LOCUS       NM_011382               6222 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus sine oculis-related homeobox 4 (Six4), transcript
            variant 1, mRNA.
ACCESSION   NM_011382 XM_916884
VERSION     NM_011382.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6222)
  AUTHORS   Wang,Y., Zhao,T., Chen,W.C., Zheng,Y., Xu,W. and Huang,S.
  TITLE     miR-540-3p partially recovers the locomotor function of spinal cord
            injury mice by targeting SIX4/Yap1 and inactivation of astrocytes
  JOURNAL   Neurol Res 46 (9), 823-834 (2024)
   PUBMED   38920017
  REMARK    GeneRIF: miR-540-3p partially recovers the locomotor function of
            spinal cord injury mice by targeting SIX4/Yap1 and inactivation of
            astrocytes.
REFERENCE   2  (bases 1 to 6222)
  AUTHORS   Racedo,S.E., Liu,Y., Shi,L., Zheng,D. and Morrow,B.E.
  TITLE     Dgcr8 functions in the secondary heart field for outflow tract and
            right ventricle development in mammals
  JOURNAL   Dev Biol 506, 72-84 (2024)
   PUBMED   38110169
REFERENCE   3  (bases 1 to 6222)
  AUTHORS   Wurmser,M., Madani,R., Chaverot,N., Backer,S., Borok,M., Dos
            Santos,M., Comai,G., Tajbakhsh,S., Relaix,F., Santolini,M.,
            Sambasivan,R., Jiang,R. and Maire,P.
  TITLE     Overlapping functions of SIX homeoproteins during embryonic
            myogenesis
  JOURNAL   PLoS Genet 19 (6), e1010781 (2023)
   PUBMED   37267426
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6222)
  AUTHORS   Prokopuk,L., Jarred,E.G., Blucher,R.O., McLaughlin,E.A.,
            Stringer,J.M. and Western,P.S.
  TITLE     An essential role for Polycomb Repressive Complex 2 in the mouse
            ovary
  JOURNAL   Reproduction 163 (3), 167-182 (2022)
   PUBMED   35084365
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6222)
  AUTHORS   Camolotto,S.A., Belova,V.K., Torre-Healy,L., Vahrenkamp,J.M.,
            Berrett,K.C., Conway,H., Shea,J., Stubben,C., Moffitt,R., Gertz,J.
            and Snyder,E.L.
  TITLE     Reciprocal regulation of pancreatic ductal adenocarcinoma growth
            and molecular subtype by HNF4alpha and SIX1/4
  JOURNAL   Gut 70 (5), 900-914 (2021)
   PUBMED   32826305
  REMARK    GeneRIF: Reciprocal regulation of pancreatic ductal adenocarcinoma
            growth and molecular subtype by HNF4alpha and SIX1/4.
REFERENCE   6  (bases 1 to 6222)
  AUTHORS   Niiya,A., Ohto,H., Kawakami,K. and Araki,M.
  TITLE     Localization of Six4/AREC3 in the developing mouse retina;
            implications in mammalian retinal development
  JOURNAL   Exp Eye Res 67 (6), 699-707 (1998)
   PUBMED   9990334
REFERENCE   7  (bases 1 to 6222)
  AUTHORS   Spitz,F., Demignon,J., Porteu,A., Kahn,A., Concordet,J.P.,
            Daegelen,D. and Maire,P.
  TITLE     Expression of myogenin during embryogenesis is controlled by
            Six/sine oculis homeoproteins through a conserved MEF3 binding site
  JOURNAL   Proc Natl Acad Sci U S A 95 (24), 14220-14225 (1998)
   PUBMED   9826681
REFERENCE   8  (bases 1 to 6222)
  AUTHORS   Ohto,H., Takizawa,T., Saito,T., Kobayashi,M., Ikeda,K. and
            Kawakami,K.
  TITLE     Tissue and developmental distribution of Six family gene products
  JOURNAL   Int J Dev Biol 42 (2), 141-148 (1998)
   PUBMED   9551859
REFERENCE   9  (bases 1 to 6222)
  AUTHORS   Kawakami,K., Ohto,H., Takizawa,T. and Saito,T.
  TITLE     Identification and expression of six family genes in mouse retina
  JOURNAL   FEBS Lett 393 (2-3), 259-263 (1996)
   PUBMED   8814301
REFERENCE   10 (bases 1 to 6222)
  AUTHORS   Kawakami,K., Ohto,H., Ikeda,K. and Roeder,R.G.
  TITLE     Structure, function and expression of a murine homeobox protein
            AREC3, a homologue of Drosophila sine oculis gene product, and
            implication in development
  JOURNAL   Nucleic Acids Res 24 (2), 303-310 (1996)
   PUBMED   8628654
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159274.2.
            
            On Apr 11, 2018 this sequence version replaced NM_011382.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D50416.1, BC137934.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-903               AC159274.2         102901-103803       c
            904-1592            AC159274.2         99219-99907         c
            1593-6222           AC159274.2         90167-94796         c
FEATURES             Location/Qualifiers
     source          1..6222
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 30.36 cM"
     gene            1..6222
                     /gene="Six4"
                     /gene_synonym="AREC3; TrexBF"
                     /note="sine oculis-related homeobox 4"
                     /db_xref="GeneID:20474"
                     /db_xref="MGI:MGI:106034"
     exon            1..903
                     /gene="Six4"
                     /gene_synonym="AREC3; TrexBF"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..2389
                     /gene="Six4"
                     /gene_synonym="AREC3; TrexBF"
                     /note="isoform 1 is encoded by transcript variant 1;
                     homeobox protein SIX4; skeletal muscle-specific
                     ARE-binding protein AREC3; sine oculis-related homeobox 4
                     homolog"
                     /codon_start=1
                     /product="homeobox protein SIX4 isoform 1"
                     /protein_id="NP_035512.1"
                     /db_xref="CCDS:CCDS25974.1"
                     /db_xref="GeneID:20474"
                     /db_xref="MGI:MGI:106034"
                     /translation="MSSSSPTGQIASAADIKQENGMESASEGQEAHREVAGGAAAGLS
                     PPAPAPFPLEPGDAAAASRVSREEGAAAAGAADQVQLHSELLGRHQHAAAAQPPLAFS
                     PDHVACVCEALQQGGNLDRLARFLWSLPQSDLLRGNESLLKARALVAFHQGIYPELYS
                     ILESHSFESANHPLLQQLWYKARYTEAERARGRPLGAVDKYRLRRKFPLPRTIWDGEE
                     TVYCFKEKSRNALKELYKQNRYPSPAEKRHLAKITGLSLTQVSNWFKNRRQRDRNPSE
                     TQSKSESDGNPSTEDESSKGHEDLSPHPLSGASDGVTNLSLSSHVEPVYMQQIGNAKI
                     SLSSSGVLLNGSLVPASTSPVFLNGNSFIQGHNGVILNGLNVGNTQTVSLNPPKMSSN
                     IVGNGIAMTDILGSTSQDVKEFKVLQSSAVNSAATTSYSPSAPVSFPGLIPCTEVKRE
                     GIQTVASQDGGSVVTFTTPVQINQYGIVQIPNSGANGQFLNGSIGFSPLQLPPVSVAA
                     SQGNLSVTPSTSDGSTFTSEPATVQHGKLFLSPLTPSAVVYTVPNSGQTVGAVKQEGL
                     ERGLVFSQLMPVNHSAQVNASLSSENLSGSGLHPLTSSLVNVSAAHGFSLTPPTLLNP
                     TELNPDLAESQPVSAPVASKCTVSSVSNTNYATLQNCSLIPGQDLLSGPMTQAALGEI
                     VPTAEEQVSHASTAVHQDFVREQRLVLQSVPNIKENFLQNSENKATNNLMMLDSKSKY
                     VLDGMVEAGCEDLGTDKKELAKLQTVQLDEDMQDL"
     exon            904..1592
                     /gene="Six4"
                     /gene_synonym="AREC3; TrexBF"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..6222
                     /gene="Six4"
                     /gene_synonym="AREC3; TrexBF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6200..6205
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Six4"
                     /gene_synonym="AREC3; TrexBF"
                     /note="hexamer: AATAAA"
     polyA_site      6222
                     /gene="Six4"
                     /gene_synonym="AREC3; TrexBF"
                     /note="major polyA site"
ORIGIN      
        1 gggaaagaaa gaggaaaaga gtgcgaggga gtgagggagg gaggaaaata aacaacaaaa
       61 aatgtcctct tcctccccca ccgggcagat tgcaagtgcg gcggacatca agcaggagaa
      121 tgggatggaa agcgcctcgg aaggacagga ggcgcaccga gaagtggcgg ggggcgcggc
      181 ggctgggctg agccccccgg ctccagctcc tttccccctg gagccggggg acgccgcggc
      241 tgcctccagg gtaagccggg aggaaggggc agcggcggcg ggagcggcag atcaggtaca
      301 actccactcg gaacttctgg gcaggcacca gcacgcagcc gccgcgcagc ccccactggc
      361 cttctcgccg gaccatgtcg cctgcgtgtg cgaggcgttg cagcaggggg gcaacctgga
      421 ccgcctggcc cggtttcttt ggtccctgcc ccagagcgat ctgctacgtg gcaacgagag
      481 ccttctgaag gcgcgagcgc tcgtggcctt ccaccagggc atctaccctg agttgtacag
      541 catcctcgag agccacagct tcgagtcggc caaccatccg ctgctgcagc agctctggta
      601 caaggcgcgc tacaccgagg ccgagcgagc gcgcggccgg ccgctgggcg ccgtggacaa
      661 gtaccggctg cgcaggaaat tccccttgcc ccgcaccatc tgggacggcg aggagacggt
      721 gtattgtttc aaggagaagt cgcgcaacgc gctcaaggag ctctacaagc agaatcgcta
      781 cccctcgccg gctgagaagc ggcacctggc caagatcacc ggcctctccc tcacccaggt
      841 cagcaactgg ttcaagaacc ggcggcagcg tgaccgaaac ccctccgaga cccagtccaa
      901 aagcgaatcg gatggcaacc ccagtaccga ggatgaatcc agcaagggac atgaggattt
      961 gtctcctcat ccactttcag gcgcatctga tggcgtcacc aacctcagcc tctctagcca
     1021 cgtggagcca gtatatatgc aacaaattgg aaatgctaag atatcactaa gctcgtctgg
     1081 agttttgttg aatggaagct tagtacctgc aagtacttca cctgtcttcc ttaatggcaa
     1141 ttcttttatt cagggacaca atggagttat ccttaatgga ctgaatgtgg gaaatacaca
     1201 gacagtgtca ctgaacccac ccaaaatgtc ttcaaacatt gtgggcaatg gcatagccat
     1261 gacagacatc ctgggatcta cctcccagga tgtgaaagaa ttcaaagtcc tccagagttc
     1321 tgctgtgaac tcagcagcca ccacctccta cagccctagt gcccctgtgt cattcccagg
     1381 gctgataccc tgcactgaag tgaaaagaga aggcattcag acagtggcct cccaggacgg
     1441 tggctctgtg gtgactttta ctacacccgt gcaaattaac cagtatggca ttgtccagat
     1501 ccctaattct ggagccaacg gccagttcct taatgggagc attggattct ctccactgca
     1561 gctgcctcct gtctcagtag cagcttcaca aggtaatctt tcagttaccc caagcacttc
     1621 ggacggaagc acatttacaa gtgagccagc cacagtccag cacggtaaac ttttcctgag
     1681 ccctcttacc cccagtgcag tggtatacac cgttcctaat tcaggccaga ctgtaggagc
     1741 tgtgaaacag gaaggcttag aaagaggcct ggtcttttct cagttgatgc ctgtcaatca
     1801 cagtgcacaa gtaaatgcaa gcctgtcttc ggaaaatctc tctgggagtg gcctccatcc
     1861 tctgacctcg tcgttggtta atgtgtccgc cgcccacggt ttttccctga ccccccctac
     1921 actacttaat cccactgagc tcaaccctga ccttgccgag agccagcccg tgtctgcacc
     1981 tgtggcaagc aaatgtactg tgtcatctgt cagcaacact aactatgcaa cccttcagaa
     2041 ctgttccctt attccggggc aagacctatt gtccggcccg atgacccagg ctgccctggg
     2101 tgagatcgta cccacagctg aagagcaggt gagccacgcc tcaacagcag tccaccagga
     2161 ttttgtcaga gaacagcgct tggttctgca gtcagtccct aacataaaag agaatttctt
     2221 acaaaattct gagaacaaag caacaaacaa cttaatgatg ttagactcga aatccaagta
     2281 cgtcctggac ggcatggttg aagccggctg tgaagacctg ggaacggaca aaaaagagct
     2341 ggccaagctc caaaccgtcc agttggatga agacatgcaa gacttataag cccgattcac
     2401 tccacatccc tccttctctg ctttaacagg agcaaatcct tttctttgcg aagccccgag
     2461 gatggagagc ttctattcat ttagaggaaa acactgtact tctgcaagca agcgcatctg
     2521 gcttgggctg catgaagagc gtagttaaat acacaggagt ggacctgcac tgccgaagcc
     2581 cctctggtca catcgtgctc gctttgaaac agatggggcg aggcaacagt gaatgcatcc
     2641 atctaaccat cgtctatcat ttagtcagca gtataactcc acaggcgaaa tggaaggtga
     2701 cagtatttca gatttaaaat gcatacacct aatttaggag attaaataat agctccaggc
     2761 tcttggaagc gatgcagttg gttttttgtt tgtttgtttg tttgtttact tttactccat
     2821 gggcattgag atggttaaga aacaatggta ctctagacta tcataagggt atatttttca
     2881 aattatgtag cttgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtacata cacacattca
     2941 tcgttttcag catttggggg aaaggcttgg ttttaagtct ctacgtgttt ccaaatgtga
     3001 ttgctaatag tcaaacgtgg cagagtaagt ttgagacgcc actaaactct gacacaactt
     3061 gggtacgaat gtaaatacag gtctctaagc aagatctgag taagtacagt gagtttttat
     3121 ttataccttg tatgtctccc ttcaggctct gtgaactgaa aagaaaatgt cttcttactg
     3181 tttaatttat atttattgtt tgagcgggaa taggacatct ttgtttccaa ccaaggtttt
     3241 ttttttgttt ttgttttttt ttgtttttgg tttttttttt tgtaattgtt atcaagagtc
     3301 tattgaggtc aatattaatt aacactgaaa caggaactgt taacccccag tactggaact
     3361 ttgtcacttc tcatcacatc cttcttactt taacaacttt gattcattta aatatgtttt
     3421 ctatagactc ctatgtgcct ttttaccttg tggccttttt attactagtc aggtacagaa
     3481 gtgtcaacag cagtgttgat ggttcttttg taccgtcaaa cagggttaag tttaccacag
     3541 aacccctgca taaggcagga cttccgtttc actaaatatc atgtggaagg tttgccatgc
     3601 acatggatag acagatatag tcgatgcttt tcattataat gaaagtagaa aagtatagaa
     3661 agaccatgaa acagcagttc tgcaggctat gactatgaaa acaacctttt tttttttaat
     3721 tctgttttgg ttttagtttt cttgagacag ggtttctctg ttaaacagag aaactgttac
     3781 tgaccatcct ggaactcact ctgtagacca ggctggcctt gaactcacag agattcacct
     3841 gcctctgcct tccaagtacc gggattcaag gcatgggcca ccactaccca gcttgacaac
     3901 aaccacttaa aataaaaaat atatatgtaa attgtactaa aaatctgttc aactgaagct
     3961 catttccagt gttttgaatt ggtcggtata catgactgtt gcctgtcgta tttaatgaag
     4021 taaatccttc cggtttctgt gggaaatttt gtttaaaagt tttagtagga ctctgcatct
     4081 atgatataac aatgcaatgc ctttatgctg ttagtccagg gcatctctga tttcagaaag
     4141 aaggcgactt tttctaaggt gacttctcag ttgctaagca caaagatagt accactcctt
     4201 ggttttgtta aggtggtgga agggtttcta actaacacac tcatcagctg agcctgcaga
     4261 gtaacggtca ctggggactt aacatttgtt gttacacaag ggaactttca gtcaagatta
     4321 agagccctat gaagaattct gtgcccatca ttttgatcaa gaacctaaat cccatttttg
     4381 tgaaattggt gaatgtccct caattgctga aatatgcaat ttgggccaga ggttgttgtt
     4441 tgtttgtttt ggatgttctt gttttatttt catgaagcca gttgcttcag tgtggttttc
     4501 cactctgaca ctacttacac agcttggctg cccccgtctc ccagttattt actgatcata
     4561 ttaatgtgat tagcatcctg gtcttgtagt atagtttaca tttttaaaaa atgttatttt
     4621 ttactagatt gctgcagata tcaagaggac attattttaa aatacctgtc tggtaaggga
     4681 agtgggaaag tcaaaacgtt ctataaggcg ggtgtgtgtg ggtgtctgcg tgcgtgtgat
     4741 ggaaaactcc catatatctg acaaaagtat cttttttatt ccgagttctt cctccttttc
     4801 tccttatgag aaagaaaaga tagcacaaaa ctaagtactt acctaggaaa tgtcttcata
     4861 ttccaacatg atgagcttct agccctacaa acaccccagg tatctataca atccacccgg
     4921 taagactcag tgctcattat gagaacttac tgttctagtc tattctttca gtaaaataag
     4981 ggccagttga tatgcagccc atgtatgtgt gaatggaata tggtaaaccc cgtgatctcc
     5041 ttgcacagaa ttgcaaatga cttttttccc caacaccaag ggcccagcct cggagccctt
     5101 ggagttcacg tggcagaata tccttcttac ataaaccaat gcttgaagat gctgcaaagg
     5161 atcctctagt gattcctgat gaggaatcag aatagaggta aataaccccc tttaaatccc
     5221 acccctgctg ctggctgtgg ggttttctgg tgccagccta tctatgcact ctatagccag
     5281 aattggcact cagctcttag ttacgtctag tagagagaat ggtctctagc attcaaagga
     5341 ggttcattcc ctcccccccc aaaacaaaca aaggcccctg tgttgtactg tataaatatc
     5401 tcatgtagat ttatagtgaa gacttaatac atgtctggtg cctttcttgt gttgtgaaag
     5461 gcaagtagat gttgtagcca taggtctgtt ttttaaatcc atagttgaat tgcacactga
     5521 ccttaactct ctgtatgtac ccttgttatt ctgcatgtta aagctggaat tcttgggcgt
     5581 gtatggcaga ctaccctgct acatcctcaa tatgtgaaca ttagtgcata aactcgagtc
     5641 ctcttttctc aagtgttttt gacagatcat ctcataaaaa taattcagga agtctgggga
     5701 aaagtcacta tgttttacaa gagcagtttc aaagtcttcc taaaacttgg atgatagacc
     5761 ctaatggtta ttttgtgtct aatcgagaca tttcgattta attagatatt accaccatat
     5821 gttttattaa tccaaattat atcgcatgtg actctttggg ttttcagggt ttctcaaaaa
     5881 aaaaaaaaag tgtatcattt tgttgcatgt actgtatgtt cagaggcaat cagttgtata
     5941 ctcaatatgg ttttactgtg ccttacctga agagaaactc tacacagaat gtatgacacg
     6001 gggtggggaa cagagcctct ctactgcact gttaggtgat agcacacggc atggcccaga
     6061 gcatttctgt gcttaattac ccaaccaaag agatctaaag tctgtatgtt gtactgtaat
     6121 gggggttatg cctggacaat ttaagtgttt tatttgtttt ctgaaatgat gtgaacttat
     6181 ttttctaaac actatgctaa ataaacttta tatttataca ta
//
