LOCUS       NM_001167876            4497 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus selection and upkeep of intraepithelial T cells 5
            (Skint5), transcript variant 1, mRNA.
ACCESSION   NM_001167876
VERSION     NM_001167876.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4497)
  AUTHORS   Boyden,L.M., Lewis,J.M., Barbee,S.D., Bas,A., Girardi,M.,
            Hayday,A.C., Tigelaar,R.E. and Lifton,R.P.
  TITLE     Skint1, the prototype of a newly identified immunoglobulin
            superfamily gene cluster, positively selects epidermal gammadelta T
            cells
  JOURNAL   Nat Genet 40 (5), 656-662 (2008)
   PUBMED   18408721
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            EU099301.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU099301.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849378,
                                           SAMN00849379 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on expression, longest
                                                protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4497              EU099301.1         1-4497
FEATURES             Location/Qualifiers
     source          1..4497
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 51.53 cM"
     gene            1..4497
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /note="selection and upkeep of intraepithelial T cells 5"
                     /db_xref="GeneID:242627"
                     /db_xref="MGI:MGI:3650151"
     exon            1..49
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            50..130
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..4440
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; selection and upkeep of intraepithelial T-cells
                     protein 5"
                     /codon_start=1
                     /product="selection and upkeep of intraepithelial T-cells
                     protein 5 isoform 1 precursor"
                     /protein_id="NP_001161348.1"
                     /db_xref="GeneID:242627"
                     /db_xref="MGI:MGI:3650151"
                     /translation="MGAVGIPLTAHCVVLFLLQMVALSSEQFTVNGLESPVLVPLDGN
                     LELSCQLSPPQQAKHMEIRWFKNRYSEPVYLYRNGKDLFGEIVYKYVERTELLKDDIG
                     KGKVTLRIFKVTSVDSGSYHCFFKDGKFYEEHIIDVKVTATSSDIQILMHPPNIKGVR
                     LECHSGGWFPQPHMEWRDSKGEYIPATSKSHSQDENEFFNMTMDLFIKSNSHWSATCY
                     IQNFVTHQEESISIVLPGVWDSWCPAWIMITLLIVIHMTYYIKLYRTYATKEMLLKSI
                     QSSSQSSTVDTEKKEWLLKSIQSRIQSSSVDAEKKEWLLKFIQSSIQSSSVDLEKKEW
                     LLKSIQSSIQSAIVDRGTKEWLLESIQSSILSSIVDQGTKVLLLKSIQSSIQSSTLDI
                     ETKELLLKSIQSSIQSSIMDLGTKELLLKIIQSSIQSSSVDLGTKELLLKIIQSSIQS
                     STVDLGTKELLLKIIQSSIQSSSVDLGTKELLLKIIQSSIQSSTVDLGTKELLLKIIQ
                     SSIQSSSVDLGAKMGLLESILSSIQSSNVDLETKVLLLKSIQSSIQSSTVYLGIKQWL
                     LERIESIIQSSSVYLDTKELLLKIIQSSIESYSVDLGNKEFLLKIILSSIQSSSVDLG
                     TKELLVKFFQSNIQSSSVIPGTKKLLVKIIQSSLQSSSVDLGTKKVLLDIIQTSIQNS
                     NVHTERKGLLLKIIQSSVQSSSVDQGTKEMLLEIIQSSIQNSSVNQWTKDLLLKIIQS
                     IIQSSSVDLGTKGFLLKIIQSSIQSSSVDIGTKSMLLKKTGLILKSSIVNPGTELLFQ
                     LIESIRHSSSVNSETKKMLSEITQSTVQSSSVNPVTEEMIEEKYQLLLQSSSVNLEAE
                     NILNVTTQWILQISSVNQGKEMLLLDKIQQILQISSVNPETKDLLLEKIELILQNPGV
                     HQETKDLLLERIQLILQNSSVQKETKYLLLERIRSILQSSCVQKETKDLLLERIQSLL
                     QSSCVQKETKDLLLEKIQLILQNSTVHQETKDLLLERIQLFLQNSTVDQETSYLLLKR
                     IQLILQSSSVKKETKEFVLYIIESILHSSSVHQETKDLLFDRVQLILESSSVQQGLKC
                     LLLNMIQVIFQRTSVQKEMKDLLFNRIPLILESSSVQQETKDKLLDIIQSILQRTSVQ
                     EETKDKLLDIIQSILQRSSVQKDTIDTLLDRIQLILQRTSVQKEMKDFLLDRIKSILE
                     SFSVHQETKKLLLNRIMSILESSTVHQETKKLLLERIQSILESSSVQQETKKLLLDRI
                     HSILKSSSVQKETKNLLLDRIHSILKSSSVQKESCNKRNPFWKKYALDLGISVFTIIV
                     VTLIMHLKQREADQHFELNTLWSKDTSVILCVLIMFNNRLKALIYFRLYGFSPPGKAH
                     KYIVNYILRFSHPVFCIVYSATILYMYLQIQNKDSLFSLYNSWMVEMEMVLIFLLVIF
                     NVKNIATVLLYFDSTTLRLFFWIKG"
     exon            131..478
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            479..760
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            761..853
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            854..916
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            917..979
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1042
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1105
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1168
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1231
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1294
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1357
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1420
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1483
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1546
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1609
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1672
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1735
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1798
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1861
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..1924
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..1987
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2050
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2113
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2176
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2239
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2302
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2303..2365
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2428
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2488
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2489..2551
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2552..2614
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2677
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2678..2740
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2741..2803
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2804..2866
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2867..2929
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2930..2992
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2993..3055
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            3056..3118
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            3119..3181
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            3182..3244
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            3245..3307
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            3308..3370
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            3371..3433
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            3434..3496
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            3497..3559
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            3560..3622
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            3623..3685
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            3686..3748
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            3749..3811
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            3812..3874
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            3875..3937
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            3938..4045
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            4046..4162
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            4163..4288
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            4289..4402
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
     exon            4403..4497
                     /gene="Skint5"
                     /gene_synonym="Skint-5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgctactttt acatggacaa gagagctgac ttaggatcaa caaactcagg tgtgatggga
       61 gctgtaggaa tacctcttac cgcacactgc gttgttttgt ttctcctcca gatggtagca
      121 ctgagttcag aacaattcac tgtgaatggc ttagagagtc cagtcttggt tccattggat
      181 ggaaacctag aactcagttg tcagttgtct ccaccacagc aagcaaaaca catggaaatt
      241 cgctggttca agaatcgcta ttcagagcca gtatacctgt atagaaatgg taaagacctt
      301 tttggagaaa ttgtctacaa gtatgtagag agaactgaac tcctgaaaga tgacatcggg
      361 aaagggaaag taaccctcag gatctttaaa gtaactagtg ttgacagtgg gtcctaccac
      421 tgcttcttca aagatggcaa gttctatgaa gagcatatca tagacgtcaa ggtcacagct
      481 acaagctcag acatacagat tcttatgcat cccccaaata tcaaaggtgt gaggttggag
      541 tgtcattcag gcggttggtt cccacagcct cacatggaat ggagagatag caaaggagag
      601 tacattccag ctacatcaaa atcccattca caggatgaaa atgaattttt caacatgaca
      661 atggaccttt ttattaaatc caactctcac tggagtgcaa cctgctatat tcaaaacttt
      721 gtaactcacc aagaagaaag cataagtatt gtcctaccag gtgtgtggga ttcatggtgt
      781 cctgcttgga taatgattac tttgctgatt gtcatccaca tgacttacta tattaaatta
      841 taccgcacat atgcgacaaa agagatgctt ttgaaaagta ttcaatcaag ttctcaaagt
      901 tccactgtgg atacagagaa aaaagagtgg ctgttgaaaa gtattcaatc aaggattcaa
      961 agttccagtg tggatgcaga gaaaaaagag tggctgttga aatttattca atcaagtatt
     1021 caaagttcca gtgtggatct agaaaaaaaa gagtggctgt tgaaaagcat tcaatcaagt
     1081 attcaaagtg ccattgtgga tcgaggaaca aaagagtggc tgttggaaag cattcaatca
     1141 agtattctaa gttccattgt ggatcaaggg acaaaagtgt tgctgttgaa aagtattcaa
     1201 tcaagcattc aaagttccac tctggatata gaaacaaagg agttgctgtt gaaaagcatt
     1261 caatcaagta ttcaaagttc cattatggat ctaggaacaa aagagttgct gttgaaaata
     1321 attcaatcga gtattcaaag ttccagtgtg gatctaggaa caaaagagtt gctgttgaaa
     1381 ataattcaat cgagtattca aagttccact gtggatctag gaacaaaaga gttgctgttg
     1441 aaaataattc aatcgagtat tcaaagttcc agtgtggatc taggaacaaa agagttgctg
     1501 ttgaaaataa ttcaatcgag tattcaaagt tccactgtgg atctaggaac aaaagagttg
     1561 ctgttgaaaa taattcaatc gagtattcaa agttccagtg tggatctagg agcaaaaatg
     1621 gggctgttgg aaagcatttt gtcaagtatt caaagttcca atgtggatct agagacaaaa
     1681 gtgttgctgt tgaaaagtat tcaatcaagt attcaaagtt ccactgtgta tctaggaata
     1741 aaacaatggc tgttggaaag aattgaatca attattcaaa gttccagtgt gtatctagat
     1801 acaaaagagt tgctgttgaa aattattcaa tcaagtattg aaagttacag tgtggatcta
     1861 gggaacaaag agtttctgtt gaaaattatt ctatcaagta tccaaagttc cagtgtggat
     1921 ctagggacaa aagagttgct ggtgaaattt tttcaatcaa atattcaaag ttccagtgtg
     1981 attccaggga caaaaaagtt gctggtgaaa attattcaat caagtcttca aagttccagt
     2041 gtggatctag ggacaaaaaa ggtgttgttg gatattattc aaacaagtat tcaaaactcc
     2101 aatgtgcata cagagagaaa agggttgctg ttgaaaatta ttcaatcaag tgttcaaagt
     2161 tccagtgtgg atcaagggac aaaagagatg ctgttggaaa ttattcaatc aagtattcaa
     2221 aattccagtg tgaatcaatg gacaaaagat ttgctgctga aaattattca atcaattatt
     2281 caaagttcca gtgtggatct agggacaaaa gggttccttt tgaaaattat tcaatcaagt
     2341 attcaaagtt ccagtgtgga tatagggacc aaatccatgc tgttgaaaaa aacaggattg
     2401 attttgaaga gttccattgt gaatccaggg acagagttgc tgtttcaact aattgaatca
     2461 attcgtcata gttccagtgt gaattcagag acaaaaaaga tgctgtctga aataactcaa
     2521 tcaactgttc aaagttccag tgtgaatcca gtgacagaag agatgataga ggagaaatat
     2581 caattgcttc ttcaaagttc cagtgtgaat ctagaagcag aaaatatact gaatgttaca
     2641 acccaatgga ttcttcaaat ttccagtgtg aatcaaggaa aagaaatgtt gctcttggat
     2701 aaaattcagc agattcttca aatttcaagt gtgaatccag aaacaaaaga tttgttgttg
     2761 gaaaaaattg agttgattct tcaaaatccc ggtgtgcatc aagagacaaa agatttgctg
     2821 ttggaaagaa ttcagctgat ccttcaaaat tcaagtgtgc aaaaagagac aaaatatttg
     2881 ctgttggaaa gaattcggtc gatccttcaa agttcgtgtg tgcaaaaaga gacaaaagat
     2941 ttgctgttgg aaagaattca gtcactcctt caaagttcgt gtgttcaaaa agagacaaaa
     3001 gatttgttgt tggaaaaaat tcagttgatt cttcaaaatt ccactgtgca tcaagaaaca
     3061 aaagatttgt tgttggaaag aattcagttg tttcttcaaa attccactgt ggatcaagag
     3121 acaagttatt tactcctgaa aagaattcag ttgattcttc aaagttccag tgtgaaaaaa
     3181 gagacaaaag agttcgtgtt gtatataatt gagtcgattc ttcacagttc cagtgtgcat
     3241 caagagacga aagatttgct gttcgacaga gttcagttga ttcttgaaag ttccagtgtg
     3301 cagcaagggt tgaaatgttt gctgttgaac atgattcagg tgatttttca aaggacaagt
     3361 gtgcaaaaag agatgaaaga tttgctattc aacagaattc cgttgattct tgaaagttcc
     3421 agtgtgcagc aagagacaaa agataagctg ttggacataa ttcagtcgat tcttcaaagg
     3481 accagtgtac aagaagagac aaaagataag ctgttggaca taattcagtc gattcttcaa
     3541 agaagcagtg tgcaaaaaga tacgatagat acgctgttgg acagaattca gttgattctt
     3601 caaagaacca gtgtgcaaaa agagatgaaa gacttcctgc tggacagaat taagtcaatt
     3661 cttgaaagtt tcagtgtgca tcaagagacg aaaaaattgc tgttgaacag aattatgtcg
     3721 attcttgaaa gttccactgt gcatcaagaa acgaaaaaat tgctgttgga gagaattcag
     3781 tcgattcttg aaagttccag tgtgcagcaa gagacaaaaa aattgctgtt ggacagaatt
     3841 cattcgattc ttaaaagttc cagtgtgcaa aaagagacaa aaaacttgct gttggacaga
     3901 attcattcga ttcttaaaag ttccagtgtg caaaaagagt cctgcaataa gagaaatcct
     3961 ttttggaaaa agtatgcatt ggacctcgga atttcagtgt tcacaattat agtagtcact
     4021 ctcattatgc atttaaaaca aagagaagca gaccaacatt ttgaactgaa tactttgtgg
     4081 tcaaaagata ctagtgtgat cctgtgtgtg ctgatcatgt ttaacaacag gctcaaggca
     4141 ttgatatact tcagactgta tggattttca cctccaggta aagcacataa gtacatagta
     4201 aactacatat taagattctc acatcccgtc ttttgcattg tctactctgc aacaatcctt
     4261 tatatgtatc tgcaaataca gaacaaagat tccttatttt ccttgtataa tagctggatg
     4321 gtagaaatgg aaatggttct aatatttctg ctcgtaattt tcaatgttaa aaacattgca
     4381 actgtattgt tatactttga cagtacaact ctacgactat tcttctggat taaaggctag
     4441 ctcagacctg tcttgccaaa gcaggctagc ccacttaggg tggagtcttc caaccta
//
