LOCUS       NM_013787               3210 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus S-phase kinase-associated protein 2 (Skp2), transcript
            variant 1, mRNA.
ACCESSION   NM_013787
VERSION     NM_013787.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3210)
  AUTHORS   Ferrena,A., Wang,J., Zhang,R., Karadal-Ferrena,B., Al-Hardan,W.,
            Singh,S., Borjihan,H., Schwartz,E.L., Zhao,H., Oktay,M.H., Yang,R.,
            Geller,D.S., Hoang,B.H. and Zheng,D.
  TITLE     SKP2 Knockout in Rb1/p53-Deficient Mouse Models of Osteosarcoma
            Induces Immune Infiltration and Drives a Transcriptional Program
            with a Favorable Prognosis
  JOURNAL   Mol Cancer Ther 23 (2), 223-234 (2024)
   PUBMED   37871911
  REMARK    GeneRIF: SKP2 Knockout in Rb1/p53-Deficient Mouse Models of
            Osteosarcoma Induces Immune Infiltration and Drives a
            Transcriptional Program with a Favorable Prognosis.
REFERENCE   2  (bases 1 to 3210)
  AUTHORS   Xie,X., Cui,Q., Jiang,T., Zhao,Z., Liu,Z., Liu,J., Yao,Q., Wang,Y.,
            Dang,E., Wang,G., Xiao,L. and Wang,N.
  TITLE     A critical role of the endothelial S-phase kinase-associated
            protein 2/phosphatase and tensin homologue axis in angiogenesis and
            psoriasis
  JOURNAL   Br J Dermatol 190 (2), 244-257 (2024)
   PUBMED   37850885
  REMARK    GeneRIF: A critical role of the endothelial S-phase
            kinase-associated protein 2/phosphatase and tensin homologue axis
            in angiogenesis and psoriasis.
            Erratum:[Br J Dermatol. 2024 Jun 20;191(1):e1. doi:
            10.1093/bjd/ljae157.. PMID: 38709154]
REFERENCE   3  (bases 1 to 3210)
  AUTHORS   Wu,Y., Li,J., Yang,X., Hou,B. and Qiao,H.
  TITLE     Immunosensitivity mediated by downregulated AKT1-SKP2 induces
            anti-PD-1-associated thyroid immune injury
  JOURNAL   Int Immunopharmacol 121, 110452 (2023)
   PUBMED   37302368
  REMARK    GeneRIF: Immunosensitivity mediated by downregulated AKT1-SKP2
            induces anti-PD-1-associated thyroid immune injury.
REFERENCE   4  (bases 1 to 3210)
  AUTHORS   Zhang,Q., Zhu,Y., Lv,C., Fang,Y., Liao,M., Xia,Y., Wei,Z. and
            Dai,Y.
  TITLE     AhR activation promotes Treg cell generation by enhancing
            Lkb1-mediated fatty acid oxidation via the Skp2/K63-ubiquitination
            pathway
  JOURNAL   Immunology 169 (4), 412-430 (2023)
   PUBMED   36930164
  REMARK    GeneRIF: AhR activation promotes Treg cell generation by enhancing
            Lkb1-mediated fatty acid oxidation via the Skp2/K63-ubiquitination
            pathway.
REFERENCE   5  (bases 1 to 3210)
  AUTHORS   Panda,D.K., Bai,X., Zhang,Y., Stylianesis,N.A., Koromilas,A.E.,
            Lipman,M.L. and Karaplis,A.C.
  TITLE     SCF-SKP2 E3 ubiquitin ligase links mTORC1/ER stress/ISR with YAP
            activation in murine renal cystogenesis
  JOURNAL   J Clin Invest 132 (24), e153943 (2022)
   PUBMED   36326820
  REMARK    GeneRIF: SCF-SKP2 E3 ubiquitin ligase links mTORC1/ER stress/ISR
            with YAP activation in murine renal cystogenesis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3210)
  AUTHORS   Maruyama,S., Hatakeyama,S., Nakayama,K., Ishida,N., Kawakami,K. and
            Nakayama,K.
  TITLE     Characterization of a mouse gene (Fbxw6) that encodes a homologue
            of Caenorhabditis elegans SEL-10
  JOURNAL   Genomics 78 (3), 214-222 (2001)
   PUBMED   11735228
REFERENCE   7  (bases 1 to 3210)
  AUTHORS   Spruck,C., Strohmaier,H., Watson,M., Smith,A.P., Ryan,A., Krek,T.W.
            and Reed,S.I.
  TITLE     A CDK-independent function of mammalian Cks1: targeting of
            SCF(Skp2) to the CDK inhibitor p27Kip1
  JOURNAL   Mol Cell 7 (3), 639-650 (2001)
   PUBMED   11463388
REFERENCE   8  (bases 1 to 3210)
  AUTHORS   Latres,E., Chiarle,R., Schulman,B.A., Pavletich,N.P., Pellicer,A.,
            Inghirami,G. and Pagano,M.
  TITLE     Role of the F-box protein Skp2 in lymphomagenesis
  JOURNAL   Proc Natl Acad Sci U S A 98 (5), 2515-2520 (2001)
   PUBMED   11226270
REFERENCE   9  (bases 1 to 3210)
  AUTHORS   Nakayama,K., Nagahama,H., Minamishima,Y.A., Matsumoto,M.,
            Nakamichi,I., Kitagawa,K., Shirane,M., Tsunematsu,R., Tsukiyama,T.,
            Ishida,N., Kitagawa,M., Nakayama,K. and Hatakeyama,S.
  TITLE     Targeted disruption of Skp2 results in accumulation of cyclin E and
            p27(Kip1), polyploidy and centrosome overduplication
  JOURNAL   EMBO J 19 (9), 2069-2081 (2000)
   PUBMED   10790373
REFERENCE   10 (bases 1 to 3210)
  AUTHORS   Hatakeyama,S., Kitagawa,M., Nakayama,K., Shirane,M., Matsumoto,M.,
            Hattori,K., Higashi,H., Nakano,H., Okumura,K., Onoe,K., Good,R.A.
            and Nakayama,K.
  TITLE     Ubiquitin-dependent degradation of IkappaBalpha is mediated by a
            ubiquitin ligase Skp1/Cul 1/F-box protein FWD1
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3859-3863 (1999)
   PUBMED   10097128
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY740905.1, AK166034.1 and AC139209.10.
            
            On Oct 26, 2013 this sequence version replaced NM_013787.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092236.1, AK032979.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               BY740905.1         2-101
            101-3202            AK166034.1         2-3103
            3203-3210           AC139209.10        57052-57059         c
FEATURES             Location/Qualifiers
     source          1..3210
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 3.84 cM"
     gene            1..3210
                     /gene="Skp2"
                     /gene_synonym="4930500A04Rik; FBXL1; FWD1; p45"
                     /note="S-phase kinase-associated protein 2"
                     /db_xref="GeneID:27401"
                     /db_xref="MGI:MGI:1351663"
     exon            1..271
                     /gene="Skp2"
                     /gene_synonym="4930500A04Rik; FBXL1; FWD1; p45"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..1538
                     /gene="Skp2"
                     /gene_synonym="4930500A04Rik; FBXL1; FWD1; p45"
                     /note="isoform a is encoded by transcript variant 1; F-box
                     protein Skp2; F-box/WD-40 protein 1; cyclin
                     A/CDK2-associated protein p45"
                     /codon_start=1
                     /product="S-phase kinase-associated protein 2 isoform a"
                     /protein_id="NP_038815.1"
                     /db_xref="CCDS:CCDS37037.1"
                     /db_xref="GeneID:27401"
                     /db_xref="MGI:MGI:1351663"
                     /translation="MHRKHLQEIPDQSGNVTTSFTWGWDSSKTSELLSGMGVSALEKE
                     EVDSENIPHGLLSNLGHPQSPPRKRVKGKGSDKDFVIIRRPKLSRENFPGVSWDSLPD
                     ELLLGIFSCLCLPELLRVSGVCKRWYRLSLDESLWQSLDLAGKNLHPDVTVRLLSRGV
                     VAFRCPRSFMEQPLGESFSSFRVQHMDLSNSVINVSNLHKILSECSKLQNLSLEGLQL
                     SDPIVKTLAQNENLVRLNLCGCSGFSESAVATLLSSCSRLDELNLSWCFDFTEKHVQA
                     AVAHLPNTITQLNLSGYRKNLQKTDLCTIIKRCPNLIRLDLSDSIMLKNDCFPEFFQL
                     NYLQHLSLSRCYDIIPDTLLELGEIPTLKTLQVFGIVPEGTLQLLREALPRLQINCAY
                     FTTIARPTMDSKKNLEIWGIKCRLTLQKPSCL"
     exon            272..543
                     /gene="Skp2"
                     /gene_synonym="4930500A04Rik; FBXL1; FWD1; p45"
                     /inference="alignment:Splign:2.1.0"
     exon            544..655
                     /gene="Skp2"
                     /gene_synonym="4930500A04Rik; FBXL1; FWD1; p45"
                     /inference="alignment:Splign:2.1.0"
     exon            656..799
                     /gene="Skp2"
                     /gene_synonym="4930500A04Rik; FBXL1; FWD1; p45"
                     /inference="alignment:Splign:2.1.0"
     exon            800..934
                     /gene="Skp2"
                     /gene_synonym="4930500A04Rik; FBXL1; FWD1; p45"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1033
                     /gene="Skp2"
                     /gene_synonym="4930500A04Rik; FBXL1; FWD1; p45"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1164
                     /gene="Skp2"
                     /gene_synonym="4930500A04Rik; FBXL1; FWD1; p45"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1216
                     /gene="Skp2"
                     /gene_synonym="4930500A04Rik; FBXL1; FWD1; p45"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1324
                     /gene="Skp2"
                     /gene_synonym="4930500A04Rik; FBXL1; FWD1; p45"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..3210
                     /gene="Skp2"
                     /gene_synonym="4930500A04Rik; FBXL1; FWD1; p45"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3183..3188
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Skp2"
                     /gene_synonym="4930500A04Rik; FBXL1; FWD1; p45"
                     /note="hexamer: AATAAA"
     regulatory      3187..3192
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Skp2"
                     /gene_synonym="4930500A04Rik; FBXL1; FWD1; p45"
                     /note="hexamer: AATACA"
     polyA_site      3201
                     /gene="Skp2"
                     /gene_synonym="4930500A04Rik; FBXL1; FWD1; p45"
     polyA_site      3207
                     /gene="Skp2"
                     /gene_synonym="4930500A04Rik; FBXL1; FWD1; p45"
                     /note="major polyA site"
ORIGIN      
        1 atcagagtgg aagaacccag gcaggactac gagctaggct cggaactaca attcccagca
       61 ggcaacgggg cgtcagaagg cggctgctgg agagcgggat gcagaactcc gcgcgcgcgg
      121 tggtgatgga acgttgctag ttcgcgggtc caactgctgg ggccccgggg atcactctaa
      181 gccgagcgct aaaacaggag tctggaaggc aggcagcgct tcaattaatt caagcattca
      241 aaactcctga atcagtggac accatgcata ggaagcacct tcaggagatt ccggaccaga
      301 gtggcaacgt caccaccagc ttcacgtggg gatgggattc cagcaagact tctgaactgc
      361 tatcaggcat gggtgtctcg gccttggaga aggaggaggt ggacagtgag aacatcccac
      421 atggactgct ctcaaacctc ggccaccccc agagccctcc aaggaaacga gtcaagggca
      481 aagggagtga caaagacttt gtgatcatcc gtcggccgaa gcttagtcgg gagaactttc
      541 caggtgtctc ctgggactcc cttccagatg agctgctcct tgggatcttt tcctgtctgt
      601 gcctccctga gctgctgaga gtctcgggcg tttgcaagag gtggtaccgc ctctcgctcg
      661 atgagtctct ctggcagtcc ctcgacctcg cgggtaaaaa tctgcaccca gacgtgactg
      721 tgcgcttgct ctcccgcggg gtggtcgcct tccgctgccc tcggtccttt atggagcagc
      781 cgctgggtga aagcttcagc tctttccggg tacagcacat ggacctgtcg aactcagtga
      841 taaatgtgtc gaacctccat aagattctgt ccgagtgctc caagctgcag aatctaagcc
      901 tggaaggcct gcagctctca gaccccattg tcaagactct tgcacagaat gaaaacttgg
      961 tgcgactaaa cctttgtggg tgctctgggt tttctgaatc tgccgtggcg actctgctaa
     1021 gcagctgctc cagactggat gagctaaatc tctcctggtg ctttgacttc actgaaaagc
     1081 acgtgcaagc ggctgtggca catttaccaa acaccatcac ccagctgaac ctcagcggct
     1141 accgaaagaa cctccagaaa acagatcttt gtaccataat taaacgatgc cccaacctca
     1201 tccgcctcga cttaagtgac agtatcatgc taaagaatga ctgctttcca gaattttttc
     1261 aactcaacta cctccaacac ctctcgctca gccggtgcta tgatataata cctgatactc
     1321 tacttgaact tggagaaatt cctacactaa aaacgctaca agtttttgga atcgtgccag
     1381 agggaaccct tcagctactg agggaagctc ttcctcggct gcagattaac tgcgcctatt
     1441 tcaccaccat tgcaaggcca actatggaca gcaagaagaa cctggagatt tggggtatca
     1501 agtgccgact gactctgcaa aagcccagtt gtctatgaag tgcttaccgc agggcggtgt
     1561 ttcctctgga acgaggaaag caggcagcaa gtccgcatgc tggagacctt ggttactctt
     1621 cctattggct ttgccttagc cttcacttta tatgtatgtt agggaaccat ttgcgagggg
     1681 gacagccacg aagtgttact ttttcaaaac tatagagccg attctgtcag tgctgtgccc
     1741 taagggccta agcggcaggt ctttggagat tttaggagag cctatgattt cagcatgctt
     1801 ttttaaaagc gacatttgag ccaactcttc caagtgccct tctaattaag tctatttaga
     1861 cccaagtttt aaaaattacc cgtggctaac aatcttcatg gtgtttgtca taactttcta
     1921 tctatttaat tattcagtat tttataaaac ttgactttga agaataagct atatgtacgg
     1981 tgagctgggc ggaaagcagc agaggctggt agcatttgag gtggtctttt ctgggattaa
     2041 cacatttcaa ctctgtgcag gcatgaggtt agtttcacag cagcacagga gtgcatgatg
     2101 tacctaaaac tctaaatgag aaaacaaaaa cacagagaca cagccggaag caggacagga
     2161 ttggtgcagg attgaaaacc tcaaaggctg ttctctaaaa gcaggttaat atgaagaagt
     2221 atcctttaat gtttttagga attctaccat gtttccagaa tcttaaatta ggtgagaaaa
     2281 tctacttgtg tgctttttaa actttataat caatgtatgt tacaatatat gtgggttgtt
     2341 tagcttttta aacttacttg ctttgtttta ggaatgtgat attattctag tcagccttct
     2401 gaaaagtcgg atagaattcc gagctgatcg ggtgtgctga tcgttccttt agtactgcgg
     2461 ttatttttta cattactctg aaatcaagaa cttgaaattc ttttaagtgg tcttaaacag
     2521 taatcgcttg aaactgcccg ttaggttact ggacctaaaa ttgttaggtt gaactgattt
     2581 ctgtccatcg gcaatctaca cgggaagcgt gcgcatgtgc agcttccgac ccgggaagcg
     2641 tgcgcatgtg cagcttcaga gcaggtgccg cggcttgcac ttcacctaag tgtttaagaa
     2701 tcacggggca ttaaaccttt tgataacata tggttttttt agcacttgat acacagaagc
     2761 aaagggatca aattgtgttt cttaaaaaat gaaaagaaaa aaaagaatta aggcagttac
     2821 ctctgtagag tatttccgtg ctacaatcca tttctattaa cttcatcaaa aacttttagt
     2881 taacaacatg aagtgccttc atctgctcag acctaaagaa cattttaagt gtcacacaag
     2941 aatggtcatg cttcaatccc ctagtagtta aaagagtgct aactactact tgaaactatt
     3001 gtttacacat tagtgatggg ctgatggcgg gctctggcct ccagatgccc tcagacatac
     3061 agtacctgtt cttccttacg caagtccagc tgtgagctat ttttgccaac atgtcgcggt
     3121 aatacatgtc gcagtaatct gtatttttgt atgtgatttc tacttttata gactgatttt
     3181 aaaataaata catttttata agaacaagta
//
