LOCUS       NM_009189               2849 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus sine oculis-related homeobox 1 (Six1), mRNA.
ACCESSION   NM_009189
VERSION     NM_009189.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2849)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 2849)
  AUTHORS   Liu,X., Cui,H., Bai,Q., Piao,H., Song,Y. and Yan,G.
  TITLE     miR-128-3p alleviates airway inflammation in asthma by targeting
            SIX1 to regulate mitochondrial fission and fusion
  JOURNAL   Int Immunopharmacol 130, 111703 (2024)
   PUBMED   38422767
  REMARK    GeneRIF: miR-128-3p alleviates airway inflammation in asthma by
            targeting SIX1 to regulate mitochondrial fission and fusion.
REFERENCE   3  (bases 1 to 2849)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2849)
  AUTHORS   Tsimpos,P., Desiderio,S., Cabochette,P., Poelvoorde,P., Kricha,S.,
            Vanhamme,L., Poulard,C. and Bellefroid,E.J.
  TITLE     Loss of G9a does not phenocopy the requirement for Prdm12 in the
            development of the nociceptive neuron lineage
  JOURNAL   Neural Dev 19 (1), 1 (2024)
   PUBMED   38167468
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2849)
  AUTHORS   Stevenson,M.J., Phanor,S.K., Patel,U., Gisselbrecht,S.S.,
            Bulyk,M.L. and O'Brien,L.L.
  TITLE     Altered binding affinity of SIX1-Q177R correlates with enhanced
            WNT5A and WNT pathway effector expression in Wilms tumor
  JOURNAL   Dis Model Mech 16 (11) (2023)
   PUBMED   37815464
REFERENCE   6  (bases 1 to 2849)
  AUTHORS   Spitz,F., Demignon,J., Porteu,A., Kahn,A., Concordet,J.P.,
            Daegelen,D. and Maire,P.
  TITLE     Expression of myogenin during embryogenesis is controlled by
            Six/sine oculis homeoproteins through a conserved MEF3 binding site
  JOURNAL   Proc Natl Acad Sci U S A 95 (24), 14220-14225 (1998)
   PUBMED   9826681
REFERENCE   7  (bases 1 to 2849)
  AUTHORS   Ohto,H., Takizawa,T., Saito,T., Kobayashi,M., Ikeda,K. and
            Kawakami,K.
  TITLE     Tissue and developmental distribution of Six family gene products
  JOURNAL   Int J Dev Biol 42 (2), 141-148 (1998)
   PUBMED   9551859
REFERENCE   8  (bases 1 to 2849)
  AUTHORS   Kawakami,K., Ohto,H., Takizawa,T. and Saito,T.
  TITLE     Identification and expression of six family genes in mouse retina
  JOURNAL   FEBS Lett 393 (2-3), 259-263 (1996)
   PUBMED   8814301
REFERENCE   9  (bases 1 to 2849)
  AUTHORS   Boucher,C.A., Carey,N., Edwards,Y.H., Siciliano,M.J. and
            Johnson,K.J.
  TITLE     Cloning of the human SIX1 gene and its assignment to chromosome 14
  JOURNAL   Genomics 33 (1), 140-142 (1996)
   PUBMED   8617500
REFERENCE   10 (bases 1 to 2849)
  AUTHORS   Oliver,G., Wehr,R., Jenkins,N.A., Copeland,N.G., Cheyette,B.N.,
            Hartenstein,V., Zipursky,S.L. and Gruss,P.
  TITLE     Homeobox genes and connective tissue patterning
  JOURNAL   Development 121 (3), 693-705 (1995)
   PUBMED   7720577
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK131925.1, AK031122.1, AV495228.1, BB031732.1 and EH094589.1.
            
            On Apr 18, 2009 this sequence version replaced NM_009189.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031122.1, X80339.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1764              AK131925.1         2-1765
            1765-2442           AK031122.1         1520-2197
            2443-2675           AV495228.1         116-348
            2676-2721           BB031732.1         247-292
            2722-2849           EH094589.1         155-282
FEATURES             Location/Qualifiers
     source          1..2849
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 30.34 cM"
     gene            1..2849
                     /gene="Six1"
                     /note="sine oculis-related homeobox 1"
                     /db_xref="GeneID:20471"
                     /db_xref="MGI:MGI:102780"
     exon            1..846
                     /gene="Six1"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..1141
                     /gene="Six1"
                     /note="sine oculis homeobox homolog 1; sine oculis-related
                     homeobox 1 homolog"
                     /codon_start=1
                     /product="homeobox protein SIX1"
                     /protein_id="NP_033215.2"
                     /db_xref="CCDS:CCDS25973.1"
                     /db_xref="GeneID:20471"
                     /db_xref="MGI:MGI:102780"
                     /translation="MSMLPSFGFTQEQVACVCEVLQQGGNLERLGRFLWSLPACDHLH
                     KNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYVEAEKLRGRP
                     LGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRGVLREWYAHNPYPSPREKRELAEA
                     TGLTTTQVSNWFKNRRQRDRAAEAKERENTENNNSSSNKQNQLSPLEGGKPLMSSSEE
                     EFSPPQSPDQNSVLLLQSNMGHARSSNYSLPGLTASQPSHGLQAHQHQLQDSLLGPLT
                     SSLVDLGS"
     exon            847..2849
                     /gene="Six1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1831..1836
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Six1"
                     /note="hexamer: AATACA"
     polyA_site      1856
                     /gene="Six1"
                     /note="major polyA site"
     regulatory      2140..2145
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Six1"
                     /note="hexamer: ATTAAA"
     polyA_site      2161
                     /gene="Six1"
     regulatory      2695..2700
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Six1"
                     /note="hexamer: ATTAAA"
     polyA_site      2716
                     /gene="Six1"
                     /note="major polyA site"
     regulatory      2831..2836
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Six1"
                     /note="hexamer: AATATA"
     polyA_site      2847
                     /gene="Six1"
ORIGIN      
        1 aagttccccg gcaaccagca gcatccaccc ggcggcaggc gggagccagc gaggcccaga
       61 aggctgtaga gaacgccagc cactcggagt ctagctcacc cctacttctc ttcgtcttcc
      121 ttggcctccc acccgccgag gttcgactgg tctcttcgcc cgcgccaagg ctagggaggg
      181 ggttaggagc agccgcgccc ccctccccgc ggcagccgcc ccctgctctc ccagctctgc
      241 tcactgccgc gtgcgcccgg gcccgtgcgc cccggcagcg ccagccatgt cgatgctgcc
      301 gtcgtttggt tttacgcaag agcaagtggc gtgcgtgtgc gaagttctgc agcaaggagg
      361 gaacctggaa cgcctgggca ggttcttgtg gtcgttgccc gcctgcgatc acctgcacaa
      421 gaacgagagc gtgctcaagg ccaaggcggt ggtcgccttc caccgcggca acttccgcga
      481 gctctacaag atactggaga gccaccagtt ctcgcctcac aatcacccca aactgcagca
      541 gctgtggctg aaagcgcact acgtggaggc cgagaaactt cgcggccgac ccctgggtgc
      601 cgtgggcaaa tatcgggtgc gccgaaaatt cccgttgccg cggaccatct gggacggcga
      661 ggagaccagc tactgcttta aggagaagtc tcggggcgtg ctgcgggagt ggtacgcgca
      721 caacccctac ccctcaccga gggagaaacg ggagctggcc gaggccaccg gcctcaccac
      781 cacccaggtc agcaactggt ttaagaaccg gaggcaaaga gaccgggccg ccgaggccaa
      841 ggaaagggag aacaccgaaa acaataactc ctcctccaac aagcagaatc aactctctcc
      901 tctggaaggg ggcaagccgc tcatgtccag ctcagaagag gagttctcac ccccccaaag
      961 tccagaccag aactcggtcc ttctgctcca gagcaatatg ggccacgcca ggagctcaaa
     1021 ctattctctt ccaggcctca cagcctccca gcccagccac ggtctgcaag cccatcagca
     1081 ccagctccag gactctctgc tgggcccact cacctccagt ttggtggact tgggttccta
     1141 agtggggaga tattggggcc ttgaagggat ggccggagca gcaaccaacc gcagcaatct
     1201 aggggacact tgtacataga agccagggac aattctgcag cttgtttctg gggttctttg
     1261 cgcagaaagg aaccacaggc tttcacaatt gtctttttaa aaattacaac caacagcggt
     1321 ctcagttgag catcctctcc ctcctctcca actcttaata cccttgcatt tcccctccca
     1381 ctaaaaggtc aggaaataac aaaaacagcc aggcttggtt ctgggcaacc caggcatcct
     1441 ttacagtagt cccttattcc acctcttctt cctcctcctc ctcgtcttct tttaatgaac
     1501 agaaattaca aatcagctgg attgtaatta tttttttaat ttatttatgg agaaacggtt
     1561 tagggaagag gaaaaggaaa tgaagagaga tcaaaataat gaaaacaaga aaccttcagt
     1621 gtgaggggaa ctggctgcct tcttaagaca aataggaaaa ctataatcac agctgttttt
     1681 tgatgggaag attaagttta catttttcat atttagtgtt aaataatttt atgtagatta
     1741 aaataaaaga gcagtattag caagggaaac aagtgcctaa atgtcttaat gctctctatg
     1801 ggaggcggtt agggtagcag cgatgttagt aatacaacta tttttgtcaa atttaatagg
     1861 ggttttggtg attgttttct tgttttgttt tgttttttaa tttttatgac aaactctaaa
     1921 cgtgtaccaa cgagggaggg ggaaaacccg ctttcctaaa tgtcatcagt tcttcctcag
     1981 aaactctcct atctgtaggc tgcctctgtg cagagggctc tgctactact cctagttcct
     2041 acttacaaga gggtgccaac caatctggca gcccggtgtt tgttactaaa acagcatgtg
     2101 tttttaggcc tcctttctat tgtacctaaa ccagtctaaa ttaaaactca gtagcccagc
     2161 aggagtttga ttctgtttct gaaaggtgag ttgtgtattg ctgtcaccgg gcctatttaa
     2221 aaacaagttt tcttgctttc ttagtagtag ttgtgagttg cagagggtat ttttgaagtc
     2281 tgtcacccga aacagagaga atagtggcta ggttaatgat atgacgaaag aaaaaaaaaa
     2341 ttagccttgg gtatttattt atttttttgt tatttagaaa tgcagttttg tttaccactg
     2401 tttcttctcc acagccttca tatgttagct tggctctttt gtgttagcaa cttatgaaaa
     2461 gactgtgaca gcaaacctaa tttatctatt tttttaaaag ggaactcgaa caagaattta
     2521 agattatgaa ttgaattgta caaataaaaa agcaggtcat cggaagctct tttgtcagat
     2581 agtgcccaga aaaatcccag gaatcaagaa ggctccatga tctttttgcc tggggcaaaa
     2641 tgatgtatct tctgtattta gcttttaaga ctagtaagac aaatggcatt atttattaaa
     2701 attctactca ggataacagg gttggcttgc tcatgctttg taaaatattg ttccccaggg
     2761 agagtttatt tattttctga catgacagtt tcataatttt gatttttcct catctataag
     2821 tgtcaatatt aatatatttc tttcttatc
//
