LOCUS       NM_011381               3680 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus sine oculis-related homeobox 3 (Six3), mRNA.
ACCESSION   NM_011381 XM_985177 XM_985808
VERSION     NM_011381.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3680)
  AUTHORS   Ferrena,A., Zhang,X., Shrestha,R., Zheng,D. and Liu,W.
  TITLE     Six3 and Six6 jointly control diverse target genes in multiple cell
            populations over developmental trajectories of mouse embryonic
            retinal progenitor cells
  JOURNAL   PLoS One 19 (10), e0308839 (2024)
   PUBMED   39446806
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3680)
  AUTHORS   Dudukcu,O., Raj,D.D.A., van de Haar,L.L., Grossouw,L.M.,
            Linders,L.E., Garritsen,O., Adolfs,Y., van Kronenburg,N.C.H.,
            Broekhoven,M.H., Kapteijns,T.H.W., Meye,F.J. and Pasterkamp,R.J.
  TITLE     Molecular diversity and migration of GABAergic neurons in the
            developing ventral midbrain
  JOURNAL   iScience 27 (11), 111239 (2024)
   PUBMED   39569362
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3680)
  AUTHORS   Yu,H., Chiang,A., Rubinstein,M. and Low,M.J.
  TITLE     The homeodomain transcription factor Six3 regulates hypothalamic
            Pomc expression and its absence from POMC neurons induces
            hyperphagia and mild obesity in male mice
  JOURNAL   Mol Metab 87, 101993 (2024)
   PUBMED   39025297
  REMARK    GeneRIF: The homeodomain transcription factor Six3 regulates
            hypothalamic Pomc expression and its absence from POMC neurons
            induces hyperphagia and mild obesity in male mice.
REFERENCE   4  (bases 1 to 3680)
  AUTHORS   Schott,M., Leon-Perinan,D., Splendiani,E., Strenger,L., Licha,J.R.,
            Pentimalli,T.M., Schallenberg,S., Alles,J., Samut Tagliaferro,S.,
            Boltengagen,A., Ehrig,S., Abbiati,S., Dommerich,S., Pagani,M.,
            Ferretti,E., Macino,G., Karaiskos,N. and Rajewsky,N.
  TITLE     Open-ST: High-resolution spatial transcriptomics in 3D
  JOURNAL   Cell 187 (15), 3953-3972 (2024)
   PUBMED   38917789
REFERENCE   5  (bases 1 to 3680)
  AUTHORS   Takata,N., Miska,J.M., Morgan,M.A., Patel,P., Billingham,L.K.,
            Joshi,N., Schipma,M.J., Dumar,Z.J., Joshi,N.R., Misharin,A.V.,
            Embry,R.B., Fiore,L., Gao,P., Diebold,L.P., McElroy,G.S.,
            Shilatifard,A., Chandel,N.S. and Oliver,G.
  TITLE     Lactate-dependent transcriptional regulation controls mammalian eye
            morphogenesis
  JOURNAL   Nat Commun 14 (1), 4129 (2023)
   PUBMED   37452018
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3680)
  AUTHORS   Furukawa,T., Kozak,C.A. and Cepko,C.L.
  TITLE     rax, a novel paired-type homeobox gene, shows expression in the
            anterior neural fold and developing retina
  JOURNAL   Proc Natl Acad Sci U S A 94 (7), 3088-3093 (1997)
   PUBMED   9096350
REFERENCE   7  (bases 1 to 3680)
  AUTHORS   Sornson,M.W., Wu,W., Dasen,J.S., Flynn,S.E., Norman,D.J.,
            O'Connell,S.M., Gukovsky,I., Carriere,C., Ryan,A.K., Miller,A.P.,
            Zuo,L., Gleiberman,A.S., Andersen,B., Beamer,W.G. and
            Rosenfeld,M.G.
  TITLE     Pituitary lineage determination by the Prophet of Pit-1 homeodomain
            factor defective in Ames dwarfism
  JOURNAL   Nature 384 (6607), 327-333 (1996)
   PUBMED   8934515
REFERENCE   8  (bases 1 to 3680)
  AUTHORS   Kawakami,K., Ohto,H., Takizawa,T. and Saito,T.
  TITLE     Identification and expression of six family genes in mouse retina
  JOURNAL   FEBS Lett 393 (2-3), 259-263 (1996)
   PUBMED   8814301
REFERENCE   9  (bases 1 to 3680)
  AUTHORS   Oliver,G., Mailhos,A., Wehr,R., Copeland,N.G., Jenkins,N.A. and
            Gruss,P.
  TITLE     Six3, a murine homologue of the sine oculis gene, demarcates the
            most anterior border of the developing neural plate and is
            expressed during eye development
  JOURNAL   Development 121 (12), 4045-4055 (1995)
   PUBMED   8575305
REFERENCE   10 (bases 1 to 3680)
  AUTHORS   Oliver,G., Wehr,R., Jenkins,N.A., Copeland,N.G., Cheyette,B.N.,
            Hartenstein,V., Zipursky,S.L. and Gruss,P.
  TITLE     Homeobox genes and connective tissue patterning
  JOURNAL   Development 121 (3), 693-705 (1995)
   PUBMED   7720577
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD351258.1, BC098096.1 and AC166821.2.
            
            On Sep 17, 2009 this sequence version replaced NM_011381.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098096.1, D83145.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849388, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-380               CD351258.1         1-380
            381-1592            BC098096.1         1-1212
            1593-3680           AC166821.2         82017-84104
FEATURES             Location/Qualifiers
     source          1..3680
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 55.42 cM"
     gene            1..3680
                     /gene="Six3"
                     /gene_synonym="E130112M24Rik; Six3a; Six3alpha; Six3b;
                     Six3beta"
                     /note="sine oculis-related homeobox 3"
                     /db_xref="GeneID:20473"
                     /db_xref="MGI:MGI:102764"
     exon            1..1215
                     /gene="Six3"
                     /gene_synonym="E130112M24Rik; Six3a; Six3alpha; Six3b;
                     Six3beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             407..1408
                     /gene="Six3"
                     /gene_synonym="E130112M24Rik; Six3a; Six3alpha; Six3b;
                     Six3beta"
                     /note="sine oculis homeobox homolog 3; sine oculis-related
                     homeobox 3 homolog"
                     /codon_start=1
                     /product="homeobox protein SIX3"
                     /protein_id="NP_035511.2"
                     /db_xref="CCDS:CCDS50203.1"
                     /db_xref="GeneID:20473"
                     /db_xref="MGI:MGI:102764"
                     /translation="MVFRSPLDLYSSHFLLPNFADSHHCSLLLASSGGGSGASGGGGG
                     AGGGGGGNRAGGGGAGGAGGGSGGGGSRAPPEELSMFQLPTLNFSPEQVASVCETLEE
                     TGDIERLGRFLWSLPVAPGACEAINKHESILRARAVVAFHTGNFRDLYHILENHKFTK
                     ESHGKLQAMWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERT
                     RSLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNRLQHQAI
                     GPSGMRSLAEPGCPTHGSAESPSTAASPTTSVSSLTERADTGTSILSVTSSDSECDV"
     exon            1216..3680
                     /gene="Six3"
                     /gene_synonym="E130112M24Rik; Six3a; Six3alpha; Six3b;
                     Six3beta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2685..2690
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Six3"
                     /gene_synonym="E130112M24Rik; Six3a; Six3alpha; Six3b;
                     Six3beta"
                     /note="hexamer: AATACA"
     polyA_site      2711
                     /gene="Six3"
                     /gene_synonym="E130112M24Rik; Six3a; Six3alpha; Six3b;
                     Six3beta"
                     /note="major polyA site"
ORIGIN      
        1 attgctgtgg aatcgctgaa tcttgactcg gccgtggttg gctctcgctc tcctctctcc
       61 ctctccctct ctctgcctcg ggctcgcgct ctctctctct ctctctctct ctctctctct
      121 ctctctctct ctctctctct ctctctctgc gcgcgcgcac cgggccgctc tccttcctcc
      181 ctctctatgt ggctgcgcgg gtgtgtgtgt atgtggatgt gtgtggggtg tgggtgtccc
      241 ttacgtcctt cctcctcccc ctccttctcc ttctgctccc ccctcctttc catctcctcc
      301 tcccccctct cctctccctc ctcctggtcc tcatcgcccc tctcctcctc ttcctcccct
      361 ctctcttcct ctccctgaat tttttcctct cctctcaggt cagtccatgg tattccgctc
      421 ccccctagat ctctattcct cccacttctt gttgccaaac ttcgccgatt ctcaccactg
      481 ctccctactt ctggcgagta gcggcggcgg gagcggtgcg agcggcggcg gcggcggcgc
      541 gggaggaggc ggcggcggga accgtgcggg aggcggcggt gctggcggag caggcggcgg
      601 cagcggcggc ggcggctcca gggccccccc ggaagagttg tccatgttcc agttgcccac
      661 cctcaacttc tcgccggagc aggtggccag cgtctgcgag acgctggagg agacgggcga
      721 catcgagcgg ctgggccgct tcctctggtc gctgcccgtg gcccccgggg cgtgcgaggc
      781 catcaacaaa cacgagtcga tcctgcgcgc gcgcgctgtc gtcgccttcc acaccggcaa
      841 cttccgcgac ctgtaccaca tcctggagaa ccacaagttc actaaggagt ctcacggcaa
      901 gctgcaagcc atgtggctcg aggcgcacta ccaggaggcc gagaagctgc gcggccgccc
      961 gctcggcccg gtggacaagt accgcgtgcg caagaagttc cctctgccgc gcaccatctg
     1021 ggatggcgag cagaagaccc attgcttcaa ggagcggact cggagcctgc tgcgggagtg
     1081 gtacctgcag gatccctacc ccaaccccag caagaaacgc gaactggcgc aggccaccgg
     1141 cctcaccccc acacaagtag gcaactggtt taagaaccgg cgacagcgcg accgcgcagc
     1201 ggcggccaag aacaggctcc agcatcaggc catcgggccg agcgggatgc gctcgctggc
     1261 cgagcccggc tgccccacgc acggctcagc agagtcaccg tccacggcgg ccagcccgac
     1321 caccagtgtg tccagcctga cggagcgcgc ggacaccggc acttcgatcc tctcggtaac
     1381 ctccagcgac tcggaatgtg atgtatgata gccaaggccg ccctactcct ccccctcctc
     1441 cccttccacc ttcccctcct cttcgtaacc ctgctcctct tcctcttctt ctactccatc
     1501 cctagaacaa accgaaatca ggatacacag acagatacac acacaagtcc atacacactc
     1561 ccaccccagc caaaaatata tttaaaaaaa aacaagaaaa ataaattaac ctcaaaccat
     1621 caacaacccc accaccacct actaccacgg ccaccccaaa ggaccgcgac gccaacagac
     1681 agtcacaaac gctgatgttg cgggcagaaa gcataaaaga ggtgacaatt gtatactttc
     1741 taggacaagc acggcttctc cttttggttc ccacggaccc ggcaccccac ctgcatgacg
     1801 atttatttgt atctgggaaa atattctctc tagtttaaaa tgatttaaag agactataca
     1861 aaaaaacaaa aacaaaaaca aaaaaaaaac accaccaccg ccgctgcgac aagacgacaa
     1921 aaagcagaca aaaagaaaaa aatctgacct ctccgttttg aatttgttgt ttaaaaaaaa
     1981 aaaaggaaag aaagatagga aaaaactcct cgagagaaat agcaaatgtt tctaccttct
     2041 gttgctcttt tctcctttgg ccctctctct ctctctctct ctctctctct ctctctctct
     2101 ctctctctct ctctctctgt ttttaagtcc aagtattggt caaacaaaat gcaatcctct
     2161 gtttttgttc agccgacaat cattttcttc gtaagcacct ttttctctcc actctgtcac
     2221 tgcctgtgtg ggtactggtt ataaatgtgg aaaaagaata gttatgactg taacagattt
     2281 ttatttttat ttcaaaattt tatatgaatt atgtatatct taatgatcgg tcattttccc
     2341 agtttgtaat atatgtgtag aaattgcttg tatatgatcc ctgctttttt ctcctctccc
     2401 ttctctctct cctccctcct tccctcccac tcacctcttt ccttttgggg attctcggcg
     2461 tcgacttggc gatcgaggtt tggcgaggtg gccagggtta gagagagaga aagagagaga
     2521 gggaccctgt cgctagtgaa agcagagagt gagaccgtag tattcttatg caaaagctat
     2581 tcaagttttt cctagccgct ttggaggccc cattcactcc tgtagagcgc ttttactgtt
     2641 atcttaactg cgtgtttatc tatatgtaaa aactttctaa agcaaataca gtattctcca
     2701 ttttcttatc actcccagag actggtgttt gtgtccgccc tggcaaacag ctcccgggtg
     2761 ctgtaacagc ccagcttccc gcttgctctc tctaactcgc tggccgccag agccagagcc
     2821 ggggaggggg aaggatgcca aatgtgagtg gaaaactgga aacaaacact tgcttgggga
     2881 aagggagccc aaacaggatc ccgagggaaa ggcaaagggg gcatgagggt agggggttac
     2941 aactagtttc ttccatgaca agatgtcagg cctgaatcct ccccggagtg ctgtaccctg
     3001 gatttgctgc atctcgcggc gcttgtgagc ccttggaatg tttggtagcc ttctagttgc
     3061 ctgcttttta aaaaggagaa accctaaggc tccctaaccc aagcgaccgt cctaagcaca
     3121 gctgcaattc tattttcctt gtattttttt taatctctct ctcttttttg gaggagatgt
     3181 aaagtggtta actagggccc agatgaacaa gggtcgggag tgggtgggag aaggaggcag
     3241 ttttctgact tcagggcctg aaatgcggtt gctctccctc ccaccttcat tggcatcctt
     3301 gtccgaccga gtcacctgtc ttaagattct ggatctatgt gtctgaaaaa aaaatgtcct
     3361 tgtcttttgg gatcacctgg agtcccttag tttctgaagg atttttggtt cgtttgcatg
     3421 gtaaaggaaa accagtaaca aaacaaaaaa ctaccccttg ctgaccacgt tcctctgctg
     3481 gccccaagct ttcctggccg gctgtggccg cacaactccc gaggagagct ggctgggagg
     3541 aagtggttct gctgctctgg gccaaggcgg cctgcgcgct tgagaagggg ccaaagaggt
     3601 gatttcagaa aacttgcctt cacttgaaaa gtccaatttc aaagctaggg gggattaaaa
     3661 agaaaccagt ctgaaattta
//
