LOCUS       NM_001102662            1260 bp    mRNA    linear   ROD 31-JUL-2024
DEFINITION  Mus musculus selection and upkeep of intraepithelial T cells 1
            (Skint1), mRNA.
ACCESSION   NM_001102662 XM_001474878 XM_001479153
VERSION     NM_001102662.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1260)
  AUTHORS   Munoz-Ruiz,M., Llorian,M., D'Antuono,R., Pavlova,A.,
            Mavrigiannaki,A.M., McKenzie,D., Garcia-Cassani,B., Iannitto,M.L.,
            Wu,Y., Dart,R., Davies,D., Jamal-Hanjani,M., Jandke,A.,
            Ushakov,D.S. and Hayday,A.C.
  TITLE     IFN-gamma-dependent interactions between tissue-intrinsic
            gammadelta T cells and tissue-infiltrating CD8 T cells limit
            allergic contact dermatitis
  JOURNAL   J Allergy Clin Immunol 152 (6), 1520-1540 (2023)
   PUBMED   37562754
REFERENCE   2  (bases 1 to 1260)
  AUTHORS   McKenzie,D.R., Hart,R., Bah,N., Ushakov,D.S., Munoz-Ruiz,M.,
            Feederle,R. and Hayday,A.C.
  TITLE     Normality sensing licenses local T cells for innate-like tissue
            surveillance
  JOURNAL   Nat Immunol 23 (3), 411-422 (2022)
   PUBMED   35165446
REFERENCE   3  (bases 1 to 1260)
  AUTHORS   Jandke,A., Melandri,D., Monin,L., Ushakov,D.S., Laing,A.G.,
            Vantourout,P., East,P., Nitta,T., Narita,T., Takayanagi,H.,
            Feederle,R. and Hayday,A.
  TITLE     Butyrophilin-like proteins display combinatorial diversity in
            selecting and maintaining signature intraepithelial gammadelta T
            cell compartments
  JOURNAL   Nat Commun 11 (1), 3769 (2020)
   PUBMED   32724083
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1260)
  AUTHORS   Narita,T., Nitta,T., Nitta,S., Okamura,T. and Takayanagi,H.
  TITLE     Mice lacking all of the Skint family genes
  JOURNAL   Int Immunol 30 (7), 301-309 (2018)
   PUBMED   29718261
REFERENCE   5  (bases 1 to 1260)
  AUTHORS   Van Hede,D., Polese,B., Humblet,C., Wilharm,A., Renoux,V.,
            Dortu,E., de Leval,L., Delvenne,P., Desmet,C.J., Bureau,F.,
            Vermijlen,D. and Jacobs,N.
  TITLE     Human papillomavirus oncoproteins induce a reorganization of
            epithelial-associated gammadelta T cells promoting tumor formation
  JOURNAL   Proc Natl Acad Sci U S A 114 (43), E9056-E9065 (2017)
   PUBMED   29073102
REFERENCE   6  (bases 1 to 1260)
  AUTHORS   Zhao,Y., Bian,G., Yu,C., Liu,F., Liu,L., Guo,H., Guo,J., Ju,G. and
            Wang,J.
  TITLE     Cross-reactivity of anti-programmed death ligand 2 polyclonal
            antibody in mouse tissues
  JOURNAL   Sci China Life Sci 55 (11), 940-947 (2012)
   PUBMED   23090063
REFERENCE   7  (bases 1 to 1260)
  AUTHORS   Turchinovich,G. and Hayday,A.C.
  TITLE     Skint-1 identifies a common molecular mechanism for the development
            of interferon-gamma-secreting versus interleukin-17-secreting
            gammadelta T cells
  JOURNAL   Immunity 35 (1), 59-68 (2011)
   PUBMED   21737317
  REMARK    GeneRIF: identifies a common molecular mechanism for the
            development of interferon-gamma-secreting versus
            interleukin-17-secreting gammadelta T cells
REFERENCE   8  (bases 1 to 1260)
  AUTHORS   Barbee,S.D., Woodward,M.J., Turchinovich,G., Mention,J.J.,
            Lewis,J.M., Boyden,L.M., Lifton,R.P., Tigelaar,R. and Hayday,A.C.
  TITLE     Skint-1 is a highly specific, unique selecting component for
            epidermal T cells
  JOURNAL   Proc Natl Acad Sci U S A 108 (8), 3330-3335 (2011)
   PUBMED   21300860
  REMARK    GeneRIF: transgenic Skint-1, across a broad range of transgenic
            Skint-1, across a broad range of expression levels, precisely and
            selectively determines the Vgamma5Vdelta1(+) dendritic epidermal
            T-cell compartment
REFERENCE   9  (bases 1 to 1260)
  AUTHORS   Jin,Y., Xia,M., Saylor,C.M., Narayan,K., Kang,J., Wiest,D.L.,
            Wang,Y. and Xiong,N.
  TITLE     Cutting edge: Intrinsic programming of thymic gammadeltaT cells for
            specific peripheral tissue localization
  JOURNAL   J Immunol 185 (12), 7156-7160 (2010)
   PUBMED   21068400
REFERENCE   10 (bases 1 to 1260)
  AUTHORS   Boyden,L.M., Lewis,J.M., Barbee,S.D., Bas,A., Girardi,M.,
            Hayday,A.C., Tigelaar,R.E. and Lifton,R.P.
  TITLE     Skint1, the prototype of a newly identified immunoglobulin
            superfamily gene cluster, positively selects epidermal gammadelta T
            cells
  JOURNAL   Nat Genet 40 (5), 656-662 (2008)
   PUBMED   18408721
  REMARK    GeneRIF: Skint1 is the prototypic member of a rapidly evolving
            family of at least 11 genes in mouse, with greatest similarity to
            the butyrophilin genes.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from EF494889.1.
            
            On or before Sep 2, 2007 this sequence version replaced
            XM_001479153.1, XM_001474878.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF494889.1, EF494890.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1260
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 51.53 cM"
     gene            1..1260
                     /gene="Skint1"
                     /gene_synonym="Skint-1"
                     /note="selection and upkeep of intraepithelial T cells 1"
                     /db_xref="GeneID:639781"
                     /db_xref="MGI:MGI:3649627"
     exon            1..75
                     /gene="Skint1"
                     /gene_synonym="Skint-1"
                     /inference="alignment:Splign:2.1.0"
     exon            76..156
                     /gene="Skint1"
                     /gene_synonym="Skint-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..1175
                     /gene="Skint1"
                     /gene_synonym="Skint-1"
                     /note="selection and upkeep of intraepithelial T-cells
                     protein 1; skint 1; Immunoglobulin-like and transmembrane
                     domain-containing protein expressed in skin and thymus
                     protein 1"
                     /codon_start=1
                     /product="selection and upkeep of intraepithelial T-cells
                     protein 1 precursor"
                     /protein_id="NP_001096132.1"
                     /db_xref="CCDS:CCDS51267.1"
                     /db_xref="GeneID:639781"
                     /db_xref="MGI:MGI:3649627"
                     /translation="MGSTGLCFYGHCIVMFLLQMVTASSEPFIVNGLEGPVLASLGGN
                     LELSCQLSPPQQAQHMEIRWFRNLYTEPVHLYRDGKDMFGEIISKYVERTELLKDGIG
                     EGKVTLRIFNVTVDDDGSYHCVFKDGDFYEEHITEVKITAINLQVQIHVHPPNTKGVI
                     VECHSGGWFPRPLMQWRDRRGEVIPAASKSHSQGRDKLFNMKISLLISESFFQKVICC
                     LQNPLTGQEERTSVILSDAFFSWNRIWKMILGIILSMMVVSIFVFSCLLHHEHKVCKW
                     KWDAPWIKGLLIMTSSMVTVVLVMVYLHMKQRVPVSDVHFELDTLWVEDISVILCSLM
                     VPATMLVSYTYFRLKDWCQHNHAQRVFTSN"
     exon            157..504
                     /gene="Skint1"
                     /gene_synonym="Skint-1"
                     /inference="alignment:Splign:2.1.0"
     exon            505..786
                     /gene="Skint1"
                     /gene_synonym="Skint-1"
                     /inference="alignment:Splign:2.1.0"
     exon            787..897
                     /gene="Skint1"
                     /gene_synonym="Skint-1"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1005
                     /gene="Skint1"
                     /gene_synonym="Skint-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1128
                     /gene="Skint1"
                     /gene_synonym="Skint-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1260
                     /gene="Skint1"
                     /gene_synonym="Skint-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagacatcta ggtgatctaa ctgggagtat ctctacagaa acaaaaggga gctgacccag
       61 gatccccagg tccaagtgca atgggatcca caggactatg tttttatgga cactgtattg
      121 tcatgttcct tcttcagatg gtcacagcaa gctcagagcc atttatagtg aacggcttag
      181 aggggccagt cttggcttca ttgggtggaa acttagaact cagttgtcag ttgtctccac
      241 cacaacaagc ccagcacatg gagattcgct ggttccggaa cctctataca gagcctgtgc
      301 acctgtacag agatggcaaa gacatgtttg gagaaattat ctccaagtat gtggaacgta
      361 cagaactctt aaaagatggg attggagaag ggaaagtgac ccttaggatc tttaatgtga
      421 ctgttgatga tgatgggtct taccactgtg tgttcaaaga tggtgatttc tatgaagagc
      481 acataacaga ggtcaagatc acagccataa acttacaggt acagattcat gtgcaccctc
      541 ctaataccaa aggtgtgata gtggagtgtc actctggagg ttggttccca cgacctctca
      601 tgcaatggag agacagaaga ggggaggtca ttccagctgc atcaaaatcc cactcacagg
      661 gtagagacaa actgttcaat atgaagatat cccttctcat tagtgaaagc ttcttccaga
      721 aagtcatttg ttgtcttcag aaccctctaa caggccaaga ggaaaggaca agtgttattc
      781 tatcagatgc atttttttca tggaatagga tttggaaaat gattctgggt ataatactat
      841 ctatgatggt ggtctctatc tttgttttta gttgtctgct acatcatgag cataaagttt
      901 gtaagtggaa gtgggatgct ccttggataa aaggattatt aataatgaca tcttctatgg
      961 tgactgttgt attagtcatg gtgtatttac atatgaaaca aagagttcca gtttcagatg
     1021 tacattttga attggatact ttgtgggtgg aagacataag tgtaatcctg tgttcactga
     1081 tggttcctgc caccatgctt gtttcctata catatttcag gttgaaagac tggtgccagc
     1141 acaatcatgc tcagagagtc ttcaccagca actgatggaa acaggtgaaa agatccacat
     1201 ccaaacatta agcagatttt ggggaatcct atagaaggaa gggcaaggaa tgtaagaacc
//
