LOCUS       NM_011543               1454 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus S-phase kinase-associated protein 1 (Skp1), mRNA.
ACCESSION   NM_011543
VERSION     NM_011543.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1454)
  AUTHORS   Li,R., Sano,T., Mizokami,A., Fukuda,T., Shinjo,T., Iwashita,M.,
            Yamashita,A., Sanui,T., Nakatsu,Y., Sotomaru,Y., Asano,T.,
            Kanematsu,T. and Nishimura,F.
  TITLE     miR-582-5p targets Skp1 and regulates NF-kappaB signaling-mediated
            inflammation
  JOURNAL   Arch Biochem Biophys 734, 109501 (2023)
   PUBMED   36592647
  REMARK    GeneRIF: miR-582-5p targets Skp1 and regulates NF-kappaB
            signaling-mediated inflammation.
REFERENCE   2  (bases 1 to 1454)
  AUTHORS   Yoo,D., Park,J., Lee,C., Song,I., Lee,Y.H., Yun,T., Lee,H.,
            Heguy,A., Han,J.Y., Dasen,J.S., Kim,H. and Baek,M.
  TITLE     Little skate genome provides insights into genetic programs
            essential for limb-based locomotion
  JOURNAL   Elife 11, e78345 (2022)
   PUBMED   36288084
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1454)
  AUTHORS   Guan,Y., Lin,H., Leu,N.A., Ruthel,G., Fuchs,S.Y., Busino,L., Luo,M.
            and Wang,P.J.
  TITLE     SCF ubiquitin E3 ligase regulates DNA double-strand breaks in early
            meiotic recombination
  JOURNAL   Nucleic Acids Res 50 (9), 5129-5144 (2022)
   PUBMED   35489071
  REMARK    GeneRIF: Loss of SKP1 prior to meiosis leads to aberrant
            localization of DSB repair proteins and a failure in synapsis
            initiation in meiosis of both males and females as well as a defect
            in sister chromatid cohesion. FBXO47 interacts with SKP1 and
            HORMAD1 and targets HORMAD1 for polyubiquitination and degradation
            in HEK293T cells.
REFERENCE   4  (bases 1 to 1454)
  AUTHORS   Tanno,N., Takemoto,K., Takada-Horisawa,Y., Shimada,R., Fujimura,S.,
            Tani,N., Takeda,N., Araki,K. and Ishiguro,K.I.
  TITLE     FBXO47 is essential for preventing the synaptonemal complex from
            premature disassembly in mouse male meiosis
  JOURNAL   iScience 25 (4), 104008 (2022)
   PUBMED   35310947
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1454)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1454)
  AUTHORS   Hatakeyama,S., Kitagawa,M., Nakayama,K., Shirane,M., Matsumoto,M.,
            Hattori,K., Higashi,H., Nakano,H., Okumura,K., Onoe,K., Good,R.A.
            and Nakayama,K.
  TITLE     Ubiquitin-dependent degradation of IkappaBalpha is mediated by a
            ubiquitin ligase Skp1/Cul 1/F-box protein FWD1
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3859-3863 (1999)
   PUBMED   10097128
REFERENCE   7  (bases 1 to 1454)
  AUTHORS   Sowden,J.C., Morrison,K., Putt,W., Beddington,R. and Edwards,Y.H.
  TITLE     The identification of novel sequences expressed in the mouse
            notochord
  JOURNAL   Mamm Genome 8 (1), 42-44 (1997)
   PUBMED   9021147
REFERENCE   8  (bases 1 to 1454)
  AUTHORS   Brown,K.A., Leek,J.P., Lench,N.J., Moynihan,L.M., Markham,A.F. and
            Mueller,R.F.
  TITLE     Human sequences homologous to the gene for the cochlear protein
            Ocp-II do not map to currently known non-syndromic hearing loss
            loci
  JOURNAL   Ann Hum Genet 60 (5), 385-389 (1996)
   PUBMED   8912791
REFERENCE   9  (bases 1 to 1454)
  AUTHORS   Sowden,J., Morrison,K., Schofield,J., Putt,W. and Edwards,Y.
  TITLE     A novel cDNA with homology to an RNA polymerase II elongation
            factor maps to human chromosome 5q31 (TCEB1L) and to mouse
            chromosome 11 (Tceb1l)
  JOURNAL   Genomics 29 (1), 145-151 (1995)
   PUBMED   8530064
REFERENCE   10 (bases 1 to 1454)
  AUTHORS   Bach,I., Galcheva-Gargova,Z., Mattei,M.G., Simon-Chazottes,D.,
            Guenet,J.L., Cereghini,S. and Yaniv,M.
  TITLE     Cloning of human hepatic nuclear factor 1 (HNF1) and chromosomal
            localization of its gene in man and mouse
  JOURNAL   Genomics 8 (1), 155-164 (1990)
   PUBMED   1707031
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU841654.1, AK012498.1 and AK078330.1.
            
            On Oct 30, 2007 this sequence version replaced NM_011543.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078330.1, AK002983.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                BU841654.1         4-45
            43-842              AK012498.1         2-801
            843-1454            AK078330.1         829-1440
FEATURES             Location/Qualifiers
     source          1..1454
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 31.86 cM"
     gene            1..1454
                     /gene="Skp1"
                     /gene_synonym="15kDa; 2610043E24Rik; 2610206H23Rik; EMC19;
                     OCP-II; OCP2; p19A; p19Skp1; Skp1a; Tceb1l"
                     /note="S-phase kinase-associated protein 1"
                     /db_xref="GeneID:21402"
                     /db_xref="MGI:MGI:103575"
     exon            1..124
                     /gene="Skp1"
                     /gene_synonym="15kDa; 2610043E24Rik; 2610206H23Rik; EMC19;
                     OCP-II; OCP2; p19A; p19Skp1; Skp1a; Tceb1l"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..616
                     /gene="Skp1"
                     /gene_synonym="15kDa; 2610043E24Rik; 2610206H23Rik; EMC19;
                     OCP-II; OCP2; p19A; p19Skp1; Skp1a; Tceb1l"
                     /EC_number="3.1.1.3"
                     /note="cyclin-A/CDK2-associated protein p19; S-phase
                     kinase-associated protein 1A"
                     /codon_start=1
                     /product="S-phase kinase-associated protein 1"
                     /protein_id="NP_035673.3"
                     /db_xref="CCDS:CCDS24669.1"
                     /db_xref="GeneID:21402"
                     /db_xref="MGI:MGI:103575"
                     /translation="MPTIKLQSSDGEIFEVDVEIAKQSVTIKTMLEDLGMDDEGDDDP
                     VPLPNVNAAILKKVIQWCTHHKDDPPPPEDDENKEKRTDDIPVWDQEFLKVDQGTLFE
                     LILAANYLDIKGLLDVTCKTVANMIKGKTPEEIRKTFNIKNDFTEEEEAQVRKENQWC
                     EEK"
     exon            125..221
                     /gene="Skp1"
                     /gene_synonym="15kDa; 2610043E24Rik; 2610206H23Rik; EMC19;
                     OCP-II; OCP2; p19A; p19Skp1; Skp1a; Tceb1l"
                     /inference="alignment:Splign:2.1.0"
     exon            222..295
                     /gene="Skp1"
                     /gene_synonym="15kDa; 2610043E24Rik; 2610206H23Rik; EMC19;
                     OCP-II; OCP2; p19A; p19Skp1; Skp1a; Tceb1l"
                     /inference="alignment:Splign:2.1.0"
     exon            296..439
                     /gene="Skp1"
                     /gene_synonym="15kDa; 2610043E24Rik; 2610206H23Rik; EMC19;
                     OCP-II; OCP2; p19A; p19Skp1; Skp1a; Tceb1l"
                     /inference="alignment:Splign:2.1.0"
     exon            440..580
                     /gene="Skp1"
                     /gene_synonym="15kDa; 2610043E24Rik; 2610206H23Rik; EMC19;
                     OCP-II; OCP2; p19A; p19Skp1; Skp1a; Tceb1l"
                     /inference="alignment:Splign:2.1.0"
     exon            581..1454
                     /gene="Skp1"
                     /gene_synonym="15kDa; 2610043E24Rik; 2610206H23Rik; EMC19;
                     OCP-II; OCP2; p19A; p19Skp1; Skp1a; Tceb1l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      814..819
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Skp1"
                     /gene_synonym="15kDa; 2610043E24Rik; 2610206H23Rik; EMC19;
                     OCP-II; OCP2; p19A; p19Skp1; Skp1a; Tceb1l"
                     /note="hexamer: AATAAA"
     polyA_site      845
                     /gene="Skp1"
                     /gene_synonym="15kDa; 2610043E24Rik; 2610206H23Rik; EMC19;
                     OCP-II; OCP2; p19A; p19Skp1; Skp1a; Tceb1l"
                     /note="major polyA site"
     regulatory      1409..1414
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Skp1"
                     /gene_synonym="15kDa; 2610043E24Rik; 2610206H23Rik; EMC19;
                     OCP-II; OCP2; p19A; p19Skp1; Skp1a; Tceb1l"
                     /note="hexamer: AATAAA"
     polyA_site      1436
                     /gene="Skp1"
                     /gene_synonym="15kDa; 2610043E24Rik; 2610206H23Rik; EMC19;
                     OCP-II; OCP2; p19A; p19Skp1; Skp1a; Tceb1l"
                     /note="major polyA site"
ORIGIN      
        1 gcgtcccgct gctataaaag gcgacgccgc gcggcgccgc tcgagtggcc ttgttctcga
       61 tacttcgttg tggttgtgaa ctctgtccgg cagcctcggg cctgcggtct tgagacggag
      121 caccatgcct acgataaagt tgcagagttc tgatggagag atatttgaag ttgatgtaga
      181 aattgccaaa caatctgtga ctatcaagac catgctggaa gatttgggaa tggatgatga
      241 aggagatgat gatcctgttc ctttaccaaa tgttaatgca gcaattctaa agaaggtcat
      301 tcagtggtgc acccaccaca aagatgaccc tcctcctcct gaggatgatg aaaacaaaga
      361 aaagcggaca gatgatattc ctgtttggga ccaagaattc ctgaaagttg accaaggaac
      421 actttttgaa cttattctgg ctgcaaacta cttagacatc aaaggtttgc ttgatgtcac
      481 atgcaagact gtggccaata tgattaaggg gaaaactcct gaggagattc gtaaaacctt
      541 caatatcaaa aatgacttta ctgaagagga agaggcccag gtacgcaaag agaaccaatg
      601 gtgtgaagag aagtgaactg ctgtgcctgt cactgtaaca ctagaagggt tgttccaaat
      661 gctagttgca ctgctctgtt tataattgtt aatattagag atcagtagac aaacatcgcc
      721 ttgtcttcac tgcatgtgta gttccagtcc agatcagacc tgtggctgag tttcttctgt
      781 gagcagaagt ttccttttcc ccccattact ctgaataaaa ccgaactatg ggttctctgc
      841 ggaaagtggc attttgggct ttccctttct gtaaagtgat ttctgcctct agttcattgt
      901 ccagttaact tcagtgagcc tttcaaagtt gacattgtaa ataaaacaac ttaagaaaag
      961 tatgctgaaa tagaattaac aaaacatgat acttgttcat gaatcggaaa ctggaatagg
     1021 gcagcttgaa gttaaccatg tgggtgtctt ccaacctcta tgctgctggt aagcttgagt
     1081 gcagctgggc tctcttaatt ggatctgagg ccttgttttt tctttttttt tttctttttt
     1141 ttttttttaa tcttctcagc tttgaatatg ttgcctagag atttagttta ctacccagtt
     1201 tgtggttttg gagtgggaac tgtaactcaa caatttgtta gcttttcaat taaaaaagac
     1261 acttacttca tgtggtatgt catcttttta tcatcattgt tcccaggtgg agaaacacta
     1321 cttgcatgta aaaattaatt taacctttta acattaaagt gtatggtaaa actcagaaaa
     1381 cagccatcct aagtgcaaga tgcttttcaa taaaaagtag tacaataggt agtaaacagt
     1441 tgcttttgtg gatg
//
