LOCUS       NM_198605               2268 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Mus musculus spindle and kinetochore associated complex subunit 3
            (Ska3), transcript variant 1, mRNA.
ACCESSION   NM_198605 XM_127866
VERSION     NM_198605.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2268)
  AUTHORS   Xie,L., Cheng,S., Fan,Z., Sang,H., Li,Q. and Wu,S.
  TITLE     SKA3, negatively regulated by miR-128-3p, promotes the progression
            of non-small-cell lung cancer
  JOURNAL   Per Med 19 (3), 193-205 (2022)
   PUBMED   34533066
  REMARK    GeneRIF: SKA3, negatively regulated by miR-128-3p, promotes the
            progression of non-small-cell lung cancer.
REFERENCE   2  (bases 1 to 2268)
  AUTHORS   Gao,W., Zhang,Y., Luo,H., Niu,M., Zheng,X., Hu,W., Cui,J., Xue,X.,
            Bo,Y., Dai,F., Lu,Y., Yang,D., Guo,Y., Guo,H., Li,H., Zhang,Y.,
            Yang,T., Li,L., Zhang,L., Hou,R., Wen,S., An,C., Ma,T., Jin,L.,
            Xu,W. and Wu,Y.
  TITLE     Targeting SKA3 suppresses the proliferation and chemoresistance of
            laryngeal squamous cell carcinoma via impairing PLK1-AKT
            axis-mediated glycolysis
  JOURNAL   Cell Death Dis 11 (10), 919 (2020)
   PUBMED   33106477
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2268)
  AUTHORS   Zhang,Q.H., Qi,S.T., Wang,Z.B., Yang,C.R., Wei,Y.C., Chen,L.,
            Ouyang,Y.C., Hou,Y., Schatten,H. and Sun,Q.Y.
  TITLE     Localization and function of the Ska complex during mouse oocyte
            meiotic maturation
  JOURNAL   Cell Cycle 11 (5), 909-916 (2012)
   PUBMED   22336914
  REMARK    GeneRIF: The Ska3 subunit was only localized on spindle
            microtubules from the Pro-MI to MII stages in mouse oocyte meiosis
            and knockdown by Morpholino injection into mouse oocytes resulted
            in spindle movement defects and enlarged polar bodies.
REFERENCE   4  (bases 1 to 2268)
  AUTHORS   Lampert,F. and Westermann,S.
  TITLE     A blueprint for kinetochores - new insights into the molecular
            mechanics of cell division
  JOURNAL   Nat Rev Mol Cell Biol 12 (7), 407-412 (2011)
   PUBMED   21633384
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2268)
  AUTHORS   Theis,M., Slabicki,M., Junqueira,M., Paszkowski-Rogacz,M.,
            Sontheimer,J., Kittler,R., Heninger,A.K., Glatter,T., Kruusmaa,K.,
            Poser,I., Hyman,A.A., Pisabarro,M.T., Gstaiger,M., Aebersold,R.,
            Shevchenko,A. and Buchholz,F.
  TITLE     Comparative profiling identifies C13orf3 as a component of the Ska
            complex required for mammalian cell division
  JOURNAL   EMBO J 28 (10), 1453-1465 (2009)
   PUBMED   19387489
REFERENCE   6  (bases 1 to 2268)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC119813.16.
            
            On Mar 24, 2023 this sequence version replaced NM_198605.3.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK089223.1, BC117501.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               AC119813.16        81065-81225         c
            162-223             AC119813.16        77956-78017         c
            224-389             AC119813.16        77091-77256         c
            390-798             AC119813.16        75209-75617         c
            799-905             AC119813.16        71700-71806         c
            906-991             AC119813.16        66635-66720         c
            992-1192            AC119813.16        64998-65198         c
            1193-1296           AC119813.16        63030-63133         c
            1297-2268           AC119813.16        61615-62586         c
FEATURES             Location/Qualifiers
     source          1..2268
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 30.51 cM"
     gene            1..2268
                     /gene="Ska3"
                     /gene_synonym="F630043A04Rik"
                     /note="spindle and kinetochore associated complex subunit
                     3"
                     /db_xref="GeneID:219114"
                     /db_xref="MGI:MGI:3041235"
     exon            1..161
                     /gene="Ska3"
                     /gene_synonym="F630043A04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1294
                     /gene="Ska3"
                     /gene_synonym="F630043A04Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     spindle and kinetochore-associated protein 3; SKA complex
                     subunit 3"
                     /codon_start=1
                     /product="SKA complex subunit 3 isoform 1"
                     /protein_id="NP_941007.1"
                     /db_xref="CCDS:CCDS27160.1"
                     /db_xref="GeneID:219114"
                     /db_xref="MGI:MGI:3041235"
                     /translation="MNPIQSFHCKLRGLATTLDSETARLLRALDGEDSDFEDSPGRIL
                     HDLHSEVQTLKDNVNALLDEARLENQESTRFKKATKILMEKNSADVRKLREFFQKYGY
                     QARDKEDSGCEHRVNNSTPELAVCKDIQKAGVKELSDPCVPSGSVSEEPLRSPQLSDF
                     GLQRYIISQVPANPPQTAASLKEERVAETPPAKDPSVQVLKTPRCALRMDDFECETPK
                     LEHFGISEHTMCLNEDYTMGLKNMKNIKSSLLSGVSGEAIGTGPVTSDNSFAIPGPII
                     QQMEENDVEYVSSPLPPKFCTPGLKIPSTMDRTDLVSIDYPLSKPNSSSTDLEIKDCV
                     PLILNSDECYQSFAEPPSSAITSCENFATPSPPKVTAIPEDILQMITKHSSNLASPLD
                     VKVMPRRKGTRGAANKENW"
     exon            162..223
                     /gene="Ska3"
                     /gene_synonym="F630043A04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            224..389
                     /gene="Ska3"
                     /gene_synonym="F630043A04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            390..798
                     /gene="Ska3"
                     /gene_synonym="F630043A04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            799..905
                     /gene="Ska3"
                     /gene_synonym="F630043A04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            906..991
                     /gene="Ska3"
                     /gene_synonym="F630043A04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1192
                     /gene="Ska3"
                     /gene_synonym="F630043A04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1296
                     /gene="Ska3"
                     /gene_synonym="F630043A04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..2268
                     /gene="Ska3"
                     /gene_synonym="F630043A04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2244..2249
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ska3"
                     /gene_synonym="F630043A04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2268
                     /gene="Ska3"
                     /gene_synonym="F630043A04Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtgtagcgcg ttcgttcgag gggactggag gtcagcagtc ggctcggcgg ccctcagcat
       61 gaaccccatc cagagtttcc actgtaagct gcggggtctg gccaccacgc tggacagcga
      121 gacggcccgg ctgctgagag cgctggacgg cgaggacagc gactttgaag attctccagg
      181 gagaattttg catgaccttc attcagaagt ccagactcta aaggataatg ttaatgctct
      241 tctcgatgaa gcaagattgg agaaccaaga aagcacaagg ttcaaaaagg caacaaaaat
      301 actgatggaa aaaaactcag cagacgtcag aaaactaaga gagtttttcc agaagtatgg
      361 ctaccaagcg cgtgacaagg aggattcagg ctgtgagcac agagtgaaca actccacccc
      421 agagttagct gtgtgtaaag acattcaaaa ggccggtgtg aaggagctgt ctgatccctg
      481 tgttccgagc ggttctgttt ctgaagagcc tctgcgaagc ccacagctct cagactttgg
      541 acttcagcgg tacataattt cccaagtccc agccaaccct ccccagacag ctgccagcct
      601 caaagaagaa cgtgtagctg agacccctcc tgccaaagac ccctctgttc aagtgctgaa
      661 gaccccgcgg tgtgctctaa ggatggatga ttttgagtgt gaaactccta aattagaaca
      721 ctttggtata tctgaacata ctatgtgttt aaatgaagat tacacaatgg gacttaaaaa
      781 tatgaagaac attaaaagtt cccttttgag tggtgtcagt ggagaagcca taggaactgg
      841 gcctgtgacc agtgataatt cttttgccat tcctggtccc ataatccagc agatggaaga
      901 aaacgatgtg gaatacgtaa gttcaccatt gccacctaaa ttctgcactc ctggtttgaa
      961 aattccttct acaatggaca gaacagattt ggtatctata gattatccac tatcaaagcc
     1021 aaatagttca tcaactgatt tggaaattaa agattgtgtt ccgttaattt taaattcaga
     1081 tgaatgctat cagagttttg cagagccccc ttcttcagca attacttctt gtgaaaattt
     1141 tgcaacacca tctcctccga aagttactgc gattccagaa gacattctcc agatgataac
     1201 aaagcacagc tcaaacctag cttctccctt ggatgttaaa gtgatgccac ggaggaaggg
     1261 cacccgaggc gctgccaaca aggaaaactg gtaacggaat tctacagtgg atacatccaa
     1321 tacagaagct agacagaaca ggaaagtgag ctggactaag gttctcagga ttataactgg
     1381 ttagcacaga ccagtagaag tggagagagg gctcctgctg gcagtcagtc ttctttctcc
     1441 cagtctctct tatttcattc ttacgggaat gtttccgttt caccgcactg tggtggcctt
     1501 tccagcttga ccacccagca gatcccgatt ctacctggaa gattctgaac acctactctg
     1561 agccagaagc cttgggaacg tcttgattct ggaactatct aatggccttt gagcccaaga
     1621 tccttctgat ccaagaacag ttagaaagta attctccaag ttcatgacag tgctacttgg
     1681 gagagctttg tgctgcagcc aggtagggaa tgaggagctg gtgttctgaa gagtccagct
     1741 acaattttga gaaataattg gcaaatacca gttgactgac tagttttggg aatttctttc
     1801 tcccaataca gggtttctct gtgtagctgt ggcagtcctg aaacttactc tgtagaccag
     1861 gctagatcct cctgtctctg cctcttgagt agaaattaaa gatgtgtacc accaccgtct
     1921 ggcagcttta ggaaattttg tgtggcataa agattattct aattgtgcat tgaaaatcaa
     1981 gtggagagct agagagatgg ctcagtggtt aagagcactg actgttcttc cagaggtcct
     2041 gagttcaatt cccagcaacc acatggtggt aacaaccatc tgtaatggga tccgttgccc
     2101 tcttctggcg tgtctaaaga ccgctacaat gtactcatct acataaataa ttctgtttaa
     2161 aaaaaaatca agtggaaaaa ttccaggata atactaataa gtgcttgtat tttttgttgt
     2221 tgttgttatt gtacataatg taaaataaat gattttctga gtagccca
//
