
            colony-stimulating factor (GM-CSF)beta receptor is impaired.
REFERENCE   6  (residues 1 to 259)
  AUTHORS   Pakuts,B., Debonneville,C., Liontos,L.M., Loreto,M.P. and
            McGlade,C.J.
  TITLE     The Src-like adaptor protein 2 regulates colony-stimulating
            factor-1 receptor signaling and down-regulation
  JOURNAL   J Biol Chem 282 (25), 17953-17963 (2007)
   PUBMED   17353186
  REMARK    GeneRIF: SLAP-2 plays a role in c-Cbl-dependent down-regulation of
            CSF-1R signaling
REFERENCE   7  (residues 1 to 259)
  AUTHORS   Loreto,M.P. and McGlade,C.J.
  TITLE     Cloning and characterization of human Src-like adaptor protein 2
            and a novel splice isoform, SLAP-2-v
  JOURNAL   Oncogene 22 (2), 266-273 (2003)
   PUBMED   12527895
REFERENCE   8  (residues 1 to 259)
  AUTHORS   Loreto,M.P., Berry,D.M. and McGlade,C.J.
  TITLE     Functional cooperation between c-Cbl and Src-like adaptor protein 2
            in the negative regulation of T-cell receptor signaling
  JOURNAL   Mol Cell Biol 22 (12), 4241-4255 (2002)
   PUBMED   12024036
REFERENCE   9  (residues 1 to 259)
  AUTHORS   Pandey,A., Ibarrola,N., Kratchmarova,I., Fernandez,M.M.,
            Constantinescu,S.N., Ohara,O., Sawasdikosol,S., Lodish,H.F. and
            Mann,M.
  TITLE     A novel Src homology 2 domain-containing molecule, Src-like adapter
            protein-2 (SLAP-2), which negatively regulates T cell receptor
            signaling
  JOURNAL   J Biol Chem 277 (21), 19131-19138 (2002)
   PUBMED   11891219
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL935150.10 and BC052655.1.
            
            On Oct 5, 2017 this sequence version replaced XP_006500468.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088672.1, AF287467.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..259
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 77.89 cM"
     Protein         1..259
                     /product="src-like-adapter 2"
                     /note="modulator of antigen receptor signaling MARS;
                     src-like adapter protein 2"
                     /calculated_mol_wt=28345
     Region          1..30
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R4L0.3)"
     Region          35..89
                     /region_name="SH3"
                     /note="Src Homology 3 domain superfamily; cl17036"
                     /db_xref="CDD:473055"
     Site            order(40,42,45,49,66..67,82,84..85)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212690"
     Region          82..185
                     /region_name="SH2_SLAP"
                     /note="Src homology 2 domain found in Src-like adaptor
                     proteins; cd10344"
                     /db_xref="CDD:198207"
     Site            order(100,120,146,148)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198207"
     Site            order(147,175)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198207"
     Region          190..259
                     /region_name="SLA C-terminal"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R4L0.3)"
     CDS             1..259
                     /gene="Sla2"
                     /gene_synonym="A930009E21Rik; SLAP-2; SLAP2"
                     /coded_by="NM_001356495.1:386..1165"
                     /db_xref="CCDS:CCDS38302.1"
                     /db_xref="GeneID:77799"
                     /db_xref="MGI:MGI:1925049"
ORIGIN      
        1 mgslssrgkt sspspsssgp dqepvsmqpe rhkvtavalg sfpageqarl slrlgeplti
       61 isedgdwwtv qsevsgreyh mpsvyvakva hgwlyeglsr ekaeellllp gnpggaflir
      121 esqtrrgcys lsvrlsrpas wdrirhyriq rldngwlyis prltfpslha lvehyselad
      181 giccplrepc vlqklgplpg kdtpppvtvp tsslnwkkld rsllfleapa sgeasllseg
      241 lreslssyis laedpldda
//
