LOCUS       NM_019436               1201 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus suppression inducing transmembrane adaptor 1 (Sit1),
            mRNA.
ACCESSION   NM_019436
VERSION     NM_019436.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1201)
  AUTHORS   Arndt,B., Kalinski,T., Reinhold,D., Thielitz,A., Roessner,A.,
            Schraven,B. and Simeoni,L.
  TITLE     Cooperative immunoregulatory function of the transmembrane adaptor
            proteins SIT and LAX
  JOURNAL   J Leukoc Biol 93 (3), 353-362 (2013)
   PUBMED   23307938
  REMARK    GeneRIF: SIT and LAX are important negative regulators of immune
            responses that functionally cooperate.
REFERENCE   2  (bases 1 to 1201)
  AUTHORS   Arndt,B., Krieger,T., Kalinski,T., Thielitz,A., Reinhold,D.,
            Roessner,A., Schraven,B. and Simeoni,L.
  TITLE     The transmembrane adaptor protein SIT inhibits TCR-mediated
            signaling
  JOURNAL   PLoS One 6 (9), e23761 (2011)
   PUBMED   21957439
  REMARK    GeneRIF: SIT as an important modulator of TCR-mediated signaling
            that regulates T-cell activation, homeostasis and tolerance
REFERENCE   3  (bases 1 to 1201)
  AUTHORS   Koelsch,U., Schraven,B. and Simeoni,L.
  TITLE     SIT and TRIM determine T cell fate in the thymus
  JOURNAL   J Immunol 181 (9), 5930-5939 (2008)
   PUBMED   18941181
  REMARK    GeneRIF: SIT and T cell receptor-interacting molecule (TRIM)
            regulate cell fate of developing thymocytes and are essential
            regulators of central tolerance.
REFERENCE   4  (bases 1 to 1201)
  AUTHORS   Posevitz,V., Arndt,B., Krieger,T., Warnecke,N., Schraven,B. and
            Simeoni,L.
  TITLE     Regulation of T cell homeostasis by the transmembrane adaptor
            protein SIT
  JOURNAL   J Immunol 180 (3), 1634-1642 (2008)
   PUBMED   18209059
  REMARK    GeneRIF: SIT negatively regulates T cell homeostasis.
REFERENCE   5  (bases 1 to 1201)
  AUTHORS   Simeoni,L., Posevitz,V., Kolsch,U., Meinert,I., Bruyns,E.,
            Pfeffer,K., Reinhold,D. and Schraven,B.
  TITLE     The transmembrane adapter protein SIT regulates thymic development
            and peripheral T-cell functions
  JOURNAL   Mol Cell Biol 25 (17), 7557-7568 (2005)
   PUBMED   16107703
  REMARK    GeneRIF: SIT is a critical negative regulator of T-cell
            receptor-mediated signaling
REFERENCE   6  (bases 1 to 1201)
  AUTHORS   Marie-Cardine,A., Kirchgessner,H., Bruyns,E., Shevchenko,A.,
            Mann,M., Autschbach,F., Ratnofsky,S., Meuer,S. and Schraven,B.
  TITLE     SHP2-interacting transmembrane adaptor protein (SIT), a novel
            disulfide-linked dimer regulating human T cell activation
  JOURNAL   J Exp Med 189 (8), 1181-1194 (1999)
   PUBMED   10209036
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC064055.1.
            
            On Apr 22, 2009 this sequence version replaced NM_019436.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ236881.1, BC064055.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1201              BC064055.1         14-1214
FEATURES             Location/Qualifiers
     source          1..1201
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 23.04 cM"
     gene            1..1201
                     /gene="Sit1"
                     /gene_synonym="Sit"
                     /note="suppression inducing transmembrane adaptor 1"
                     /db_xref="GeneID:54390"
                     /db_xref="MGI:MGI:1889342"
     exon            1..172
                     /gene="Sit1"
                     /gene_synonym="Sit"
                     /inference="alignment:Splign:2.1.0"
     exon            173..311
                     /gene="Sit1"
                     /gene_synonym="Sit"
                     /inference="alignment:Splign:2.1.0"
     exon            312..370
                     /gene="Sit1"
                     /gene_synonym="Sit"
                     /inference="alignment:Splign:2.1.0"
     exon            371..435
                     /gene="Sit1"
                     /gene_synonym="Sit"
                     /inference="alignment:Splign:2.1.0"
     exon            436..1201
                     /gene="Sit1"
                     /gene_synonym="Sit"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgtcagtg ttggcgatgc tgagctgtgg aggccaggtt taaggagaca ttcgggttgt
       61 gggggctgtg acaagctgtc aggccataag taggactgac ccctgactct cacaccagca
      121 gcagtcatga gcagagatta caactgtacc actgacgatc aactcgcatg ggggatcccc
      181 tccataagcc acgcgtgggg actgtgggcc ctcttaggag ttgtgacggt gctgcttctc
      241 atctcattgg ctgcactctt gtcccagtgg acccgtggtc ggagaaggaa ccaggaggga
      301 cagggaccac tctccggaag gtccgcggaa gaagttcccc tgtatggcaa cctgcactat
      361 ttacagacag gtcggctgtc tcaagaacca aggtcagaag agcaggaccc accatcctct
      421 ggaggccttg ccaggggggc ggaggaggcc atgtgctaca ctagcctgca gctgcgacca
      481 gctcaaggtc ggatccccag ctctggaaac cccatcaagt actgtgaggt ggtgctggac
      541 tctgagccaa agccccaggc cccaggccct gagccggaac tttatgcctc cgtgtgtgcc
      601 cagacccgca gaggccgggc ttccttccca gatcaagcct atgccaacag ccagcctgca
      661 cccagctgag gaggacctgg aactgtgggc acccatggct cagctactgg gtcagggact
      721 cctgctgtcc tggctagggc atgtttggtt tctaaccacc tccagggcat tgagactttg
      781 ctgagtggca ggagcatcct aagttgcatg acagcgtcca tacatctcag agtcggaagc
      841 ctcctggttt cctgaggaag gagttgcaaa gagagatctc cacacttacc ttttctacgt
      901 tctcctgtaa gcccccaaac tcgttgctca cacctttccc tccatttagg gtttagccag
      961 gttcccccat gtcctctcta agcttacgca gatacctcat tgtctcctca gacacaggaa
     1021 gtgggcaggg agaagtgggt agaagccaga gaggatgtgg gtggatatca tgcatgggag
     1081 agcccacagc tggaaggctc ctagggtccc aagtttggtt tctgacctga aagctgggga
     1141 cagagaatgg ccttcatgct gttgcctctg gcgtcccctg ggtttcaaat aaagcatcac
     1201 a
//
