LOCUS       NM_011383               2853 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus sine oculis-related homeobox 5 (Six5), mRNA.
ACCESSION   NM_011383 XM_620429
VERSION     NM_011383.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2853)
  AUTHORS   Wurmser,M., Madani,R., Chaverot,N., Backer,S., Borok,M., Dos
            Santos,M., Comai,G., Tajbakhsh,S., Relaix,F., Santolini,M.,
            Sambasivan,R., Jiang,R. and Maire,P.
  TITLE     Overlapping functions of SIX homeoproteins during embryonic
            myogenesis
  JOURNAL   PLoS Genet 19 (6), e1010781 (2023)
   PUBMED   37267426
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2853)
  AUTHORS   Wurmser,M., Chaverot,N., Madani,R., Sakai,H., Negroni,E.,
            Demignon,J., Saint-Pierre,B., Mouly,V., Amthor,H., Tapscott,S.,
            Birchmeier,C., Tajbakhsh,S., Le Grand,F., Sotiropoulos,A. and
            Maire,P.
  TITLE     SIX1 and SIX4 homeoproteins regulate PAX7+ progenitor cell
            properties during fetal epaxial myogenesis
  JOURNAL   Development 147 (19) (2020)
   PUBMED   32591430
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2853)
  AUTHORS   Takahashi,M., Tamura,M., Sato,S. and Kawakami,K.
  TITLE     Mice doubly deficient in Six4 and Six5 show ventral body wall
            defects reproducing human omphalocele
  JOURNAL   Dis Model Mech 11 (10) (2018)
   PUBMED   30237319
  REMARK    GeneRIF: Six4 and Six5 are required for growth and morphological
            change of the primary abdominal wall.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2853)
  AUTHORS   Zhang,Q., Shao,J., Fan,H.Y. and Yu,C.
  TITLE     Evolutionarily-conserved MZIP2 is essential for crossover formation
            in mammalian meiosis
  JOURNAL   Commun Biol 1, 147 (2018)
   PUBMED   30272023
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2853)
  AUTHORS   Yajima,H. and Kawakami,K.
  TITLE     Low Six4 and Six5 gene dosage improves dystrophic phenotype and
            prolongs life span of mdx mice
  JOURNAL   Dev Growth Differ 58 (6), 546-561 (2016)
   PUBMED   27224259
  REMARK    GeneRIF: The results indicated that low Six4 and Six5 gene dosage
            improved dystrophic phenotypes of Dmd(mdx) /Y mice by enhancing
            muscle regeneration, and suggested that SIX4 and SIX5 are
            potentially useful de novo targets in therapeutic applications
            against muscle disorders, including DMD.
REFERENCE   6  (bases 1 to 2853)
  AUTHORS   Murakami,Y., Ohto,H., Ikeda,U., Shimada,K., Momoi,T. and
            Kawakami,K.
  TITLE     Promoter of mDMAHP/Six5: differential utilization of multiple
            transcription initiation sites and positive/negative regulatory
            elements
  JOURNAL   Hum Mol Genet 7 (13), 2103-2112 (1998)
   PUBMED   9817928
REFERENCE   7  (bases 1 to 2853)
  AUTHORS   Ohto,H., Takizawa,T., Saito,T., Kobayashi,M., Ikeda,K. and
            Kawakami,K.
  TITLE     Tissue and developmental distribution of Six family gene products
  JOURNAL   Int J Dev Biol 42 (2), 141-148 (1998)
   PUBMED   9551859
REFERENCE   8  (bases 1 to 2853)
  AUTHORS   Heath,S.K., Carne,S., Hoyle,C., Johnson,K.J. and Wells,D.J.
  TITLE     Characterisation of expression of mDMAHP, a homeodomain-encoding
            gene at the murine DM locus
  JOURNAL   Hum Mol Genet 6 (5), 651-657 (1997)
   PUBMED   9158137
REFERENCE   9  (bases 1 to 2853)
  AUTHORS   Kawakami,K., Ohto,H., Takizawa,T. and Saito,T.
  TITLE     Identification and expression of six family genes in mouse retina
  JOURNAL   FEBS Lett 393 (2-3), 259-263 (1996)
   PUBMED   8814301
REFERENCE   10 (bases 1 to 2853)
  AUTHORS   Boucher,C.A., King,S.K., Carey,N., Krahe,R., Winchester,C.L.,
            Rahman,S., Creavin,T., Meghji,P., Bailey,M.E., Chartier,F.L. et al.
  TITLE     A novel homeodomain-encoding gene is associated with a large CpG
            island interrupted by the myotonic dystrophy unstable (CTG)n repeat
  JOURNAL   Hum Mol Genet 4 (10), 1919-1925 (1995)
   PUBMED   8595416
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC145199.3.
            
            On Aug 19, 2005 this sequence version replaced XM_620429.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D83146.1, SRR7652917.330692.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-875               AC145199.3         114444-115318       c
            876-1663            AC145199.3         112843-113630       c
            1664-2853           AC145199.3         111517-112706       c
FEATURES             Location/Qualifiers
     source          1..2853
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.46 cM"
     gene            1..2853
                     /gene="Six5"
                     /gene_synonym="Dmahp; MDMAHP; TrexBF"
                     /note="sine oculis-related homeobox 5"
                     /db_xref="GeneID:20475"
                     /db_xref="MGI:MGI:106220"
     exon            1..875
                     /gene="Six5"
                     /gene_synonym="Dmahp; MDMAHP; TrexBF"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..2253
                     /gene="Six5"
                     /gene_synonym="Dmahp; MDMAHP; TrexBF"
                     /note="sine oculis homeobox homolog 5; DM locus-associated
                     homeodomain protein homolog; sine oculis-related homeobox
                     5 homolog"
                     /codon_start=1
                     /product="homeobox protein SIX5"
                     /protein_id="NP_035513.1"
                     /db_xref="CCDS:CCDS20889.1"
                     /db_xref="GeneID:20475"
                     /db_xref="MGI:MGI:106220"
                     /translation="MATSPAEPSAGPAARGEAAAATEEQEEEARQLLQTLQAAEGEAA
                     AAGAGDAAAAADSGSPSGPGSPRETVTEVPTGLRFSPEQVACVCEALLQAGHAGRLSR
                     FLGALPPAERLRGSDPVLRARALVAFQRGEYAELYQLLESRPFPAAHHAFLQDLYLRA
                     RYHEAERARGRALGAVDKYRLRKKFPLPKTIWDGEETVYCFKERSRAALKACYRGNRY
                     PTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGTGGGAPCKSESDGNPTTEDESSRS
                     PEDLERGVASMAAEAPAQSSIFLAGATSPATCPASSSILVNGSFLAASSPPAVLLNGS
                     PVIINSLALGENSSLGPLLLTGGSAPQPQPSLQGVSEAKNSLVLDPQTGEVRLDEAQS
                     EAPETKGVHGTTGEEIPGALPQVVPGPPPASTFPLTPGAVPAVAAPQVVPLSPSSGYP
                     TGLSPTSPRLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPTNVHLINS
                     SVGVTALQLPSSTAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPP
                     APSLALPLKQEPAITVPEGALPVGPSPTLPEGHTLGPISTQPLPPASVVTSGTSLPFS
                     PDSSGLLSSFSAPLPEGLMLSPAAVPVWPAGLELSTGVEGLGTQATHTVLRLPDPDPQ
                     GLLLGATTGTEVDEGLEAEAKVLTQLQSVPVEEPLEL"
     exon            876..1663
                     /gene="Six5"
                     /gene_synonym="Dmahp; MDMAHP; TrexBF"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..2853
                     /gene="Six5"
                     /gene_synonym="Dmahp; MDMAHP; TrexBF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2832..2837
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Six5"
                     /gene_synonym="Dmahp; MDMAHP; TrexBF"
                     /note="hexamer: ATTAAA"
     polyA_site      2851
                     /gene="Six5"
                     /gene_synonym="Dmahp; MDMAHP; TrexBF"
                     /note="major polyA site"
ORIGIN      
        1 gggggggcgg cgaggaggac tgggcggagg agggggctgg ggaagcccgc gggaggcggc
       61 aaaggaggga ggaactttcc aaagttgcca aacatggcta cctcgcctgc ggagccgagc
      121 gcggggcccg cggctcgggg ggaggcggcg gcggcgaccg aggagcagga ggaggaagcg
      181 cgccagcttc tgcagactct gcaggcagcc gagggggagg cggcggcggc cggggcggga
      241 gatgcggcgg cggcggcgga ctctgggtcc ccgagtggcc cggggtctcc ccgggagacc
      301 gtgaccgagg tgcccactgg ccttcgcttc tcgcccgaac aggtggcatg cgtgtgcgag
      361 gcgctgctgc aggcgggcca cgccggccgc ttgagccgct tcctgggcgc gctgcccccg
      421 gccgagcgcc tacgtggcag cgatccggtg ctgcgcgcgc gggccctagt ggccttccag
      481 cggggtgaat acgccgagct ctaccaactt ctcgagagcc gccctttccc cgccgcccac
      541 cacgccttcc tgcaggacct ctacctgcgc gcgcgctacc acgaggccga gcgggcccgt
      601 ggccgtgcgc tgggcgctgt ggacaaatac cggctgcgca agaagttccc tctgcccaag
      661 accatctggg atggcgagga gaccgtctat tgcttcaagg agcgctcgcg agcggcgctc
      721 aaggcctgct accgcggcaa ccgctatccc acgcctgacg agaagcgccg cctggccacg
      781 ctcaccggcc tctcgcttac acaggtcagc aactggttca agaaccggcg acagcgcgac
      841 cgcactggga ccggcggtgg agcgccttgc aaaagcgagt ctgatgggaa ccccactacg
      901 gaggatgagt ccagccgcag tccagaggac ctggagaggg gtgtggcctc catggctgct
      961 gaggcccccg cccagagttc catcttcctg gcgggggcca cctctcctgc aacgtgccct
     1021 gcctcctcct ctatcctagt gaatgggagc ttcctggccg ccagcagtcc cccagcagtg
     1081 ctcctcaatg gtagcccagt cattatcaat agcttggccc taggagagaa ctccagcttg
     1141 gggcccttgc tactcacagg aggaagtgcc cctcaaccac agcccagtct ccaaggggtc
     1201 agtgaggcca agaattctct ggtcctggac cctcagacag gagaggttcg actggatgag
     1261 gctcagtctg aggcccctga gaccaaaggg gttcatggga ctactggaga ggaaatccca
     1321 ggagccctgc cccaagtagt cccaggcccc ccacctgcct ccacctttcc tctgaccccg
     1381 ggagctgtgc ctgctgtggc tgctcctcag gttgtaccgc tctccccttc ttctgggtac
     1441 ccaacaggcc tgagccccac ctccccacgg ctgaacttgc cccaggtggt gcccacctct
     1501 caggtggtaa ccctgcctca ggctgtgggg ccactccagc tgttggcagc tgggccaggc
     1561 agtcctgtga aggtggcagc tgcagcgggg cctaccaatg tgcacctgat aaactctagt
     1621 gtgggagtga ctgcgctgca acttccctcg tccactgctc caggaaactt cctcctggcc
     1681 aaccctgtgt ctggtagccc cattgtcact ggggtagctg tgcagcaggg caagatcatc
     1741 ctcactgcca ccttccccac cagcatgctc gtctcccagg tcctgcctcc tgcccccagt
     1801 ctagccctgc ccctgaagca agagccagct atcacagtgc ctgaaggagc tctcccagtg
     1861 ggccccagcc ccaccctccc agagggtcac actctggggc caatctctac tcagccactg
     1921 ccacctgctt ctgttgtcac ctctggcacc agcctgcctt tctccccgga ctcctctggc
     1981 ctgctttcca gcttctcagc acccctacct gaaggtctga tgttgtcacc tgcagctgtg
     2041 ccagtctggc cagcagggct ggaactgagc acaggagtag aagggctggg gacacaggcc
     2101 acccacactg tgctgaggct gccagaccct gacccccagg gactgcttct gggggctaca
     2161 acagggactg aggttgatga ggggctagaa gctgaggcca aggtcctgac ccagctgcag
     2221 tcggtacccg tggaggagcc cttggaactg tgactgcctg catttaacca cttcttctga
     2281 caatggtgtc aaggtgctag gacaggaaga ggaaccctca gtaaagtggc tgcagtctga
     2341 agtcccacac tacagctctc ctacctggat aagctataag ccctacagga gctacaggga
     2401 ccaccacagg tcagggaact gtcctcctga tggcagatct tgttacagcc ctctccttgc
     2461 tctgcctgcc caatatgtgt gggcactagg ggtcttgact tgggctttgc catcctctac
     2521 ataatactag tgtgagaagg ccctgccaag tggctaattt ccagatggca ccctcactat
     2581 aacactatta atagccccac tgatacccat ttcccaaaat ttcctgagag accagggtgg
     2641 cctagggaca gcccttcctg ttgaggaggg ctgatgggtg tacagggccc ttcccctgct
     2701 tccctggact tgagctccag gatccagccc cagaccaaag atttccctgt tccctagggc
     2761 aactctggcc cctttgtcta gtttgtattg taaatcttta tttttctagg atatgttatg
     2821 cctccatttc aattaaagtc aagtaaacag aca
//
