LOCUS       NM_021337               3972 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus SKI2 subunit of superkiller complex (Skic2), mRNA.
ACCESSION   NM_021337
VERSION     NM_021337.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3972)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3972)
  AUTHORS   Yang,K., Han,J., Asada,M., Gill,J.G., Park,J.Y., Sathe,M.N.,
            Gattineni,J., Wright,T., Wysocki,C.A., de la Morena,M.T.,
            Garza,L.A. and Yan,N.
  TITLE     Cytoplasmic RNA quality control failure engages mTORC1-mediated
            autoinflammatory disease
  JOURNAL   J Clin Invest 132 (2) (2022)
   PUBMED   35040435
REFERENCE   3  (bases 1 to 3972)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 3972)
  AUTHORS   Allcock,R.J., Martin,A.M. and Price,P.
  TITLE     The mouse as a model for the effects of MHC genes on human disease
  JOURNAL   Immunol Today 21 (7), 328-332 (2000)
   PUBMED   10871872
  REMARK    Review article
REFERENCE   5  (bases 1 to 3972)
  AUTHORS   Yang,Z. and Yu,C.Y.
  TITLE     Organizations and gene duplications of the human and mouse MHC
            complement gene clusters
  JOURNAL   Exp Clin Immunogenet 17 (1), 1-17 (2000)
   PUBMED   10686478
REFERENCE   6  (bases 1 to 3972)
  AUTHORS   Lee,C.G., Eki,T., Okumura,K., da Costa Soares,V. and Hurwitz,J.
  TITLE     Molecular analysis of the cDNA and genomic DNA encoding mouse RNA
            helicase A
  JOURNAL   Genomics 47 (3), 365-371 (1998)
   PUBMED   9480750
REFERENCE   7  (bases 1 to 3972)
  AUTHORS   Gee,S., Krauss,S.W., Miller,E., Aoyagi,K., Arenas,J. and
            Conboy,J.G.
  TITLE     Cloning of mDEAH9, a putative RNA helicase and mammalian homologue
            of Saccharomyces cerevisiae splicing factor Prp43
  JOURNAL   Proc Natl Acad Sci U S A 94 (22), 11803-11807 (1997)
   PUBMED   9342318
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK159854.1, AK087810.1 and CF546171.1.
            
            On Feb 15, 2006 this sequence version replaced NM_021337.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159854.1, BC065999.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1683              AK159854.1         2-1684
            1684-2377           AK087810.1         2317-3010
            2378-2891           AK159854.1         2379-2892
            2892-3184           AK087810.1         3527-3819
            3185-3892           AK087810.1         3821-4528
            3893-3972           CF546171.1         470-549
FEATURES             Location/Qualifiers
     source          1..3972
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.39 cM"
     gene            1..3972
                     /gene="Skic2"
                     /gene_synonym="4930534J06Rik; Ddx13; SKI; Ski2; Ski2w;
                     Skiv2l"
                     /note="SKI2 subunit of superkiller complex"
                     /db_xref="GeneID:108077"
                     /db_xref="MGI:MGI:1099835"
     exon            1..71
                     /gene="Skic2"
                     /gene_synonym="4930534J06Rik; Ddx13; SKI; Ski2; Ski2w;
                     Skiv2l"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..3784
                     /gene="Skic2"
                     /gene_synonym="4930534J06Rik; Ddx13; SKI; Ski2; Ski2w;
                     Skiv2l"
                     /EC_number="3.6.4.13"
                     /note="superkiller viralicidic activity 2-like; SKI2
                     subunit of superkiller complex protein"
                     /codon_start=1
                     /product="superkiller complex protein 2"
                     /protein_id="NP_067312.2"
                     /db_xref="CCDS:CCDS28661.1"
                     /db_xref="GeneID:108077"
                     /db_xref="MGI:MGI:1099835"
                     /translation="MMETERLVLPPLDPLNLPLRALEVGCTGRWELLNVPGPPESTLP
                     HGLPPCAPDLCQEAEQLFLSSPAWLPLHGVEHSARKWQRKTDPWSLLAAVETPVPSDL
                     QAQRHPTTGHILGYKEVLLENTNLSATTSLSLRRPPGPASQSLWGNPTQYPFWPGGMD
                     EPSITDLHTREEAEEEIDFEKDLLTVPPGFKKGVDFAPKDHPAPVPGLLSLSRLLEPL
                     DLSGGDEDEGEAAGGPRGDNASPSPSGTPLVRASSLEDLVLKEAATVVSTPEPPKPPP
                     QEQWAVPVDVTSPVGDFYRLIPQPAFQWAFEPDVFQKQAILHLEQHDSVFVAAHTSAG
                     KTVVAEYAIALAQKHMTRTIYTSPIKALSNQKFRDFRNTFGDVGLLTGDVQLHPEASC
                     LIMTTEILRSMLYSGSDVIRDLEWVIFDEVHYINDAERGVVWEEVLIMLPEHVSIILL
                     SATVPNALEFADWIGRLKRRQIYVISTVARPVPLEHYLFTGNSPKTQGELFLLLDSRG
                     AFHTQGYYAAVEAKKERMSKHAQTFGAKQPTHQGGPAQDRGVYLSLLASLRTRAQLPV
                     VVFTFSRGRCDEQASGLTSLDLTTSSEKSEIHLFLQRCLARLRGSDRQLPQVLHMSEL
                     LRRGLGVHHSGILPILKEIVEMLFSRGLVKVLFATETFAMGVNMPARTVVFDSMRKHD
                     GSTFRDLLPGEYVQMAGRAGRRGLDPTGTVILLCKGRVPEMADLHRMMMGKPSQLQSQ
                     FRLTYTMILNLLRVDALRVEDMMKRSFSEFPSRKDSKAHEQALADLTKRLGALEEPDV
                     TGQLADLPEYYSWAEELTETQNMIQRRIMESVNGLKSLSVGRVVVVKNEEHHNALGVI
                     LQVSSNSTSRVFTTLVLCDKPVVSDNPRDKGPATPDVPHPDDLIGFKLFLPEGPCEHT
                     VAKLQPGDVAAISTKVLRVNGEKISEDFSKRQQPKFRKDPPLAAVTTAVQELLRLAQS
                     YPAGPPTLDPINDLQLKDVAVVEGGLRARKLEELIRGAQCVHSPRFPAQYVKLRERMQ
                     IQKEMERLRFLLSDQSLLLLPEYHQRVEVLRTLGYVDEAGTVKLAGRVACAMSSHELL
                     LTELMFDNALSALRPEEIAALLSGLVCQSPGDPGDQLPSTLKQGVERVKAVAKRIGEV
                     QVACGLNQTVEEFVGELNFGLVEVVYEWARGMPFSELAGLSGTPEGLVVRCIQRLAEM
                     CRSLRGAARLVGEPVLGAKMETAATLLRRDIVFAASLYTQ"
     exon            72..175
                     /gene="Skic2"
                     /gene_synonym="4930534J06Rik; Ddx13; SKI; Ski2; Ski2w;
                     Skiv2l"
                     /inference="alignment:Splign:2.1.0"
     exon            176..285
                     /gene="Skic2"
                     /gene_synonym="4930534J06Rik; Ddx13; SKI; Ski2; Ski2w;
                     Skiv2l"
                     /inference="alignment:Splign:2.1.0"
     exon            286..403
                     /gene="Skic2"
                     /gene_synonym="4930534J06Rik; Ddx13; SKI; Ski2; Ski2w;
                     Skiv2l"
                     /inference="alignment:Splign:2.1.0"
     exon            404..518
                     /gene="Skic2"
                     /gene_synonym="4930534J06Rik; Ddx13; SKI; Ski2; Ski2w;
                     Skiv2l"
                     /inference="alignment:Splign:2.1.0"
     exon            519..593
                     /gene="Skic2"
                     /gene_synonym="4930534J06Rik; Ddx13; SKI; Ski2; Ski2w;
                     Skiv2l"
                     /inference="alignment:Splign:2.1.0"
     exon            594..647
                     /gene="Skic2"
                     /gene_synonym="4930534J06Rik; Ddx13; SKI; Ski2; Ski2w;
                     Skiv2l"
                     /inference="alignment:Splign:2.1.0"
     exon            648..829
                     /gene="Skic2"
                     /gene_synonym="4930534J06Rik; Ddx13; SKI; Ski2; Ski2w;
                     Skiv2l"
                     /inference="alignment:Splign:2.1.0"
     exon            830..958
                     /gene="Skic2"
                     /gene_synonym="4930534J06Rik; Ddx13; SKI; Ski2; Ski2w;
                     Skiv2l"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1104
                     /gene="Skic2"
                     /gene_synonym="4930534J06Rik; Ddx13; SKI; Ski2; Ski2w;
                     Skiv2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1251
                     /gene="Skic2"
                     /gene_synonym="4930534J06Rik; Ddx13; SKI; Ski2; Ski2w;
                     Skiv2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1336
                     /gene="Skic2"
                     /gene_synonym="4930534J06Rik; Ddx13; SKI; Ski2; Ski2w;
                     Skiv2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1443
                     /gene="Skic2"
                     /gene_synonym="4930534J06Rik; Ddx13; SKI; Ski2; Ski2w;
                     Skiv2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1590
                     /gene="Skic2"
                     /gene_synonym="4930534J06Rik; Ddx13; SKI; Ski2; Ski2w;
                     Skiv2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1687
                     /gene="Skic2"
                     /gene_synonym="4930534J06Rik; Ddx13; SKI; Ski2; Ski2w;
                     Skiv2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1900
                     /gene="Skic2"
                     /gene_synonym="4930534J06Rik; Ddx13; SKI; Ski2; Ski2w;
                     Skiv2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2011
                     /gene="Skic2"
                     /gene_synonym="4930534J06Rik; Ddx13; SKI; Ski2; Ski2w;
                     Skiv2l"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2242
                     /gene="Skic2"
                     /gene_synonym="4930534J06Rik; Ddx13; SKI; Ski2; Ski2w;
                     Skiv2l"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..2380
                     /gene="Skic2"
                     /gene_synonym="4930534J06Rik; Ddx13; SKI; Ski2; Ski2w;
                     Skiv2l"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..2518
                     /gene="Skic2"
                     /gene_synonym="4930534J06Rik; Ddx13; SKI; Ski2; Ski2w;
                     Skiv2l"
                     /inference="alignment:Splign:2.1.0"
     exon            2519..2623
                     /gene="Skic2"
                     /gene_synonym="4930534J06Rik; Ddx13; SKI; Ski2; Ski2w;
                     Skiv2l"
                     /inference="alignment:Splign:2.1.0"
     exon            2624..2774
                     /gene="Skic2"
                     /gene_synonym="4930534J06Rik; Ddx13; SKI; Ski2; Ski2w;
                     Skiv2l"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..2901
                     /gene="Skic2"
                     /gene_synonym="4930534J06Rik; Ddx13; SKI; Ski2; Ski2w;
                     Skiv2l"
                     /inference="alignment:Splign:2.1.0"
     exon            2902..3112
                     /gene="Skic2"
                     /gene_synonym="4930534J06Rik; Ddx13; SKI; Ski2; Ski2w;
                     Skiv2l"
                     /inference="alignment:Splign:2.1.0"
     exon            3113..3223
                     /gene="Skic2"
                     /gene_synonym="4930534J06Rik; Ddx13; SKI; Ski2; Ski2w;
                     Skiv2l"
                     /inference="alignment:Splign:2.1.0"
     exon            3224..3442
                     /gene="Skic2"
                     /gene_synonym="4930534J06Rik; Ddx13; SKI; Ski2; Ski2w;
                     Skiv2l"
                     /inference="alignment:Splign:2.1.0"
     exon            3443..3583
                     /gene="Skic2"
                     /gene_synonym="4930534J06Rik; Ddx13; SKI; Ski2; Ski2w;
                     Skiv2l"
                     /inference="alignment:Splign:2.1.0"
     exon            3584..3963
                     /gene="Skic2"
                     /gene_synonym="4930534J06Rik; Ddx13; SKI; Ski2; Ski2w;
                     Skiv2l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3928..3933
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Skic2"
                     /gene_synonym="4930534J06Rik; Ddx13; SKI; Ski2; Ski2w;
                     Skiv2l"
                     /note="hexamer: AATAAA"
     polyA_site      3945
                     /gene="Skic2"
                     /gene_synonym="4930534J06Rik; Ddx13; SKI; Ski2; Ski2w;
                     Skiv2l"
                     /note="major polyA site"
ORIGIN      
        1 gtggttactc tgagtttccg ggctgctcgg gagctgccgc ggctccagga tgatggagac
       61 ggagcgactc gttctgcctc ccctagatcc cctgaactta ccccttcgag ctctggaagt
      121 ggggtgcact ggccgttggg agctgctgaa cgtgccaggg cctccagaga gcactctccc
      181 ccatggcctc cctccatgcg ccccagatct gtgccaggaa gcagagcagc tgtttctgtc
      241 gtctccagcc tggcttcctc tacacggtgt agagcactca gctcgaaaat ggcagaggaa
      301 gacggatccc tggtcactcc tggctgccgt ggagactcca gtcccatctg accttcaggc
      361 ccagagacac ccaaccacag gccatatact gggctataag gaggtcctgc tggagaacac
      421 aaatctgtca gctacaacct ccttgtccct tcgccggcct ccagggccag cctcccagtc
      481 gctatggggc aatccaacac agtacccttt ctggccaggt gggatggatg agcccagcat
      541 aactgatctg catactcggg aggaagctga ggaggagata gactttgaga aagatcttct
      601 cactgtccca cctggcttca agaaaggggt ggattttgcc cccaaagatc atccagctcc
      661 tgtgccaggt ttgctcagcc tcagccgtct gctggagcct cttgatctga gtggaggtga
      721 cgaggatgaa ggcgaggcag caggaggccc tagaggggac aatgcctccc cctccccctc
      781 tggtactccc ctggtccgag caagcagctt ggaggatcta gtgttgaagg aagctgccac
      841 agtcgtatct accccggagc ctcccaaacc tccacctcag gaacagtggg ctgtgcctgt
      901 ggacgtcacc tcccctgtgg gcgactttta ccgtctcatc cctcagccag ctttccagtg
      961 ggcatttgag ccagatgtgt ttcagaagca ggccatcctg cacttggagc agcacgactc
     1021 tgtctttgtt gcagctcaca catctgctgg gaagacagtg gtggctgaat atgccatcgc
     1081 cctggcccag aaacacatga ctcgtaccat ctacacttct cctatcaaag ccctgagcaa
     1141 ccagaagttt cgggacttcc ggaacacatt tggggatgta gggctgctca caggggatgt
     1201 gcagctgcac ccagaggcct cctgcctcat catgaccacg gagatccttc gctccatgct
     1261 gtacagtggc tccgacgtca tccgagacct ggagtgggtc atctttgatg aagtccacta
     1321 tatcaatgat gctgagcgtg gggtcgtgtg ggaggaggtg ctcatcatgc ttcctgagca
     1381 cgtctccatc atccttctga gtgccaccgt ccccaatgcc ctggagtttg ctgactggat
     1441 cgggcggctg aagcggaggc agatctatgt gatcagcacg gttgcccggc cggtccccct
     1501 ggagcactat ctcttcacag ggaacagccc caagacgcag ggcgagctct tcctgctgct
     1561 ggactcccga ggggccttcc acacccaggg gtactatgct gcagtggagg ccaagaaaga
     1621 gaggatgagc aagcacgccc agactttcgg ggccaagcag cccacgcacc agggtgggcc
     1681 tgcacaggac cgcggggtgt acctgtccct gctggcttcc ctccggaccc gggctcagtt
     1741 gccagtggta gtgttcacct tctcccgagg ccgctgtgat gagcaggctt cgggcctcac
     1801 ctctctagac ctcacgacaa gctcggagaa gagtgagatc cacctcttcc tgcagcgctg
     1861 ccttgcacgg ctccgaggct ctgaccgaca gctaccccag gtcctgcaca tgtcggagct
     1921 ccttcgccga ggcctaggtg tgcaccacag cggcatcctg cccatcctta aggagattgt
     1981 ggaaatgctt ttcagcaggg gcctggtcaa ggtcttgttt gccaccgaga cttttgccat
     2041 gggggtaaac atgccagcca ggacggtggt gtttgactcc atgcgcaaac atgatggctc
     2101 taccttccgg gacctgctgc ctggggagta cgtgcagatg gcaggccggg caggccggag
     2161 gggcctggac cccacgggca ccgtcatcct tctctgtaag ggccgagtgc ctgagatggc
     2221 agatctacac cgcatgatga tggggaaacc atcccaactt cagtcccagt tccgcctcac
     2281 atataccatg atcctcaacc tgctgcgggt ggatgccctc agagtggagg acatgatgaa
     2341 gaggagcttc tcagagttcc catcccgcaa ggacagcaag gcccatgagc aggctctggc
     2401 tgacctcacc aagaggctgg gggctttgga ggagcctgat gtgactggtc agttggctga
     2461 cctacctgag tattacagct gggcggagga gctgacagag acccagaaca tgatccagcg
     2521 acgcatcatg gagtctgtga atgggctgaa atctctctca gtgggaaggg tggtagttgt
     2581 gaagaatgag gaacatcaca atgcactggg tgtgatcctg caggtctcct caaactccac
     2641 cagcagggta tttacaacat tggtcttgtg tgataagcct gttgtgtctg ataacccaag
     2701 ggacaagggg ccagccactc cagatgtgcc ccacccagat gaccttatag gcttcaagct
     2761 gttcctgcct gaagggccct gtgagcacac cgtggccaag ctccagccag gagatgtggc
     2821 tgccatctct accaaagtgc tccgggtgaa tggggagaag atctctgagg actttagcaa
     2881 gaggcagcaa ccaaaattca gaaaggaccc tccccttgcg gctgtgacca ctgctgttca
     2941 ggagctgctg cgtctggctc agtcctatcc agcaggaccc ccaacccttg accctatcaa
     3001 cgacctgcaa ctcaaggatg tggcagtggt agaaggtggg ctccgggccc ggaagctgga
     3061 ggagctgatc cgcggggctc agtgtgtgca cagcccccgg tttcctgccc agtacgtgaa
     3121 gctgcgggag cgaatgcaga ttcagaagga aatggagagg ctgcgcttcc tcctgtctga
     3181 ccagtcgctg ttactgctcc ctgagtacca ccagcgtgta gaggtgctcc ggactctggg
     3241 ctatgtggat gaggctggca cagtgaagct ggcaggccga gtggcctgtg ccatgagcag
     3301 ccatgagctg ctcctcactg aactcatgtt tgacaatgca ctgagcgctc tgcgaccaga
     3361 ggaaatcgca gctctgctct ctggcctggt gtgccagagc cccggggacc ctggcgacca
     3421 gctcccaagt accctcaaac agggggtaga acgagtcaaa gctgtggcca agcggattgg
     3481 cgaggttcag gtggcctgtg gcctgaacca gacagtggag gagtttgtgg gagagctgaa
     3541 ttttgggctg gtagaggttg tgtatgagtg ggctaggggt atgcccttct ccgagttggc
     3601 agggctctca gggacccctg agggcttggt cgtccgctgc atccagcgtc tggctgagat
     3661 gtgtcgctcg cttcgaggag cagcacgttt ggtgggtgag cctgtgctgg gtgccaagat
     3721 ggagacggca gccaccttgt tacggcggga catcgtcttc gcagccagcc tctacaccca
     3781 gtaaaggatg tgtggataga aatgtaacaa taagctgggt tgtagtagca gcgaaggggc
     3841 agataaatct ctttgagttt gatgccaacc atgttttgaa aaaactaaaa acaaacaaaa
     3901 aaaaccccct aaaaacccaa aaatataaat aaagagcaaa ccagagtgct tggagtatgg
     3961 taaaaaaaaa aa
//
