LOCUS       NM_011385               5481 bp    mRNA    linear   ROD 26-FEB-2023
DEFINITION  Mus musculus ski sarcoma viral oncogene homolog (avian) (Ski),
            transcript variant 1, mRNA.
ACCESSION   NM_011385 XM_990039
VERSION     NM_011385.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5481)
  AUTHORS   Zhai Y, Ye SY, Wang QS, Xiong RP, Fu SY, Du H, Xu YW, Peng Y, Huang
            ZZ, Yang N, Zhao Y, Ning YL, Li P and Zhou YG.
  TITLE     Overexpressed ski efficiently promotes neurorestoration, increases
            neuronal regeneration, and reduces astrogliosis after traumatic
            brain injury
  JOURNAL   Gene Ther 30 (1-2), 75-87 (2023)
   PUBMED   35132206
  REMARK    GeneRIF: Overexpressed ski efficiently promotes neurorestoration,
            increases neuronal regeneration, and reduces astrogliosis after
            traumatic brain injury.
REFERENCE   2  (bases 1 to 5481)
  AUTHORS   Wu B, Zhang G, Guo Z, Wang G, Xu X, Li JL, Whitmire JK, Zheng J and
            Wan YY.
  TITLE     The SKI proto-oncogene restrains the resident CD103+CD8+ T cell
            response in viral clearance
  JOURNAL   Cell Mol Immunol 18 (10), 2410-2421 (2021)
   PUBMED   32612153
  REMARK    GeneRIF: The SKI proto-oncogene restrains the resident
            CD103(+)CD8(+) T cell response in viral clearance.
REFERENCE   3  (bases 1 to 5481)
  AUTHORS   Ma J and Lwigale P.
  TITLE     Transformation of the Transcriptomic Profile of Mouse Periocular
            Mesenchyme During Formation of the Embryonic Cornea
  JOURNAL   Invest Ophthalmol Vis Sci 60 (2), 661-676 (2019)
   PUBMED   30786278
REFERENCE   4  (bases 1 to 5481)
  AUTHORS   Zhang S, Takaku M, Zou L, Gu AD, Chou WC, Zhang G, Wu B, Kong Q,
            Thomas SY, Serody JS, Chen X, Xu X, Wade PA, Cook DN, Ting JPY and
            Wan YY.
  TITLE     Reversing SKI-SMAD4-mediated suppression is essential for TH17 cell
            differentiation
  JOURNAL   Nature 551 (7678), 105-109 (2017)
   PUBMED   29072299
  REMARK    GeneRIF: study reveals a critical mechanism by which TGFbeta
            controls TH17 cell differentiation and uncovers the SKI-SMAD4 axis
            as a potential therapeutic target for treating TH17-related
            diseases
REFERENCE   5  (bases 1 to 5481)
  AUTHORS   Wang W, Song B, Anbarchian T, Shirazyan A, Sadik JE and Lyons KM.
  TITLE     Smad2 and Smad3 Regulate Chondrocyte Proliferation and
            Differentiation in the Growth Plate
  JOURNAL   PLoS Genet 12 (10), e1006352 (2016)
   PUBMED   27741240
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5481)
  AUTHORS   Pearson-White S, Deacon D, Crittenden R, Brady G, Iscove N and
            Quesenberry PJ.
  TITLE     The ski/sno protooncogene family in hematopoietic development
  JOURNAL   Blood 86 (6), 2146-2155 (1995)
   PUBMED   7662963
REFERENCE   7  (bases 1 to 5481)
  AUTHORS   Engert JC, Servaes S, Sutrave P, Hughes SH and Rosenthal N.
  TITLE     Activation of a muscle-specific enhancer by the Ski proto-oncogene
  JOURNAL   Nucleic Acids Res 23 (15), 2988-2994 (1995)
   PUBMED   7659522
REFERENCE   8  (bases 1 to 5481)
  AUTHORS   Autieri MV, Kozak CA, Cohen JA and Prystowsky MB.
  TITLE     Genomic organization and genetic mapping of the neuroimmune gene
            I2rf5 to mouse chromosome 4
  JOURNAL   Genomics 25 (1), 282-284 (1995)
   PUBMED   7774930
REFERENCE   9  (bases 1 to 5481)
  AUTHORS   Goodwin RG, Anderson D, Jerzy R, Davis T, Brannan CI, Copeland NG,
            Jenkins NA and Smith CA.
  TITLE     Molecular cloning and expression of the type 1 and type 2 murine
            receptors for tumor necrosis factor
  JOURNAL   Mol Cell Biol 11 (6), 3020-3026 (1991)
   PUBMED   1645445
REFERENCE   10 (bases 1 to 5481)
  AUTHORS   Nomura N, Sasamoto S, Ishii S, Date T, Matsui M and Ishizaki R.
  TITLE     Isolation of human cDNA clones of ski and the ski-related gene, sno
  JOURNAL   Nucleic Acids Res 17 (14), 5489-5500 (1989)
   PUBMED   2762147
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL670413.19, CA750434.1, CA451127.1, CB722801.1, CN526656.1 and
            AW491584.1.
            
            [WARNING] On Jan 19, 2024 this sequence was replaced by
            NM_011385.3.
            
            On Aug 26, 2006 this sequence version replaced NM_011385.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.37676.1, AF435852.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-359               AL670413.19        180829-181187       c
            360-984             CA750434.1         1-625
            985-1331            CA451127.1         309-655
            1332-1940           CB722801.1         41-649
            1941-2548           CN526656.1         85-692
            2549-5199           AL670413.19        112993-115643       c
            5200-5481           AW491584.1         1-282               c
FEATURES             Location/Qualifiers
     source          1..5481
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 86.17 cM"
     gene            1..5481
                     /gene="Ski"
                     /gene_synonym="2310012I02Rik; 2610001A11Rik"
                     /note="ski sarcoma viral oncogene homolog (avian)"
                     /db_xref="GeneID:20481"
                     /db_xref="MGI:MGI:98310"
     exon            1..984
                     /gene="Ski"
                     /gene_synonym="2310012I02Rik; 2610001A11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..2199
                     /gene="Ski"
                     /gene_synonym="2310012I02Rik; 2610001A11Rik"
                     /note="isoform 1 is encoded by transcript variant 1; ski
                     oncogene; C-ski; proto-oncogene c-Ski; Sloan-Kettering
                     viral oncogene homolog"
                     /codon_start=1
                     /product="ski oncogene isoform 1"
                     /protein_id="NP_035515.2"
                     /db_xref="CCDS:CCDS19024.1"
                     /db_xref="GeneID:20481"
                     /db_xref="MGI:MGI:98310"
                     /translation="MEAAAAGRGGFQPHPGLQKTLEQFHLSSMSSLGGPAAFSARWAQ
                     EAYKKESAKEAGAATVPAPVPTAAEPPPVLHLPAIQPPPPVLPGPFFMPSDRSTERCE
                     TVLEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINSVCDELHIYCSRCTADQLEI
                     LKVMGILPFSAPSCGLITKTDAERLCNALLYGGAYPPPCKKELAASLALGLELSERSV
                     RVYHECFGKCKGLLVPELYSSPSAACIQCLDCRLMYPPHKFVVHSHKALENRTCHWGF
                     DSANWRAYILLSQDYTGKEEQARLGRCLDDVKEKFDYANKYKRRVPRVSEPPASIRPK
                     TDDTSSQSPASSEKDKQSTWLRTLAGSSNKSLGCTHPRQRLSAFRPWSPAVSASEKET
                     SPHLPALIRDSFYSYKSFETAVAPNVALAPPTQQKVVNSPPCTTVVSRAPEPLTTCIQ
                     PRKRKLTLDTAGAPDMLTPVAAAEEDKDSEAEVEVESREEFTSSLSSLSSPSFTSSSS
                     AKDLSSPGMHAPPVVAPDAAAHVDAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVV
                     KMRVKQEEKLTAALQAKRSLHQELEFLRVAKKEKLREATEAKRSLRKEIERLRAENEK
                     KMKEANESRVRLKRELEQARQVRVCDKGCEAGRLRAKYSAQIEDLQAKLQHAEADREQ
                     LRADLLREREAREHLEKVVRELQEQLRPRPRPEHPGGESNAELGP"
     exon            985..1107
                     /gene="Ski"
                     /gene_synonym="2310012I02Rik; 2610001A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1223
                     /gene="Ski"
                     /gene_synonym="2310012I02Rik; 2610001A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1486
                     /gene="Ski"
                     /gene_synonym="2310012I02Rik; 2610001A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1779
                     /gene="Ski"
                     /gene_synonym="2310012I02Rik; 2610001A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..2010
                     /gene="Ski"
                     /gene_synonym="2310012I02Rik; 2610001A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..5465
                     /gene="Ski"
                     /gene_synonym="2310012I02Rik; 2610001A11Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcccgatc gcaccatgga agctgcagcg gccggccggg gcggcttcca gccgcacccg
       61 gggctgcaga agacgctgga gcagttccac ctgagctcca tgagctcgct gggcggcccg
      121 gccgctttct cggcgcgctg ggcgcaggag gcctacaaga aggagagcgc caaggaggcg
      181 ggtgcggcca cagtgccggc gccggtgccc actgccgcgg agccgccgcc cgtgctgcac
      241 ctgcctgcca tccagccgcc gccgcccgtg cttcccgggc ccttcttcat gccgtcggac
      301 cgctccaccg agcgctgtga gaccgtgctg gaaggggaga ccatctcttg tttcgtggtg
      361 ggaggtgaga agcgtctgtg cctgccgcag atcctcaact cggtgctgcg cgacttctca
      421 ctgcagcaga tcaactccgt gtgcgatgag ctgcacatct actgctcgcg ctgcaccgcc
      481 gaccagctgg agatcctcaa agtcatgggc atcctgccct tctccgcgcc ctcctgcggg
      541 ctcatcacta agacggacgc cgagcgcctg tgcaacgcgc tgctctacgg cggcgcctac
      601 ccgccgcctt gcaagaagga gttggcggcc agcctggcgc tgggcctgga gctcagcgaa
      661 cgcagcgtcc gcgtgtacca cgagtgcttc ggcaagtgca aagggctgct ggtgcccgag
      721 ctgtacagca gtcccagcgc tgcctgcatc cagtgcctcg actgccgcct catgtacccg
      781 ccgcacaagt tcgttgtaca ctcgcacaag gccctggaga accggacctg ccactggggc
      841 ttcgactcag ccaactggcg ggcctacatc ctgctgagcc aggactacac gggcaaggag
      901 gagcaggccc gccttggccg ctgcctggac gacgtgaagg agaagttcga ctatgccaac
      961 aagtacaagc ggagggtgcc ccgggtctca gagcccccag cttccataag acccaaaaca
     1021 gacgacactt cctcacagtc ccctgcgtct tctgagaagg acaagcagtc cacttggctg
     1081 cggaccttgg ctggttcctc caataagagc ctcggctgca ctcaccctcg ccagcgcctt
     1141 tctgctttcc ggccctggtc ccctgcagtg tctgcgagtg agaaagagac gtccccacac
     1201 ctcccagctt tgattcgaga cagcttctac tcctacaaga gctttgagac agccgtggcc
     1261 cccaatgtgg ccctagcacc accaacccag caaaaggttg tgaacagtcc accctgcacc
     1321 accgtggtct cccgggcacc agagcctctt actacttgta tccagccacg aaaacggaag
     1381 ctgactctgg acacagcagg agccccagac atgctgacac ctgtggctgc tgcagaggaa
     1441 gacaaggatt ctgaggccga ggttgaagtt gaaagcagag aggagttcac ctcctccttg
     1501 tcctcgctgt cctctccgtc ctttacctcg tccagctctg ccaaggatct aagctcccca
     1561 ggcatgcatg ctccgcccgt ggttgccccc gatgctgcag cccatgttga tgccccaagt
     1621 gggctggagg cagagttgga gcacctgcgg caagccctgg agggtggcct ggatactaag
     1681 gaagccaaag aaaagttcct gcatgaggtg gtcaaaatgc gagttaagca agaggaaaag
     1741 ctgacagcag ccctgcaggc taagcgcagc ctgcaccagg agctagaatt cttgcgtgtg
     1801 gccaagaagg agaaactgcg ggaagccaca gaggccaagc gcagtttgag gaaagagatt
     1861 gagcggctcc gagctgaaaa cgagaagaag atgaaagagg ccaacgagtc ccgggtgcgc
     1921 ctgaagcgag agctggagca ggcgcggcag gtccgggtgt gtgacaaggg ctgcgaggcc
     1981 gggcgcctgc gtgccaagta ctcagcccag attgaggacc tgcaagcgaa gctgcagcat
     2041 gcggaggccg accgcgagca gcttcgagct gacctgctgc gggaacgtga ggcccgcgag
     2101 catctggaga aggtggtgag ggagcttcag gagcagctgc ggcctcggcc acggcctgag
     2161 catcctggag gtgagagcaa cgctgagctg ggtccctagc ctgggcagtg attgccactg
     2221 ccacgtggac ccctatgcgt gcgcagaggg cagcgggtat gtggctttgc aggcccggcc
     2281 catgcctctg cagccacaca gcacaacgtc tctactgtgc ctattaccaa gcgagtgttt
     2341 gtaaccacat acttttggaa tccactgcaa aattttctac tggccaagtt caagtgagca
     2401 agccatgccc ccagctgcag tcagagttga gaccggctct gtggctcgta gctggttctc
     2461 tgcttgctag aacattctaa catttacact tttgttataa gctatttaaa accagtaagg
     2521 agacttgata ttcagagaat caacatgttt tttaatgact aactgtaaaa ggcccctaca
     2581 cgtgacgcca tctggacacc cactctggcg ggggtggcac cacccaccgc cgtcctggga
     2641 agccatcacc gctcatctgt gcccgcggct acaagaggac agcaagggtt ttcttcagag
     2701 tctatttttt cagcaacaag gaccccagtc ttcctgctgc tgccaggaag agcagggaga
     2761 gcgccgcgtg cgagatgagc cccaacactg cccgccttac cgccgctgcc ccgcccatca
     2821 ccatcaccac taaccccgcc ctgcgggcac caggaggcct gagcctcggt ttgcccaggc
     2881 ccctgggtgc ccctgcccac ctacaccttg aggggctgac ctgtgttagg cagtggccat
     2941 ggcccagtgt gatgttgtgt tgctcacaca cgccacccag ccacccatgc gctgcctgac
     3001 cacagcaacc ccctcccgtg cggcagacgt cactcctcgc atcgtgagct gaggctgcag
     3061 cattggaaca aaacagcatt acatcacttt tcctttaatt tttttttcct tttgttttgt
     3121 tgttgtttgt tgttcattta aacatgtatt tagaactgca ctttgtcaga accttccagt
     3181 cccttcttac tccccggtta actgaggttt ttaccaattt ctagagcagt tcaaacccta
     3241 agtgctcaag cgcttacaca tcccctctgg tgcttggttg aacaagggaa tcacgagaca
     3301 atgaaaatgc agagactgaa cttgggggtc gttctgtgcc ttccagcatc ttgtacagca
     3361 aaccctgact tgtctttata cccccaaaat accgtcttca gtagcgactg aatctgccac
     3421 tgtcaaaata cgttacttgc atttattcca aataatctcg tttactctta actgtttatg
     3481 caaattgtat aaggtttctt atgcccaagc ttgaaaaatg atttcccagt agacaagagg
     3541 cccccaccca tcctccaatt gtgtttattt acatgagaag atcatacaaa agccctccgc
     3601 tctagtccta gcagggcagc catgagccga ggggaggtgg agaaggcttg tgcaggtaca
     3661 aacgacctca aggactgtgg cctgcaactg gagactgcta agccctgacg tctggtgccg
     3721 aggtcgtctg cagggttttg cccttggttt actgaggggg gctgagctgc tgctggtccc
     3781 cccttctgac gtgcaatgca aaagggacat catgtatacg cagcatttat ttggagtttt
     3841 tcctttggct ttttttcctc tctttttcag ttatgaaact tgtatgcatg gatttcacat
     3901 ctccatagct agacccgcca tgggcattat gaccgtgtct cctaaagggt cggttttgtt
     3961 acgcaacacg aagaatgctg tctcagcctt gtttttctag agttgtgttt ttcagtcatt
     4021 tcttcaagaa aaactaaaat gatttagttg gagcaaagct ttaagtgtgt tggtgtgctt
     4081 ctgtgtggct gtccctgttg ctagcagatc acagtgattt ggtcccattg gagcctttgg
     4141 ccccaggggc actcactttt tctcatcaga gtctctcctt gccacagccc gggtcaccat
     4201 cggttccctg gcctccctcc gtggtccagc actggcccca gtatgctgtg tatgcagcag
     4261 ggactctttt ccccacatgc caggatgact tggatctggg aagggcgtgt catctcagtt
     4321 tgttcctccc gcacccctcc tccccctgct tcctgtggga tcagagtaag gctcctgttg
     4381 gccagtagct tgtgatctgg gacctctggg gcctcgtgtc tgcctcactc ccgggcccca
     4441 gtcctgggtg aagttggcaa agcactgggt atcttgtgcg gctgccgtgg aaggcggccc
     4501 tgctcgatgc agggtctgca gtggcctgag ggcagccagg cactgcatgc ctgtctcctt
     4561 atgaggaagg ctgcaaattt cagagaaagg gaggtgaggt ttccaccatg ttggctgttg
     4621 actctccctg tatgttaaac ccttgaccag tttactcgtt tctatcctgg aagattttta
     4681 acaaagggaa aaaccaacag caataagtca ttggtgagca gctaactcgc tcattgatga
     4741 gcagctaact ctcacacaca tacacacaca cacacacaca cacacacccc gacaccctgc
     4801 ttttcataca gaactagcca atgtaaagat gactcacatg taaatacttt tttccatttc
     4861 acaccgttgt attataagtg tatatggcga ctccttttcc agaaactttt cttacctgtt
     4921 ggttgtcttg tttcctgggt tgtttttaac tgaagacaaa attgctcatt tgccagaggg
     4981 gacagaagca tcttgtggca tttcccatgt ggtggcctcc atggcaccca ctctcccagt
     5041 tcctatgcag gttatcccct gtggtttctc cccacatgcc taccctacct agggctgagg
     5101 gggaggggct cttgctttaa gtcagaagtc tcaaatgaca tgctcatcaa ttaaaggaaa
     5161 aaaaaaaccc cacctcaacc ttcataactg cccaacaact acccccaccc ccacccgcgc
     5221 cctccagtcc tacgctgctg ctaacgacaa tacgacggct tactctgcta ctcgagaact
     5281 atttttatgt aattaatgta tgctttcttg tttataaatg cctgatttaa aaaaaaaaaa
     5341 gaggaaacaa agaaaaagct tggcatattt atctatttct ctgtgtacct gttagtcctt
     5401 ttgccctctc ctctccccac cccccagaaa cagatgacgt tgtacaataa aggactttgc
     5461 gagtaaaaaa aaaaaaaaaa a
//
