LOCUS       NM_001029841            2654 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus src-like adaptor (Sla), transcript variant 1, mRNA.
ACCESSION   NM_001029841
VERSION     NM_001029841.5
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2654)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2654)
  AUTHORS   Sharma,N., Ponce,M., Kaul,S., Pan,Z., Berry,D.M., Eiwegger,T. and
            McGlade,C.J.
  TITLE     SLAP Is a Negative Regulator of FcepsilonRI Receptor-Mediated
            Signaling and Allergic Response
  JOURNAL   Front Immunol 10, 1020 (2019)
   PUBMED   31156621
  REMARK    GeneRIF: SLAP Is a Negative Regulator of FcepsilonRI
            Receptor-Mediated Signaling and Allergic Response.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2654)
  AUTHORS   Loo,L., Simon,J.M., Xing,L., McCoy,E.S., Niehaus,J.K., Guo,J.,
            Anton,E.S. and Zylka,M.J.
  TITLE     Single-cell transcriptomic analysis of mouse neocortical
            development
  JOURNAL   Nat Commun 10 (1), 134 (2019)
   PUBMED   30635555
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2654)
  AUTHORS   Jelencic,V., Sestan,M., Kavazovic,I., Lenartic,M., Marinovic,S.,
            Holmes,T.D., Prchal-Murphy,M., Lisnic,B., Sexl,V., Bryceson,Y.T.,
            Wensveen,F.M. and Polic,B.
  TITLE     NK cell receptor NKG2D sets activation threshold for the NCR1
            receptor early in NK cell development
  JOURNAL   Nat Immunol 19 (10), 1083-1092 (2018)
   PUBMED   30224819
  REMARK    Erratum:[Nat Immunol. 2025 Jan;26(1):146. doi:
            10.1038/s41590-024-02038-x.. PMID: 39562744]
REFERENCE   5  (bases 1 to 2654)
  AUTHORS   Lefebvre,J., Clarkson,M., Massa,F., Bradford,S.T., Charlet,A.,
            Buske,F., Lacas-Gervais,S., Schulz,H., Gimpel,C., Hata,Y.,
            Schaefer,F. and Schedl,A.
  TITLE     Alternatively spliced isoforms of WT1 control podocyte-specific
            gene expression
  JOURNAL   Kidney Int 88 (2), 321-331 (2015)
   PUBMED   25993318
REFERENCE   6  (bases 1 to 2654)
  AUTHORS   Venables,J.P., Vernet,C., Chew,S.L., Elliott,D.J., Cowmeadow,R.B.,
            Wu,J., Cooke,H.J., Artzt,K. and Eperon,I.C.
  TITLE     T-STAR/ETOILE: a novel relative of SAM68 that interacts with an
            RNA-binding protein implicated in spermatogenesis
  JOURNAL   Hum Mol Genet 8 (6), 959-969 (1999)
   PUBMED   10332027
REFERENCE   7  (bases 1 to 2654)
  AUTHORS   Roche,S., Alonso,G., Kazlauskas,A., Dixit,V.M., Courtneidge,S.A.
            and Pandey,A.
  TITLE     Src-like adaptor protein (Slap) is a negative regulator of
            mitogenesis
  JOURNAL   Curr Biol 8 (17), 975-978 (1998)
   PUBMED   9742401
REFERENCE   8  (bases 1 to 2654)
  AUTHORS   Brinkmeier,M.L. and Camper,S.A.
  TITLE     Localization of somatostatin receptor genes on mouse chromosomes 2,
            11, 12, 15, and 17: correlation with growth QTLs
  JOURNAL   Genomics 43 (1), 9-14 (1997)
   PUBMED   9226367
REFERENCE   9  (bases 1 to 2654)
  AUTHORS   Angrist,M., Wells,D.E., Chakravarti,A. and Pandey,A.
  TITLE     Chromosomal localization of the mouse Src-like adapter protein
            (Slap) gene and its putative human homolog SLA
  JOURNAL   Genomics 30 (3), 623-625 (1995)
   PUBMED   8825655
REFERENCE   10 (bases 1 to 2654)
  AUTHORS   Pandey,A., Duan,H. and Dixit,V.M.
  TITLE     Characterization of a novel Src-like adapter protein that
            associates with the Eck receptor tyrosine kinase
  JOURNAL   J Biol Chem 270 (33), 19201-19204 (1995)
   PUBMED   7543898
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC107859.7 and AC157560.3.
            
            On Sep 1, 2022 this sequence version replaced NM_001029841.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036167.1, SRR10662773.136121.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                AC107859.7         94274-94366         c
            94-191              AC157560.3         16102-16199
            192-291             AC157560.3         23850-23949
            292-378             AC157560.3         25319-25405
            379-482             AC157560.3         27845-27948
            483-614             AC157560.3         30462-30593
            615-762             AC157560.3         33874-34021
            763-2654            AC157560.3         34875-36766
FEATURES             Location/Qualifiers
     source          1..2654
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 29.3 cM"
     gene            1..2654
                     /gene="Sla"
                     /gene_synonym="Slap; Slap-1"
                     /note="src-like adaptor"
                     /db_xref="GeneID:20491"
                     /db_xref="MGI:MGI:104295"
     exon            1..93
                     /gene="Sla"
                     /gene_synonym="Slap; Slap-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..976
                     /gene="Sla"
                     /gene_synonym="Slap; Slap-1"
                     /note="isoform a is encoded by transcript variant 1;
                     src-like-adapter protein 1"
                     /codon_start=1
                     /product="src-like-adapter isoform a"
                     /protein_id="NP_001025012.1"
                     /db_xref="CCDS:CCDS49622.1"
                     /db_xref="GeneID:20491"
                     /db_xref="MGI:MGI:104295"
                     /translation="MLCRLRVPSTAQGEKEMGNSMKSTSPPSERPLSSSEGLESDFLA
                     VLTDYPSPDISPPIFRRGEKLRVISDEGGWWKAISLSTGRESYIPGICVARVYHGWLF
                     EGLGRDKAEELLQLPDTKIGSFMIRESETKKGFYSLSVRHRQVKHYRIFRLPNNWYYI
                     SPRLTFQCLEDLVTHYSEVADGLCCVLTTPCLAQNIPAPTSHPSPCTSPGSPVTLRQK
                     TFDWKRVSRLQEGSEGAENPLRVDESLFSYGLRESIASYLSLTGDDSSSFDRKKKSLS
                     LMYTGSKRKSSFFSAPQYFED"
     exon            94..191
                     /gene="Sla"
                     /gene_synonym="Slap; Slap-1"
                     /inference="alignment:Splign:2.1.0"
     exon            192..291
                     /gene="Sla"
                     /gene_synonym="Slap; Slap-1"
                     /inference="alignment:Splign:2.1.0"
     exon            292..378
                     /gene="Sla"
                     /gene_synonym="Slap; Slap-1"
                     /inference="alignment:Splign:2.1.0"
     exon            379..482
                     /gene="Sla"
                     /gene_synonym="Slap; Slap-1"
                     /inference="alignment:Splign:2.1.0"
     exon            483..614
                     /gene="Sla"
                     /gene_synonym="Slap; Slap-1"
                     /inference="alignment:Splign:2.1.0"
     exon            615..762
                     /gene="Sla"
                     /gene_synonym="Slap; Slap-1"
                     /inference="alignment:Splign:2.1.0"
     exon            763..2654
                     /gene="Sla"
                     /gene_synonym="Slap; Slap-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2623..2628
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sla"
                     /gene_synonym="Slap; Slap-1"
                     /note="hexamer: ATTAAA"
     regulatory      2628..2633
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sla"
                     /gene_synonym="Slap; Slap-1"
                     /note="hexamer: AGTAAA"
     polyA_site      2644
                     /gene="Sla"
                     /gene_synonym="Slap; Slap-1"
                     /note="major polyA site"
     polyA_site      2654
                     /gene="Sla"
                     /gene_synonym="Slap; Slap-1"
                     /note="major polyA site"
ORIGIN      
        1 aatagaatgc ttcgacttcc gaaataagat cattctaagc aagcggaggc tttctacctt
       61 cccaggaatc catgtgaccc ccatgctctg caggcttcga gtaccttcca cagctcaagg
      121 agagaaagag atggggaata gcatgaaatc cacatctcca ccttcggaga ggccgttatc
      181 cagcagtgag ggacttgaaa gtgacttcct ggctgtgctg actgactacc catctcctga
      241 cattagcccc ccaatattcc ggagaggaga gaaactgcgt gtaatttctg atgaaggggg
      301 ctggtggaaa gccatttctc tcagcactgg ccgggaaagt tatattccag ggatatgtgt
      361 ggccagagtg taccatggct ggctgtttga aggactgggc agggacaagg ctgaggaact
      421 gctgcagctg ccagatacaa agattggtag cttcatgatt cgagagagtg aaacaaagaa
      481 aggtttctat tcgctgtctg tgagacacag gcaggtgaag cattatcgaa tcttccgtct
      541 tcccaacaac tggtactaca tctcaccaag gctcaccttc caatgcctgg aggacctggt
      601 gactcattat tctgaagtgg ctgatggtct atgctgtgtg ctcaccacac cctgtctggc
      661 acagaacata cctgctccaa catcccaccc atcaccttgc accagccctg gttcacctgt
      721 caccttgcgc cagaagacct ttgactggaa gagggtatcc agattgcaag aaggttcaga
      781 gggagcagag aacccactca gagtggacga atcccttttc agctatggtc ttcgggaaag
      841 cattgcctct tacctgtccc tgacagggga tgacagcagc tccttcgacc ggaagaagaa
      901 gagtctctcc ctaatgtaca ctggcagcaa acgcaagagt tccttttttt cagcacccca
      961 gtactttgaa gattaatgac ctggcttgta cacacacaca aaaaaacaaa ggctttgact
     1021 gtcacctggg gtcttacgga ggccagcatt cctccttggt tacctcaggt cttccaggaa
     1081 tcaagggaaa ccacacagag actgccttta cacactgatc agaggaactc ttccctgatg
     1141 tctgatcagt attgtggagt cacatcatgt ttaaatcatg atgaaatggg gcagtgcgtc
     1201 aaagaactgt gtgtgtatgt agaacagaac acttttgcaa gagtacttgg agactgactc
     1261 caactcgaaa tccaaatggc ccttctctga gaccatgtgg aaagcatcca tctgagaaag
     1321 aacatgggga agatgacttc ctagctccag aatgacctct acctggagcc aaactacctt
     1381 tataggtcca gtgagacttt tgggttatgt ctcttctctt tctaaaggac cagtgacact
     1441 aaaaaaatat tccgaaggga ttaaatctct gagccgaatg gaatctttag cactcagggg
     1501 tattgaagtc acgtgggcat tagatggcca tgctaagcca caggaaagta tagggtagtg
     1561 agggagaaaa caggagaggg aggaggcagc tctactggaa aaacttctca gatagacagt
     1621 tttgactcat ccagttgttg gggttctatg ttttagaacc cccattcctc atgcccatag
     1681 gaagatgcct gggtgaaata ctgtgctgag gtcaaatggg aataaatgag gtatgagtgg
     1741 aattccttaa tgctgggatt ccggctggag cagagagata aggagaacaa catgatgtaa
     1801 ccctgaatgt gaaacaggag gaaccttcac agttacaatg aactgaggag gagtgagggt
     1861 tatccaggtg ctcttattcc catggatcta caaggaatac aaggcttgtt ggaccaagta
     1921 gattagaatg cttagtgttt gtttgtttgt tgctgttttg ttttattcta taaggaagct
     1981 ggttagcttt agagaattaa tttatcctgt atattttcct gtaagaaggg ctggcgtctg
     2041 catgaataag aatgcccctt tctgggaaag gggaactgga gaagctgaat gctgccatag
     2101 atgattgtga gaggtgagag aaaacccaca gggcactaag gaaagagaag ccttcattct
     2161 ctctcacacc tatatcctgc tggaatggga gacaggatag tcatggctat tcatccctgt
     2221 ctatcacaag gattcttggt aagagaaata caggagggat ttgtcaccca tcatgtgcat
     2281 tccatatacc tgggctcagc ctgcagatgg tacaagcata cgccttgaca tgacgtgaca
     2341 tatcgtcaga tctggtgttt ttacacctag aggcatgggt gttctctgag gtctttcaaa
     2401 atggctattt caaagatact cgtcagtgtg tgagaaacaa atgtcacaca aggtcagtaa
     2461 cttctgctat gaggccatga tctctggctc ctgatgtatc tctgttcact atcttctgtg
     2521 ctgttttctg ttgtggtcaa tgtgattgga actttgagta gtatttgggg gtacttctaa
     2581 gtgggaagca ttacactttg ccaaatcatg tatttattcc tgattaaagt aaaactaata
     2641 cttatttaac cttg
//
