LOCUS       NM_018773               1656 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus src family associated phosphoprotein 2 (Skap2), mRNA.
ACCESSION   NM_018773
VERSION     NM_018773.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1656)
  AUTHORS   Ye,Q., Bhojwani,A. and Hu,J.K.
  TITLE     Understanding the development of oral epithelial organs through
            single cell transcriptomic analysis
  JOURNAL   Development 149 (16) (2022)
   PUBMED   35831953
REFERENCE   2  (bases 1 to 1656)
  AUTHORS   Takagane,K., Umakoshi,M., Itoh,G., Kuriyama,S., Goto,A. and
            Tanaka,M.
  TITLE     SKAP2 suppresses inflammation-mediated tumorigenesis by regulating
            SHP-1 and SHP-2
  JOURNAL   Oncogene 41 (8), 1087-1099 (2022)
   PUBMED   35034964
  REMARK    GeneRIF: SKAP2 suppresses inflammation-mediated tumorigenesis by
            regulating SHP-1 and SHP-2.
REFERENCE   3  (bases 1 to 1656)
  AUTHORS   Nguyen,G.T., Xu,S., Adams,W., Leong,J.M., Bunnell,S.C.,
            Mansour,M.K., Sykes,D.B. and Mecsas,J.
  TITLE     Neutrophils require SKAP2 for reactive oxygen species production
            following C-type lectin and Candida stimulation
  JOURNAL   iScience 24 (8), 102871 (2021)
   PUBMED   34386732
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1656)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1656)
  AUTHORS   Shaban,L., Nguyen,G.T., Mecsas-Faxon,B.D., Swanson,K.D., Tan,S. and
            Mecsas,J.
  TITLE     Yersinia pseudotuberculosis YopH targets SKAP2-dependent and
            independent signaling pathways to block neutrophil antimicrobial
            mechanisms during infection
  JOURNAL   PLoS Pathog 16 (5), e1008576 (2020)
   PUBMED   32392230
  REMARK    GeneRIF: These findings reveal that YopH prevents activation of
            both SKAP2-dependent and -independent neutrophilic defenses,
            uncouple integrin- and GPCR-dependent ROS production from FcgammaR
            responses based on their SKAP2 dependency, and show that SKAP2 is
            not required for degranulation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1656)
  AUTHORS   Curtis,D.J., Jane,S.M., Hilton,D.J., Dougherty,L., Bodine,D.M. and
            Begley,C.G.
  TITLE     Adaptor protein SKAP55R is associated with myeloid differentiation
            and growth arrest
  JOURNAL   Exp Hematol 28 (11), 1250-1259 (2000)
   PUBMED   11063873
REFERENCE   7  (bases 1 to 1656)
  AUTHORS   Black,D.S., Marie-Cardine,A., Schraven,B. and Bliska,J.B.
  TITLE     The Yersinia tyrosine phosphatase YopH targets a novel
            adhesion-regulated signalling complex in macrophages
  JOURNAL   Cell Microbiol 2 (5), 401-414 (2000)
   PUBMED   11207596
REFERENCE   8  (bases 1 to 1656)
  AUTHORS   Timms,J.F., Swanson,K.D., Marie-Cardine,A., Raab,M., Rudd,C.E.,
            Schraven,B. and Neel,B.G.
  TITLE     SHPS-1 is a scaffold for assembling distinct adhesion-regulated
            multi-protein complexes in macrophages
  JOURNAL   Curr Biol 9 (16), 927-930 (1999)
   PUBMED   10469599
REFERENCE   9  (bases 1 to 1656)
  AUTHORS   Marie-Cardine,A., Verhagen,A.M., Eckerskorn,C. and Schraven,B.
  TITLE     SKAP-HOM, a novel adaptor protein homologous to the FYN-associated
            protein SKAP55
  JOURNAL   FEBS Lett 435 (1), 55-60 (1998)
   PUBMED   9755858
REFERENCE   10 (bases 1 to 1656)
  AUTHORS   Zambrowicz,B.P., Friedrich,G.A., Buxton,E.C., Lilleberg,S.L.,
            Person,C. and Sands,A.T.
  TITLE     Disruption and sequence identification of 2,000 genes in mouse
            embryonic stem cells
  JOURNAL   Nature 392 (6676), 608-611 (1998)
   PUBMED   9560157
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC003711.1.
            
            On Jun 19, 2003 this sequence version replaced NM_018773.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003711.1, SRR1660815.108317.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1656
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 25.35 cM"
     gene            1..1656
                     /gene="Skap2"
                     /gene_synonym="2610021A10Rik; mSKAP55R; RA70; Saps; Scap2;
                     SKAP-HOM"
                     /note="src family associated phosphoprotein 2"
                     /db_xref="GeneID:54353"
                     /db_xref="MGI:MGI:1889206"
     exon            1..215
                     /gene="Skap2"
                     /gene_synonym="2610021A10Rik; mSKAP55R; RA70; Saps; Scap2;
                     SKAP-HOM"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..1225
                     /gene="Skap2"
                     /gene_synonym="2610021A10Rik; mSKAP55R; RA70; Saps; Scap2;
                     SKAP-HOM"
                     /note="SKAP55 homologue; Src-associated adaptor protein;
                     pyk2/RAFTK-associated protein; src-associated adapter
                     protein with PH and SH3 domains; src kinase-associated
                     phosphoprotein 55-related protein"
                     /codon_start=1
                     /product="src kinase-associated phosphoprotein 2"
                     /protein_id="NP_061243.1"
                     /db_xref="CCDS:CCDS20137.1"
                     /db_xref="GeneID:54353"
                     /db_xref="MGI:MGI:1889206"
                     /translation="MPNPSCTSSPGPLPEEIRNLLADVETFVADTLKGENLSKKAKEK
                     RESLIKKIKDVKSVYLQEFQDKGDAEDGDEYDDPFAGPADTISLASERYDKDDDGPSD
                     GNQFPPIAAQDLPFVIKAGYLEKRRKDHSFLGFEWQKRWCALSKTVFYYYGSDKDKQQ
                     KGEFAIDGYDVRMNNTLRKDGKKDCCFEICAPDKRIYQFTAASPKDAEEWVQQLKFIL
                     QDLGSDVIPEDDEERGELYDDVDHPAAVSSPQRSQPIDDEIYEELPEEEEDTASVKMD
                     EQGKGSRDSVHHTSGDKSTDYANFYQGLWDCTGALSDELSFKRGDVIYILSKEYNRYG
                     WWVGEMKGAIGLVPKAYLMEMYDI"
     exon            216..321
                     /gene="Skap2"
                     /gene_synonym="2610021A10Rik; mSKAP55R; RA70; Saps; Scap2;
                     SKAP-HOM"
                     /inference="alignment:Splign:2.1.0"
     exon            322..347
                     /gene="Skap2"
                     /gene_synonym="2610021A10Rik; mSKAP55R; RA70; Saps; Scap2;
                     SKAP-HOM"
                     /inference="alignment:Splign:2.1.0"
     exon            348..455
                     /gene="Skap2"
                     /gene_synonym="2610021A10Rik; mSKAP55R; RA70; Saps; Scap2;
                     SKAP-HOM"
                     /inference="alignment:Splign:2.1.0"
     exon            456..533
                     /gene="Skap2"
                     /gene_synonym="2610021A10Rik; mSKAP55R; RA70; Saps; Scap2;
                     SKAP-HOM"
                     /inference="alignment:Splign:2.1.0"
     exon            534..617
                     /gene="Skap2"
                     /gene_synonym="2610021A10Rik; mSKAP55R; RA70; Saps; Scap2;
                     SKAP-HOM"
                     /inference="alignment:Splign:2.1.0"
     exon            618..742
                     /gene="Skap2"
                     /gene_synonym="2610021A10Rik; mSKAP55R; RA70; Saps; Scap2;
                     SKAP-HOM"
                     /inference="alignment:Splign:2.1.0"
     exon            743..806
                     /gene="Skap2"
                     /gene_synonym="2610021A10Rik; mSKAP55R; RA70; Saps; Scap2;
                     SKAP-HOM"
                     /inference="alignment:Splign:2.1.0"
     exon            807..941
                     /gene="Skap2"
                     /gene_synonym="2610021A10Rik; mSKAP55R; RA70; Saps; Scap2;
                     SKAP-HOM"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1019
                     /gene="Skap2"
                     /gene_synonym="2610021A10Rik; mSKAP55R; RA70; Saps; Scap2;
                     SKAP-HOM"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1132
                     /gene="Skap2"
                     /gene_synonym="2610021A10Rik; mSKAP55R; RA70; Saps; Scap2;
                     SKAP-HOM"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1233
                     /gene="Skap2"
                     /gene_synonym="2610021A10Rik; mSKAP55R; RA70; Saps; Scap2;
                     SKAP-HOM"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1639
                     /gene="Skap2"
                     /gene_synonym="2610021A10Rik; mSKAP55R; RA70; Saps; Scap2;
                     SKAP-HOM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1616..1621
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Skap2"
                     /gene_synonym="2610021A10Rik; mSKAP55R; RA70; Saps; Scap2;
                     SKAP-HOM"
                     /note="hexamer: AATAAA"
     polyA_site      1639
                     /gene="Skap2"
                     /gene_synonym="2610021A10Rik; mSKAP55R; RA70; Saps; Scap2;
                     SKAP-HOM"
                     /note="major polyA site"
ORIGIN      
        1 gggagggggc agggcccggc gtccagcgac cgctggctgg agagctagtg acttccttgt
       61 tggcagtctc ggacgggccg tgtccggagt cgtagcctct cggtgcttac tcggaccgct
      121 attgcgagtc taggtccaag ccattatcat gcccaacccc agctgtacct cttctcccgg
      181 ccctctccct gaggaaatta ggaacctgtt ggcagatgtt gaaacatttg tggcagacac
      241 actgaaagga gaaaatttat ccaagaaagc caaggaaaag agagaatctc tcattaagaa
      301 gataaaagat gtaaagtctg tctatcttca ggaatttcaa gacaaaggtg atgctgagga
      361 cggcgatgaa tatgacgatc cctttgctgg gcctgcagac acgatttcct tagcctcaga
      421 gcgctacgat aaagatgatg atggcccctc tgatggaaac cagtttcctc ccattgcagc
      481 ccaggacctt ccttttgtca taaaggctgg ctacctggaa aaacgcagaa aagatcacag
      541 ctttctgggg tttgaatggc agaaacggtg gtgtgcgctc agcaaaacag tgttctatta
      601 ttacgggagc gataaagaca agcaacagaa aggtgaattt gcaatagatg gctatgatgt
      661 cagaatgaac aacaccctta ggaaggatgg aaagaaagat tgctgttttg aaatctgtgc
      721 tcccgacaaa cgtatctatc agtttacagc agcctctccc aaagatgctg aggaatgggt
      781 ccagcagctg aaatttatac tacaagacct gggatccgac gttattcctg aggatgatga
      841 ggaaagagga gaattatatg atgacgttga ccatcctgct gccgtcagca gcccgcagag
      901 gagccagcca atcgatgatg agatttatga ggagctccca gaggaggaag aggacactgc
      961 ttcagtgaag atggacgagc aagggaaggg aagtcgggac agtgtgcatc acacctcagg
     1021 agataaaagc actgattacg ctaattttta ccagggtctg tgggactgca ctggagctct
     1081 gtctgatgag ttgtccttta agcgtggtga tgtgatttac attcttagca aggaatacaa
     1141 tagatatggc tggtgggtag gagagatgaa gggagccatt ggcttggtgc ctaaagccta
     1201 cctaatggag atgtatgata tttgagagtc tggagaagtc ttgtgtctgt ctgcaagtgc
     1261 cttggaacat ggaatgcctg agtgcctgct cggagccacc ttcctttggg tgaacattcc
     1321 tgcctcagct gccattcgat gtagtcacgc actaaagcac tctgatgtca gattgagcag
     1381 gcagtgatgg gttacattag atacaagcag tagagataag acctgttgct gttttgcaaa
     1441 taataattag ttttaattta cccgtttggt ttgtatggta gaattcactg tgattgtacg
     1501 tgaatcttag tcattgaagc gccggtgagg gttgctgttt ctcttagtcg ctgggtgtaa
     1561 gttattttta gagtgccaca aataatttcc tagactttgt acattttgag tcaataataa
     1621 agacttcttt aaagctgtaa aaaaaaaaaa aaaaaa
//
