LOCUS       NP_035512                775 aa            linear   ROD 25-FEB-2025
DEFINITION  homeobox protein SIX4 isoform 1 [Mus musculus].
ACCESSION   NP_035512 XP_921977
VERSION     NP_035512.1
DBSOURCE    REFSEQ: accession NM_011382.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 775)
  AUTHORS   Wang,Y., Zhao,T., Chen,W.C., Zheng,Y., Xu,W. and Huang,S.
  TITLE     miR-540-3p partially recovers the locomotor function of spinal cord
            injury mice by targeting SIX4/Yap1 and inactivation of astrocytes
  JOURNAL   Neurol Res 46 (9), 823-834 (2024)
   PUBMED   38920017
  REMARK    GeneRIF: miR-540-3p partially recovers the locomotor function of
            spinal cord injury mice by targeting SIX4/Yap1 and inactivation of
            astrocytes.
REFERENCE   2  (residues 1 to 775)
  AUTHORS   Racedo,S.E., Liu,Y., Shi,L., Zheng,D. and Morrow,B.E.
  TITLE     Dgcr8 functions in the secondary heart field for outflow tract and
            right ventricle development in mammals
  JOURNAL   Dev Biol 506, 72-84 (2024)
   PUBMED   38110169
REFERENCE   3  (residues 1 to 775)
  AUTHORS   Wurmser,M., Madani,R., Chaverot,N., Backer,S., Borok,M., Dos
            Santos,M., Comai,G., Tajbakhsh,S., Relaix,F., Santolini,M.,
            Sambasivan,R., Jiang,R. and Maire,P.
  TITLE     Overlapping functions of SIX homeoproteins during embryonic
            myogenesis
  JOURNAL   PLoS Genet 19 (6), e1010781 (2023)
   PUBMED   37267426
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 775)
  AUTHORS   Prokopuk,L., Jarred,E.G., Blucher,R.O., McLaughlin,E.A.,
            Stringer,J.M. and Western,P.S.
  TITLE     An essential role for Polycomb Repressive Complex 2 in the mouse
            ovary
  JOURNAL   Reproduction 163 (3), 167-182 (2022)
   PUBMED   35084365
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 775)
  AUTHORS   Camolotto,S.A., Belova,V.K., Torre-Healy,L., Vahrenkamp,J.M.,
            Berrett,K.C., Conway,H., Shea,J., Stubben,C., Moffitt,R., Gertz,J.
            and Snyder,E.L.
  TITLE     Reciprocal regulation of pancreatic ductal adenocarcinoma growth
            and molecular subtype by HNF4alpha and SIX1/4
  JOURNAL   Gut 70 (5), 900-914 (2021)
   PUBMED   32826305
  REMARK    GeneRIF: Reciprocal regulation of pancreatic ductal adenocarcinoma
            growth and molecular subtype by HNF4alpha and SIX1/4.
REFERENCE   6  (residues 1 to 775)
  AUTHORS   Niiya,A., Ohto,H., Kawakami,K. and Araki,M.
  TITLE     Localization of Six4/AREC3 in the developing mouse retina;
            implications in mammalian retinal development
  JOURNAL   Exp Eye Res 67 (6), 699-707 (1998)
   PUBMED   9990334
REFERENCE   7  (residues 1 to 775)
  AUTHORS   Spitz,F., Demignon,J., Porteu,A., Kahn,A., Concordet,J.P.,
            Daegelen,D. and Maire,P.
  TITLE     Expression of myogenin during embryogenesis is controlled by
            Six/sine oculis homeoproteins through a conserved MEF3 binding site
  JOURNAL   Proc Natl Acad Sci U S A 95 (24), 14220-14225 (1998)
   PUBMED   9826681
REFERENCE   8  (residues 1 to 775)
  AUTHORS   Ohto,H., Takizawa,T., Saito,T., Kobayashi,M., Ikeda,K. and
            Kawakami,K.
  TITLE     Tissue and developmental distribution of Six family gene products
  JOURNAL   Int J Dev Biol 42 (2), 141-148 (1998)
   PUBMED   9551859
REFERENCE   9  (residues 1 to 775)
  AUTHORS   Kawakami,K., Ohto,H., Takizawa,T. and Saito,T.
  TITLE     Identification and expression of six family genes in mouse retina
  JOURNAL   FEBS Lett 393 (2-3), 259-263 (1996)
   PUBMED   8814301
REFERENCE   10 (residues 1 to 775)
  AUTHORS   Kawakami,K., Ohto,H., Ikeda,K. and Roeder,R.G.
  TITLE     Structure, function and expression of a murine homeobox protein
            AREC3, a homologue of Drosophila sine oculis gene product, and
            implication in development
  JOURNAL   Nucleic Acids Res 24 (2), 303-310 (1996)
   PUBMED   8628654
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159274.2.
            
            On Dec 7, 2005 this sequence version replaced XP_921977.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D50416.1, BC137934.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..775
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 30.36 cM"
     Protein         1..775
                     /product="homeobox protein SIX4 isoform 1"
                     /note="homeobox protein SIX4; skeletal muscle-specific
                     ARE-binding protein AREC3; sine oculis-related homeobox 4
                     homolog"
                     /calculated_mol_wt=82132
     Region          1..76
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61321.1)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UIU6; propagated from
                     UniProtKB/Swiss-Prot (Q61321.1)"
     Region          101..210
                     /region_name="SIX1_SD"
                     /note="Transcriptional regulator, SIX1, N-terminal SD
                     domain; pfam16878"
                     /db_xref="CDD:465293"
     Region          221..275
                     /region_name="homeodomain"
                     /note="Homeodomain; DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; cd00086"
                     /db_xref="CDD:238039"
     Site            order(222,262,265..266,269)
                     /site_type="other"
                     /note="specific DNA base contacts [nucleotide binding]"
                     /db_xref="CDD:238039"
     Region          263..313
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61321.1)"
     Region          582..775
                     /region_name="Transactivation domain"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61321.1)"
     Site            634
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UIU6; propagated from
                     UniProtKB/Swiss-Prot (Q61321.1)"
     CDS             1..775
                     /gene="Six4"
                     /gene_synonym="AREC3; TrexBF"
                     /coded_by="NM_011382.3:62..2389"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS25974.1"
                     /db_xref="GeneID:20474"
                     /db_xref="MGI:MGI:106034"
ORIGIN      
        1 mssssptgqi asaadikqen gmesasegqe ahrevaggaa aglsppapap fplepgdaaa
       61 asrvsreega aaagaadqvq lhsellgrhq haaaaqppla fspdhvacvc ealqqggnld
      121 rlarflwslp qsdllrgnes llkaralvaf hqgiypelys ileshsfesa nhpllqqlwy
      181 karyteaera rgrplgavdk yrlrrkfplp rtiwdgeetv ycfkeksrna lkelykqnry
      241 pspaekrhla kitglsltqv snwfknrrqr drnpsetqsk sesdgnpste desskghedl
      301 sphplsgasd gvtnlslssh vepvymqqig nakislsssg vllngslvpa stspvflngn
      361 sfiqghngvi lnglnvgntq tvslnppkms snivgngiam tdilgstsqd vkefkvlqss
      421 avnsaattsy spsapvsfpg lipctevkre giqtvasqdg gsvvtfttpv qinqygivqi
      481 pnsgangqfl ngsigfsplq lppvsvaasq gnlsvtpsts dgstftsepa tvqhgklfls
      541 pltpsavvyt vpnsgqtvga vkqeglergl vfsqlmpvnh saqvnaslss enlsgsglhp
      601 ltsslvnvsa ahgfsltppt llnptelnpd laesqpvsap vaskctvssv sntnyatlqn
      661 cslipgqdll sgpmtqaalg eivptaeeqv shastavhqd fvreqrlvlq svpnikenfl
      721 qnsenkatnn lmmldsksky vldgmveagc edlgtdkkel aklqtvqlde dmqdl
//
