LOCUS       NM_011380               2108 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus sine oculis-related homeobox 2 (Six2), mRNA.
ACCESSION   NM_011380
VERSION     NM_011380.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2108)
  AUTHORS   Hudacova,E., Abaffy,P., Kaplan,M.M., Krausova,M., Kubista,M. and
            Machon,O.
  TITLE     Single-cell transcriptomic resolution of osteogenesis during
            craniofacial morphogenesis
  JOURNAL   Bone 190, 117297 (2025)
   PUBMED   39461490
REFERENCE   2  (bases 1 to 2108)
  AUTHORS   Pina,J.O., Raju,R., Roth,D.M., Winchester,E.W., Padilla,C.,
            Iben,J., Faucz,F.R., Cotney,J.L. and D'Souza,R.N.
  TITLE     Spatial Multi-omics Reveals the Role of the Wnt Modulator, Dkk2, in
            Palatogenesis'
  JOURNAL   J Dent Res 103 (13), 1412-1420 (2024)
   PUBMED   38910391
REFERENCE   3  (bases 1 to 2108)
  AUTHORS   Cai,S. and Yin,N.
  TITLE     Single-cell transcriptome and chromatin accessibility mapping of
            upper lip and primary palate fusion
  JOURNAL   J Cell Mol Med 28 (19), e70128 (2024)
   PUBMED   39392189
REFERENCE   4  (bases 1 to 2108)
  AUTHORS   Bugacov,H., Der,B., Briantseva,B.M., Guo,Q., Kim,S., Lindstrom,N.O.
            and McMahon,A.P.
  TITLE     Dose-dependent responses to canonical Wnt transcriptional complexes
            in the regulation of mammalian nephron progenitors
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39250420
REFERENCE   5  (bases 1 to 2108)
  AUTHORS   Song,L., Li,Q., Xia,L., Sahay,A.E., Qiu,Q., Li,Y., Li,H.,
            Sasaki,K., Susztak,K., Wu,H. and Wan,L.
  TITLE     Single-cell multiomics reveals ENL mutation perturbs kidney
            developmental trajectory by rewiring gene regulatory landscape
  JOURNAL   Nat Commun 15 (1), 5937 (2024)
   PUBMED   39009564
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2108)
  AUTHORS   Kawakami,K., Ohto,H., Takizawa,T. and Saito,T.
  TITLE     Identification and expression of six family genes in mouse retina
  JOURNAL   FEBS Lett 393 (2-3), 259-263 (1996)
   PUBMED   8814301
REFERENCE   7  (bases 1 to 2108)
  AUTHORS   Torres,M., Gomez-Pardo,E., Dressler,G.R. and Gruss,P.
  TITLE     Pax-2 controls multiple steps of urogenital development
  JOURNAL   Development 121 (12), 4057-4065 (1995)
   PUBMED   8575306
REFERENCE   8  (bases 1 to 2108)
  AUTHORS   Oliver,G., Mailhos,A., Wehr,R., Copeland,N.G., Jenkins,N.A. and
            Gruss,P.
  TITLE     Six3, a murine homologue of the sine oculis gene, demarcates the
            most anterior border of the developing neural plate and is
            expressed during eye development
  JOURNAL   Development 121 (12), 4045-4055 (1995)
   PUBMED   8575305
REFERENCE   9  (bases 1 to 2108)
  AUTHORS   Holmberg,M., Leonardsson,G. and Ny,T.
  TITLE     The species-specific differences in the cAMP regulation of the
            tissue-type plasminogen activator gene between rat, mouse and human
            is caused by a one-nucleotide substitution in the cAMP-responsive
            element of the promoters
  JOURNAL   Eur J Biochem 231 (2), 466-474 (1995)
   PUBMED   7543410
REFERENCE   10 (bases 1 to 2108)
  AUTHORS   Oliver,G., Wehr,R., Jenkins,N.A., Copeland,N.G., Cheyette,B.N.,
            Hartenstein,V., Zipursky,S.L. and Gruss,P.
  TITLE     Homeobox genes and connective tissue patterning
  JOURNAL   Development 121 (3), 693-705 (1995)
   PUBMED   7720577
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC068021.1 and AC166821.2.
            
            On Apr 18, 2009 this sequence version replaced NM_011380.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D83147.1, X80338.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1578              BC068021.1         1-1578
            1579-2108           AC166821.2         142181-142710       c
FEATURES             Location/Qualifiers
     source          1..2108
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 55.72 cM"
     gene            1..2108
                     /gene="Six2"
                     /note="sine oculis-related homeobox 2"
                     /db_xref="GeneID:20472"
                     /db_xref="MGI:MGI:102778"
     exon            1..862
                     /gene="Six2"
                     /inference="alignment:Splign:2.1.0"
     exon            863..2108
                     /gene="Six2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1431..1436
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Six2"
                     /note="hexamer: AATAAA"
     polyA_site      1452
                     /gene="Six2"
     regulatory      2079..2084
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Six2"
                     /note="hexamer: AATAAA"
     polyA_site      2099
                     /gene="Six2"
                     /note="major polyA site"
ORIGIN      
        1 cgaacgagcg aggagccggc gagcgagcgg cgggcgggcg cggagcatgc ggagcggcgc
       61 cccgggcggc ctccgggctt gggcgcgggc gaggcgcgcg ggcggcgggg gcgcggagct
      121 gcgcggggcc ggcggcggga gcgaggacgg atcgttgtga ctcaggagtc gctcgggagc
      181 cggcgcctgg ccagggggcc ccgcccgcct gtcggccggc cggggccggc ggggaggcgc
      241 ccatgcgggg ccgcgaagcg cggtgagggc gcgcgcgggc gggcgggcgc gcagccgcca
      301 ccatgtccat gctgcccacc ttcggcttca cgcaggagca agtggcgtgc gtgtgcgagg
      361 tgctgcagca gggcggcaac atcgagcggc tgggtcgctt cctgtggtcg ctgcccgcct
      421 gcgagcacct ccacaagaat gaaagcgtgc tcaaggccaa ggccgtggtg gccttccacc
      481 ggggcaactt ccgcgagctc tacaaaatcc tggagagcca ccagttctcg ccgcacaacc
      541 acgccaagct gcagcagttg tggctcaagg cgcactacat cgaggcggag aagctgcgcg
      601 gccggccgct gggcgccgtg ggcaagtacc gcgtgcggcg caagttcccg ctgccccgct
      661 ccatctggga cggcgaggag accagctact gcttcaagga gaagagccgc agcgtgctgc
      721 gcgagtggta cgctcacaac ccctacccgt cgccacgaga gaagcgcgag ctggccgagg
      781 ccaccggcct caccaccacg caagtcagca actggttcaa gaaccggcgg cagcgcgaca
      841 gggcggccga ggccaaggaa agggagaaca gcgagaactc caattccagc agccacaacc
      901 cgctggcttc ctcgctcaat ggcagtggca agtcggtgct aggcagttcc gaggatgaga
      961 agacgccgtc ggggactcca gaccactcgt cgtccagtcc cgctctgttg ctcagcccgc
     1021 cgccgccccc tgggctgcct tccctgcaca gcctgggcca ccctccgggc ccgagcgcag
     1081 tacccgtacc agtgcccggt ggaggcggcg cggacccact gcagcatcac cacagcctgc
     1141 aggactccat actcaacccc atgtcggcca accttgtgga cctgggctcc tagagctctg
     1201 ttcgcctccg ggcgcttgct ttccgtgctt gatgaagcgg tgtgggaggg cgatagattc
     1261 tggagtctgt gccgcgtact ggaagactgc cctgccacgc tggagcggca gaaccggcgg
     1321 cgggacaaag tggacaatgg tctgctcggt atcctttggg gattcatttt caacaagttg
     1381 cttttgagat cctttggagg ccagagaccg agtcttgaac taggcaaggg aataaattat
     1441 aagccaccac caccccgatt tttaaaaaat ctcttctcct ttctctctcc tttttctttc
     1501 ctctactttc ctttcgagtt tatttcattt ttttctctct ccccgcttta cgttttctct
     1561 ttccctcctt tataaatatc tctctctctc tctctctctc tctctctctc tctctctctc
     1621 tctctctctc tctcatttct cacattgtat ccccagtctt tcttccttct ggtgtcatct
     1681 atttgagttc ctttctcaac tttctaagag tccgacgtga tgtgaacgga ggtagacatt
     1741 ctgggtcttc ggtcctcaaa gacatctccc tcctctcagt gtgagcctaa ggtgccagct
     1801 tctgactaac aaatgagcaa gaaaggctgc accccagaag cacctgaatt ctcatttctc
     1861 tctctctctc tctctctctc tctctctctc tctctctctc tctctctctc tctctctctc
     1921 tctctccctc ttccccacct cgctggttct tctcttcctc ctgggactgt gacctccgtg
     1981 ctcccagccc agagtgcctc cgcagccgca gacttgcctg ttccatttta cgccctcatg
     2041 tgaatgttcg tcgggagata tttctgcttt tattttataa taaaattaga aaccataaat
     2101 atatggat
//
