LOCUS       NM_011384               4019 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus sine oculis-related homeobox 6 (Six6), mRNA.
ACCESSION   NM_011384
VERSION     NM_011384.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4019)
  AUTHORS   Ferrena,A., Zhang,X., Shrestha,R., Zheng,D. and Liu,W.
  TITLE     Six3 and Six6 jointly control diverse target genes in multiple cell
            populations over developmental trajectories of mouse embryonic
            retinal progenitor cells
  JOURNAL   PLoS One 19 (10), e0308839 (2024)
   PUBMED   39446806
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4019)
  AUTHORS   Yu,H., Chiang,A., Rubinstein,M. and Low,M.J.
  TITLE     The homeodomain transcription factor Six3 regulates hypothalamic
            Pomc expression and its absence from POMC neurons induces
            hyperphagia and mild obesity in male mice
  JOURNAL   Mol Metab 87, 101993 (2024)
   PUBMED   39025297
REFERENCE   3  (bases 1 to 4019)
  AUTHORS   Bando,H., Brinkmeier,M.L., Castinetti,F., Fang,Q., Lee,M.S.,
            Saveanu,A., Albarel,F., Dupuis,C., Brue,T. and Camper,S.A.
  TITLE     Heterozygous variants in SIX3 and POU1F1 cause pituitary hormone
            deficiency in mouse and man
  JOURNAL   Hum Mol Genet 32 (3), 367-385 (2023)
   PUBMED   35951005
REFERENCE   4  (bases 1 to 4019)
  AUTHORS   Yu,H., Rubinstein,M. and Low,M.J.
  TITLE     Developmental single-cell transcriptomics of hypothalamic POMC
            neurons reveal the genetic trajectories of multiple
            neuropeptidergic phenotypes
  JOURNAL   Elife 11, e72883 (2022)
   PUBMED   35044906
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4019)
  AUTHORS   Cheng,A.H., Fung,S.W., Hegazi,S., Abdalla,O.H.M.H. and Cheng,H.M.
  TITLE     SOX2 Regulates Neuronal Differentiation of the Suprachiasmatic
            Nucleus
  JOURNAL   Int J Mol Sci 23 (1), 229 (2021)
   PUBMED   35008655
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4019)
  AUTHORS   Mui,S.H., Hindges,R., O'Leary,D.D., Lemke,G. and Bertuzzi,S.
  TITLE     The homeodomain protein Vax2 patterns the dorsoventral and
            nasotemporal axes of the eye
  JOURNAL   Development 129 (3), 797-804 (2002)
   PUBMED   11830578
REFERENCE   7  (bases 1 to 4019)
  AUTHORS   Jean,D., Bernier,G. and Gruss,P.
  TITLE     Six6 (Optx2) is a novel murine Six3-related homeobox gene that
            demarcates the presumptive pituitary/hypothalamic axis and the
            ventral optic stalk
  JOURNAL   Mech Dev 84 (1-2), 31-40 (1999)
   PUBMED   10473118
REFERENCE   8  (bases 1 to 4019)
  AUTHORS   Toy,J. and Sundin,O.H.
  TITLE     Expression of the optx2 homeobox gene during mouse development
  JOURNAL   Mech Dev 83 (1-2), 183-186 (1999)
   PUBMED   10381579
REFERENCE   9  (bases 1 to 4019)
  AUTHORS   Lopez-Rios,J., Gallardo,M.E., Rodriguez de Cordoba,S. and
            Bovolenta,P.
  TITLE     Six9 (Optx2), a new member of the six gene family of transcription
            factors, is expressed at early stages of vertebrate ocular and
            pituitary development
  JOURNAL   Mech Dev 83 (1-2), 155-159 (1999)
   PUBMED   10381575
REFERENCE   10 (bases 1 to 4019)
  AUTHORS   Toy,J., Yang,J.M., Leppert,G.S. and Sundin,O.H.
  TITLE     The optx2 homeobox gene is expressed in early precursors of the eye
            and activates retina-specific genes
  JOURNAL   Proc Natl Acad Sci U S A 95 (18), 10643-10648 (1998)
   PUBMED   9724757
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC159823.2 and AK029309.1.
            
            On Sep 15, 2015 this sequence version replaced NM_011384.4.
            
            Summary: This gene encodes a homeobox protein that is similar to
            the Drosophila 'sine oculis' gene product. This gene is found in a
            cluster of related genes on chromosome 12 and is thought to be
            involved in eye development. The encoded transcription factor
            regulates early progenitor cell proliferation during mammalian
            retinogenesis and pituitary development. Mice lacking this gene
            exhibit abnormal development of the suprachiasmatic nucleus and
            circadian rhythms. [provided by RefSeq, Sep 2015].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029309.1, BC138839.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AC159823.2         70372-70434
            64-1268             AK029309.1         2-1206
            1269-3988           AC159823.2         72639-75358
            3989-4019           AK029309.1         3927-3957
FEATURES             Location/Qualifiers
     source          1..4019
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 30.31 cM"
     gene            1..4019
                     /gene="Six6"
                     /gene_synonym="Optx2; Six9"
                     /note="sine oculis-related homeobox 6"
                     /db_xref="GeneID:20476"
                     /db_xref="MGI:MGI:1341840"
     exon            1..746
                     /gene="Six6"
                     /gene_synonym="Optx2; Six9"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..915
                     /gene="Six6"
                     /gene_synonym="Optx2; Six9"
                     /note="optic homeobox 2; sine oculis homeobox homolog 6;
                     sine oculis-related homeobox 6 homolog"
                     /codon_start=1
                     /product="homeobox protein SIX6"
                     /protein_id="NP_035514.1"
                     /db_xref="CCDS:CCDS25972.1"
                     /db_xref="GeneID:20476"
                     /db_xref="MGI:MGI:1341840"
                     /translation="MFQLPILNFSPQQVAGVCETLEESGDVERLGRFLWSLPVAPAAC
                     EALNKNESVLRARAIVAFHGGNYRELYHILENHKFTKESHAKLQALWLEAHYQEAEKL
                     RGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRHLLREWYLQDPYPNPSKKRE
                     LAQATGLTPTQVGNWFKNRRQRDRAAAAKNRLQQQVLSQGPGRVLRSEGEGTPEVLGV
                     ASSPAASLSSKAATSAISITSSDSECDI"
     exon            747..4019
                     /gene="Six6"
                     /gene_synonym="Optx2; Six9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1409..1414
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Six6"
                     /gene_synonym="Optx2; Six9"
                     /note="hexamer: AATAAA"
     polyA_site      1444
                     /gene="Six6"
                     /gene_synonym="Optx2; Six9"
                     /note="major polyA site"
     regulatory      3999..4004
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Six6"
                     /gene_synonym="Optx2; Six9"
                     /note="hexamer: AATAAA"
     polyA_site      4019
                     /gene="Six6"
                     /gene_synonym="Optx2; Six9"
ORIGIN      
        1 agtagcggca cggtctagct ggctggcttt tcctagctga gcaagcgcag ccgaacccaa
       61 cccacagctc ttccaggcgg gaaggctccc cccgactctg taacccccag ccgcaccccg
      121 ctcggcccgc gggcatctgc tgcgtgtccc acccggggcg cccgcgcagc ctcgatgttc
      181 cagctgccca ttttgaattt cagcccccag caagtagccg gggtatgtga gaccctggag
      241 gaaagcggcg acgtggagcg cctaggtcgc ttcctatggt cgctgcccgt ggccccagca
      301 gcttgtgaag cccttaacaa gaatgagtcg gtgctgcgag cgagagccat cgtggctttc
      361 cacggtggca actaccgcga gctttatcat atcctggaaa atcataagtt tactaaggaa
      421 tcgcacgcca agctgcaggc gctgtggctc gaagcgcatt accaggaggc agagaagctg
      481 cgtggacggc ccctagggcc agtagacaag taccgagtaa ggaagaagtt cccgctgccg
      541 cggaccattt gggatggcga acagaagact cactgcttca aggagcgcac gcggcacctg
      601 cttcgagagt ggtaccttca ggacccatat cccaacccca gcaaaaagcg agagctcgcc
      661 caggcaaccg gactgacccc cacacaggtg ggcaactggt tcaaaaaccg cagacaaaga
      721 gaccgggcag ctgcagccaa aaacagactc cagcagcagg ttctgtcgca gggccccggg
      781 cgggtgctac gctcggaggg tgagggaacg cctgaggtgt tgggcgtcgc ctccagcccg
      841 gctgccagtc tgtcgagcaa ggcggccact tcggccatct ccatcacatc cagcgacagt
      901 gagtgcgaca tctgagctgc ccactcatca cacttagaat ccagtgtaaa aatgagatac
      961 acaaaataaa aaaagagaga gaaagagaga ggacaagacc agcaaatacg gcgctggcag
     1021 aagccccgtg gccagggacc cgcgggccta aaggctctag aagcgagaat ccatcgcgac
     1081 tctggggcat gcggtgaggc ctgacccaat gctacttctc ttcgcattgc ttttcctgaa
     1141 ggatctggct gcaaagactc ctttggaaca gaactgcact ctgagagcct gcccttgagt
     1201 ctcctgcggg tatttcactt cgaaaggacg ctgttatata tatgtataac ttttgctttg
     1261 aaggtttctt ttttaaaaaa caaaacaaaa catatatatg ctgtttattt acttatttaa
     1321 aagacttcca tgataggttt ctctgtagct tggggaactt gctgttttga atgagcaagc
     1381 tcacgcgttc tgtgtgaaga agccaaataa taaaacaact tggtggataa cctttcttaa
     1441 ttaagagagc tgctatctca gattttaaaa atcactctta tttcctttgc tgggcacgca
     1501 gcatggagtc ttattcaaat tgtctctcca acttctctat atcctctgac atctcagtat
     1561 atttatattt taagcagcca cagataaacc gctaactaac cgccacatcg gattgtatga
     1621 aaatgtatgc atgtgtatac ataaacatat gcacattgcc atattaaacc cagaatttgg
     1681 aacatgaaca tgccatctat ggcagcgctc tacattcgcc acacaggtga tcatggtttg
     1741 tccacctaat catttttatg aagtgttagt gattttcaag aacaatttta gaagacaaat
     1801 tttagactca ggtaatgaat cgtattttac aaaaatgcca agacacgagg gctttatgat
     1861 taaaaagtgt ttccattttg tttgaggtac tctcccactc agaaacttat ggtcattcaa
     1921 ggtaagcatg tagcacaggt agaatactta ctaagtgctg taggtcttat taagaccatt
     1981 taaaaagata ggagaggttg atactaacca ggctagcatc ttcctgcttc agaaatgggt
     2041 tttagtcaac taaattattt tcaccaggag aaatactaag ataggagaca gtatgcaggc
     2101 tttatattga ccagaaagca tgctacagag aaatgacagg cattttctaa atcagtgctc
     2161 tacatttaac atgcaaacaa ttcatcagga agttcgttgc cttgggacta gccttcatta
     2221 aaatataaaa tattcttagc atgtaattgt tctttgtaca tacacacaca tataccacat
     2281 gcacacatac acacacgtac acactctacc acttttgcac taagaacgta aataatatcc
     2341 atattatcta agattttgct ttgcctagtg aaatggattg cacattacaa attttaatat
     2401 tgatctttaa atctcagcca gttagagttc ttttaattca cctctcacct gctaaaaatt
     2461 tctgaaggca aaaaatgtta aagtaccaaa caaatgaaaa ctggagttat gaaagaaaat
     2521 aggtggtcaa gtggctattg gaagcccagg acgtgagaaa gggctgatgt attacgtgta
     2581 tgtatgtatg tatgtatgta tgtatgcatg catgtatgta tatatgtaca tttgtatgta
     2641 tgtatgtatg agtgtgtgtt tgaatgtata tatgcatgta tacatatttg tttgtatgtc
     2701 acttaagcag agttggctac tgtgggcttt aaaattgtca tcactgagtc cacttgttcc
     2761 atagctagaa aattgttgca aattgaaact ctcatagcaa aagatggaca ggtttaggaa
     2821 gcttttgtgg tcaaacaggt aattcccaag tcaaacaaat actcttcagt ggctcaagaa
     2881 agccttccat ggtaaagcta tatcttttga tttctaaagt ccctgtcgat tctttgggtg
     2941 acaaggagca gtttgggcct ccagaggggg aaaataaaag gcatcaagaa tgcaaatatt
     3001 aagaaattgt tcactttcct ggtcatgtga gtgacatgtc ctagcgacct gaaactgagt
     3061 atctccttaa ttttgtgcct tggttggtgg tggtgactct aactagcaga cctctggagg
     3121 tttggggtca gcctggtcta caaggtgagt ttcagaccaa ccttggctac acagtgaggt
     3181 tttgttttgt tgtttttaaa cacagagtgt ttcagaaagc aacaccataa ttgcacccga
     3241 ggttctcccg cctcacaata ggctagaatc agcctagcag gattgcactt cagtggaaaa
     3301 ttcatggctc tcaatcttat aatccagctc catccgaaac tcatttcagc tatgaatgat
     3361 ccagagccag aaaatggaga catttattgg caaaatttat ctcttatctt tgtgatccca
     3421 ggtcaaacag aaaagacaga atgaactaat tagtaaaatg atggacaaga atttgagatt
     3481 ctaaaaatcc taacatactt gccagtttca aatgtctgaa acagatggaa acacccaccc
     3541 tctccagaat tagagtaagg ctgcaggaac taagctttct ccgtataaaa caatgtttaa
     3601 tgatacttac ggaaaagcag aaggccaaac agtgaaggtt tttaaaggag atatactatt
     3661 tccttaaatt aacaagctgc ccaagaatta cgtttaaagt agttataatg cttcaatagc
     3721 atgcagactt attcatccga tttcatgttg aaatcttggg gccaccaaca ttgtttgaag
     3781 aatgcttttg tatgtttacc tgaaatctga tgacacgtaa ttgctttgtg actaatactt
     3841 ggaatgaccc taggttggaa attagcccag atcttcaaac agcaatttac tcaatcaccc
     3901 gaatcagccc ataaacatgt gttataaaga ttttacattt ttatatcaat tttatcctga
     3961 cctagactgc gttaaattcg aggcagtgga aaggctccaa taaaagtctc tgaatcgcg
//
