LOCUS       NM_011386               6683 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus SKI-like (Skil), transcript variant 1, mRNA.
ACCESSION   NM_011386
VERSION     NM_011386.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6683)
  AUTHORS   Hung,Y.S., Lin,W.M., Wang,Y.C., Kuo,W.C., Chen,Y.Y., Fann,M.J.,
            Yu,J.Y. and Wong,Y.H.
  TITLE     Protogenin facilitates trunk-to-tail HOX code transition via
            modulating GDF11/SMAD2 signaling in mammalian embryos
  JOURNAL   Commun Biol 7 (1), 1669 (2024)
   PUBMED   39702818
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6683)
  AUTHORS   Zou,S., Huang,Y., Yang,Z., Zhang,J., Meng,M., Zhang,Y., Feng,J.,
            Sun,R., Li,W., Wang,W., Lopez,J.G. and Fang,L.
  TITLE     NSUN2 promotes colorectal cancer progression by enhancing SKIL mRNA
            stabilization
  JOURNAL   Clin Transl Med 14 (3), e1621 (2024)
   PUBMED   38468490
  REMARK    GeneRIF: NSUN2 promotes colorectal cancer progression by enhancing
            SKIL mRNA stabilization.
REFERENCE   3  (bases 1 to 6683)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 6683)
  AUTHORS   Xu,H., Wu,L., Nguyen,H.H., Mesa,K.R., Raghavan,V., Episkopou,V. and
            Littman,D.R.
  TITLE     Arkadia-SKI/SnoN signaling differentially regulates
            TGF-beta-induced iTreg and Th17 cell differentiation
  JOURNAL   J Exp Med 218 (11) (2021)
   PUBMED   34473197
  REMARK    GeneRIF: Arkadia-SKI/SnoN signaling differentially regulates
            TGF-beta-induced iTreg and Th17 cell differentiation.
REFERENCE   5  (bases 1 to 6683)
  AUTHORS   Zhu,Q. and Luo,K.
  TITLE     SnoN in regulation of embryonic development and tissue
            morphogenesis
  JOURNAL   FEBS Lett 586 (14), 1971-1976 (2012)
   PUBMED   22710172
  REMARK    Review article
REFERENCE   6  (bases 1 to 6683)
  AUTHORS   Macias-Silva,M., Li,W., Leu,J.I., Crissey,M.A. and Taub,R.
  TITLE     Up-regulated transcriptional repressors SnoN and Ski bind Smad
            proteins to antagonize transforming growth factor-beta signals
            during liver regeneration
  JOURNAL   J Biol Chem 277 (32), 28483-28490 (2002)
   PUBMED   12023281
REFERENCE   7  (bases 1 to 6683)
  AUTHORS   Shinagawa,T., Dong,H.D., Xu,M., Maekawa,T. and Ishii,S.
  TITLE     The sno gene, which encodes a component of the histone deacetylase
            complex, acts as a tumor suppressor in mice
  JOURNAL   EMBO J 19 (10), 2280-2291 (2000)
   PUBMED   10811619
REFERENCE   8  (bases 1 to 6683)
  AUTHORS   Pearson-White,S. and Crittenden,R.
  TITLE     Proto-oncogene Sno expression, alternative isoforms and immediate
            early serum response
  JOURNAL   Nucleic Acids Res 25 (14), 2930-2937 (1997)
   PUBMED   9207045
REFERENCE   9  (bases 1 to 6683)
  AUTHORS   Pelzer,T., Lyons,G.E., Kim,S. and Moreadith,R.W.
  TITLE     Cloning and characterization of the murine homolog of the sno
            proto-oncogene reveals a novel splice variant
  JOURNAL   Dev Dyn 205 (2), 114-125 (1996)
   PUBMED   8834472
REFERENCE   10 (bases 1 to 6683)
  AUTHORS   Pearson-White,S., Deacon,D., Crittenden,R., Brady,G., Iscove,N. and
            Quesenberry,P.J.
  TITLE     The ski/sno protooncogene family in hematopoietic development
  JOURNAL   Blood 86 (6), 2146-2155 (1995)
   PUBMED   7662963
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC117590.14.
            
            On Dec 23, 2021 this sequence version replaced NM_011386.3.
            
            Summary: This gene encodes a member of a small family of proteins
            that play a key role in the response of cells to extracellular
            growth signals. The encoded protein regulates members of the
            transforming growth factor beta signaling pathway. It is highly
            expressed in certain cancer cells, where it may have both
            tumor-suppressing and tumor-promoting roles. Alternatively spliced
            transcript variants encoding multiple isoforms have been observed
            for this gene. [provided by RefSeq, Nov 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223969.3606.1,
                                           SRR1660817.52878.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                AC117590.14        98441-98488         c
            49-1765             AC117590.14        95179-96895         c
            1766-1863           AC117590.14        81876-81973         c
            1864-2096           AC117590.14        79958-80190         c
            2097-2320           AC117590.14        76559-76782         c
            2321-2545           AC117590.14        76001-76225         c
            2546-6683           AC117590.14        71006-75143         c
FEATURES             Location/Qualifiers
     source          1..6683
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 15.12 cM"
     gene            1..6683
                     /gene="Skil"
                     /gene_synonym="Skir; sno; SnoN"
                     /note="SKI-like"
                     /db_xref="GeneID:20482"
                     /db_xref="MGI:MGI:106203"
     exon            1..48
                     /gene="Skil"
                     /gene_synonym="Skir; sno; SnoN"
                     /inference="alignment:Splign:2.1.0"
     exon            49..1765
                     /gene="Skil"
                     /gene_synonym="Skir; sno; SnoN"
                     /inference="alignment:Splign:2.1.0"
     CDS             677..2704
                     /gene="Skil"
                     /gene_synonym="Skir; sno; SnoN"
                     /note="isoform a is encoded by transcript variant 1;
                     ski-like protein; ski-related oncogene; ski/sno related"
                     /codon_start=1
                     /product="ski-like protein isoform a"
                     /protein_id="NP_035516.2"
                     /db_xref="CCDS:CCDS38408.1"
                     /db_xref="GeneID:20482"
                     /db_xref="MGI:MGI:106203"
                     /translation="MENLQSKFSLVQGSNKKLNGMEDDGSPPVKKMMTDIHANGKTLT
                     KVKKEHLDDYGDASVEPDGEHAKRNRVSLPETLNLNPSLKHTLAQFHLSSQSSLGGPA
                     AFSARYSQESMSPTVFLPLPSPQVLPGPLLIPSDSSTELTQTLLEGESISCFQVGGEK
                     RLCLPQVLNSVLREFSLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLI
                     TLTDAQRLCNALLRPRTFPQNGSILPAKSSLAQLKETGSAFEVEHECLGKCQGLFAPQ
                     FYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPDKRTCHWGFESAKWHCYLHVNQKYLG
                     TPEEKKLKIILEEMKEKFSMRNGKRIQSKTDTPSGMELPSWYPVIKQEGDHVPQTHSF
                     LHPSYYLYMCDKVVAPNVSLTSAASQSKEATKAETSKSTSKQSEKPHESSQHQKTVSY
                     PDVSLEEQEKMDLKTSRELYSCLDSSISNNSTSRKKSESAVCSLVRGTSKRDSEDSSP
                     LLVRDGEDDKGKIMEDVMRTYVRQQEKLNSILQRKQQLQMEVEMLSSSKAMKELTEEQ
                     QNLQKELESLQSEHAQRMEEFYIEQRDLEKKLEQVMQQKCTCDSTLEKDREAEYAAQL
                     AELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQIGKSSKPSKD"
     exon            1766..1863
                     /gene="Skil"
                     /gene_synonym="Skir; sno; SnoN"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..2096
                     /gene="Skil"
                     /gene_synonym="Skir; sno; SnoN"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2320
                     /gene="Skil"
                     /gene_synonym="Skir; sno; SnoN"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2545
                     /gene="Skil"
                     /gene_synonym="Skir; sno; SnoN"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..6683
                     /gene="Skil"
                     /gene_synonym="Skir; sno; SnoN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6644..6649
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Skil"
                     /gene_synonym="Skir; sno; SnoN"
                     /note="hexamer: AATAAA"
     regulatory      6663..6668
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Skil"
                     /gene_synonym="Skir; sno; SnoN"
                     /note="hexamer: AATGAA"
     polyA_site      6668
                     /gene="Skil"
                     /gene_synonym="Skir; sno; SnoN"
                     /note="major polyA site"
     polyA_site      6683
                     /gene="Skil"
                     /gene_synonym="Skir; sno; SnoN"
ORIGIN      
        1 acagcgaagg cggctggcga gcgacggcga cggcgacggc gggcacagat caattaaaag
       61 aagaatgagc tgtaatccct gaagataaaa ctggacagct ttttcattta gtatatgtat
      121 atttttaatt ataaaagttc aggtggagtc ttcagtttat cagtactgag cagcagatca
      181 ccattttcag ggacgatacc tgcctcttct tttttggtgt tcttggcaaa aattaaaccc
      241 attgcgtcat tgtaactcat gtttgggtgt agtttcagga tacagtcatg gtataaactt
      301 cccacatgct ttgcttaaaa aacaaaacca accaaactca accattacac cgaactttgg
      361 acttcttgaa ttgagcttta ttttaatata aatacctgaa gtgattttct cagaagtgtg
      421 cttacgatta tattcttatt tgttattaga agcaaacaaa actgagaagt tttgtagcat
      481 tttcaattat atcttaaagt acagctaaac caaaacagag ttgtacaatc tattgagtaa
      541 gaaaattcat ctttggaaag taaacatttc taagtgagtc ataagtattt gtatacattc
      601 cccttttctc ttcagattag gaactgagaa caacatgcca gttgcagact taatcgttta
      661 aagcaccagt gtggccatgg aaaacctcca gtctaagttc tccttagttc agggttcaaa
      721 taaaaagctg aacggcatgg aggatgatgg cagtcctcct gtgaaaaaaa tgatgaccga
      781 cattcatgcc aatgggaaaa ccctgaccaa ggtgaagaag gagcacttag atgactatgg
      841 agatgcatcc gtggagccgg atggcgagca cgccaagcga aaccgtgttt ctctacctga
      901 aactttaaat ttaaacccca gtctgaaaca cacgctggca caattccact taagcagtca
      961 gagctctttg ggtggaccag cagcattttc tgctcgatat tcccaggaga gcatgtcacc
     1021 gactgtattc ctgcctcttc cctctcctca ggttcttccc ggccctcttc tcattccttc
     1081 tgatagctcc acagagctca ctcagactct tttggaaggg gagtctattt cttgttttca
     1141 agttggagga gaaaagagac tctgtttgcc ccaagtctta aactctgtcc tccgagaatt
     1201 ttcactccag cagataaaca cagtatgtga tgagctgtac atctattgtt caaggtgtac
     1261 ttcagaccag cttcatatct taaaggtctt agggatactc ccatttaatg ctccatcctg
     1321 tgggctgatc acgttgaccg atgcacaaag actctgtaat gctttactgc ggccacgaac
     1381 ttttcctcaa aatggtagca tacttcctgc taaaagctct ctggcccagt tgaaggaaac
     1441 tggcagtgcc tttgaagtgg aacatgaatg cttgggcaaa tgtcagggtc tctttgcgcc
     1501 tcagttttat gttcagcccg acgctccctg tatccagtgc ctggagtgct gtggaatgtt
     1561 tgctccccag acgttcgtca tgcattcgca cagatcccct gacaagagaa cttgccattg
     1621 gggctttgag tcagccaagt ggcactgtta ccttcatgtg aaccaaaaat acctagggac
     1681 acccgaagaa aagaaactga agataatttt agaagaaatg aaggagaagt ttagcatgag
     1741 aaatggaaag agaatccaat caaagacaga tacaccatcg ggaatggaat tgccatcatg
     1801 gtatcctgtt ataaaacagg aaggtgacca tgttccccag acacattcat ttttacaccc
     1861 cagctactac ctgtacatgt gtgacaaagt ggttgcaccg aatgtgtcgc tcacatctgc
     1921 tgcgtcccag tctaaagagg ccaccaaggc agagacaagt aagtccacct ccaaacagtc
     1981 agaaaagcct catgagagta gtcagcatca aaaaacagtg tcttacccag acgtctcact
     2041 tgaggagcag gagaaaatgg atttaaaaac cagtagagaa ttatacagtt gtttagattc
     2101 atcaatctca aataattcta caagtagaaa gaaatctgag tctgctgtgt gcagcttagt
     2161 gagaggcaca agcaagcgtg attcagaaga ttcctctcca cttctggtca gagatggtga
     2221 agacgacaag gggaagatca tggaagacgt gatgagaacc tatgtaagac agcaggagaa
     2281 gctgaactcc attctgcaga ggaagcagca gctgcagatg gaggtggaga tgctgagcag
     2341 ttcaaaggcg atgaaggagc tcactgaaga gcagcagaat ctacagaaag agcttgagtc
     2401 gttacagagt gagcatgctc agaggatgga ggaattctat attgaacaga gagacttaga
     2461 gaaaaagctg gagcaggtga tgcagcagaa atgcacctgt gactcaacct tggagaagga
     2521 cagggaggcc gagtatgcgg ctcagctggc agaactgagg caaagactag accatgctga
     2581 ggccgacagg caggaactcc aagatgaact cagacaggag cgggaggcga gacagaagct
     2641 ggagatgatg ataaaggagc tgaagctgca gattggcaag tcgtccaagc cctccaagga
     2701 ctaagagctg aagaagacac acctgtgtgt ggttgacagg gctttgtgtt tgtcgcttgc
     2761 tttgaaaatt gaattctaac atcttatttg catgaaggta gctaggcatt ctgttcattt
     2821 gtatggcagc aaaagtgaag attatatatt aatacaaaat tttccatttc caaatgaatg
     2881 aaaatgtatg cttctttgta cttttccagt gggcttggta ataataacct gtgtaatttg
     2941 agcctgtggt cagtctacct gtatttctaa cagttgcata ctttccaaag ctgcagtctg
     3001 tggtggagag tacctgtgtc catggtatgc aatatttcag gctcagctta gatacagagg
     3061 taatgtttat gatacaaagc tattttgtat ccttctcatt acagactctt gggaagccgg
     3121 ttgttaattt gttcaggttg tagagtgggt ttcttctgtt tcctcctaga ggaatttgat
     3181 tgatggaatg atagtaccac ctccctaaca aacagtgtgt gtgtgtggag gggaggggca
     3241 gcctttgctg tgccctgatg ctgcacacaa gaagcagttg taatttgtct ttctgtttaa
     3301 gagtgactat ctctagattg tgtgtgtgag acttcagaaa attaaaatga tttctgaact
     3361 tttcctgtta acagtggtgt ggaagtactc attcatgctc acgaggaaaa tggattccac
     3421 tgatgtacgt tggttcctat gtaactcata atcttcttgt acagttttat atgtagtctt
     3481 acaaaggtct tatgaaattt atataatgga tttttttctt ttaaattata aaatactaaa
     3541 tatcttgaag attattttgg acttttgtat gtttaaatgt tatcttaaaa cttgcacgaa
     3601 tggaccatta tgactcttta atcttaaaat caggaattta cagtcagcta agaatatgtg
     3661 gtaggttaac agtccacaat tgaagtatct gctactagca ggaattttag atgacaaatg
     3721 aattccgtga tttggggaag ggcagccttt gcacttttct ttgtttttgt tttttgcaca
     3781 taaagtctga tgtttttatc accgaatttc acattagcag atgcttggct tgaaatttgc
     3841 tagggaaaat tttcggggaa ctttgtaatt ttttggtttt gttctgtttg gccaccactt
     3901 tgcagggatc ctcttgcctc tgcccacagt actgggtcga caggcctgag ctctgccacc
     3961 accggccctg tgcaggtttt agggatgttt ctgaaagcag ccctggcatt atcttctgtt
     4021 gcgtgtgccc cgggctgtct catagcgcta catgcacttg agatctgtgc ttaggaacaa
     4081 cttggagttt ggctgtcact gtcctccatg cggtaagaca tcggagccct gggttatcat
     4141 acctgcttat ggtcatactt tgtttcataa tacttgttta aaagatactt ttctactttc
     4201 caaacgggag tttgttttct aaatatattg tgaccttact gtggatttat tctactctgc
     4261 tctataattt agtgtggtga cttctgtaac cttgggagaa gcacgatagg tggcacaggg
     4321 accatgtatg tcattgtatt tagatctgga gggaggaagc cacgggcacc tgtaaagccg
     4381 ccttagctta gtagtcagtc cattgtaccc cagcttggct gcgtgggagg cacactcaag
     4441 gactcgcacc atttattttt ctgacagact cagaagtgtt ctgcttgggt gctgcttata
     4501 agtgtgattc ttctagtctt gaaacttgcc tcgtgacatt gttgagcggt agtcttcact
     4561 ttccagaaga tgaaatgatg tgccatcgtt ttctgtctaa acttccttac aatttttaat
     4621 caactgtaaa tagcatatct actgctgttg aaagtaactt taatttacat tgcatcatat
     4681 agcttgaaaa ccacctttga cattctgtaa taccccacaa gtgacctctg ctaaaatatc
     4741 cagatgaagc ttacttcgtg catgctcatt ctgtgtgctg gttgctctcg taaggttggc
     4801 tttggtgtga ggtctcgtgt gctatgccaa gttcactagg caagcagatt ttccttcaga
     4861 gtccatactc tgtttaggga ggaatgagac catttattct gagaaactat gtttaggagt
     4921 ggaagaaaca cagcgttagc tttcatactg agcaaagact gacgttgcta tgggtggtct
     4981 ctctctgtgg tccagactga gggctttgca ccaagtactt aagtgtggaa gctcctgtgc
     5041 catcaaggag gagtttaaac aaaccacctg ccaatcacag ctgagactga gcaccgaaag
     5101 attctaccaa cttaggtttg gctcgggctt taacagtttt gaagtatagt ctttagcttg
     5161 aatctcttgt gttttttgaa gataaggatg ttttatgctt cttgagctaa ttttataaca
     5221 tatttaatat ataacctgtt tatatgtaaa atcttttgta caggggtggg aaggagtaat
     5281 gaaaaacctg atttgtacat agtgaagttt atgtgcagac cgaagtcagt gaaccagtaa
     5341 ctgaggtgtt tgcaggctct ccacatcctt cagagtccgt gaagcgccca gtctgtgtgt
     5401 ctctggttcc tgtctgcaga aaagcaaaat gaaaaggaag cacaagtaat aggaactgtg
     5461 cccgaggtat ttccctagca ggagctgcaa agctggtcct gggggtctgc atcccctctg
     5521 gaaggcctgc cccacatgcc gtgctctgag tgaggaggga aggatgtgtg tttttgtttg
     5581 ttatgcattt actctttagg gcaggacgtt acaaactgat ggtaaattgt gttcatgcta
     5641 tgtacatgtg ctcctgaact tggatctact tgttaatggt tccatggaag caatcagcag
     5701 tgtgtgacat gaactgctgc attatgtatt tacttgtgga actgagatat gtaaacagag
     5761 cttacctttt tttttttttt ttttttttct agtgtaaaat acttaagcat ttccactatt
     5821 ggaagaaaaa acatatatgg acattttgta ttgtatcttg tttaaaagga cagtcttttt
     5881 taatcttccc acttaaatgg cttttaaaat atataataca atttgaagct tgtttagaaa
     5941 taggattaaa tgtcttatat agtgctacag ttttggaatt agaaagtgat caactataaa
     6001 acattttaaa attaagccca gaaaacaaaa tagtgtttaa agttagttta gtataaaaga
     6061 aatttataag atttttttct tcaatataag atacctcact tgagaataaa gaaagcacag
     6121 cacatttaaa gtaattctca tgaaaacccc attaaaataa ttgctaaacc taggacatct
     6181 tttgagttgt tagagtttgg gataaatgta gtcaccatta gtttctctgc tggaaggact
     6241 taccttggta attttaaggc agtgtaatag ttcaattatt cctcagtttc taacctgtga
     6301 aggcagtaag tgaatggtcc cttctgcaac tactgaaaca aattagctac attgagcata
     6361 attgataatt ttgccaatgc atatagtttt atgattaaaa ttgctgtggt tggttgcatt
     6421 acatgacaca caaaactgtc ctctacctca cgtgaaataa atattttata tggttttact
     6481 aaaaaaaaaa gactcatcta tctggttact tagtttacaa attttggatt atatttattg
     6541 aaacatgaca tactgtgctc ttggcttata cctcaattgt attttgagat gtttgccatt
     6601 ttcatgcctt gtacataact tgtatagatt ggatgatatt cccaataaaa acttttaatg
     6661 ccaatgaagt ttggttcaag tca
//
