LOCUS       NM_023191               1225 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus SKI8 subunit of superkiller complex (Skic8),
            transcript variant 2, mRNA.
ACCESSION   NM_023191
VERSION     NM_023191.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1225)
  AUTHORS   Strikoudis,A., Lazaris,C., Trimarchi,T., Galvao Neto,A.L., Yang,Y.,
            Ntziachristos,P., Rothbart,S., Buckley,S., Dolgalev,I.,
            Stadtfeld,M., Strahl,B.D., Dynlacht,B.D., Tsirigos,A. and
            Aifantis,I.
  TITLE     Regulation of transcriptional elongation in pluripotency and cell
            differentiation by the PHD-finger protein Phf5a
  JOURNAL   Nat Cell Biol 18 (11), 1127-1138 (2016)
   PUBMED   27749823
REFERENCE   2  (bases 1 to 1225)
  AUTHORS   Cai,Y., Yoneda,M., Tomita,T., Kurotani,R., Okamoto,M., Kido,T.,
            Abe,H., Mitzner,W., Guha,A. and Kimura,S.
  TITLE     Transgenically-expressed secretoglobin 3A2 accelerates resolution
            of bleomycin-induced pulmonary fibrosis in mice
  JOURNAL   BMC Pulm Med 15, 72 (2015)
   PUBMED   26178733
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1225)
  AUTHORS   Higa,L.A., Wu,M., Ye,T., Kobayashi,R., Sun,H. and Zhang,H.
  TITLE     CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat
            proteins and regulates histone methylation
  JOURNAL   Nat Cell Biol 8 (11), 1277-1283 (2006)
   PUBMED   17041588
REFERENCE   4  (bases 1 to 1225)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
REFERENCE   5  (bases 1 to 1225)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159892.2 and AK013114.1.
            
            On Oct 1, 2013 this sequence version replaced NM_023191.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same protein (isoform a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF309554.1, BC023026.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AC159892.2         41314-41350         c
            38-1218             AK013114.1         2-1182
            1219-1225           AC159892.2         23954-23960         c
FEATURES             Location/Qualifiers
     source          1..1225
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 29.73 cM"
     gene            1..1225
                     /gene="Skic8"
                     /gene_synonym="2700038L12Rik; 2810418I05Rik; REC14; Ski8;
                     Wdr61"
                     /note="SKI8 subunit of superkiller complex"
                     /db_xref="GeneID:66317"
                     /db_xref="MGI:MGI:1917493"
     exon            1..75
                     /gene="Skic8"
                     /gene_synonym="2700038L12Rik; 2810418I05Rik; REC14; Ski8;
                     Wdr61"
                     /inference="alignment:Splign:2.1.0"
     exon            76..126
                     /gene="Skic8"
                     /gene_synonym="2700038L12Rik; 2810418I05Rik; REC14; Ski8;
                     Wdr61"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..1032
                     /gene="Skic8"
                     /gene_synonym="2700038L12Rik; 2810418I05Rik; REC14; Ski8;
                     Wdr61"
                     /note="isoform a is encoded by transcript variant 2; WD
                     repeat-containing protein 61; meiotic recombination
                     protein REC14; WD repeat domain 61; SKI8 subunit of
                     superkiller complex protein; superkiller complex protein
                     8"
                     /codon_start=1
                     /product="superkiller complex protein 8 isoform a"
                     /protein_id="NP_075680.1"
                     /db_xref="CCDS:CCDS23194.1"
                     /db_xref="GeneID:66317"
                     /db_xref="MGI:MGI:1917493"
                     /translation="MTNQYSILFKQEQAHDDAIWSVAWETNKKENIETVVTGSLDDLV
                     KVWKWRDERLELQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQMKSI
                     DAGPVDAWTLAFSPDSQYLATGTHMGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDG
                     KYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYD
                     VQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCIHTFFDHQDQ
                     VWGVKYNGNGSKIVSVGDDQEIHVYDCPI"
     exon            127..154
                     /gene="Skic8"
                     /gene_synonym="2700038L12Rik; 2810418I05Rik; REC14; Ski8;
                     Wdr61"
                     /inference="alignment:Splign:2.1.0"
     exon            155..260
                     /gene="Skic8"
                     /gene_synonym="2700038L12Rik; 2810418I05Rik; REC14; Ski8;
                     Wdr61"
                     /inference="alignment:Splign:2.1.0"
     exon            261..433
                     /gene="Skic8"
                     /gene_synonym="2700038L12Rik; 2810418I05Rik; REC14; Ski8;
                     Wdr61"
                     /inference="alignment:Splign:2.1.0"
     exon            434..582
                     /gene="Skic8"
                     /gene_synonym="2700038L12Rik; 2810418I05Rik; REC14; Ski8;
                     Wdr61"
                     /inference="alignment:Splign:2.1.0"
     exon            583..676
                     /gene="Skic8"
                     /gene_synonym="2700038L12Rik; 2810418I05Rik; REC14; Ski8;
                     Wdr61"
                     /inference="alignment:Splign:2.1.0"
     exon            677..770
                     /gene="Skic8"
                     /gene_synonym="2700038L12Rik; 2810418I05Rik; REC14; Ski8;
                     Wdr61"
                     /inference="alignment:Splign:2.1.0"
     exon            771..863
                     /gene="Skic8"
                     /gene_synonym="2700038L12Rik; 2810418I05Rik; REC14; Ski8;
                     Wdr61"
                     /inference="alignment:Splign:2.1.0"
     exon            864..942
                     /gene="Skic8"
                     /gene_synonym="2700038L12Rik; 2810418I05Rik; REC14; Ski8;
                     Wdr61"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1225
                     /gene="Skic8"
                     /gene_synonym="2700038L12Rik; 2810418I05Rik; REC14; Ski8;
                     Wdr61"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1196..1201
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Skic8"
                     /gene_synonym="2700038L12Rik; 2810418I05Rik; REC14; Ski8;
                     Wdr61"
                     /note="hexamer: AATAAA"
     polyA_site      1216
                     /gene="Skic8"
                     /gene_synonym="2700038L12Rik; 2810418I05Rik; REC14; Ski8;
                     Wdr61"
                     /note="major polyA site"
ORIGIN      
        1 ttcgttagct catccacgag cgccacggtc gtgctccact gacgtcaggc gtgctgtgcg
       61 gctggctgta cggtgaactg tctggccttt agcgcttcat ccttggttaa ggaaatgacc
      121 aaccagtaca gtattctctt caagcaagag caagcccatg atgatgccat atggtcagtt
      181 gcctgggaga caaacaaaaa ggaaaacatt gaaacagtgg tcacaggatc cctggatgac
      241 ctggtgaagg tctggaaatg gcgtgatgag aggctggagc tccagtggag cctggaggga
      301 catcagctcg gggtggtgtc tgtggacatc agccacactc ttcccattgc tgcatccagc
      361 tctctagacg ctcatattcg cctctgggac ttggaaaatg gcaaacagat gaagtctata
      421 gatgcaggac cagtggatgc ctggactttg gcattttctc ctgactccca gtatctggcc
      481 acaggaactc acatggggaa agtgaacatt tttggtgtgg aaagtggaaa aaaagaatat
      541 tctttggaca ctagaggaaa attcatcctt agtattgcat atagtcctga tgggaaatac
      601 ctggccagcg gagccataga cggaatcatc aatatttttg acattgcaac tggaaagctt
      661 ttgcatacgc tggaaggcca tgcgatgccc attcgctcct tgaccttttc ccctgactcc
      721 cagctccttg tcacggcttc agatgatggc tacatcaaga tctatgatgt acaacatgcc
      781 aatttggctg gcacactgag tggccatgcg tcctgggtgt tgaatgttgc gttctgtcct
      841 gatgacactc actttgtctc cagttcatct gacaaaagtg tgaaggtttg ggatgttgga
      901 acaaggacct gtattcacac cttctttgat caccaggatc aggtttgggg agtaaaatat
      961 aatggaaatg gatcaaaaat tgtatctgtt ggagatgacc aggaaattca tgtctatgac
     1021 tgcccaattt aaacaccagc atcctcgggg ctagggcctc agactacaca gggttgatca
     1081 tgacattcct cagatttttt ggcatactta aagtacagca tatattgtag aacttttgta
     1141 gatacaatat aaatttttcc tgttttattg gaaatgttct tcatatttta atgtaaataa
     1201 agcattctta atgcaaccac ctgca
//
