LOCUS       NM_001039090            6545 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus SKI-like (Skil), transcript variant 2, mRNA.
ACCESSION   NM_001039090
VERSION     NM_001039090.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6545)
  AUTHORS   Hung,Y.S., Lin,W.M., Wang,Y.C., Kuo,W.C., Chen,Y.Y., Fann,M.J.,
            Yu,J.Y. and Wong,Y.H.
  TITLE     Protogenin facilitates trunk-to-tail HOX code transition via
            modulating GDF11/SMAD2 signaling in mammalian embryos
  JOURNAL   Commun Biol 7 (1), 1669 (2024)
   PUBMED   39702818
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6545)
  AUTHORS   Zou,S., Huang,Y., Yang,Z., Zhang,J., Meng,M., Zhang,Y., Feng,J.,
            Sun,R., Li,W., Wang,W., Lopez,J.G. and Fang,L.
  TITLE     NSUN2 promotes colorectal cancer progression by enhancing SKIL mRNA
            stabilization
  JOURNAL   Clin Transl Med 14 (3), e1621 (2024)
   PUBMED   38468490
  REMARK    GeneRIF: NSUN2 promotes colorectal cancer progression by enhancing
            SKIL mRNA stabilization.
REFERENCE   3  (bases 1 to 6545)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 6545)
  AUTHORS   Xu,H., Wu,L., Nguyen,H.H., Mesa,K.R., Raghavan,V., Episkopou,V. and
            Littman,D.R.
  TITLE     Arkadia-SKI/SnoN signaling differentially regulates
            TGF-beta-induced iTreg and Th17 cell differentiation
  JOURNAL   J Exp Med 218 (11) (2021)
   PUBMED   34473197
  REMARK    GeneRIF: Arkadia-SKI/SnoN signaling differentially regulates
            TGF-beta-induced iTreg and Th17 cell differentiation.
REFERENCE   5  (bases 1 to 6545)
  AUTHORS   Zhu,Q. and Luo,K.
  TITLE     SnoN in regulation of embryonic development and tissue
            morphogenesis
  JOURNAL   FEBS Lett 586 (14), 1971-1976 (2012)
   PUBMED   22710172
  REMARK    Review article
REFERENCE   6  (bases 1 to 6545)
  AUTHORS   Macias-Silva,M., Li,W., Leu,J.I., Crissey,M.A. and Taub,R.
  TITLE     Up-regulated transcriptional repressors SnoN and Ski bind Smad
            proteins to antagonize transforming growth factor-beta signals
            during liver regeneration
  JOURNAL   J Biol Chem 277 (32), 28483-28490 (2002)
   PUBMED   12023281
REFERENCE   7  (bases 1 to 6545)
  AUTHORS   Shinagawa,T., Dong,H.D., Xu,M., Maekawa,T. and Ishii,S.
  TITLE     The sno gene, which encodes a component of the histone deacetylase
            complex, acts as a tumor suppressor in mice
  JOURNAL   EMBO J 19 (10), 2280-2291 (2000)
   PUBMED   10811619
REFERENCE   8  (bases 1 to 6545)
  AUTHORS   Pearson-White,S. and Crittenden,R.
  TITLE     Proto-oncogene Sno expression, alternative isoforms and immediate
            early serum response
  JOURNAL   Nucleic Acids Res 25 (14), 2930-2937 (1997)
   PUBMED   9207045
REFERENCE   9  (bases 1 to 6545)
  AUTHORS   Pelzer,T., Lyons,G.E., Kim,S. and Moreadith,R.W.
  TITLE     Cloning and characterization of the murine homolog of the sno
            proto-oncogene reveals a novel splice variant
  JOURNAL   Dev Dyn 205 (2), 114-125 (1996)
   PUBMED   8834472
REFERENCE   10 (bases 1 to 6545)
  AUTHORS   Pearson-White,S., Deacon,D., Crittenden,R., Brady,G., Iscove,N. and
            Quesenberry,P.J.
  TITLE     The ski/sno protooncogene family in hematopoietic development
  JOURNAL   Blood 86 (6), 2146-2155 (1995)
   PUBMED   7662963
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC117590.14.
            
            On Dec 20, 2021 this sequence version replaced NM_001039090.2.
            
            Summary: This gene encodes a member of a small family of proteins
            that play a key role in the response of cells to extracellular
            growth signals. The encoded protein regulates members of the
            transforming growth factor beta signaling pathway. It is highly
            expressed in certain cancer cells, where it may have both
            tumor-suppressing and tumor-promoting roles. Alternatively spliced
            transcript variants encoding multiple isoforms have been observed
            for this gene. [provided by RefSeq, Nov 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK171402.1, AK154471.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                AC117590.14        98441-98488         c
            49-1765             AC117590.14        95179-96895         c
            1766-1863           AC117590.14        81876-81973         c
            1864-1958           AC117590.14        80096-80190         c
            1959-2182           AC117590.14        76559-76782         c
            2183-2407           AC117590.14        76001-76225         c
            2408-6545           AC117590.14        71006-75143         c
FEATURES             Location/Qualifiers
     source          1..6545
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 15.12 cM"
     gene            1..6545
                     /gene="Skil"
                     /gene_synonym="Skir; sno; SnoN"
                     /note="SKI-like"
                     /db_xref="GeneID:20482"
                     /db_xref="MGI:MGI:106203"
     exon            1..48
                     /gene="Skil"
                     /gene_synonym="Skir; sno; SnoN"
                     /inference="alignment:Splign:2.1.0"
     exon            49..1765
                     /gene="Skil"
                     /gene_synonym="Skir; sno; SnoN"
                     /inference="alignment:Splign:2.1.0"
     CDS             677..2566
                     /gene="Skil"
                     /gene_synonym="Skir; sno; SnoN"
                     /note="isoform b is encoded by transcript variant 2;
                     ski-like protein; ski-related oncogene; ski/sno related"
                     /codon_start=1
                     /product="ski-like protein isoform b"
                     /protein_id="NP_001034179.1"
                     /db_xref="CCDS:CCDS50886.1"
                     /db_xref="GeneID:20482"
                     /db_xref="MGI:MGI:106203"
                     /translation="MENLQSKFSLVQGSNKKLNGMEDDGSPPVKKMMTDIHANGKTLT
                     KVKKEHLDDYGDASVEPDGEHAKRNRVSLPETLNLNPSLKHTLAQFHLSSQSSLGGPA
                     AFSARYSQESMSPTVFLPLPSPQVLPGPLLIPSDSSTELTQTLLEGESISCFQVGGEK
                     RLCLPQVLNSVLREFSLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLI
                     TLTDAQRLCNALLRPRTFPQNGSILPAKSSLAQLKETGSAFEVEHECLGKCQGLFAPQ
                     FYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPDKRTCHWGFESAKWHCYLHVNQKYLG
                     TPEEKKLKIILEEMKEKFSMRNGKRIQSKTDTPSGMELPSWYPVIKQEGDHVPQTHSF
                     LHPSYYLYMCDKVVAPNVSLTSAASQSKEATKAETNSSISNNSTSRKKSESAVCSLVR
                     GTSKRDSEDSSPLLVRDGEDDKGKIMEDVMRTYVRQQEKLNSILQRKQQLQMEVEMLS
                     SSKAMKELTEEQQNLQKELESLQSEHAQRMEEFYIEQRDLEKKLEQVMQQKCTCDSTL
                     EKDREAEYAAQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQIGKSS
                     KPSKD"
     exon            1766..1863
                     /gene="Skil"
                     /gene_synonym="Skir; sno; SnoN"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..1958
                     /gene="Skil"
                     /gene_synonym="Skir; sno; SnoN"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2182
                     /gene="Skil"
                     /gene_synonym="Skir; sno; SnoN"
                     /inference="alignment:Splign:2.1.0"
     exon            2183..2407
                     /gene="Skil"
                     /gene_synonym="Skir; sno; SnoN"
                     /inference="alignment:Splign:2.1.0"
     exon            2408..6545
                     /gene="Skil"
                     /gene_synonym="Skir; sno; SnoN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6506..6511
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Skil"
                     /gene_synonym="Skir; sno; SnoN"
                     /note="hexamer: AATAAA"
     regulatory      6525..6530
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Skil"
                     /gene_synonym="Skir; sno; SnoN"
                     /note="hexamer: AATGAA"
     polyA_site      6530
                     /gene="Skil"
                     /gene_synonym="Skir; sno; SnoN"
                     /note="major polyA site"
     polyA_site      6545
                     /gene="Skil"
                     /gene_synonym="Skir; sno; SnoN"
ORIGIN      
        1 acagcgaagg cggctggcga gcgacggcga cggcgacggc gggcacagat caattaaaag
       61 aagaatgagc tgtaatccct gaagataaaa ctggacagct ttttcattta gtatatgtat
      121 atttttaatt ataaaagttc aggtggagtc ttcagtttat cagtactgag cagcagatca
      181 ccattttcag ggacgatacc tgcctcttct tttttggtgt tcttggcaaa aattaaaccc
      241 attgcgtcat tgtaactcat gtttgggtgt agtttcagga tacagtcatg gtataaactt
      301 cccacatgct ttgcttaaaa aacaaaacca accaaactca accattacac cgaactttgg
      361 acttcttgaa ttgagcttta ttttaatata aatacctgaa gtgattttct cagaagtgtg
      421 cttacgatta tattcttatt tgttattaga agcaaacaaa actgagaagt tttgtagcat
      481 tttcaattat atcttaaagt acagctaaac caaaacagag ttgtacaatc tattgagtaa
      541 gaaaattcat ctttggaaag taaacatttc taagtgagtc ataagtattt gtatacattc
      601 cccttttctc ttcagattag gaactgagaa caacatgcca gttgcagact taatcgttta
      661 aagcaccagt gtggccatgg aaaacctcca gtctaagttc tccttagttc agggttcaaa
      721 taaaaagctg aacggcatgg aggatgatgg cagtcctcct gtgaaaaaaa tgatgaccga
      781 cattcatgcc aatgggaaaa ccctgaccaa ggtgaagaag gagcacttag atgactatgg
      841 agatgcatcc gtggagccgg atggcgagca cgccaagcga aaccgtgttt ctctacctga
      901 aactttaaat ttaaacccca gtctgaaaca cacgctggca caattccact taagcagtca
      961 gagctctttg ggtggaccag cagcattttc tgctcgatat tcccaggaga gcatgtcacc
     1021 gactgtattc ctgcctcttc cctctcctca ggttcttccc ggccctcttc tcattccttc
     1081 tgatagctcc acagagctca ctcagactct tttggaaggg gagtctattt cttgttttca
     1141 agttggagga gaaaagagac tctgtttgcc ccaagtctta aactctgtcc tccgagaatt
     1201 ttcactccag cagataaaca cagtatgtga tgagctgtac atctattgtt caaggtgtac
     1261 ttcagaccag cttcatatct taaaggtctt agggatactc ccatttaatg ctccatcctg
     1321 tgggctgatc acgttgaccg atgcacaaag actctgtaat gctttactgc ggccacgaac
     1381 ttttcctcaa aatggtagca tacttcctgc taaaagctct ctggcccagt tgaaggaaac
     1441 tggcagtgcc tttgaagtgg aacatgaatg cttgggcaaa tgtcagggtc tctttgcgcc
     1501 tcagttttat gttcagcccg acgctccctg tatccagtgc ctggagtgct gtggaatgtt
     1561 tgctccccag acgttcgtca tgcattcgca cagatcccct gacaagagaa cttgccattg
     1621 gggctttgag tcagccaagt ggcactgtta ccttcatgtg aaccaaaaat acctagggac
     1681 acccgaagaa aagaaactga agataatttt agaagaaatg aaggagaagt ttagcatgag
     1741 aaatggaaag agaatccaat caaagacaga tacaccatcg ggaatggaat tgccatcatg
     1801 gtatcctgtt ataaaacagg aaggtgacca tgttccccag acacattcat ttttacaccc
     1861 cagctactac ctgtacatgt gtgacaaagt ggttgcaccg aatgtgtcgc tcacatctgc
     1921 tgcgtcccag tctaaagagg ccaccaaggc agagacaaat tcatcaatct caaataattc
     1981 tacaagtaga aagaaatctg agtctgctgt gtgcagctta gtgagaggca caagcaagcg
     2041 tgattcagaa gattcctctc cacttctggt cagagatggt gaagacgaca aggggaagat
     2101 catggaagac gtgatgagaa cctatgtaag acagcaggag aagctgaact ccattctgca
     2161 gaggaagcag cagctgcaga tggaggtgga gatgctgagc agttcaaagg cgatgaagga
     2221 gctcactgaa gagcagcaga atctacagaa agagcttgag tcgttacaga gtgagcatgc
     2281 tcagaggatg gaggaattct atattgaaca gagagactta gagaaaaagc tggagcaggt
     2341 gatgcagcag aaatgcacct gtgactcaac cttggagaag gacagggagg ccgagtatgc
     2401 ggctcagctg gcagaactga ggcaaagact agaccatgct gaggccgaca ggcaggaact
     2461 ccaagatgaa ctcagacagg agcgggaggc gagacagaag ctggagatga tgataaagga
     2521 gctgaagctg cagattggca agtcgtccaa gccctccaag gactaagagc tgaagaagac
     2581 acacctgtgt gtggttgaca gggctttgtg tttgtcgctt gctttgaaaa ttgaattcta
     2641 acatcttatt tgcatgaagg tagctaggca ttctgttcat ttgtatggca gcaaaagtga
     2701 agattatata ttaatacaaa attttccatt tccaaatgaa tgaaaatgta tgcttctttg
     2761 tacttttcca gtgggcttgg taataataac ctgtgtaatt tgagcctgtg gtcagtctac
     2821 ctgtatttct aacagttgca tactttccaa agctgcagtc tgtggtggag agtacctgtg
     2881 tccatggtat gcaatatttc aggctcagct tagatacaga ggtaatgttt atgatacaaa
     2941 gctattttgt atccttctca ttacagactc ttgggaagcc ggttgttaat ttgttcaggt
     3001 tgtagagtgg gtttcttctg tttcctccta gaggaatttg attgatggaa tgatagtacc
     3061 acctccctaa caaacagtgt gtgtgtgtgg aggggagggg cagcctttgc tgtgccctga
     3121 tgctgcacac aagaagcagt tgtaatttgt ctttctgttt aagagtgact atctctagat
     3181 tgtgtgtgtg agacttcaga aaattaaaat gatttctgaa cttttcctgt taacagtggt
     3241 gtggaagtac tcattcatgc tcacgaggaa aatggattcc actgatgtac gttggttcct
     3301 atgtaactca taatcttctt gtacagtttt atatgtagtc ttacaaaggt cttatgaaat
     3361 ttatataatg gatttttttc ttttaaatta taaaatacta aatatcttga agattatttt
     3421 ggacttttgt atgtttaaat gttatcttaa aacttgcacg aatggaccat tatgactctt
     3481 taatcttaaa atcaggaatt tacagtcagc taagaatatg tggtaggtta acagtccaca
     3541 attgaagtat ctgctactag caggaatttt agatgacaaa tgaattccgt gatttgggga
     3601 agggcagcct ttgcactttt ctttgttttt gttttttgca cataaagtct gatgttttta
     3661 tcaccgaatt tcacattagc agatgcttgg cttgaaattt gctagggaaa attttcgggg
     3721 aactttgtaa ttttttggtt ttgttctgtt tggccaccac tttgcaggga tcctcttgcc
     3781 tctgcccaca gtactgggtc gacaggcctg agctctgcca ccaccggccc tgtgcaggtt
     3841 ttagggatgt ttctgaaagc agccctggca ttatcttctg ttgcgtgtgc cccgggctgt
     3901 ctcatagcgc tacatgcact tgagatctgt gcttaggaac aacttggagt ttggctgtca
     3961 ctgtcctcca tgcggtaaga catcggagcc ctgggttatc atacctgctt atggtcatac
     4021 tttgtttcat aatacttgtt taaaagatac ttttctactt tccaaacggg agtttgtttt
     4081 ctaaatatat tgtgacctta ctgtggattt attctactct gctctataat ttagtgtggt
     4141 gacttctgta accttgggag aagcacgata ggtggcacag ggaccatgta tgtcattgta
     4201 tttagatctg gagggaggaa gccacgggca cctgtaaagc cgccttagct tagtagtcag
     4261 tccattgtac cccagcttgg ctgcgtggga ggcacactca aggactcgca ccatttattt
     4321 ttctgacaga ctcagaagtg ttctgcttgg gtgctgctta taagtgtgat tcttctagtc
     4381 ttgaaacttg cctcgtgaca ttgttgagcg gtagtcttca ctttccagaa gatgaaatga
     4441 tgtgccatcg ttttctgtct aaacttcctt acaattttta atcaactgta aatagcatat
     4501 ctactgctgt tgaaagtaac tttaatttac attgcatcat atagcttgaa aaccaccttt
     4561 gacattctgt aataccccac aagtgacctc tgctaaaata tccagatgaa gcttacttcg
     4621 tgcatgctca ttctgtgtgc tggttgctct cgtaaggttg gctttggtgt gaggtctcgt
     4681 gtgctatgcc aagttcacta ggcaagcaga ttttccttca gagtccatac tctgtttagg
     4741 gaggaatgag accatttatt ctgagaaact atgtttagga gtggaagaaa cacagcgtta
     4801 gctttcatac tgagcaaaga ctgacgttgc tatgggtggt ctctctctgt ggtccagact
     4861 gagggctttg caccaagtac ttaagtgtgg aagctcctgt gccatcaagg aggagtttaa
     4921 acaaaccacc tgccaatcac agctgagact gagcaccgaa agattctacc aacttaggtt
     4981 tggctcgggc tttaacagtt ttgaagtata gtctttagct tgaatctctt gtgttttttg
     5041 aagataagga tgttttatgc ttcttgagct aattttataa catatttaat atataacctg
     5101 tttatatgta aaatcttttg tacaggggtg ggaaggagta atgaaaaacc tgatttgtac
     5161 atagtgaagt ttatgtgcag accgaagtca gtgaaccagt aactgaggtg tttgcaggct
     5221 ctccacatcc ttcagagtcc gtgaagcgcc cagtctgtgt gtctctggtt cctgtctgca
     5281 gaaaagcaaa atgaaaagga agcacaagta ataggaactg tgcccgaggt atttccctag
     5341 caggagctgc aaagctggtc ctgggggtct gcatcccctc tggaaggcct gccccacatg
     5401 ccgtgctctg agtgaggagg gaaggatgtg tgtttttgtt tgttatgcat ttactcttta
     5461 gggcaggacg ttacaaactg atggtaaatt gtgttcatgc tatgtacatg tgctcctgaa
     5521 cttggatcta cttgttaatg gttccatgga agcaatcagc agtgtgtgac atgaactgct
     5581 gcattatgta tttacttgtg gaactgagat atgtaaacag agcttacctt tttttttttt
     5641 tttttttttt ctagtgtaaa atacttaagc atttccacta ttggaagaaa aaacatatat
     5701 ggacattttg tattgtatct tgtttaaaag gacagtcttt tttaatcttc ccacttaaat
     5761 ggcttttaaa atatataata caatttgaag cttgtttaga aataggatta aatgtcttat
     5821 atagtgctac agttttggaa ttagaaagtg atcaactata aaacatttta aaattaagcc
     5881 cagaaaacaa aatagtgttt aaagttagtt tagtataaaa gaaatttata agattttttt
     5941 cttcaatata agatacctca cttgagaata aagaaagcac agcacattta aagtaattct
     6001 catgaaaacc ccattaaaat aattgctaaa cctaggacat cttttgagtt gttagagttt
     6061 gggataaatg tagtcaccat tagtttctct gctggaagga cttaccttgg taattttaag
     6121 gcagtgtaat agttcaatta ttcctcagtt tctaacctgt gaaggcagta agtgaatggt
     6181 cccttctgca actactgaaa caaattagct acattgagca taattgataa ttttgccaat
     6241 gcatatagtt ttatgattaa aattgctgtg gttggttgca ttacatgaca cacaaaactg
     6301 tcctctacct cacgtgaaat aaatatttta tatggtttta ctaaaaaaaa aagactcatc
     6361 tatctggtta cttagtttac aaattttgga ttatatttat tgaaacatga catactgtgc
     6421 tcttggctta tacctcaatt gtattttgag atgtttgcca ttttcatgcc ttgtacataa
     6481 cttgtataga ttggatgata ttcccaataa aaacttttaa tgccaatgaa gtttggttca
     6541 agtca
//
