LOCUS       NM_001103199            3824 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus selection and upkeep of intraepithelial T cells 6
            (Skint6), mRNA.
ACCESSION   NM_001103199 XM_144000 XR_035585
VERSION     NM_001103199.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3824)
  AUTHORS   Xu,Z., Xu,J., Ju,J. and Morel,L.
  TITLE     A Skint6 allele potentially contributes to mouse lupus
  JOURNAL   Genes Immun 18 (3), 111-117 (2017)
   PUBMED   28490805
  REMARK    GeneRIF: Skint6 variant in the rec1d1 interval is the most likely
            causative gene of mouse lupus.
REFERENCE   2  (bases 1 to 3824)
  AUTHORS   Boyden,L.M., Lewis,J.M., Barbee,S.D., Bas,A., Girardi,M.,
            Hayday,A.C., Tigelaar,R.E. and Lifton,R.P.
  TITLE     Skint1, the prototype of a newly identified immunoglobulin
            superfamily gene cluster, positively selects epidermal gammadelta T
            cells
  JOURNAL   Nat Genet 40 (5), 656-662 (2008)
   PUBMED   18408721
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            EU099304.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU099304.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3824
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 51.53 cM"
     gene            1..3824
                     /gene="Skint6"
                     /note="selection and upkeep of intraepithelial T cells 6"
                     /db_xref="GeneID:230622"
                     /db_xref="MGI:MGI:3649262"
     exon            1..49
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            50..130
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..3777
                     /gene="Skint6"
                     /note="selection and upkeep of intraepithelial T-cells
                     protein 6"
                     /codon_start=1
                     /product="selection and upkeep of intraepithelial T-cells
                     protein 6 precursor"
                     /protein_id="NP_001096669.1"
                     /db_xref="CCDS:CCDS51269.1"
                     /db_xref="GeneID:230622"
                     /db_xref="MGI:MGI:3649262"
                     /translation="MGTIGVPLTAHCVVLFLLQMVALSTEQFTVNGLESPVLVPLGGN
                     LELSCQLSPPQQAKHMEIRWFKNRYSEPVYLYRNGKDLNEAIVYKYVERTELLKDDIG
                     KGKVTLRIFKVTSVDSGSYHCFFKDDKFYEEHIIEVKVTATSSDIQILMHPPNSTGVR
                     LECHSGGWFPQPHMEWRDSKGEYIPATSKSHSQDENEFFNMTMDLFIKSNSYWSAACY
                     IQNFVTHQEESISFVLPGTKVLLLKNIQSIFQSSSVDLEKKDMLLKSIKSRFQSSSVD
                     PEKKERLLKIIQSRIESSSVDQETKALLLESIQSSIENSTVDLETKVWLLESIKSSIQ
                     NSSVDPETKELLLERIKSSIENSTVDLGTKEWLLESIQSSIQSSSVDLGTKKMLLKII
                     QSSIQSFSVYIGTKEWLLERVQSSIQSSSVDLGTKELLLEIIQSSIEGYSVELGIEEL
                     LSKIILSSIQSSRVDLGIKELLVKICQSSIQSTSVILETKEWLVKIFQSNIQSSSMDL
                     ETKVWLVKFFQSSIQSSSMDLGTIKWLVKNVQSNIQSSRVDLETKRMLLEIIQSSIQN
                     SSVHRGTKKMLLKVIQSSIQSFSVDLETKEWLLKIIQSSIQSSSVDIGTKSMLLKKIG
                     LILRSSIVNPGTELLFQIIQSDLQSSSVNTETREMLFEITQPTVQSSSVNSVTEELLE
                     ENYQLLLQSSSVNLEAENILNDTTQRILQLSSVNQGREKLLLDRIQQILQSSSVNPET
                     KCWLLKRIQFILENPSVHQEKKDLLLERIHLILQSSSVQKETKSLLLGSIQSILHSFS
                     VQKETKYLLLEKIQLILQNSSVHQETKDLLLKIIQLILQYSSVHEATSKLLLERIQLI
                     LQSSSVQKETKDLLLNRIFSILQNSCVDQGVKYFLLNIIHPILQKTSVHQETKSMLLD
                     RIELILQSSSMQQETKNHLLDQIEQILQDTTVHQETKDLLLNRIELILQNSSVQQETK
                     ELLMDKIDSILRYTWVHQETKDLLLNRIELILQSSSVQEETKNFLCNIIASILQSTSM
                     HQEKKKLLLGRIELILQSSSVQQETKKLLLKIVQSSSPSSSVRLESCNKRNPFWKKHA
                     LDLGISVFAIIVVTLIRHLNQREADQHFELDTLWSKDTSVILCVLIMFNNRLKALIYF
                     RLYGYSPPGKTYKYIVNYILRFSQPLFFIVYSAIILVMHLQIQNTDSLFSLYNSWMVE
                     MIMVLGLLLAIFNVKNIATALLHLGRTTLRLFRIKD"
     exon            131..478
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            479..760
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            761..823
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            824..886
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            887..949
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1012
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1075
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1138
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1201
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1264
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1327
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1390
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1453
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1516
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1579
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1642
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1705
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1768
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1831
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1894
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..1957
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2017
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2080
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2143
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2206
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2269
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..2332
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..2395
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2458
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2521
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            2522..2584
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            2585..2647
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            2648..2710
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            2711..2773
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..2836
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            2837..2899
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            2900..2962
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            2963..3025
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            3026..3088
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            3089..3151
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            3152..3214
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            3215..3277
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            3278..3385
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            3386..3502
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            3503..3628
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            3629..3742
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
     exon            3743..3824
                     /gene="Skint6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgctactttt atatggacaa gagagctgac ttaggatcaa caggctcagg tgtaatggga
       61 actataggag tacctcttac tgcacactgt gttgttttgt ttctcctcca gatggtagca
      121 ctgagtacag aacaattcac tgtgaatggc ttagagagtc cagtcttggt tccattgggt
      181 ggaaatctag aactcagttg tcagttgtct ccaccacaac aagcaaagca catggaaatt
      241 cgctggttca agaatcgcta ttcagagcca gtatacctgt atagaaatgg taaagacctg
      301 aatgaagcaa ttgtctacaa gtatgtagag agaactgaac tcctgaaaga tgacatcggg
      361 aaagggaaag taaccctcag gatctttaaa gtaactagtg ttgatagtgg gtcctaccac
      421 tgcttcttca aagatgacaa gttctatgaa gagcatatca tagaagtcaa ggtcacagct
      481 acaagctcag acatacagat tcttatgcat cccccaaaca gcacaggtgt gaggttggag
      541 tgtcattcag gaggttggtt cccacagcct cacatggaat ggagagacag caaaggagag
      601 tacattccag ctacatcaaa atcccattca caggatgaaa atgaattttt caacatgaca
      661 atggaccttt ttattaaatc caactcctac tggagtgctg cctgctacat tcaaaacttt
      721 gtaactcacc aagaagaaag cataagcttt gtcctaccag ggacaaaagt gttgctgttg
      781 aaaaatattc aatcaatttt tcaaagttcc agtgtggatc tagagaaaaa agatatgctt
      841 ttgaaaagta ttaaatcaag atttcaaagt tccagtgtgg atccagagaa aaaagagagg
      901 ctgttgaaaa ttattcaatc aaggattgaa agttccagtg tcgatcaaga gacaaaggcg
      961 ttgctgttgg aaagtattca gtcgagtatt gaaaattcca ctgtggatct agaaacaaaa
     1021 gtgtggcttt tggaaagcat caaatcaagt attcaaaatt ccagtgtgga tccagagaca
     1081 aaagaattgc tgttggaaag aattaagtca agtatagaaa attccactgt ggatctaggg
     1141 acaaaagagt ggctgttgga aagcatccaa tcaagtattc aaagttccag tgtggatcta
     1201 gggacaaaaa agatgctgtt gaaaattatt caatcaagta ttcaaagttt cagtgtttat
     1261 ataggaacaa aagagtggct gttggaaagg gttcaatcaa gtattcaaag ttccagtgtg
     1321 gatctaggga cgaaagagtt gctgttggaa attattcaat caagtattga aggttacagt
     1381 gtggagctag ggattgaaga gttgctgtca aaaattattc tatcaagtat ccaaagttcc
     1441 agggtggatc tagggataaa agagttgctg gtgaaaattt gtcaatcaag tattcaaagt
     1501 accagtgtga ttctagagac taaagaatgg ctggtgaaaa tttttcaatc aaatattcaa
     1561 agttccagta tggatctaga gacaaaagtg tggctggtga aattttttca atcaagtatt
     1621 caaagttcca gtatggatct agggacaata aaatggctgg tgaaaaatgt tcaatcaaat
     1681 attcaaagtt ccagagtgga tctagagaca aaaaggatgc tgttggaaat tattcaatca
     1741 agtattcaaa attccagtgt gcatagaggg accaaaaaaa tgctgctgaa agttattcaa
     1801 tcaagtattc aaagtttcag tgtggatcta gagacaaagg agtggctgtt gaaaattatt
     1861 caatcaagta ttcaaagttc cagtgtggat atagggacca aatccatgct gttgaaaaaa
     1921 ataggattga ttttgaggag ttccattgtg aatccaggga cagagttgct gtttcaaata
     1981 attcaatcag atcttcaaag ttccagtgtg aatacagaga caagagagat gctgtttgaa
     2041 ataactcaac caactgttca aagttccagt gtgaattcag tgacagaaga gttgctggaa
     2101 gaaaattatc aactgcttct tcaaagttcc agtgtgaatt tagaagcaga aaatatactg
     2161 aatgatacaa ctcaaaggat tcttcaactt tccagtgtga atcaaggaag agaaaagttg
     2221 ctcttggaca gaattcagca gattcttcaa agttcaagtg tgaatccaga aacaaaatgt
     2281 tggttgttga aaagaattca gttcattctt gaaaatccca gtgtgcatca agagaaaaaa
     2341 gatttgctct tggaaagaat tcacttgatt cttcaaagtt ccagtgtgca aaaagagaca
     2401 aaatctttgc tgttgggaag tattcagtcg atccttcata gtttcagtgt gcaaaaagag
     2461 acaaaatatt tgttgttgga aaaaattcag ttgattcttc aaaattccag tgtacatcaa
     2521 gaaaccaaag atttgttgtt gaaaataatt cagttgattc ttcaatattc cagtgtgcat
     2581 gaagctacaa gtaaattact cttggaaaga attcagttga ttcttcaaag ttccagtgtg
     2641 caaaaagaaa caaaagattt gttgttgaat agaattttct cgatccttca aaattcctgt
     2701 gtggatcaag gggtaaaata tttcctgttg aatataattc atccgattct tcaaaaaacc
     2761 agcgtgcatc aagagacaaa aagtatgctg ttggacagaa ttgagttgat tcttcaaagt
     2821 tccagtatgc aacaagagac aaaaaatcac ctgttggatc aaattgagca gattcttcaa
     2881 gatacaacag tgcatcaaga gacaaaagat ttgctgttga acagaattga gttgattctt
     2941 caaaattcca gtgtgcaaca agagactaaa gaattgctga tggacaaaat tgattcgatt
     3001 cttcgatata cctgggtgca tcaagagaca aaagatttgc tgttgaacag aattgagctg
     3061 attcttcaaa gttccagtgt gcaagaagag acaaaaaatt tcctgtgtaa tataattgcg
     3121 tcgattcttc aaagcaccag catgcatcaa gagaaaaaga aattgctgtt gggcagaatt
     3181 gagttgattc ttcaaagttc cagtgtgcaa caagagacaa aaaagttgct gttgaaaatt
     3241 gttcaatcaa gttctccaag ttcctctgtg cgtctagagt cctgcaataa gagaaatcct
     3301 ttttggaaaa agcatgcatt ggacctcgga atttcagtgt tcgcaattat agtagtcact
     3361 ctcattaggc atttaaatca aagagaggca gaccaacatt ttgaactgga tactttgtgg
     3421 tcaaaagata ctagtgtgat cctgtgtgtg ctgatcatgt ttaacaacag gctcaaggca
     3481 ttgatttact tcagactgta tggatattca cctccaggta aaacatataa atacatagta
     3541 aactacatat taagattctc tcaacccctg tttttcatag tctactctgc aataatcctt
     3601 gttatgcatc tgcaaataca gaacacagat tcattatttt ccttgtacaa tagctggatg
     3661 gtagaaatga taatggttct aggattacta ctcgcaattt tcaatgttaa aaacattgca
     3721 actgcattat tacacttagg ccgtacaact ctacgactat tccggattaa agactagctc
     3781 agacctggct tatcaaagca cttagggtgg agtcttccaa ccta
//
